JP2014526447A5 - - Google Patents
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- Publication number
- JP2014526447A5 JP2014526447A5 JP2014528879A JP2014528879A JP2014526447A5 JP 2014526447 A5 JP2014526447 A5 JP 2014526447A5 JP 2014528879 A JP2014528879 A JP 2014528879A JP 2014528879 A JP2014528879 A JP 2014528879A JP 2014526447 A5 JP2014526447 A5 JP 2014526447A5
- Authority
- JP
- Japan
- Prior art keywords
- nasal
- nose
- carrier material
- powder
- inhaled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001331 Nose Anatomy 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 210000003928 Nasal Cavity Anatomy 0.000 description 1
- 229940100662 Nasal Drops Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000717 retained Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
担体物質が固体である、経鼻投与に適合された医薬製剤には、例えば２０〜５００ミクロンの範囲の粒径を有し、鼻から吸い込んで摂取される方法で、すなわち鼻の近傍に保持され、粉末を含有する容器から鼻腔を経由した急速な吸入により投与される粗粉末を含む。担体物質として液体を伴う鼻腔用スプレーまたは点鼻剤に好適な製剤には、水または油中の活性化合物溶液が包含される。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011112978.6 | 2011-09-09 | ||
| DE102011112978A DE102011112978A1 (de) | 2011-09-09 | 2011-09-09 | Benzonitrilderivate |
| PCT/EP2012/003449 WO2013034238A1 (de) | 2011-09-09 | 2012-08-13 | Benzonitrilderivate als kinasehemmer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526447A JP2014526447A (ja) | 2014-10-06 |
| JP2014526447A5 true JP2014526447A5 (ja) | 2015-10-01 |
| JP6060163B2 JP6060163B2 (ja) | 2017-01-11 |
Family
ID=46679243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528879A Expired - Fee Related JP6060163B2 (ja) | 2011-09-09 | 2012-08-13 | キナーゼインヒビターとしてのベンゾニトリル誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8969335B2 (ja) |
| EP (1) | EP2753615B1 (ja) |
| JP (1) | JP6060163B2 (ja) |
| KR (1) | KR101985984B1 (ja) |
| CN (1) | CN103930416B (ja) |
| AR (1) | AR087807A1 (ja) |
| AU (1) | AU2012306746B2 (ja) |
| BR (1) | BR112014005226A2 (ja) |
| CA (1) | CA2848148C (ja) |
| DE (1) | DE102011112978A1 (ja) |
| DK (1) | DK2753615T3 (ja) |
| EA (1) | EA025038B1 (ja) |
| ES (1) | ES2644128T3 (ja) |
| HK (1) | HK1199880A1 (ja) |
| HR (1) | HRP20171296T1 (ja) |
| HU (1) | HUE036774T2 (ja) |
| IL (1) | IL231382A (ja) |
| IN (1) | IN2014KN00769A (ja) |
| LT (1) | LT2753615T (ja) |
| MX (1) | MX344335B (ja) |
| NO (1) | NO2753615T3 (ja) |
| PL (1) | PL2753615T3 (ja) |
| PT (1) | PT2753615T (ja) |
| RS (1) | RS56481B1 (ja) |
| SG (1) | SG2014015234A (ja) |
| SI (1) | SI2753615T1 (ja) |
| WO (1) | WO2013034238A1 (ja) |
| ZA (1) | ZA201402561B (ja) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6267193B2 (ja) * | 2012-05-22 | 2018-01-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 置換ジピリジルアミン類及びそれらの使用 |
| GB201303109D0 (en) | 2013-02-21 | 2013-04-10 | Domainex Ltd | Novel pyrimidine compounds |
| CN105164114B (zh) | 2013-05-01 | 2018-03-23 | 豪夫迈·罗氏有限公司 | C‑连接的杂环烷基取代的嘧啶类和它们的用途 |
| KR102359214B1 (ko) | 2014-04-04 | 2022-02-07 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
| TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
| CN104201295B (zh) * | 2014-09-16 | 2017-05-03 | 深圳市华星光电技术有限公司 | Oled的封装方法及oled结构 |
| ES2727376T3 (es) | 2014-09-26 | 2019-10-15 | Gilead Sciences Inc | Derivados de aminotriazina útiles como compuestos inhibidores de quinasa de unión TANK |
| US9994547B2 (en) | 2014-10-06 | 2018-06-12 | Takeda Pharmaceutical Company Limited | Heteroarylamide inhibitors of TBK1 |
| CN106854174A (zh) * | 2015-12-08 | 2017-06-16 | 湖南华腾制药有限公司 | 一种4位取代哌啶衍生物的制备方法 |
| CN108430993A (zh) * | 2015-12-17 | 2018-08-21 | 吉利德科学公司 | Tank-结合激酶抑制剂化合物 |
| US10894784B2 (en) | 2015-12-18 | 2021-01-19 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| CN107286076A (zh) * | 2016-04-05 | 2017-10-24 | 湖南华腾制药有限公司 | 一种哌啶类化合物的制备方法 |
| CN107400082A (zh) * | 2016-05-19 | 2017-11-28 | 湖南华腾制药有限公司 | 一种取代哌啶衍生物的制备方法 |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| DE102016113714A1 (de) | 2016-07-26 | 2018-02-01 | Rosa Karl | Transfektionsverfahren mit nicht-viralen Genliefersystemen |
| CN107698491A (zh) * | 2016-08-08 | 2018-02-16 | 湖南华腾制药有限公司 | 一种取代哌啶衍生物的制备方法 |
| CN107778215A (zh) * | 2016-08-30 | 2018-03-09 | 湖南华腾制药有限公司 | 一种氟取代哌啶衍生物的制备方法 |
| CN107778216A (zh) * | 2016-08-30 | 2018-03-09 | 湖南华腾制药有限公司 | 一种氟取代哌啶衍生物的制备方法 |
| CN108117510A (zh) * | 2016-11-29 | 2018-06-05 | 湖南华腾制药有限公司 | 一种哌啶衍生物的制备方法 |
| CN108610309A (zh) * | 2016-12-13 | 2018-10-02 | 湖南华腾制药有限公司 | 一种哌啶衍生物的制备方法 |
| GB201702947D0 (en) | 2017-02-23 | 2017-04-12 | Domainex Ltd | Novel compounds |
| CN111247135A (zh) * | 2017-10-17 | 2020-06-05 | 默克专利股份公司 | 嘧啶ΤΒΚ/ΙΚΚε抑制剂化合物及其用途 |
| CN111247134A (zh) | 2017-10-17 | 2020-06-05 | 默克专利股份公司 | 嘧啶ΤΒΚ/ΙΚΚε抑制剂化合物及其用途 |
| WO2020118683A1 (en) * | 2018-12-14 | 2020-06-18 | Lynk Pharmaceuticals Co. Ltd. | Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| WO2020206588A1 (en) * | 2019-04-08 | 2020-10-15 | Lynk Pharmaceuticals Co., Ltd. | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| CN110627775A (zh) * | 2019-10-24 | 2019-12-31 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
| CN112209886A (zh) * | 2020-11-09 | 2021-01-12 | 沈阳药科大学 | 2-(3-氰基-4-烷氧基)苯基嘧啶衍生物及其制备方法和用途 |
| CN113024565B (zh) * | 2021-03-31 | 2022-09-13 | 上海启甄环境科技有限公司 | 一种放射性同位素碳-14标记依鲁替尼及其合成方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| US7304071B2 (en) | 2002-08-14 | 2007-12-04 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
| SE0203754D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| BRPI0412347A (pt) | 2003-07-30 | 2006-09-05 | Cyclacel Ltd | 2-aminofenil-4-fenilpiridinas como inibidores de quinase |
| EP2016075A1 (en) | 2006-05-03 | 2009-01-21 | AstraZeneca AB | Thiazole derivatives and their use as anti-tumour agents |
| WO2008065155A1 (en) * | 2006-11-30 | 2008-06-05 | Ingenium Pharmaceuticals Gmbh | Cdk inhibitors for treating pain |
| ES2557930T3 (es) * | 2007-03-12 | 2016-01-29 | Ym Biosciences Australia Pty Ltd | Compuestos de fenilaminopirimidina y usos de los mismos |
| WO2009030890A1 (en) | 2007-09-03 | 2009-03-12 | University Court Of The University Of Dundee | Pyrimidine compounds for the treatment of cancer, septic shock and/or primary open angle glaucoma |
| US8530480B2 (en) | 2007-09-04 | 2013-09-10 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
| JP2011500778A (ja) | 2007-10-25 | 2011-01-06 | アストラゼネカ・アクチエボラーグ | ピリジン及びピラジン誘導体−０８３ |
| US20100056524A1 (en) | 2008-04-02 | 2010-03-04 | Mciver Edward Giles | Compound |
| GB0903759D0 (en) | 2009-03-04 | 2009-04-15 | Medical Res Council | Compound |
| WO2010151747A1 (en) | 2009-06-26 | 2010-12-29 | Cystic Fibrosis Foundation Therapeutics, Inc. | Pyrimine compounds and methods of making and using same |
| CA2777762A1 (en) | 2009-10-12 | 2011-04-21 | Myrexis, Inc. | Amino - pyrimidine compounds as inhibitors of tbk1 and/or ikk epsilon |
| GB201012105D0 (en) * | 2010-07-19 | 2010-09-01 | Domainex Ltd | Novel pyrimidine compounds |
| EP2638018A1 (en) | 2010-11-09 | 2013-09-18 | Cellzome Limited | Pyridine compounds and aza analogues thereof as tyk2 inhibitors |
| AU2012242777A1 (en) * | 2011-04-12 | 2013-10-31 | Alzheimer's Institute Of America, Inc. | Compositions and therapeutic uses of IKK-related kinase epsilon and TANKbinding kinase 1 inhibitors |
-
2011
- 2011-09-09 DE DE102011112978A patent/DE102011112978A1/de not_active Withdrawn
-
2012
- 2012-08-13 EP EP12747896.4A patent/EP2753615B1/de active Active
- 2012-08-13 ES ES12747896.4T patent/ES2644128T3/es active Active
- 2012-08-13 EA EA201400333A patent/EA025038B1/ru not_active IP Right Cessation
- 2012-08-13 RS RS20171056A patent/RS56481B1/sr unknown
- 2012-08-13 MX MX2014002683A patent/MX344335B/es active IP Right Grant
- 2012-08-13 NO NO12747896A patent/NO2753615T3/no unknown
- 2012-08-13 AU AU2012306746A patent/AU2012306746B2/en not_active Ceased
- 2012-08-13 CA CA2848148A patent/CA2848148C/en active Active
- 2012-08-13 HU HUE12747896A patent/HUE036774T2/hu unknown
- 2012-08-13 SI SI201231093T patent/SI2753615T1/sl unknown
- 2012-08-13 JP JP2014528879A patent/JP6060163B2/ja not_active Expired - Fee Related
- 2012-08-13 US US14/342,911 patent/US8969335B2/en not_active Expired - Fee Related
- 2012-08-13 DK DK12747896.4T patent/DK2753615T3/en active
- 2012-08-13 PT PT127478964T patent/PT2753615T/pt unknown
- 2012-08-13 LT LTEP12747896.4T patent/LT2753615T/lt unknown
- 2012-08-13 IN IN769KON2014 patent/IN2014KN00769A/en unknown
- 2012-08-13 SG SG2014015234A patent/SG2014015234A/en unknown
- 2012-08-13 WO PCT/EP2012/003449 patent/WO2013034238A1/de active Application Filing
- 2012-08-13 BR BR112014005226A patent/BR112014005226A2/pt not_active IP Right Cessation
- 2012-08-13 KR KR1020147008982A patent/KR101985984B1/ko active IP Right Grant
- 2012-08-13 PL PL12747896T patent/PL2753615T3/pl unknown
- 2012-08-13 CN CN201280043591.XA patent/CN103930416B/zh active Active
- 2012-09-07 AR ARP120103304A patent/AR087807A1/es not_active Application Discontinuation
-
2014
- 2014-03-06 IL IL231382A patent/IL231382A/en active IP Right Grant
- 2014-04-08 ZA ZA2014/02561A patent/ZA201402561B/en unknown
-
2015
- 2015-01-14 HK HK15100368.7A patent/HK1199880A1/xx not_active IP Right Cessation
-
2017
- 2017-08-28 HR HRP20171296TT patent/HRP20171296T1/hr unknown
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