JP2013534227A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013534227A5 JP2013534227A5 JP2013524362A JP2013524362A JP2013534227A5 JP 2013534227 A5 JP2013534227 A5 JP 2013534227A5 JP 2013524362 A JP2013524362 A JP 2013524362A JP 2013524362 A JP2013524362 A JP 2013524362A JP 2013534227 A5 JP2013534227 A5 JP 2013534227A5
- Authority
- JP
- Japan
- Prior art keywords
- nasal
- nose
- powder
- ingested
- sucking
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001331 Nose Anatomy 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 210000003928 Nasal Cavity Anatomy 0.000 description 1
- 229940100662 Nasal Drops Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000717 retained Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
担体物質が固体である、経鼻投与に適合された医薬処方物には、例えば20〜500ミクロンの範囲の粒径を有し、鼻から吸い込んで摂取される方法で、すなわち鼻の近傍に保持され、粉末を含有する容器から鼻腔を経由した急速な吸入により投与される粗粉末を含む。担体物質として液体を伴う鼻腔用スプレーまたは点鼻剤に好適な処方物には、水または油中の活性成分溶液が包含される。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102010034699.3 | 2010-08-18 | ||
DE102010034699A DE102010034699A1 (de) | 2010-08-18 | 2010-08-18 | Pyrimidinderivate |
PCT/EP2011/003597 WO2012022408A1 (de) | 2010-08-18 | 2011-07-19 | Pyrimidinderivate als fak inhibitoren |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016153334A Division JP6441861B2 (ja) | 2010-08-18 | 2016-08-04 | Fak阻害剤としてのピリミジン誘導体 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013534227A JP2013534227A (ja) | 2013-09-02 |
JP2013534227A5 true JP2013534227A5 (ja) | 2016-01-07 |
JP6049617B2 JP6049617B2 (ja) | 2016-12-21 |
Family
ID=44504442
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013524362A Expired - Fee Related JP6049617B2 (ja) | 2010-08-18 | 2011-07-19 | Fak阻害剤としてのピリミジン誘導体 |
JP2016153334A Expired - Fee Related JP6441861B2 (ja) | 2010-08-18 | 2016-08-04 | Fak阻害剤としてのピリミジン誘導体 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016153334A Expired - Fee Related JP6441861B2 (ja) | 2010-08-18 | 2016-08-04 | Fak阻害剤としてのピリミジン誘導体 |
Country Status (17)
Country | Link |
---|---|
US (1) | US8906916B2 (ja) |
EP (1) | EP2606034B1 (ja) |
JP (2) | JP6049617B2 (ja) |
CN (1) | CN103052627B (ja) |
AR (1) | AR082722A1 (ja) |
AU (1) | AU2011291110B2 (ja) |
CA (1) | CA2808540C (ja) |
DE (1) | DE102010034699A1 (ja) |
DK (1) | DK2606034T3 (ja) |
ES (1) | ES2572740T3 (ja) |
HR (1) | HRP20160562T1 (ja) |
HU (1) | HUE027846T2 (ja) |
IL (1) | IL224751A (ja) |
PL (1) | PL2606034T3 (ja) |
RS (1) | RS54882B1 (ja) |
SI (1) | SI2606034T1 (ja) |
WO (1) | WO2012022408A1 (ja) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102010034699A1 (de) * | 2010-08-18 | 2012-02-23 | Merck Patent Gmbh | Pyrimidinderivate |
CA2827172C (en) | 2011-02-17 | 2019-02-26 | Cancer Therapeutics Crc Pty Limited | Selective fak inhibitors |
CN103534241B (zh) * | 2011-02-17 | 2015-11-25 | 癌症疗法Crc私人有限公司 | Fak抑制剂 |
US9013997B2 (en) | 2012-06-01 | 2015-04-21 | Broadcom Corporation | System for performing distributed data cut-through |
WO2014027199A1 (en) * | 2012-08-14 | 2014-02-20 | Cancer Therapeutics Crc Pty Ltd | Fak and flt3 inhibitors |
JP2015524826A (ja) * | 2012-08-17 | 2015-08-27 | キャンサー・セラピューティクス・シーアールシー・ピーティーワイ・リミテッド | Vegfr3阻害剤 |
CA2882270A1 (en) | 2012-08-17 | 2014-02-20 | Cancer Therapeutics Crc Pty Limited | Vegfr3 inhibitors |
TW201412740A (zh) * | 2012-09-20 | 2014-04-01 | Bayer Pharma AG | 經取代之吡咯并嘧啶胺基苯并噻唑酮 |
JPWO2014174745A1 (ja) * | 2013-04-26 | 2017-02-23 | 国立大学法人京都大学 | Eg5阻害剤 |
US10106834B2 (en) | 2013-10-09 | 2018-10-23 | The General Hospital Corporation | Methods of diagnosing and treating B cell acute lymphoblastic leukemia |
WO2015123722A1 (en) * | 2014-02-19 | 2015-08-27 | Bionomics Limited | Inhibitors |
EP4070795A1 (en) | 2014-08-25 | 2022-10-12 | Salk Institute for Biological Studies | Novel ulk1 inhibitors and methods using same |
WO2019117813A1 (en) * | 2017-12-15 | 2019-06-20 | National University Of Singapore | Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
PT880508E (pt) | 1996-02-13 | 2003-07-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de vegf |
AU719327B2 (en) | 1996-03-05 | 2000-05-04 | Astrazeneca Ab | 4-anilinoquinazoline derivatives |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
IL152682A0 (en) | 2000-05-31 | 2003-06-24 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
AU6623301A (en) | 2000-07-07 | 2002-01-21 | Angiogene Pharm Ltd | Colchinol derivatives as vascular damaging agents |
SK52003A3 (en) | 2000-07-07 | 2003-07-01 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors, method for their preparation and pharmaceutical composition comprising the same |
DE50212771D1 (de) * | 2001-10-17 | 2008-10-23 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
EP1495016A2 (en) * | 2002-04-09 | 2005-01-12 | Astex Technology Limited | Heterocyclic compounds and their use as modulators of p38 map kinase |
UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
GEP20084357B (en) | 2002-12-20 | 2008-04-29 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
KR20080004585A (ko) | 2005-04-08 | 2008-01-09 | 바이엘 파마슈티칼스 코포레이션 | 피리미딘 유도체 및 암의 치료에서의 이의 용도 |
DK2134689T3 (da) | 2007-03-16 | 2014-06-30 | Scripps Research Inst | Inhibitorer af fokal adhæsionskinase |
EP2249650A4 (en) | 2008-02-19 | 2012-01-11 | Glaxosmithkline Llc | ANILINOPYRIDINE AS A FAK HEMMER |
EP3549934A1 (en) * | 2008-06-27 | 2019-10-09 | Celgene CAR LLC | Heteroaryl compounds and uses thereof |
UY32240A (es) | 2008-11-14 | 2010-06-30 | Boeringer Ingelheim Kg | Nuevas 2,4-diaminopirimidinas, sus sales farmacéuticamente aceptables, composiciones conteniéndolas y aplicaciones. |
TW201024281A (en) * | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
DE102010034699A1 (de) * | 2010-08-18 | 2012-02-23 | Merck Patent Gmbh | Pyrimidinderivate |
CN103534241B (zh) * | 2011-02-17 | 2015-11-25 | 癌症疗法Crc私人有限公司 | Fak抑制剂 |
CA2827172C (en) * | 2011-02-17 | 2019-02-26 | Cancer Therapeutics Crc Pty Limited | Selective fak inhibitors |
-
2010
- 2010-08-18 DE DE102010034699A patent/DE102010034699A1/de not_active Withdrawn
-
2011
- 2011-07-19 RS RS20160420A patent/RS54882B1/sr unknown
- 2011-07-19 CA CA2808540A patent/CA2808540C/en not_active Expired - Fee Related
- 2011-07-19 SI SI201130848A patent/SI2606034T1/sl unknown
- 2011-07-19 DK DK11743438.1T patent/DK2606034T3/en active
- 2011-07-19 PL PL11743438T patent/PL2606034T3/pl unknown
- 2011-07-19 WO PCT/EP2011/003597 patent/WO2012022408A1/de active Application Filing
- 2011-07-19 AU AU2011291110A patent/AU2011291110B2/en not_active Ceased
- 2011-07-19 JP JP2013524362A patent/JP6049617B2/ja not_active Expired - Fee Related
- 2011-07-19 HU HUE11743438A patent/HUE027846T2/en unknown
- 2011-07-19 EP EP11743438.1A patent/EP2606034B1/de active Active
- 2011-07-19 US US13/817,251 patent/US8906916B2/en not_active Expired - Fee Related
- 2011-07-19 CN CN201180039922.8A patent/CN103052627B/zh not_active Expired - Fee Related
- 2011-07-19 ES ES11743438.1T patent/ES2572740T3/es active Active
- 2011-08-18 AR ARP110102997A patent/AR082722A1/es unknown
-
2013
- 2013-02-17 IL IL224751A patent/IL224751A/en active IP Right Grant
-
2016
- 2016-05-24 HR HRP20160562TT patent/HRP20160562T1/hr unknown
- 2016-08-04 JP JP2016153334A patent/JP6441861B2/ja not_active Expired - Fee Related
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2014509313A5 (ja) | ||
JP2013534227A5 (ja) | ||
JP2014526447A5 (ja) | ||
JP2013544781A5 (ja) | ||
JP2013541565A5 (ja) | ||
JP2015505541A5 (ja) | ||
RU2015121091A (ru) | Порошки для ингаляции с ультранизкой плотностью | |
EA201590286A1 (ru) | Аэрозольное ингаляционное устройство | |
MX371521B (es) | Sistema de inhalacion de polvo seco. | |
BR122021002471B8 (pt) | Dispositivo de distribuição de droga nasal | |
CL2013000153A1 (es) | Metodo para entregar una solucion de un medicamento a un ojo de un sujeto que lo necesita, comprende, el proveer gotitas que contienen dicho medicamento, en donde dichas gotitas tienen un tamaño promedio de gotita por lo menos de aproximadamente 15 micrones y una velocidad de eyeccion inicial promedio entre 1 m/s y 5 m/s, y entregar dicho medicamento a dicho ojo, donde entre aproximadamente 80% y 100% de la masa de dichas gotitas es depositado en el ojo. | |
JP2017502064A5 (ja) | ||
ATE527976T1 (de) | Vorrichtung zur lagerung, unmittelbaren zubereitung und verabreichung eines wirkstoffes | |
MX354163B (es) | Sistemas y métodos de suministro de fármaco en polvo seco. | |
WO2010029441A3 (en) | Nasal delivery | |
WO2012024595A3 (en) | Circumferential aerosol device for delivering drugs to olfactory epithelium and brain | |
RS53243B (en) | INSTRUMENT, MEDIUM DOSIER - FOR SOLID DOSAGE OF MEDICINES, AS A PRACTICAL EXAMPLE OF USE OF INJECTS AND MEDIUM DOSIER | |
JP2014528470A5 (ja) | ||
MY191380A (en) | Stabilized fixed dose drug composition having mometasone and olopatadine | |
JP2020527377A5 (ja) | ||
WO2013038268A8 (en) | Tamper resistant immediate release formulations | |
JP2014530231A5 (ja) | ||
JP2016539921A5 (ja) | ||
EA201590734A8 (ru) | Вдыхаемые лекарственные средства | |
EA201700182A1 (ru) | Состав для повышения стабильности лекарственного препарата, содержащий по меньшей мере один сухой порошок, полученный распылительной сушкой |