WO2014167579A3 - Stable pharmaceutical compositions of tadalafil - Google Patents

Stable pharmaceutical compositions of tadalafil Download PDF

Info

Publication number
WO2014167579A3
WO2014167579A3 PCT/IN2014/000196 IN2014000196W WO2014167579A3 WO 2014167579 A3 WO2014167579 A3 WO 2014167579A3 IN 2014000196 W IN2014000196 W IN 2014000196W WO 2014167579 A3 WO2014167579 A3 WO 2014167579A3
Authority
WO
WIPO (PCT)
Prior art keywords
tadalafil
stable pharmaceutical
pharmaceutical compositions
present
μιτι
Prior art date
Application number
PCT/IN2014/000196
Other languages
French (fr)
Other versions
WO2014167579A2 (en
Inventor
Sautik BHATTACHARYA
Ashutosh JAMLOKI
Pavan Kumar M
Ashish SHEGAL
Original Assignee
Astron Research Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astron Research Limited filed Critical Astron Research Limited
Publication of WO2014167579A2 publication Critical patent/WO2014167579A2/en
Publication of WO2014167579A3 publication Critical patent/WO2014167579A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Abstract

The present invention relates to stable pharmaceutical compositions of Tadalafil for oral administration comprising tadalafil particles having D90 particle size greater than about 40 μιτι and one or more pharmaceutically acceptable excipients. Further the present invention also discloses the process for the preparation of the said stable pharmaceutical composition.
PCT/IN2014/000196 2013-03-28 2014-03-28 Stable pharmaceutical compositions of tadalafil WO2014167579A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1177/MUM/2013 2013-03-28
IN1177MU2013 IN2013MU01177A (en) 2013-03-28 2014-03-28

Publications (2)

Publication Number Publication Date
WO2014167579A2 WO2014167579A2 (en) 2014-10-16
WO2014167579A3 true WO2014167579A3 (en) 2014-12-24

Family

ID=51690088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000196 WO2014167579A2 (en) 2013-03-28 2014-03-28 Stable pharmaceutical compositions of tadalafil

Country Status (2)

Country Link
IN (1) IN2013MU01177A (en)
WO (1) WO2014167579A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016002581A (en) * 2016-02-26 2017-08-25 Apotex Tech Inc Novel pharmaceutical formulations comprising a pds5 inhibitor.
CN113855639B (en) * 2021-11-04 2023-03-24 昆明源瑞制药有限公司 Tadalafil tablet and preparation method thereof
CN115089551B (en) * 2022-04-07 2024-03-29 江西药都仁和制药有限公司 Tadalafil tablet and preparation method thereof
WO2023232215A1 (en) * 2022-06-02 2023-12-07 Rontis Hellas S.A. Improved pharmaceutical composition containing tadalafil and process for the preparation thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012095151A1 (en) * 2010-12-23 2012-07-19 Zaklady Farmaceutyczne Polpharma Sa Solid pharmaceutical dosage forms comprising tadalafil and methods of preparation thereof
WO2013109230A1 (en) * 2012-01-18 2013-07-25 Mahmut Bilgic Pharmaceutical compositions comprising tadalafil
EP2654723A1 (en) * 2010-12-23 2013-10-30 Zaklady Farmaceutyczne Polpharma SA Solid pharmaceutical dosage forms comprising tadalafil and methods of preparation thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012095151A1 (en) * 2010-12-23 2012-07-19 Zaklady Farmaceutyczne Polpharma Sa Solid pharmaceutical dosage forms comprising tadalafil and methods of preparation thereof
EP2654723A1 (en) * 2010-12-23 2013-10-30 Zaklady Farmaceutyczne Polpharma SA Solid pharmaceutical dosage forms comprising tadalafil and methods of preparation thereof
WO2013109230A1 (en) * 2012-01-18 2013-07-25 Mahmut Bilgic Pharmaceutical compositions comprising tadalafil

Also Published As

Publication number Publication date
WO2014167579A2 (en) 2014-10-16
IN2013MU01177A (en) 2015-04-17

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