IT1252185B - Preparazioni farmaceutiche a liberazione programmata - Google Patents

Preparazioni farmaceutiche a liberazione programmata

Info

Publication number
IT1252185B
IT1252185B ITMI913318A ITMI913318A IT1252185B IT 1252185 B IT1252185 B IT 1252185B IT MI913318 A ITMI913318 A IT MI913318A IT MI913318 A ITMI913318 A IT MI913318A IT 1252185 B IT1252185 B IT 1252185B
Authority
IT
Italy
Prior art keywords
pharmaceutical preparations
pharmaceutical compositions
programmed
ambroxol hydrochloride
programmed release
Prior art date
Application number
ITMI913318A
Other languages
English (en)
Inventor
Paolo Alberto Veronesi
Anna Maria Varonesi
Original Assignee
Therapicon Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therapicon Srl filed Critical Therapicon Srl
Publication of ITMI913318A0 publication Critical patent/ITMI913318A0/it
Priority to ITMI913318A priority Critical patent/IT1252185B/it
Priority to ES92311328T priority patent/ES2099226T3/es
Priority to JP4331350A priority patent/JPH05320044A/ja
Priority to MX9207171A priority patent/MX9207171A/es
Priority to DE69217020T priority patent/DE69217020T2/de
Priority to EP92311328A priority patent/EP0546846B1/en
Publication of ITMI913318A1 publication Critical patent/ITMI913318A1/it
Priority to US08/380,218 priority patent/US6251429B1/en
Application granted granted Critical
Publication of IT1252185B publication Critical patent/IT1252185B/it
Priority to GR970400140T priority patent/GR3022416T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants

Abstract

La presente invenzione riguarda composizioni farmaceutiche a rilascio programmato contenenti ambroxolo cloridrato, associato ad una o più sostanze filmanti ad azione ritardante, ed un procedimento per la loro preparazione.Le composizioni farmaceutiche sono ottenute sottoforma di microgranuli aventi un profilo di rilascio programmato, che permette di ottenere sufficienti livelli terapeutici di ambroxolo cloridrato durante le 24 ore successive alla somministrazione unica di una sola dose di prodotto.
ITMI913318A 1991-12-11 1991-12-11 Preparazioni farmaceutiche a liberazione programmata IT1252185B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ITMI913318A IT1252185B (it) 1991-12-11 1991-12-11 Preparazioni farmaceutiche a liberazione programmata
DE69217020T DE69217020T2 (de) 1991-12-11 1992-12-11 Arzneimittel mit gesteuerter Wirkstoffabgabe
JP4331350A JPH05320044A (ja) 1991-12-11 1992-12-11 放出をプログラム化した薬学的組成物
MX9207171A MX9207171A (es) 1991-12-11 1992-12-11 Preparaciones farmaceuticas a liberacion programada.
ES92311328T ES2099226T3 (es) 1991-12-11 1992-12-11 Composiciones farmaceuticas de liberacion programada.
EP92311328A EP0546846B1 (en) 1991-12-11 1992-12-11 Programmed-release pharmaceutical compositions
US08/380,218 US6251429B1 (en) 1991-12-11 1995-01-30 Programmed release ambroxol—HCl dosage forms
GR970400140T GR3022416T3 (en) 1991-12-11 1997-01-29 Programmed-release pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI913318A IT1252185B (it) 1991-12-11 1991-12-11 Preparazioni farmaceutiche a liberazione programmata

Publications (3)

Publication Number Publication Date
ITMI913318A0 ITMI913318A0 (it) 1991-12-11
ITMI913318A1 ITMI913318A1 (it) 1993-06-11
IT1252185B true IT1252185B (it) 1995-06-05

Family

ID=11361308

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI913318A IT1252185B (it) 1991-12-11 1991-12-11 Preparazioni farmaceutiche a liberazione programmata

Country Status (8)

Country Link
US (1) US6251429B1 (it)
EP (1) EP0546846B1 (it)
JP (1) JPH05320044A (it)
DE (1) DE69217020T2 (it)
ES (1) ES2099226T3 (it)
GR (1) GR3022416T3 (it)
IT (1) IT1252185B (it)
MX (1) MX9207171A (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5070568A1 (es) * 1998-05-22 2001-08-28 Eurand Internatrional Spa Proceso de aplicacion de capas y aparato para efectuarlo
DE19933148A1 (de) * 1999-07-20 2001-01-25 Boehringer Ingelheim Int Ambroxolhaltige Lutschtablette
JP4644397B2 (ja) 2001-09-05 2011-03-02 信越化学工業株式会社 難溶性薬物を含む医薬用固形製剤の製造方法
ITMI20032463A1 (it) * 2003-12-16 2005-06-17 Advance Holdings Ltd Soluzione acquosa concentrata a base di ambroxolo
DE102004021992A1 (de) * 2004-05-03 2005-11-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Topische Zubereitung enthaltend Ambroxol
CN1294907C (zh) * 2004-10-11 2007-01-17 成都拜特尔药业有限公司 盐酸氨溴索颗粒剂
CN101862305B (zh) * 2009-04-20 2014-05-07 北京德众万全药物技术开发有限公司 一种盐酸氨溴索缓释微丸及制备方法
JP6084355B2 (ja) * 2010-05-06 2017-02-22 大正製薬株式会社 アンブロキソール含有製剤粒子
CN105726489A (zh) * 2014-12-09 2016-07-06 澳美制药厂有限公司 盐酸氨溴索缓释制剂及其制备方法
CN105748443B (zh) * 2016-04-25 2018-09-11 华润双鹤利民药业（济南）有限公司 一种盐酸氨溴索缓释胶囊及其生产工艺

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3317530A1 (de) * 1983-05-13 1984-11-15 Dietrich Dr.med. Sta. Eulalia Ibiza Reichert Antischnarchmittel
AU574360B2 (en) * 1983-05-13 1988-07-07 Reichert, D. Antisnoring agent
DE3317558A1 (de) * 1983-05-13 1984-11-15 Dietrich Dr.med. Sta. Eulalia Ibiza Reichert Orales antischnarchmittel
JPS61502731A (ja) * 1984-05-18 1986-11-27 ワシントン　ユニバ−シイテイ−　テクノロジ−　アツソシエ−ツ　インコ−ポレ−テツド 粒子又は液滴を被覆する方法およびその装置
DE3524003A1 (de) * 1985-07-04 1987-01-08 Heumann Ludwig & Co Gmbh Arzneimittelgranulat mit verzoegerter wirkstofffreisetzung und verfahren zu seiner herstellung
SE455836B (sv) * 1985-10-11 1988-08-15 Haessle Ab Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning
JPH0761961B2 (ja) * 1986-06-24 1995-07-05 信越化学工業株式会社 被覆薬剤の製造方法
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US4996047A (en) * 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
IT1227899B (it) * 1988-12-23 1991-05-14 Poli Ind Chimica Spa Rivestimento totale o parziale di principi attivi farmaceutici e relative composizioni
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5376386A (en) * 1990-01-24 1994-12-27 British Technology Group Limited Aerosol carriers
US5084287A (en) * 1990-03-15 1992-01-28 Warner-Lambert Company Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat
US5213811A (en) * 1991-09-13 1993-05-25 Sterling Drug Inc. Oral sustained-release drug compositions
US5167964A (en) * 1992-02-14 1992-12-01 Warner-Lambert Company Semi-enteric drug delivery systems and methods for preparing same
DE19539361A1 (de) * 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
JP2000516222A (ja) * 1996-08-15 2000-12-05 ロザン ファルマ ゲゼルシャフトミットベシュレンクテル ハフツング 嚥下が容易な経口医薬組成物

Also Published As

Publication number Publication date
JPH05320044A (ja) 1993-12-03
EP0546846B1 (en) 1997-01-22
EP0546846A1 (en) 1993-06-16
DE69217020D1 (de) 1997-03-06
DE69217020T2 (de) 1997-07-31
GR3022416T3 (en) 1997-04-30
ITMI913318A1 (it) 1993-06-11
MX9207171A (es) 1994-01-31
ES2099226T3 (es) 1997-05-16
ITMI913318A0 (it) 1991-12-11
US6251429B1 (en) 2001-06-26

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950725