JP2010539101A5 - - Google Patents
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- Publication number
- JP2010539101A5 JP2010539101A5 JP2010524261A JP2010524261A JP2010539101A5 JP 2010539101 A5 JP2010539101 A5 JP 2010539101A5 JP 2010524261 A JP2010524261 A JP 2010524261A JP 2010524261 A JP2010524261 A JP 2010524261A JP 2010539101 A5 JP2010539101 A5 JP 2010539101A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- salt
- converted
- converting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 COc1c(Cc(cccc2Cl)c2F)cc(C(/C(/C(O*)=O)=C\[N+])=O)c(OC)c1 Chemical compound COc1c(Cc(cccc2Cl)c2F)cc(C(/C(/C(O*)=O)=C\[N+])=O)c(OC)c1 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97139507P | 2007-09-11 | 2007-09-11 | |
| US60/971,395 | 2007-09-11 | ||
| PCT/US2008/076002 WO2009036161A1 (en) | 2007-09-11 | 2008-09-11 | Process and intermediates for preparing integrase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013024589A Division JP2013129659A (ja) | 2007-09-11 | 2013-02-12 | インテグラーゼ阻害剤の調製のためのプロセスおよび中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539101A JP2010539101A (ja) | 2010-12-16 |
| JP2010539101A5 true JP2010539101A5 (enExample) | 2012-01-26 |
| JP5202635B2 JP5202635B2 (ja) | 2013-06-05 |
Family
ID=39887255
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524261A Expired - Fee Related JP5202635B2 (ja) | 2007-09-11 | 2008-09-11 | インテグラーゼ阻害剤の調製のためのプロセスおよび中間体 |
| JP2013024589A Withdrawn JP2013129659A (ja) | 2007-09-11 | 2013-02-12 | インテグラーゼ阻害剤の調製のためのプロセスおよび中間体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013024589A Withdrawn JP2013129659A (ja) | 2007-09-11 | 2013-02-12 | インテグラーゼ阻害剤の調製のためのプロセスおよび中間体 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8153801B2 (enExample) |
| EP (1) | EP2190804B1 (enExample) |
| JP (2) | JP5202635B2 (enExample) |
| KR (1) | KR101488550B1 (enExample) |
| CN (1) | CN101821223B (enExample) |
| AP (1) | AP2785A (enExample) |
| AR (1) | AR068403A1 (enExample) |
| AU (1) | AU2008298943B2 (enExample) |
| BR (1) | BRPI0816694A2 (enExample) |
| CA (1) | CA2698245C (enExample) |
| CO (1) | CO6270255A2 (enExample) |
| EA (1) | EA019431B1 (enExample) |
| ES (1) | ES2562080T3 (enExample) |
| MX (1) | MX2010002783A (enExample) |
| NZ (1) | NZ583647A (enExample) |
| PT (1) | PT2190804E (enExample) |
| TW (1) | TWI419867B (enExample) |
| UA (1) | UA101956C2 (enExample) |
| WO (1) | WO2009036161A1 (enExample) |
| ZA (1) | ZA201002066B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7176220B2 (en) * | 2002-11-20 | 2007-02-13 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as pharmaceutical agent |
| US20070219243A1 (en) * | 2005-12-30 | 2007-09-20 | Kearney Brian P | Method for improving the pharmacokinetics of HIV integrase inhibitors |
| CN101437801B (zh) | 2006-03-06 | 2013-02-06 | 日本烟草产业株式会社 | 制备4-氧代喹啉化合物的方法 |
| JP4669040B2 (ja) | 2006-03-06 | 2011-04-13 | 日本たばこ産業株式会社 | ４−オキソキノリン化合物の製造方法 |
| ES2536923T3 (es) | 2006-09-12 | 2015-05-29 | Gilead Sciences, Inc. | Proceso e intermedios para preparar inhibidores de la integrasa del VIH |
| SG182229A1 (en) * | 2007-06-29 | 2012-07-30 | Gilead Sciences Inc | Therapeutic compositions and the use thereof |
| WO2009006203A1 (en) * | 2007-06-29 | 2009-01-08 | Gilead Sciences, Inc. | Therapeutic compositions and the use thereof |
| AR068403A1 (es) | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
| WO2011004389A2 (en) | 2009-06-18 | 2011-01-13 | Matrix Laboratories Ltd | An improved process for the preparation of elvitegravir |
| CN102212032B (zh) * | 2011-04-20 | 2013-07-31 | 复旦大学 | 一种5-羟基喹诺酮类衍生物及其制备方法和用途 |
| US9089574B2 (en) | 2011-11-30 | 2015-07-28 | Emory University | Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections |
| EP2880017B1 (en) | 2012-08-03 | 2016-10-05 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
| CZ304984B6 (cs) * | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Zlepšený způsob výroby a nové intermediáty syntézy elvitegraviru |
| CZ304983B6 (cs) * | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Způsob výroby a nové intermediáty syntézy elvitegraviru |
| EA030003B1 (ru) | 2012-12-21 | 2018-06-29 | Джилид Сайэнс, Инк. | Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции |
| NO2865735T3 (enExample) | 2013-07-12 | 2018-07-21 | ||
| DK3019503T3 (da) | 2013-07-12 | 2017-11-20 | Gilead Sciences Inc | Polycykliske-carbamoylpyridon-forbindelser og anvendelse deraf til behandling af hiv-infektioner |
| NO2717902T3 (enExample) | 2014-06-20 | 2018-06-23 | ||
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| CA2980362C (en) | 2015-04-02 | 2020-02-25 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| CN111733133B (zh) * | 2020-07-22 | 2020-12-01 | 华夏源(上海)生命科技有限公司 | 一种促进表皮干细胞分化和生长的方法 |
| CN111944761B (zh) * | 2020-08-23 | 2021-03-26 | 泉州伟业生物医学科技有限公司 | 促进表皮干细胞分化和生长的方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1564210A (en) * | 1925-12-08 | Obin d | ||
| DE3501247A1 (de) * | 1985-01-16 | 1986-07-17 | Bayer Ag, 5090 Leverkusen | Aminoacrylsaeure-derivate |
| HUP0303991A3 (en) | 2000-12-14 | 2012-09-28 | Warner Chilcott Company | Cyclization process step in the making of quinolones and naphthyridines |
| TW200300349A (en) | 2001-11-19 | 2003-06-01 | Sankyo Co | A 4-oxoqinoline derivative |
| US20050104233A1 (en) * | 2002-05-31 | 2005-05-19 | Shinji Kato | Method of substituent introduction through halogen-metal exchange reaction |
| US6803469B2 (en) * | 2002-08-05 | 2004-10-12 | The Procter & Gamble Company | Process for preparing quinolone antibiotic intermediates |
| TW200409759A (en) | 2002-09-25 | 2004-06-16 | Wyeth Corp | Substituted 4-(indazol-3-yl)phenols |
| US7176220B2 (en) * | 2002-11-20 | 2007-02-13 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as pharmaceutical agent |
| EP1582524B1 (en) | 2004-04-02 | 2008-08-13 | Ludwig Maximilians Universität | Method of preparing organomagnesium compounds |
| EP1582523A1 (en) | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Method of preparing organomagnesium compounds |
| US7531554B2 (en) * | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| MY134672A (en) * | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| US8633219B2 (en) | 2004-05-21 | 2014-01-21 | Japan Tobacco Inc. | Combination therapy |
| WO2007063869A1 (ja) | 2005-11-30 | 2007-06-07 | Japan Tobacco Inc. | 高純度キノロン化合物の製造方法 |
| US20090233964A1 (en) * | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| JP4669040B2 (ja) * | 2006-03-06 | 2011-04-13 | 日本たばこ産業株式会社 | ４−オキソキノリン化合物の製造方法 |
| CN101437801B (zh) | 2006-03-06 | 2013-02-06 | 日本烟草产业株式会社 | 制备4-氧代喹啉化合物的方法 |
| TW200811153A (en) * | 2006-06-23 | 2008-03-01 | Japan Tobacco Inc | 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| ES2536923T3 (es) * | 2006-09-12 | 2015-05-29 | Gilead Sciences, Inc. | Proceso e intermedios para preparar inhibidores de la integrasa del VIH |
| SG182229A1 (en) * | 2007-06-29 | 2012-07-30 | Gilead Sciences Inc | Therapeutic compositions and the use thereof |
| WO2009006203A1 (en) * | 2007-06-29 | 2009-01-08 | Gilead Sciences, Inc. | Therapeutic compositions and the use thereof |
| AR068403A1 (es) * | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
-
2008
- 2008-09-10 AR ARP080103928A patent/AR068403A1/es unknown
- 2008-09-11 TW TW097134842A patent/TWI419867B/zh not_active IP Right Cessation
- 2008-09-11 CA CA2698245A patent/CA2698245C/en not_active Expired - Fee Related
- 2008-09-11 AP AP2010005187A patent/AP2785A/xx active
- 2008-09-11 BR BRPI0816694 patent/BRPI0816694A2/pt not_active IP Right Cessation
- 2008-09-11 PT PT88302559T patent/PT2190804E/pt unknown
- 2008-09-11 KR KR1020107007731A patent/KR101488550B1/ko not_active Expired - Fee Related
- 2008-09-11 AU AU2008298943A patent/AU2008298943B2/en not_active Ceased
- 2008-09-11 WO PCT/US2008/076002 patent/WO2009036161A1/en not_active Ceased
- 2008-09-11 NZ NZ583647A patent/NZ583647A/en not_active IP Right Cessation
- 2008-09-11 JP JP2010524261A patent/JP5202635B2/ja not_active Expired - Fee Related
- 2008-09-11 CN CN200880106554.2A patent/CN101821223B/zh not_active Expired - Fee Related
- 2008-09-11 US US12/676,553 patent/US8153801B2/en active Active
- 2008-09-11 MX MX2010002783A patent/MX2010002783A/es active IP Right Grant
- 2008-09-11 EA EA201070256A patent/EA019431B1/ru not_active IP Right Cessation
- 2008-09-11 EP EP08830255.9A patent/EP2190804B1/en active Active
- 2008-09-11 US US12/208,952 patent/US20090099366A1/en not_active Abandoned
- 2008-09-11 ES ES08830255.9T patent/ES2562080T3/es active Active
- 2008-11-09 UA UAA201003978A patent/UA101956C2/uk unknown
-
2010
- 2010-03-24 ZA ZA2010/02066A patent/ZA201002066B/en unknown
- 2010-04-05 CO CO10037836A patent/CO6270255A2/es active IP Right Grant
-
2012
- 2012-03-06 US US13/413,518 patent/US8440831B2/en active Active
-
2013
- 2013-02-12 JP JP2013024589A patent/JP2013129659A/ja not_active Withdrawn
- 2013-04-23 US US13/868,836 patent/US8759525B2/en active Active