JP2008500316A5 - - Google Patents
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- Publication number
- JP2008500316A5 JP2008500316A5 JP2007514085A JP2007514085A JP2008500316A5 JP 2008500316 A5 JP2008500316 A5 JP 2008500316A5 JP 2007514085 A JP2007514085 A JP 2007514085A JP 2007514085 A JP2007514085 A JP 2007514085A JP 2008500316 A5 JP2008500316 A5 JP 2008500316A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- solution
- viii
- vii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 238000000034 method Methods 0.000 claims 14
- -1 cyano, methyl Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- SXDBWCPKPHAZSM-UHFFFAOYSA-M bromate Inorganic materials [O-]Br(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-M 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 5
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 4
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 229910052783 alkali metal Inorganic materials 0.000 claims 3
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 claims 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 2
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims 1
- 229940001584 sodium metabisulfite Drugs 0.000 claims 1
- 235000010262 sodium metabisulphite Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- XQMRLAJQDHQFQY-LBAQZLPGSA-N Cc1c[n](CC(C2)ON=C2c(cc2)ccc2-c(ccc(N(C[C@H](CNc2n[o]cc2)O2)C2=O)c2)c2F)nn1 Chemical compound Cc1c[n](CC(C2)ON=C2c(cc2)ccc2-c(ccc(N(C[C@H](CNc2n[o]cc2)O2)C2=O)c2)c2F)nn1 XQMRLAJQDHQFQY-LBAQZLPGSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0411596.0A GB0411596D0 (en) | 2004-05-25 | 2004-05-25 | Chemical process |
| PCT/GB2005/002042 WO2005116017A1 (en) | 2004-05-25 | 2005-05-24 | Process for the preparation of aryl substituted oxazolidinones as intermediates for antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008500316A JP2008500316A (ja) | 2008-01-10 |
| JP2008500316A5 true JP2008500316A5 (enExample) | 2008-06-26 |
Family
ID=32670975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007514085A Pending JP2008500316A (ja) | 2004-05-25 | 2005-05-24 | 抗菌薬の中間体としてのアリール置換されたオキサゾリジノンの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090105484A1 (enExample) |
| EP (1) | EP1753751A1 (enExample) |
| JP (1) | JP2008500316A (enExample) |
| CN (1) | CN100537567C (enExample) |
| GB (1) | GB0411596D0 (enExample) |
| WO (1) | WO2005116017A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| EP2346858B1 (en) | 2008-10-10 | 2019-08-07 | Merck Sharp & Dohme Corp. | Methods for preparing oxazolidinones and compositions containing them |
| UA114068C2 (xx) | 2009-02-03 | 2017-04-25 | Кристалічні частинки (r)-3-(4-(2-(2-метилтетразол-5-іл)піридин-5-іл)-3-фторфеніл)-5-гідроксиметилоксазолідин-2-ондиводеньфосфату | |
| US8580767B2 (en) | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4741784B2 (ja) * | 2001-01-22 | 2011-08-10 | カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ | 高純度のテトラブロモビスフェノール−ａの環境にやさしい調製方法 |
| BR0212458A (pt) * | 2001-09-11 | 2004-10-19 | Astrazeneca Ab | Composto ou sal farmaceuticamente aceitável, ou um éster hidrolizável in vivo deste, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto ou sal farmaceuticamente aceitável, ou um éster hidrolizável in vivo deste, composição farmacêutica, e, processo para a preparação de um composto ou sais farmaceuticamente aceitável, ou ésteres hidrolizáveis in vivo deste |
| JP2005519870A (ja) * | 2001-10-25 | 2005-07-07 | アストラゼネカ アクチボラグ | 抗菌活性をもつアリール置換オキサゾリジノン類 |
| US7473699B2 (en) * | 2002-02-28 | 2009-01-06 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and their use as antibacterial agents |
| JP2003335762A (ja) * | 2002-05-20 | 2003-11-28 | Meiji Seika Kaisha Ltd | 新規ビフェニル誘導体 |
| TW200500360A (en) * | 2003-03-01 | 2005-01-01 | Astrazeneca Ab | Hydroxymethyl compounds |
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2004
- 2004-05-25 GB GBGB0411596.0A patent/GB0411596D0/en not_active Ceased
-
2005
- 2005-05-24 US US11/569,399 patent/US20090105484A1/en not_active Abandoned
- 2005-05-24 CN CNB2005800249846A patent/CN100537567C/zh not_active Expired - Fee Related
- 2005-05-24 JP JP2007514085A patent/JP2008500316A/ja active Pending
- 2005-05-24 WO PCT/GB2005/002042 patent/WO2005116017A1/en not_active Ceased
- 2005-05-24 EP EP05746863A patent/EP1753751A1/en not_active Withdrawn