AP2785A - Process and intermediates for preparing integrase inhibitors - Google Patents
Process and intermediates for preparing integrase inhibitorsInfo
- Publication number
- AP2785A AP2785A AP2010005187A AP2010005187A AP2785A AP 2785 A AP2785 A AP 2785A AP 2010005187 A AP2010005187 A AP 2010005187A AP 2010005187 A AP2010005187 A AP 2010005187A AP 2785 A AP2785 A AP 2785A
- Authority
- AP
- ARIPO
- Prior art keywords
- intermediates
- integrase inhibitors
- preparing integrase
- preparing
- inhibitors
- Prior art date
Links
- 229940124524 integrase inhibitor Drugs 0.000 title 1
- 239000002850 integrase inhibitor Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97139507P | 2007-09-11 | 2007-09-11 | |
| PCT/US2008/076002 WO2009036161A1 (en) | 2007-09-11 | 2008-09-11 | Process and intermediates for preparing integrase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP2010005187A0 AP2010005187A0 (en) | 2010-04-30 |
| AP2785A true AP2785A (en) | 2013-10-31 |
Family
ID=39887255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2010005187A AP2785A (en) | 2007-09-11 | 2008-09-11 | Process and intermediates for preparing integrase inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20090099366A1 (enExample) |
| EP (1) | EP2190804B1 (enExample) |
| JP (2) | JP5202635B2 (enExample) |
| KR (1) | KR101488550B1 (enExample) |
| CN (1) | CN101821223B (enExample) |
| AP (1) | AP2785A (enExample) |
| AR (1) | AR068403A1 (enExample) |
| AU (1) | AU2008298943B2 (enExample) |
| BR (1) | BRPI0816694A2 (enExample) |
| CA (1) | CA2698245C (enExample) |
| CO (1) | CO6270255A2 (enExample) |
| EA (1) | EA019431B1 (enExample) |
| ES (1) | ES2562080T3 (enExample) |
| MX (1) | MX2010002783A (enExample) |
| NZ (1) | NZ583647A (enExample) |
| PT (1) | PT2190804E (enExample) |
| TW (1) | TWI419867B (enExample) |
| UA (1) | UA101956C2 (enExample) |
| WO (1) | WO2009036161A1 (enExample) |
| ZA (1) | ZA201002066B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100665919B1 (ko) * | 2002-11-20 | 2007-03-08 | 니뽄 다바코 산교 가부시키가이샤 | 4-옥소퀴놀린 화합물 및 ｈｉｖ 인테그라제 저해제로서의그의 용도 |
| CA2847871C (en) * | 2005-12-30 | 2016-07-26 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| RS54047B1 (sr) | 2006-03-06 | 2015-10-30 | Japan Tobacco Inc. | Postupak za dobijanje jedinjenja 4-oksohinolina |
| WO2007102499A1 (ja) | 2006-03-06 | 2007-09-13 | Japan Tobacco Inc. | ４－オキソキノリン化合物の製造方法 |
| TWI411602B (zh) | 2006-09-12 | 2013-10-11 | Gilead Sciences Inc | 製造整合酶抑制劑的方法及彼所用的中間物 |
| AR067183A1 (es) * | 2007-06-29 | 2009-09-30 | Gilead Sciences Inc | Composiciones terapeuticas y metodos, usos y equipos |
| US20110009411A1 (en) * | 2007-06-29 | 2011-01-13 | Gilead Sciences ,Inc. | Therapeutic compositions and the use thereof |
| AR068403A1 (es) * | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
| WO2011004389A2 (en) | 2009-06-18 | 2011-01-13 | Matrix Laboratories Ltd | An improved process for the preparation of elvitegravir |
| CN102212032B (zh) * | 2011-04-20 | 2013-07-31 | 复旦大学 | 一种5-羟基喹诺酮类衍生物及其制备方法和用途 |
| CN104185420B (zh) | 2011-11-30 | 2017-06-09 | 埃默里大学 | 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂 |
| PT2880017T (pt) * | 2012-08-03 | 2016-12-14 | Gilead Sciences Inc | Processo e intermediários para preparar inibidores da integrase |
| CZ304983B6 (cs) * | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Způsob výroby a nové intermediáty syntézy elvitegraviru |
| CZ304984B6 (cs) * | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Zlepšený způsob výroby a nové intermediáty syntézy elvitegraviru |
| DK2822954T3 (en) | 2012-12-21 | 2016-05-30 | Gilead Sciences Inc | POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE |
| SMT201700498T1 (it) | 2013-07-12 | 2017-11-15 | Gilead Sciences Inc | Composti di carbamoilpiridone policiclici e loro uso per il trattamento di infezioni da hiv |
| NO2865735T3 (enExample) | 2013-07-12 | 2018-07-21 | ||
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| NO2717902T3 (enExample) | 2014-06-20 | 2018-06-23 | ||
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| SI3277691T1 (sl) | 2015-04-02 | 2019-04-30 | Gilead Sciences, Inc. | Policiklične spojine karbamoilpiridona in njihova farmacevtska uporaba |
| CN111733133B (zh) * | 2020-07-22 | 2020-12-01 | 华夏源(上海)生命科技有限公司 | 一种促进表皮干细胞分化和生长的方法 |
| CN111944761B (zh) * | 2020-08-23 | 2021-03-26 | 泉州伟业生物医学科技有限公司 | 促进表皮干细胞分化和生长的方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1564210A (en) * | 1925-12-08 | Obin d | ||
| WO2005113508A1 (en) * | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Stable crystal of 4-oxoquinoline compound |
| WO2008033836A2 (en) * | 2006-09-12 | 2008-03-20 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3501247A1 (de) * | 1985-01-16 | 1986-07-17 | Bayer Ag, 5090 Leverkusen | Aminoacrylsaeure-derivate |
| CN1232508C (zh) * | 2000-12-14 | 2005-12-21 | 宝洁公司 | 制取喹诺酮和二氮杂萘的环化方法步骤 |
| TW200300349A (en) | 2001-11-19 | 2003-06-01 | Sankyo Co | A 4-oxoqinoline derivative |
| AU2003235447A1 (en) * | 2002-05-31 | 2003-12-19 | Banyu Pharmaceutical Co., Ltd. | Method of substituent introduction through halogen-metal exchange reaction |
| US6803469B2 (en) | 2002-08-05 | 2004-10-12 | The Procter & Gamble Company | Process for preparing quinolone antibiotic intermediates |
| TW200409759A (en) | 2002-09-25 | 2004-06-16 | Wyeth Corp | Substituted 4-(indazol-3-yl)phenols |
| KR100665919B1 (ko) * | 2002-11-20 | 2007-03-08 | 니뽄 다바코 산교 가부시키가이샤 | 4-옥소퀴놀린 화합물 및 ｈｉｖ 인테그라제 저해제로서의그의 용도 |
| EP1582524B1 (en) | 2004-04-02 | 2008-08-13 | Ludwig Maximilians Universität | Method of preparing organomagnesium compounds |
| EP1582523A1 (en) | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Method of preparing organomagnesium compounds |
| WO2005113509A1 (en) * | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| EP2229945A1 (en) | 2004-05-21 | 2010-09-22 | Japan Tobacco, Inc. | Combinations comprising a 4-isoquinolone derivative and anti-HIV agents |
| WO2007063869A1 (ja) | 2005-11-30 | 2007-06-07 | Japan Tobacco Inc. | 高純度キノロン化合物の製造方法 |
| US20090233964A1 (en) * | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| WO2007102499A1 (ja) | 2006-03-06 | 2007-09-13 | Japan Tobacco Inc. | ４－オキソキノリン化合物の製造方法 |
| RS54047B1 (sr) * | 2006-03-06 | 2015-10-30 | Japan Tobacco Inc. | Postupak za dobijanje jedinjenja 4-oksohinolina |
| TW200811153A (en) * | 2006-06-23 | 2008-03-01 | Japan Tobacco Inc | 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| AR067183A1 (es) * | 2007-06-29 | 2009-09-30 | Gilead Sciences Inc | Composiciones terapeuticas y metodos, usos y equipos |
| US20110009411A1 (en) * | 2007-06-29 | 2011-01-13 | Gilead Sciences ,Inc. | Therapeutic compositions and the use thereof |
| AR068403A1 (es) * | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
-
2008
- 2008-09-10 AR ARP080103928A patent/AR068403A1/es unknown
- 2008-09-11 US US12/208,952 patent/US20090099366A1/en not_active Abandoned
- 2008-09-11 CA CA2698245A patent/CA2698245C/en not_active Expired - Fee Related
- 2008-09-11 EP EP08830255.9A patent/EP2190804B1/en active Active
- 2008-09-11 WO PCT/US2008/076002 patent/WO2009036161A1/en not_active Ceased
- 2008-09-11 ES ES08830255.9T patent/ES2562080T3/es active Active
- 2008-09-11 AP AP2010005187A patent/AP2785A/xx active
- 2008-09-11 KR KR1020107007731A patent/KR101488550B1/ko not_active Expired - Fee Related
- 2008-09-11 AU AU2008298943A patent/AU2008298943B2/en not_active Ceased
- 2008-09-11 CN CN200880106554.2A patent/CN101821223B/zh not_active Expired - Fee Related
- 2008-09-11 TW TW097134842A patent/TWI419867B/zh not_active IP Right Cessation
- 2008-09-11 BR BRPI0816694 patent/BRPI0816694A2/pt not_active IP Right Cessation
- 2008-09-11 NZ NZ583647A patent/NZ583647A/en not_active IP Right Cessation
- 2008-09-11 US US12/676,553 patent/US8153801B2/en active Active
- 2008-09-11 EA EA201070256A patent/EA019431B1/ru not_active IP Right Cessation
- 2008-09-11 MX MX2010002783A patent/MX2010002783A/es active IP Right Grant
- 2008-09-11 JP JP2010524261A patent/JP5202635B2/ja not_active Expired - Fee Related
- 2008-09-11 PT PT88302559T patent/PT2190804E/pt unknown
- 2008-11-09 UA UAA201003978A patent/UA101956C2/uk unknown
-
2010
- 2010-03-24 ZA ZA2010/02066A patent/ZA201002066B/en unknown
- 2010-04-05 CO CO10037836A patent/CO6270255A2/es active IP Right Grant
-
2012
- 2012-03-06 US US13/413,518 patent/US8440831B2/en active Active
-
2013
- 2013-02-12 JP JP2013024589A patent/JP2013129659A/ja not_active Withdrawn
- 2013-04-23 US US13/868,836 patent/US8759525B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1564210A (en) * | 1925-12-08 | Obin d | ||
| WO2005113508A1 (en) * | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Stable crystal of 4-oxoquinoline compound |
| WO2008033836A2 (en) * | 2006-09-12 | 2008-03-20 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
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