HK1141785A1 - 製造整合酶抑制劑的步驟和中間體 - Google Patents

製造整合酶抑制劑的步驟和中間體

Info

Publication number
HK1141785A1
HK1141785A1 HK10108239.2A HK10108239A HK1141785A1 HK 1141785 A1 HK1141785 A1 HK 1141785A1 HK 10108239 A HK10108239 A HK 10108239A HK 1141785 A1 HK1141785 A1 HK 1141785A1
Authority
HK
Hong Kong
Prior art keywords
intermediates
integrase inhibitors
preparing integrase
preparing
inhibitors
Prior art date
Application number
HK10108239.2A
Other languages
English (en)
Inventor
Dowdy Eric
Pfeiffer Steven
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of HK1141785A1 publication Critical patent/HK1141785A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK10108239.2A 2007-09-11 2010-08-30 製造整合酶抑制劑的步驟和中間體 HK1141785A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97139507P 2007-09-11 2007-09-11
PCT/US2008/076002 WO2009036161A1 (en) 2007-09-11 2008-09-11 Process and intermediates for preparing integrase inhibitors

Publications (1)

Publication Number Publication Date
HK1141785A1 true HK1141785A1 (zh) 2010-11-19

Family

ID=39887255

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10108239.2A HK1141785A1 (zh) 2007-09-11 2010-08-30 製造整合酶抑制劑的步驟和中間體

Country Status (21)

Country Link
US (4) US8153801B2 (zh)
EP (1) EP2190804B1 (zh)
JP (2) JP5202635B2 (zh)
KR (1) KR101488550B1 (zh)
CN (1) CN101821223B (zh)
AP (1) AP2785A (zh)
AR (1) AR068403A1 (zh)
AU (1) AU2008298943B2 (zh)
BR (1) BRPI0816694A2 (zh)
CA (1) CA2698245C (zh)
CO (1) CO6270255A2 (zh)
EA (1) EA019431B1 (zh)
ES (1) ES2562080T3 (zh)
HK (1) HK1141785A1 (zh)
MX (1) MX2010002783A (zh)
NZ (1) NZ583647A (zh)
PT (1) PT2190804E (zh)
TW (1) TWI419867B (zh)
UA (1) UA101956C2 (zh)
WO (1) WO2009036161A1 (zh)
ZA (1) ZA201002066B (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2004764A3 (cs) * 2002-11-20 2005-02-16 Japan Tobacco Inc 4-Oxochinolinová sloučenina a její použití jako inhibitoru HIV-integrázy
CA2635468C (en) * 2005-12-30 2016-08-09 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
US8420821B2 (en) 2006-03-06 2013-04-16 Japan Tobacco Inc. Process for production of 4-oxoquinoline compound
US8383819B2 (en) 2006-03-06 2013-02-26 Japan Tobacco Inc. Method for producing 4-oxoquinoline compound
CN101516819B (zh) 2006-09-12 2013-10-16 吉里德科学公司 制备整合酶抑制剂的方法和中间体
KR20100028656A (ko) * 2007-06-29 2010-03-12 길리애드 사이언시즈, 인코포레이티드 치료 조성물 및 그의 용도
TW200914011A (en) * 2007-06-29 2009-04-01 Gilead Sciences Inc Therapeutic compositions and methods
AR068403A1 (es) 2007-09-11 2009-11-18 Gilead Sciences Inc Proceso e intermediarios para la preparacion de inhibidores de integrasa
WO2011004389A2 (en) 2009-06-18 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of elvitegravir
CN102212032B (zh) * 2011-04-20 2013-07-31 复旦大学 一种5-羟基喹诺酮类衍生物及其制备方法和用途
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
AU2013296289B2 (en) * 2012-08-03 2017-10-05 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
CZ304983B6 (cs) * 2012-10-12 2015-03-11 Zentiva, K.S. Způsob výroby a nové intermediáty syntézy elvitegraviru
CZ304984B6 (cs) * 2012-10-12 2015-03-11 Zentiva, K.S. Zlepšený způsob výroby a nové intermediáty syntézy elvitegraviru
PT3608325T (pt) 2012-12-21 2022-10-17 Gilead Sciences Inc Compostos carbamoílpiridona policíclicos e sua utilização farmacêutica
PT3019503T (pt) 2013-07-12 2017-11-27 Gilead Sciences Inc Compostos carbamoílpiridona- policíclicos e seu uso para o tratamento de infecções por hiv
NO2865735T3 (zh) 2013-07-12 2018-07-21
NO2717902T3 (zh) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
PL3277691T3 (pl) 2015-04-02 2019-07-31 Gilead Sciences, Inc. Policykliczne związki karbamoilopirydonowe i ich zastosowanie farmaceutyczne
CN111733133B (zh) * 2020-07-22 2020-12-01 华夏源(上海)生命科技有限公司 一种促进表皮干细胞分化和生长的方法
CN111944761B (zh) * 2020-08-23 2021-03-26 泉州伟业生物医学科技有限公司 促进表皮干细胞分化和生长的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1564210A (en) * 1925-12-08 Obin d
DE3501247A1 (de) * 1985-01-16 1986-07-17 Bayer Ag, 5090 Leverkusen Aminoacrylsaeure-derivate
ES2247190T3 (es) * 2000-12-14 2006-03-01 THE PROCTER & GAMBLE COMPANY Etapa de proceso de ciclacion en la fabricacion de quinolonas y naftiridinas.
TW200300349A (en) 2001-11-19 2003-06-01 Sankyo Co A 4-oxoqinoline derivative
AU2003235447A1 (en) * 2002-05-31 2003-12-19 Banyu Pharmaceutical Co., Ltd. Method of substituent introduction through halogen-metal exchange reaction
US6803469B2 (en) * 2002-08-05 2004-10-12 The Procter & Gamble Company Process for preparing quinolone antibiotic intermediates
TW200409759A (en) 2002-09-25 2004-06-16 Wyeth Corp Substituted 4-(indazol-3-yl)phenols
CZ2004764A3 (cs) * 2002-11-20 2005-02-16 Japan Tobacco Inc 4-Oxochinolinová sloučenina a její použití jako inhibitoru HIV-integrázy
EP1582523A1 (en) 2004-04-02 2005-10-05 Ludwig-Maximilians-Universität München Method of preparing organomagnesium compounds
EP1582524B1 (en) 2004-04-02 2008-08-13 Ludwig Maximilians Universität Method of preparing organomagnesium compounds
MY134672A (en) * 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
US7531554B2 (en) 2004-05-20 2009-05-12 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as HIV integrase inhibitor
EP3287130A1 (en) 2004-05-21 2018-02-28 Japan Tobacco Inc. Combinations comprising a 4-isoquinolone derivative and protease inhibitors
WO2007063869A1 (ja) 2005-11-30 2007-06-07 Japan Tobacco Inc. 高純度キノロン化合物の製造方法
US20090233964A1 (en) * 2005-12-30 2009-09-17 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
US8420821B2 (en) 2006-03-06 2013-04-16 Japan Tobacco Inc. Process for production of 4-oxoquinoline compound
US8383819B2 (en) 2006-03-06 2013-02-26 Japan Tobacco Inc. Method for producing 4-oxoquinoline compound
TW200811153A (en) * 2006-06-23 2008-03-01 Japan Tobacco Inc 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor
CN101516819B (zh) 2006-09-12 2013-10-16 吉里德科学公司 制备整合酶抑制剂的方法和中间体
TW200914011A (en) * 2007-06-29 2009-04-01 Gilead Sciences Inc Therapeutic compositions and methods
KR20100028656A (ko) * 2007-06-29 2010-03-12 길리애드 사이언시즈, 인코포레이티드 치료 조성물 및 그의 용도
AR068403A1 (es) * 2007-09-11 2009-11-18 Gilead Sciences Inc Proceso e intermediarios para la preparacion de inhibidores de integrasa

Also Published As

Publication number Publication date
KR20100069675A (ko) 2010-06-24
CN101821223A (zh) 2010-09-01
WO2009036161A1 (en) 2009-03-19
AU2008298943A1 (en) 2009-03-19
EA019431B1 (ru) 2014-03-31
EP2190804B1 (en) 2015-11-18
US20100292480A1 (en) 2010-11-18
JP5202635B2 (ja) 2013-06-05
ZA201002066B (en) 2010-12-29
AU2008298943B2 (en) 2013-10-10
ES2562080T3 (es) 2016-03-02
TWI419867B (zh) 2013-12-21
CA2698245C (en) 2015-06-16
MX2010002783A (es) 2010-03-31
US8153801B2 (en) 2012-04-10
CA2698245A1 (en) 2009-03-19
KR101488550B1 (ko) 2015-02-02
CN101821223B (zh) 2014-07-09
AP2785A (en) 2013-10-31
UA101956C2 (uk) 2013-05-27
BRPI0816694A2 (pt) 2015-03-17
NZ583647A (en) 2012-07-27
US8440831B2 (en) 2013-05-14
US20120238758A1 (en) 2012-09-20
TW200927716A (en) 2009-07-01
JP2010539101A (ja) 2010-12-16
CO6270255A2 (es) 2011-04-20
US8759525B2 (en) 2014-06-24
AR068403A1 (es) 2009-11-18
AP2010005187A0 (en) 2010-04-30
US20130253200A1 (en) 2013-09-26
EA201070256A1 (ru) 2010-12-30
EP2190804A1 (en) 2010-06-02
PT2190804E (pt) 2016-03-15
US20090099366A1 (en) 2009-04-16
JP2013129659A (ja) 2013-07-04

Similar Documents

Publication Publication Date Title
HK1223370A1 (zh) 製備整合酶抑制劑的方法和中間體
AP2785A (en) Process and intermediates for preparing integrase inhibitors
IL283038A (en) Processes for preparing intermediates for protein tyrosine kinase inhibitors
HK1245785A1 (zh) 用於製備藥物藥劑的方法和中間體
PT3617194T (pt) Processos e intermediários para inibidores carbamoilpiridona da integrase do vih
IL198117A0 (en) Process for preparing indol-5-oxy-quinazoline derivatives and intermediates
IL202228A0 (en) Process for preparing bepotastine and intermediates used therein
EP2244561A4 (en) APPARATUS FOR CONCHYLICULTURE
ZA201000397B (en) Process for preparing oxazolidine-and oxazolidinone-aminodiols and related intermediates
PL2142561T3 (pl) Sposób wytwarzania inhibitorów aromatazy
IL199785A0 (en) Process and intermediates for preparing arzoxifene
EG27000A (en) Process for the preparation of ibodutant (MEN15596) and related intermediates