JP2010528987A - C型肝炎ウイルス複製の新規大環状阻害剤 - Google Patents

C型肝炎ウイルス複製の新規大環状阻害剤 Download PDF

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JP2010528987A
JP2010528987A JP2010507576A JP2010507576A JP2010528987A JP 2010528987 A JP2010528987 A JP 2010528987A JP 2010507576 A JP2010507576 A JP 2010507576A JP 2010507576 A JP2010507576 A JP 2010507576A JP 2010528987 A JP2010528987 A JP 2010528987A
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JP2010528987A5 (enExample
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ローレンス・エム・ブラット
リン・パン
スコット・シーワート
スティーヴン・ダブリュー・アンドリューズ
ピエール・マーティン
アンドレアス・シューマッハー
レオニード・ビーゲルマン
ジャンウェイ・リウ
ケビン・コンドロスキー
ユトン・ジャン
ロバート・カウス
エイプリル・ケネディ
ティモシー・カーチャー
マイケル・リヨン
ビン・ワン
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インターミューン・インコーポレーテッド
アレイ・バイオファーマ・インコーポレーテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
JP2010507576A 2007-05-03 2008-05-02 C型肝炎ウイルス複製の新規大環状阻害剤 Pending JP2010528987A (ja)

Applications Claiming Priority (4)

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US91589607P 2007-05-03 2007-05-03
US95763007P 2007-08-23 2007-08-23
US1564407P 2007-12-20 2007-12-20
PCT/US2008/062552 WO2008137779A2 (en) 2007-05-03 2008-05-02 Novel macrocyclic inhibitors of hepatitis c virus replication

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JP2010528987A true JP2010528987A (ja) 2010-08-26
JP2010528987A5 JP2010528987A5 (enExample) 2011-06-16

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US (1) US20090155209A1 (enExample)
EP (2) EP2177523A1 (enExample)
JP (1) JP2010528987A (enExample)
KR (1) KR20100024920A (enExample)
CN (1) CN101784549A (enExample)
AP (1) AP2009005053A0 (enExample)
AR (1) AR066448A1 (enExample)
AU (1) AU2008247509A1 (enExample)
BR (1) BRPI0811020A2 (enExample)
CA (1) CA2686138A1 (enExample)
CL (1) CL2008001274A1 (enExample)
CO (1) CO6251243A2 (enExample)
EA (1) EA200971026A1 (enExample)
EC (1) ECSP099780A (enExample)
IL (1) IL201757A0 (enExample)
MA (1) MA31496B1 (enExample)
MX (1) MX2009011867A (enExample)
NZ (1) NZ581606A (enExample)
SG (1) SG174809A1 (enExample)
TN (1) TN2009000457A1 (enExample)
TW (1) TW200906830A (enExample)
WO (1) WO2008137779A2 (enExample)

Cited By (5)

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Publication number Priority date Publication date Assignee Title
JP2011520906A (ja) * 2008-05-15 2011-07-21 ブリストル−マイヤーズ スクイブ カンパニー C型肝炎ウイルス阻害剤
WO2013129549A1 (ja) * 2012-02-29 2013-09-06 東レ株式会社 体腔液貯留抑制剤
JP2014502620A (ja) * 2010-12-30 2014-02-03 エナンタ ファーマシューティカルズ インコーポレイテッド 大環状c型肝炎セリンプロテアーゼ阻害剤
JP2014508116A (ja) * 2010-12-14 2014-04-03 メルク・シャープ・アンド・ドーム・コーポレーション 大環状ラクタムの調製のための方法および中間体
JP2015533836A (ja) * 2012-10-19 2015-11-26 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company C型肝炎ウイルス阻害剤

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