CN101784549A - 丙型肝炎病毒复制的新颖大环抑制剂 - Google Patents

丙型肝炎病毒复制的新颖大环抑制剂 Download PDF

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Publication number
CN101784549A
CN101784549A CN200880018710A CN200880018710A CN101784549A CN 101784549 A CN101784549 A CN 101784549A CN 200880018710 A CN200880018710 A CN 200880018710A CN 200880018710 A CN200880018710 A CN 200880018710A CN 101784549 A CN101784549 A CN 101784549A
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compound
ifn
formula
week
administering
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Pending
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CN200880018710A
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Chinese (zh)
Inventor
劳伦斯·M·布拉特
潘林
斯科特·塞韦特
史蒂文·W·安德鲁斯
皮埃尔·马丁
安德烈亚斯·舒马赫
利奥尼德·拜格尔曼
刘建伟
凯文·孔德罗斯基
江育童
罗伯特·考斯
阿普里尔·肯尼迪
蒂莫西·克尔彻
迈克尔·莱昂
王彬
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Array Biopharma Inc
Intermune Inc
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Array Biopharma Inc
Intermune Inc
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Application filed by Array Biopharma Inc, Intermune Inc filed Critical Array Biopharma Inc
Publication of CN101784549A publication Critical patent/CN101784549A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CN200880018710A 2007-05-03 2008-05-02 丙型肝炎病毒复制的新颖大环抑制剂 Pending CN101784549A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US91589607P 2007-05-03 2007-05-03
US60/915,896 2007-05-03
US95763007P 2007-08-23 2007-08-23
US60/957,630 2007-08-23
US1564407P 2007-12-20 2007-12-20
US61/015,644 2007-12-20
PCT/US2008/062552 WO2008137779A2 (en) 2007-05-03 2008-05-02 Novel macrocyclic inhibitors of hepatitis c virus replication

Publications (1)

Publication Number Publication Date
CN101784549A true CN101784549A (zh) 2010-07-21

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880018710A Pending CN101784549A (zh) 2007-05-03 2008-05-02 丙型肝炎病毒复制的新颖大环抑制剂

Country Status (22)

Country Link
US (1) US20090155209A1 (enExample)
EP (2) EP2160392A2 (enExample)
JP (1) JP2010528987A (enExample)
KR (1) KR20100024920A (enExample)
CN (1) CN101784549A (enExample)
AP (1) AP2009005053A0 (enExample)
AR (1) AR066448A1 (enExample)
AU (1) AU2008247509A1 (enExample)
BR (1) BRPI0811020A2 (enExample)
CA (1) CA2686138A1 (enExample)
CL (1) CL2008001274A1 (enExample)
CO (1) CO6251243A2 (enExample)
EA (1) EA200971026A1 (enExample)
EC (1) ECSP099780A (enExample)
IL (1) IL201757A0 (enExample)
MA (1) MA31496B1 (enExample)
MX (1) MX2009011867A (enExample)
NZ (1) NZ581606A (enExample)
SG (1) SG174809A1 (enExample)
TN (1) TN2009000457A1 (enExample)
TW (1) TW200906830A (enExample)
WO (1) WO2008137779A2 (enExample)

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WO2008137779A2 (en) 2008-11-13
EA200971026A1 (ru) 2011-02-28
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AR066448A1 (es) 2009-08-19
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