JP2010527368A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010527368A5 JP2010527368A5 JP2010508521A JP2010508521A JP2010527368A5 JP 2010527368 A5 JP2010527368 A5 JP 2010527368A5 JP 2010508521 A JP2010508521 A JP 2010508521A JP 2010508521 A JP2010508521 A JP 2010508521A JP 2010527368 A5 JP2010527368 A5 JP 2010527368A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- compound
- alkoxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 52
- 229910052739 hydrogen Inorganic materials 0.000 claims 42
- 239000001257 hydrogen Substances 0.000 claims 28
- 229910052794 bromium Inorganic materials 0.000 claims 27
- 229910052736 halogen Inorganic materials 0.000 claims 27
- 150000002367 halogens Chemical class 0.000 claims 27
- 150000002431 hydrogen Chemical class 0.000 claims 27
- 229910052801 chlorine Inorganic materials 0.000 claims 26
- 125000001475 halogen functional group Chemical group 0.000 claims 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000004093 cyano group Chemical group *C#N 0.000 claims 19
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 18
- 125000005110 aryl thio group Chemical group 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 15
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 13
- -1 C 1 -C 6 -alkoxy Chemical group 0.000 claims 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 12
- 208000015181 infectious disease Diseases 0.000 claims 12
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 11
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 11
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 10
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 10
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 9
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 244000000013 helminth Species 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000004414 alkyl thio group Chemical group 0.000 claims 7
- 125000004438 haloalkoxy group Chemical group 0.000 claims 7
- 125000004692 haloalkylcarbonyl group Chemical group 0.000 claims 7
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 claims 7
- 125000004995 haloalkylthio group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 108010034145 Helminth Proteins Proteins 0.000 claims 6
- 125000003282 alkyl amino group Chemical group 0.000 claims 6
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 6
- 244000078703 ectoparasite Species 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 5
- 241000238876 Acari Species 0.000 claims 4
- 241000255925 Diptera Species 0.000 claims 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 239000002917 insecticide Substances 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 241000244186 Ascaris Species 0.000 claims 2
- 241000244036 Brugia Species 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 241000244160 Echinococcus Species 0.000 claims 2
- 241000498256 Enterobius Species 0.000 claims 2
- 241000315566 Habronema Species 0.000 claims 2
- 235000019687 Lamb Nutrition 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241001137882 Nematodirus Species 0.000 claims 2
- 241000243795 Ostertagia Species 0.000 claims 2
- 241001674048 Phthiraptera Species 0.000 claims 2
- 241000545593 Scolytinae Species 0.000 claims 2
- 241000256103 Simuliidae Species 0.000 claims 2
- 241000258242 Siphonaptera Species 0.000 claims 2
- 241000607216 Toxascaris Species 0.000 claims 2
- 241000244031 Toxocara Species 0.000 claims 2
- 241000243774 Trichinella Species 0.000 claims 2
- 241000223259 Trichoderma Species 0.000 claims 2
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 2
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 claims 2
- GOPDFXUMARJJEA-UHFFFAOYSA-N amino(nitro)azanide Chemical compound N[N-][N+]([O-])=O GOPDFXUMARJJEA-UHFFFAOYSA-N 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 150000001728 carbonyl compounds Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 244000079386 endoparasite Species 0.000 claims 2
- 210000002816 gill Anatomy 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000005493 quinolyl group Chemical group 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 125000003418 alkyl amino alkoxy group Chemical group 0.000 claims 1
- 125000004687 alkyl sulfinyl alkyl group Chemical group 0.000 claims 1
- 125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000003863 ammonium salts Chemical class 0.000 claims 1
- SCJNCDSAIRBRIA-DOFZRALJSA-N arachidonyl-2'-chloroethylamide Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCCl SCJNCDSAIRBRIA-DOFZRALJSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 1
- 125000004984 dialkylaminoalkoxy group Chemical group 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000007074 heterocyclization reaction Methods 0.000 claims 1
- QHDRKFYEGYYIIK-UHFFFAOYSA-N isovaleronitrile Chemical compound CC(C)CC#N QHDRKFYEGYYIIK-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 238000007248 oxidative elimination reaction Methods 0.000 claims 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 0 CC(C(C*C=*)=PN*C(*)=O)=* Chemical compound CC(C(C*C=*)=PN*C(*)=O)=* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93048507P | 2007-05-15 | 2007-05-15 | |
| US60/930,485 | 2007-05-15 | ||
| PCT/US2008/063417 WO2008144275A1 (en) | 2007-05-15 | 2008-05-12 | Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527368A JP2010527368A (ja) | 2010-08-12 |
| JP2010527368A5 true JP2010527368A5 (enExample) | 2011-06-30 |
| JP5562840B2 JP5562840B2 (ja) | 2014-07-30 |
Family
ID=38608776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508521A Expired - Fee Related JP5562840B2 (ja) | 2007-05-15 | 2008-05-12 | アリーロアゾール−２−イルシアノエチルアミノ化合物、これらの製造方法及び使用方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8088801B2 (enExample) |
| EP (4) | EP3428148B1 (enExample) |
| JP (1) | JP5562840B2 (enExample) |
| KR (3) | KR101472649B1 (enExample) |
| CN (2) | CN103483263B (enExample) |
| AR (1) | AR066571A1 (enExample) |
| AU (1) | AU2008254279B2 (enExample) |
| BR (2) | BRPI0811635B1 (enExample) |
| CA (1) | CA2684764C (enExample) |
| CL (1) | CL2008001430A1 (enExample) |
| CY (3) | CY1116858T1 (enExample) |
| DK (4) | DK2639228T3 (enExample) |
| EA (1) | EA016912B1 (enExample) |
| ES (4) | ES2714578T3 (enExample) |
| HK (1) | HK1258915A1 (enExample) |
| HR (4) | HRP20151058T2 (enExample) |
| HU (4) | HUE029127T2 (enExample) |
| LT (3) | LT3088384T (enExample) |
| ME (1) | ME03373B (enExample) |
| MX (1) | MX2009012082A (enExample) |
| MY (1) | MY154464A (enExample) |
| NZ (1) | NZ580968A (enExample) |
| PL (4) | PL3428148T3 (enExample) |
| PT (4) | PT3088384T (enExample) |
| RS (4) | RS58416B1 (enExample) |
| SG (3) | SG169989A1 (enExample) |
| SI (4) | SI3428148T1 (enExample) |
| TR (1) | TR201903663T4 (enExample) |
| TW (1) | TWI441633B (enExample) |
| UY (1) | UY31093A1 (enExample) |
| WO (1) | WO2008144275A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0819849B8 (pt) * | 2007-11-26 | 2021-05-25 | Merial Ltd | sistemas de solvente para formulações pour on para combater parasitas |
| KR101782311B1 (ko) * | 2008-10-21 | 2017-09-27 | 메리얼 인코포레이티드 | 티오아미드 화합물, 이의 제조 방법 및 사용 방법 |
| AR074024A1 (es) | 2008-11-14 | 2010-12-15 | Merial Ltd | Compuesto de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, composicion plaguicida y su uso para prevenir la infeccion parasitaria |
| WO2010059529A2 (en) | 2008-11-19 | 2010-05-27 | Merial Limited | Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof |
| TWI457347B (zh) | 2008-12-04 | 2014-10-21 | Merial Ltd | 二聚合的阿佛菌素（ａｖｅｒｍｅｃｔｉｎ）及密倍脈心（ｍｉｌｂｅｍｙｃｉｎ）衍生物 |
| DE102009012423A1 (de) * | 2009-03-10 | 2010-09-16 | Bayer Animal Health Gmbh | Zubereitung auf Ölbasis |
| UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
| HUE042360T2 (hu) | 2011-09-12 | 2019-06-28 | Merial Inc | Izoxazolin hatóanyagot tartalmazó parazitaellenes készítmények, ezek elõállítása és alkalmazása |
| US8962681B2 (en) | 2011-10-19 | 2015-02-24 | Zoetis Llc | Use of aminoacetonitrile derivatives against endoparasites |
| CA2855954C (en) | 2011-11-17 | 2020-09-01 | Merial Limited | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof. |
| MX379693B (es) | 2011-12-02 | 2025-03-11 | Merial Ltd | Formulaciones de moxidectina inyectables de larga acción y formas de cristal de moxidectina novedosas. |
| AP2014007874A0 (en) | 2012-02-06 | 2014-08-31 | Merial Ltd | Parasiticidal oral veterinary compositions comprising systemetically- acting active agents, methods and uses thereof |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| CN108685894B (zh) | 2012-04-04 | 2022-04-26 | 英特维特国际股份有限公司 | 软咀嚼药用产品 |
| CA2870956C (en) | 2012-04-20 | 2020-03-31 | Merial Limited | Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof |
| UY34997A (es) * | 2012-08-30 | 2014-03-31 | Nihon Nohyaku Co Ltd | Agente de control de endoparásitos y método para usarlo |
| US8822689B2 (en) * | 2012-09-19 | 2014-09-02 | Merial Limited | Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof |
| NZ716598A (en) | 2012-11-20 | 2017-02-24 | Merial Inc | Anthelmintic compounds and compositions and method of using thereof |
| NZ710855A (en) * | 2013-03-14 | 2020-03-27 | Dow Agrosciences Llc | Molecules having certain pesticidal utilities, and intermediates, compositions, and processes related thereto |
| CN103267808A (zh) * | 2013-04-22 | 2013-08-28 | 上海谱尼测试技术有限公司 | 一种电子电气产品中地乐酚含量的测定方法 |
| WO2015066277A1 (en) | 2013-11-01 | 2015-05-07 | Merial Limited | Antiparisitic and pesticidal isoxazoline compounds |
| JP6682719B2 (ja) | 2014-04-17 | 2020-04-15 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 寄生生物から動物を保護するためのマロノニトリル化合物の使用 |
| NZ726874A (en) | 2014-05-19 | 2018-03-23 | Merial Inc | Anthelmintic compounds |
| ES2723969T3 (es) | 2014-06-19 | 2019-09-04 | Merial Inc | Composiciones parasiticidas que comprenden derivados de indol, procedimientos y usos de las mismas |
| AU2015339096B2 (en) | 2014-10-31 | 2018-08-02 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal composition comprising fipronil |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| RS62130B1 (sr) | 2015-05-20 | 2021-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Antihelmintička depsipeptidna jedinjenja |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| CN106106475A (zh) * | 2016-06-22 | 2016-11-16 | 叶松 | 一种防治梨食芽蛾的组合物及其制备方法 |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| JP2019535655A (ja) | 2016-10-14 | 2019-12-12 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 殺虫性及び殺寄生虫性ビニルイソオキサゾリン化合物 |
| BR112019009977A2 (pt) | 2016-11-16 | 2019-08-27 | Boehringer Ingelheim Animal Health Usa Inc | compostos depsipeptídicos anti-helmínticos |
| CN106918705B (zh) * | 2017-01-22 | 2023-06-13 | 贵州勤邦食品安全科学技术有限公司 | 检测甲氰菊酯的试纸及其应用 |
| MX2020001724A (es) | 2017-08-14 | 2020-07-29 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas. |
| CN108033925A (zh) * | 2017-12-27 | 2018-05-15 | 温州大学 | 一种苯并三氮唑化合物及其制备方法 |
| US11583545B2 (en) | 2018-02-08 | 2023-02-21 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| MX2021000293A (es) | 2018-07-09 | 2021-07-15 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos antihelminticos. |
| CN108752217B (zh) * | 2018-07-18 | 2021-08-06 | 浙江沙星科技有限公司 | 一种度鲁特韦关键中间体2,4-二氟苄胺的合成方法 |
| US11773066B2 (en) | 2018-11-20 | 2023-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| CN109694472B (zh) * | 2018-12-13 | 2021-06-29 | 万华化学集团股份有限公司 | 功能性聚醚起始剂及其合成和在聚醚合成中的应用 |
| AU2020231319A1 (en) | 2019-03-01 | 2021-10-21 | Boehringer Ingelheim Animal Health USA Inc. | Injectable clorsulon compositions, methods and uses thereof |
| KR20220002890A (ko) | 2019-03-19 | 2022-01-07 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물 |
| CN110470768B (zh) * | 2019-08-27 | 2022-05-24 | 谱尼测试集团吉林有限公司 | 一种测定水质中吡嘧磺隆、三唑磷、丁草胺残留量的方法 |
| BR112022024156A2 (pt) | 2020-05-29 | 2023-02-14 | Boehringer Ingelheim Animal Health Usa Inc | Compostos heterocílicos antelmínticos |
| EP4262789A1 (en) | 2020-12-21 | 2023-10-25 | Boehringer Ingelheim Vetmedica GmbH | Parasiticidal collar comprising isoxazoline compounds |
| US12258193B2 (en) | 2022-02-17 | 2025-03-25 | Boehringer Ingelheim Vetmedica Gmbh | Method and system for providing a fluid product mailer |
| CN115888184B (zh) * | 2022-11-10 | 2026-03-13 | 上海市精神卫生中心（上海市心理咨询培训中心） | 一种用于血液镁离子检测的固相萃取装置及其应用 |
| CN115770411B (zh) * | 2022-11-10 | 2025-07-25 | 上海市精神卫生中心（上海市心理咨询培训中心） | 一种键合原卟啉的镁离子固相萃取剂及其应用 |
| CN117143519B (zh) * | 2023-05-05 | 2025-05-02 | 迪力阀门科技有限公司 | 一种耐高温蝶阀及其生产工艺 |
| WO2025257633A1 (en) | 2024-06-12 | 2025-12-18 | Boehringer Ingelheim Vetmedica Gmbh | Long-acting castor oil-containing injectable formulations and methods of use thereof |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6426333B1 (en) | 1996-09-19 | 2002-07-30 | Merial | Spot-on formulations for combating parasites |
| FR2753377B1 (fr) | 1996-09-19 | 1999-09-24 | Rhone Merieux | Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides |
| NL160809C (nl) | 1970-05-15 | 1979-12-17 | Duphar Int Res | Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen. |
| JPS4914624A (enExample) | 1972-06-08 | 1974-02-08 | ||
| US3950360A (en) | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| US3818047A (en) | 1972-08-07 | 1974-06-18 | C Henrick | Substituted pyrones |
| SE434277B (sv) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| CH604517A5 (enExample) | 1976-08-19 | 1978-09-15 | Ciba Geigy Ag | |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4134973A (en) | 1977-04-11 | 1979-01-16 | Merck & Co., Inc. | Carbohydrate derivatives of milbemycin and processes therefor |
| US4199569A (en) | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4144352A (en) | 1977-12-19 | 1979-03-13 | Merck & Co., Inc. | Milbemycin compounds as anthelmintic agents |
| US4203976A (en) | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| JPS57139012A (en) | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | Anthelmintic composition |
| US4427663A (en) | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| DE3235931A1 (de) | 1982-09-29 | 1984-03-29 | Bayer Ag, 5090 Leverkusen | Koeder zur bekaempfung von ungeziefer |
| JPS59199673A (ja) | 1983-04-25 | 1984-11-12 | Sumitomo Chem Co Ltd | 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤 |
| EP0179022B1 (de) | 1984-10-18 | 1990-11-07 | Ciba-Geigy Ag | Benzoylphenylharnstoffe |
| ATE67493T1 (de) | 1985-02-04 | 1991-10-15 | Bayer Agrochem Kk | Heterocyclische verbindungen. |
| EP0237482A1 (de) | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen |
| RU2024527C1 (ru) | 1986-03-25 | 1994-12-15 | Санкио Компани Лимитед | Способ получения макролидных соединений |
| DE3778768D1 (de) | 1986-07-02 | 1992-06-11 | Ciba Geigy Ag | Pestizide. |
| US4855317A (en) | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
| US4871719A (en) | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
| US4874749A (en) | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| DE3888936T2 (de) | 1987-11-03 | 1994-07-21 | Beecham Group Plc | Zwischenprodukte für die Herstellung makrolider Antibiotika mit anthelmintischer Wirkung. |
| NZ232422A (en) | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
| NZ247278A (en) | 1991-02-12 | 1995-03-28 | Ancare Distributors | Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier |
| US5345377A (en) | 1992-10-30 | 1994-09-06 | Electric Power Research Institute, Inc. | Harmonic controller for an active power line conditioner |
| GB9300883D0 (en) | 1993-01-18 | 1993-03-10 | Pfizer Ltd | Antiparasitic agents |
| US5537529A (en) * | 1993-04-22 | 1996-07-16 | Apple Computer, Inc. | Apparatus and method for creating versions of computer models and creating communications incorporating created versions therefrom |
| US5399582A (en) | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
| US5806078A (en) * | 1994-06-09 | 1998-09-08 | Softool Corporation | Version management system |
| AUPM969994A0 (en) | 1994-11-28 | 1994-12-22 | Virbac S.A. | Equine anthelmintic formulations |
| US5962499A (en) | 1995-03-20 | 1999-10-05 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| US6221894B1 (en) | 1995-03-20 | 2001-04-24 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| FR2739255B1 (fr) | 1995-09-29 | 1998-09-04 | Rhone Merieux | Composition antiparasitaire pour le traitement et la protection des animaux de compagnie |
| US6366933B1 (en) * | 1995-10-27 | 2002-04-02 | At&T Corp. | Method and apparatus for tracking and viewing changes on the web |
| IE80657B1 (en) | 1996-03-29 | 1998-11-04 | Merial Sas | Insecticidal combination to control mammal fleas in particular fleas on cats and dogs |
| US5885607A (en) | 1996-03-29 | 1999-03-23 | Rhone Merieux | N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs |
| FR2752525B1 (fr) | 1996-08-20 | 2000-05-05 | Rhone Merieux | Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede |
| US6010710A (en) | 1996-03-29 | 2000-01-04 | Merial | Direct pour-on skin solution for antiparasitic use in cattle and sheep |
| US6366930B1 (en) * | 1996-04-12 | 2002-04-02 | Computer Associates Think, Inc. | Intelligent data inventory & asset management systems method and apparatus |
| US6998131B2 (en) | 1996-09-19 | 2006-02-14 | Merial Limited | Spot-on formulations for combating parasites |
| US6207647B1 (en) | 1997-07-18 | 2001-03-27 | Smithkline Beecham Corporation | RatA |
| US5909689A (en) * | 1997-09-18 | 1999-06-01 | Sony Corporation | Automatic update of file versions for files shared by several computers which record in respective file directories temporal information for indicating when the files have been created |
| US7062497B2 (en) * | 1998-01-22 | 2006-06-13 | Adobe Systems Incorporated | Maintaining document state history |
| US6239077B1 (en) | 1998-05-01 | 2001-05-29 | Nihon Nohyaku Co., Ltd. | Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof |
| DE19823396A1 (de) | 1998-05-26 | 1999-12-02 | Bayer Ag | Synergistische insektizide Mischungen |
| US6174540B1 (en) | 1998-09-14 | 2001-01-16 | Merck & Co., Inc. | Long acting injectable formulations containing hydrogenated caster oil |
| EP1094411A1 (en) * | 1999-10-20 | 2001-04-25 | Sun Microsystems, Inc. | Handling of different versions of a document |
| US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
| US6399786B1 (en) | 2000-07-14 | 2002-06-04 | Merck & Co., Inc. | Nonacyclic nodulisporic acid derivatives |
| AU2002224942A1 (en) | 2000-12-20 | 2002-07-01 | Syngenta Participations Ag | N-acyl aminoacetonitriles having pesticidal properties |
| DE60126838T2 (de) * | 2000-12-20 | 2007-11-08 | Novartis Ag | Amidoacetonitrile zur Bekämpfung von Endoparasiten |
| AR035531A1 (es) * | 2001-01-22 | 2004-06-02 | Novartis Ag | Composicion para el control de plagas endoparasiticas en ganados y animales domesticos, un metodo para su control y el uso de dicha composicion para la preparacion de medicamentos |
| RU2284990C2 (ru) * | 2001-05-15 | 2006-10-10 | Новартис Аг | Производные бензамидоацетонитрила, способ их получения, содержащая их композиция для борьбы с нематодами и их применение |
| AR036054A1 (es) * | 2001-06-15 | 2004-08-04 | Novartis Ag | Uso de compuestos de aminoacetonitrilo para el control de plagas, una composicion y un proceso para dicho control y una composicion farmaceutica contra parasitos |
| CN1564809A (zh) * | 2001-10-04 | 2005-01-12 | 诺瓦提斯公司 | 有机化合物 |
| CN1545500A (zh) * | 2001-10-04 | 2004-11-10 | 诺瓦提斯公司 | 作为抗寄生虫剂的羰氧基-氰基甲基化合物 |
| TW200300140A (en) * | 2001-11-14 | 2003-05-16 | Novartis Ag | Organic compounds |
| AR037746A1 (es) * | 2001-12-06 | 2004-12-01 | Novartis Ag | Compuestos derivados de amidoacetonitrilo, un procedimiento para su preparacion, un procedimiento para la preparacion de compuestos intermediarios, una composicion para combatir parasitos, un procedimiento para combatir dichos parasitos, y el empleo de dichos derivados para la preparacion de una com |
| AR038156A1 (es) * | 2002-01-21 | 2004-12-29 | Novartis Ag | Compuestos de amidoacetonitrilo, proceso para su preparacion, composicion para controlar los parasitos, y uso de estos compuestos para preparar una composicion farmaceutica |
| US7421660B2 (en) * | 2003-02-04 | 2008-09-02 | Cataphora, Inc. | Method and apparatus to visually present discussions for data mining purposes |
| TW200305556A (en) | 2002-03-21 | 2003-11-01 | Novartis Ag | Organic compounds |
| AR040082A1 (es) * | 2002-05-22 | 2005-03-16 | Novartis Ag | Derivados de n-acilaminoacetonitrilo y su uso para el control de parasitos |
| TW200400931A (en) * | 2002-05-22 | 2004-01-16 | Novartis Ag | Organic compounds |
| AR039961A1 (es) * | 2002-06-06 | 2005-03-09 | Novartis Ag | Derivados de amidoacetonitrilo y su uso como pesticida |
| TW200406386A (en) * | 2002-06-07 | 2004-05-01 | Novartis Ag | Organic compounds |
| TW200400932A (en) * | 2002-06-19 | 2004-01-16 | Novartis Ag | Organic compounds |
| GB0214117D0 (en) * | 2002-06-19 | 2002-07-31 | Syngenta Participations Ag | N-sulphonylaminoacetonitriles having pesticidal properties |
| US7001889B2 (en) | 2002-06-21 | 2006-02-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
| TW200409760A (en) | 2002-09-11 | 2004-06-16 | Novartis Ag | Organic compounds |
| AU2004265101B2 (en) * | 2003-08-14 | 2009-06-11 | F. Hoffmann-La Roche Ag | Gabanergic modulators |
| US8627489B2 (en) * | 2003-10-31 | 2014-01-07 | Adobe Systems Incorporated | Distributed document version control |
| GB0402677D0 (en) * | 2003-11-06 | 2004-03-10 | Novartis Ag | Organic compounds |
| AR046757A1 (es) | 2003-12-10 | 2005-12-21 | Novartis Ag | Amidoacetonitrilos utiles como pesticidas |
| EP1716511A1 (en) * | 2004-02-20 | 2006-11-02 | Dow Jones Reuters Business Interactive, LLC | Intelligent search and retrieval system and method |
| TW200613251A (en) | 2004-06-10 | 2006-05-01 | Novartis Ag | Organic compounds |
| US7702618B1 (en) * | 2004-07-26 | 2010-04-20 | Google Inc. | Information retrieval system for archiving multiple document versions |
| WO2006043654A1 (ja) | 2004-10-22 | 2006-04-27 | Nihon Nohyaku Co., Ltd. | アセトニトリル誘導体及び有害生物防除剤並びにその使用方法 |
| ES2388869T3 (es) | 2004-11-09 | 2012-10-19 | Novartis Ag | Procedimiento para la preparación de enantiómeros de compuestos de amidoacetonitrilo a partir de sus racematos |
| US7788237B2 (en) * | 2004-12-17 | 2010-08-31 | Microsoft Corporation | Method and system for tracking changes in a document |
| US7593943B2 (en) * | 2005-01-14 | 2009-09-22 | Microsoft Corporation | Method and system for synchronizing multiple user revisions to a shared object |
| KR100878824B1 (ko) | 2005-04-01 | 2009-01-14 | 엘지전자 주식회사 | 스케일러블 비디오 신호 인코딩 및 디코딩 방법 |
| US20070057967A1 (en) * | 2005-07-13 | 2007-03-15 | Armstrong Orin R | System and method for the display of versioned documents and amendments |
| WO2007017088A1 (en) | 2005-07-25 | 2007-02-15 | Novartis Ag | Amidonitrile compounds |
| US8316292B1 (en) * | 2005-11-18 | 2012-11-20 | Google Inc. | Identifying multiple versions of documents |
| US20070150433A1 (en) * | 2005-12-22 | 2007-06-28 | Mediatek Inc. | Method for managing file in version control system |
| US7809688B2 (en) * | 2006-08-04 | 2010-10-05 | Apple Inc. | Managing backup of content |
| US8136292B2 (en) * | 2009-11-13 | 2012-03-20 | Wayne Steven Morgan | Device and method for support of sheet material |
-
2008
- 2008-05-12 PT PT16156007T patent/PT3088384T/pt unknown
- 2008-05-12 HU HUE13156235A patent/HUE029127T2/en unknown
- 2008-05-12 EA EA200901529A patent/EA016912B1/ru not_active IP Right Cessation
- 2008-05-12 DK DK13156235.7T patent/DK2639228T3/en active
- 2008-05-12 LT LTEP16156007.3T patent/LT3088384T/lt unknown
- 2008-05-12 CN CN201310237628.9A patent/CN103483263B/zh not_active Expired - Fee Related
- 2008-05-12 HU HUE16156007A patent/HUE042633T2/hu unknown
- 2008-05-12 SI SI200832142T patent/SI3428148T1/sl unknown
- 2008-05-12 HU HUE08769452A patent/HUE025612T2/en unknown
- 2008-05-12 ES ES16156007T patent/ES2714578T3/es active Active
- 2008-05-12 ES ES13156235.7T patent/ES2597083T3/es active Active
- 2008-05-12 SI SI200831511T patent/SI2155699T1/sl unknown
- 2008-05-12 EP EP18176862.3A patent/EP3428148B1/en active Active
- 2008-05-12 WO PCT/US2008/063417 patent/WO2008144275A1/en not_active Ceased
- 2008-05-12 PL PL18176862T patent/PL3428148T3/pl unknown
- 2008-05-12 RS RS20190299A patent/RS58416B1/sr unknown
- 2008-05-12 DK DK16156007.3T patent/DK3088384T3/en active
- 2008-05-12 JP JP2010508521A patent/JP5562840B2/ja not_active Expired - Fee Related
- 2008-05-12 BR BRPI0811635A patent/BRPI0811635B1/pt not_active IP Right Cessation
- 2008-05-12 CN CN2008800199272A patent/CN101743230B/zh not_active Expired - Fee Related
- 2008-05-12 RS RS20160804A patent/RS55271B1/sr unknown
- 2008-05-12 RS RS20201172A patent/RS60858B1/sr unknown
- 2008-05-12 PT PT87694527T patent/PT2155699E/pt unknown
- 2008-05-12 PT PT131562357T patent/PT2639228T/pt unknown
- 2008-05-12 SI SI200831683A patent/SI2639228T1/sl unknown
- 2008-05-12 MX MX2009012082A patent/MX2009012082A/es active IP Right Grant
- 2008-05-12 SI SI200832045T patent/SI3088384T1/sl unknown
- 2008-05-12 BR BR122018010599-2A patent/BR122018010599B1/pt not_active IP Right Cessation
- 2008-05-12 PL PL08769452T patent/PL2155699T3/pl unknown
- 2008-05-12 KR KR1020127024602A patent/KR101472649B1/ko not_active Expired - Fee Related
- 2008-05-12 ES ES18176862T patent/ES2825198T3/es active Active
- 2008-05-12 TR TR2019/03663T patent/TR201903663T4/tr unknown
- 2008-05-12 CA CA2684764A patent/CA2684764C/en not_active Expired - Fee Related
- 2008-05-12 HR HRP20151058TT patent/HRP20151058T2/hr unknown
- 2008-05-12 DK DK18176862.3T patent/DK3428148T3/da active
- 2008-05-12 DK DK08769452.7T patent/DK2155699T5/en active
- 2008-05-12 EP EP08769452.7A patent/EP2155699B9/en active Active
- 2008-05-12 LT LTEP18176862.3T patent/LT3428148T/lt unknown
- 2008-05-12 LT LTEP13156235.7T patent/LT2639228T/lt unknown
- 2008-05-12 EP EP13156235.7A patent/EP2639228B1/en active Active
- 2008-05-12 KR KR1020097026098A patent/KR101292600B1/ko not_active Expired - Fee Related
- 2008-05-12 US US12/119,150 patent/US8088801B2/en active Active
- 2008-05-12 PL PL13156235T patent/PL2639228T3/pl unknown
- 2008-05-12 AU AU2008254279A patent/AU2008254279B2/en not_active Ceased
- 2008-05-12 PT PT181768623T patent/PT3428148T/pt unknown
- 2008-05-12 HU HUE18176862A patent/HUE050538T2/hu unknown
- 2008-05-12 ME MEP-2019-70A patent/ME03373B/me unknown
- 2008-05-12 KR KR1020147023167A patent/KR101546639B1/ko not_active Expired - Fee Related
- 2008-05-12 EP EP16156007.3A patent/EP3088384B1/en active Active
- 2008-05-12 RS RS20150630 patent/RS54332B9/sr unknown
- 2008-05-12 PL PL16156007T patent/PL3088384T3/pl unknown
- 2008-05-12 NZ NZ580968A patent/NZ580968A/en not_active IP Right Cessation
- 2008-05-12 ES ES08769452.7T patent/ES2549377T3/es active Active
- 2008-05-15 TW TW097117864A patent/TWI441633B/zh not_active IP Right Cessation
- 2008-05-15 CL CL2008001430A patent/CL2008001430A1/es unknown
- 2008-05-15 AR ARP080102049A patent/AR066571A1/es active IP Right Grant
- 2008-05-15 UY UY31093A patent/UY31093A1/es active IP Right Grant
- 2008-05-15 MY MYPI20081615A patent/MY154464A/en unknown
- 2008-06-27 SG SG201101085-7A patent/SG169989A1/en unknown
- 2008-06-27 SG SG200804913-2A patent/SG148142A1/en unknown
- 2008-06-27 SG SG10201601056XA patent/SG10201601056XA/en unknown
-
2010
- 2010-08-06 HK HK19101392.1A patent/HK1258915A1/zh unknown
-
2011
- 2011-12-14 US US13/325,467 patent/US8283475B2/en active Active
-
2015
- 2015-09-29 CY CY20151100864T patent/CY1116858T1/el unknown
-
2016
- 2016-09-28 HR HRP20161240TT patent/HRP20161240T1/hr unknown
- 2016-10-05 CY CY20161100989T patent/CY1118346T1/el unknown
-
2019
- 2019-03-01 HR HRP20190408TT patent/HRP20190408T1/hr unknown
- 2019-03-12 CY CY20191100291T patent/CY1121854T1/el unknown
-
2020
- 2020-08-26 HR HRP20201340TT patent/HRP20201340T1/hr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012506441A5 (enExample) | ||
| CA2580843A1 (en) | Control of parasites in animals by the use of trifluoromethanesulfonanilide oxime ether derivatives | |
| ES2326979T3 (es) | Compuestos de piperidina y composiciones farmaceuticas que contienen a los mismos. | |
| ES2309564T3 (es) | Compuestos de fenil-carboxamida utiles para el tratamiento del dolor. | |
| RU2488582C2 (ru) | Бициклозамещенные азопроизводные пиразолона, способ их получения и фармацевтическое применение | |
| ES2300613T3 (es) | Derivados terapeuticos de piperacina utiles para tratar el dolor. | |
| RU2006147267A (ru) | Конденсированное гетероциклическое соединение | |
| ES2963111T3 (es) | Derivados de 4-(1,3,4-oxadiazol-2-il)piridina-2(1H)-ona como inhibidores de la histona desacetilasa 6 (HDAC6) para el tratamiento de infecciones E.G | |
| JP2018502912A5 (enExample) | ||
| RU2003117476A (ru) | Аминотиазолы и их применение в качестве антагонистов рецептора аденозина | |
| PE20080360A1 (es) | Derivados 4-bencilftalazinona 2-sustituidos como antagonistas de histaminas h1 y h3 | |
| PT1487829E (pt) | Derivados de tiadiazolilpiperazina úteis para o tratamento ou a prevenção da dor | |
| RU2010126056A (ru) | Органические соединения | |
| JP2006501181A5 (enExample) | ||
| RU2009141185A (ru) | Инсектицидные производные арилизоксазолина | |
| JP2018524336A5 (enExample) | ||
| DE602007008616D1 (de) | Verfahren zur herstellung von 4'-azidocytidinderivaten | |
| CY1110952T1 (el) | Παραγωγα κινουκλιδινης και η χρηση αυτων ως μουσκαρινικοι ανταγωνιστες υποδοχεων μ3 | |
| RU2009123525A (ru) | ПРОИЗВОДНЫЕ 5-СУЛЬФАНИЛМЕТИЛ[1,2,4}ТРИАЗОЛ[1,5-а]ПИРИМИДИН-7-ОЛА В КАЧЕСТВЕ АНТАГОНИСТОВ CXCR2 | |
| JP2017512835A5 (enExample) | ||
| RU2005133994A (ru) | Оксимные производные и их применение в качестве фармацевтически активных агентов | |
| RU2011108404A (ru) | Новые ациламинобензамидные производные | |
| RU2011127451A (ru) | ПРОИЗВОДНЫЕ ТИЕНО[3,2-c]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗ ДЛЯ ПРИМЕНЕНИЯ В ЛЕЧЕНИИ РАКА | |
| PE20060602A1 (es) | Derivados de heteroaril acil pirrolidina como inhibidores del virus de la hepatitis c (hcv) | |
| JP2007502817A5 (enExample) |