JP2012506441A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012506441A5 JP2012506441A5 JP2011533272A JP2011533272A JP2012506441A5 JP 2012506441 A5 JP2012506441 A5 JP 2012506441A5 JP 2011533272 A JP2011533272 A JP 2011533272A JP 2011533272 A JP2011533272 A JP 2011533272A JP 2012506441 A5 JP2012506441 A5 JP 2012506441A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- alkyl
- alkoxy
- alkylthio
- alkylsulfinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000005843 halogen group Chemical group 0.000 claims 66
- -1 C 1 -C 6 - alkyl Chemical group 0.000 claims 30
- 125000004093 cyano group Chemical group *C#N 0.000 claims 29
- 229910052736 halogen Inorganic materials 0.000 claims 27
- 150000002367 halogens Chemical class 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000001424 substituent group Chemical group 0.000 claims 25
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 24
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 24
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 23
- 125000005110 aryl thio group Chemical group 0.000 claims 22
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 22
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 21
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 16
- 125000001309 chloro group Chemical group Cl* 0.000 claims 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 244000079386 endoparasite Species 0.000 claims 5
- 125000001246 bromo group Chemical group Br* 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 208000006968 Helminthiasis Diseases 0.000 claims 2
- UYJXRRSPUVSSMN-UHFFFAOYSA-P ammonium sulfide Chemical compound [NH4+].[NH4+].[S-2] UYJXRRSPUVSSMN-UHFFFAOYSA-P 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 claims 2
- 125000005493 quinolyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 125000004970 halomethyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- HYHCSLBZRBJJCH-UHFFFAOYSA-M sodium hydrosulfide Chemical compound [Na+].[SH-] HYHCSLBZRBJJCH-UHFFFAOYSA-M 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 0 CC(*)(C(N)=S)N(*)** Chemical compound CC(*)(C(N)=S)N(*)** 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10711408P | 2008-10-21 | 2008-10-21 | |
| US61/107,114 | 2008-10-21 | ||
| PCT/US2009/061337 WO2010048191A1 (en) | 2008-10-21 | 2009-10-20 | Thioamide compounds, method of making and method of using thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012506441A JP2012506441A (ja) | 2012-03-15 |
| JP2012506441A5 true JP2012506441A5 (enExample) | 2012-12-06 |
| JP5614853B2 JP5614853B2 (ja) | 2014-10-29 |
Family
ID=41404569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533272A Active JP5614853B2 (ja) | 2008-10-21 | 2009-10-20 | チオアミド化合物、その製造方法及び使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7964621B2 (enExample) |
| EP (1) | EP2358687B9 (enExample) |
| JP (1) | JP5614853B2 (enExample) |
| KR (2) | KR101782308B1 (enExample) |
| CN (1) | CN102239151B (enExample) |
| AU (1) | AU2009307736B2 (enExample) |
| BR (1) | BRPI0920145B8 (enExample) |
| CA (1) | CA2741186C (enExample) |
| CL (1) | CL2011000917A1 (enExample) |
| EA (1) | EA026649B1 (enExample) |
| ES (1) | ES2393965T3 (enExample) |
| MX (1) | MX2011004217A (enExample) |
| NZ (1) | NZ592382A (enExample) |
| WO (1) | WO2010048191A1 (enExample) |
| ZA (1) | ZA201103033B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH669977A5 (enExample) | 1986-02-27 | 1989-04-28 | Bbc Brown Boveri & Cie | |
| WO2012020568A1 (ja) * | 2010-08-10 | 2012-02-16 | 川崎重工業株式会社 | 原動機システム及び船舶 |
| PL3172964T3 (pl) | 2011-09-12 | 2021-03-08 | Boehringer Ingelheim Animal Health USA Inc. | Kompozycje przeciwpasożytniczne zawierające izoksazolinową substancję czynną, sposób i ich zastosowania |
| LT2811998T (lt) | 2012-02-06 | 2019-02-25 | Merial, Inc. | Paraziticidinės peroralinės veterinarinės kompozicijos, apimančios sistemiškai veikiančius aktyviuosius agentus, būdai ir jų panaudojimas |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| PL2922845T3 (pl) | 2012-11-20 | 2018-11-30 | Merial, Inc. | Związki przeciwrobacze oraz ich kompozycje i sposób stosowania |
| CN103073487B (zh) * | 2013-01-15 | 2014-11-19 | 西华大学 | N-双取代硫代乙酰胺类化合物的合成方法 |
| AR094961A1 (es) | 2013-03-15 | 2015-09-09 | Lilly Co Eli | 1-hidroxi-benzooxaboroles como agentes antiparasitarios |
| DK3063144T3 (da) | 2013-11-01 | 2021-10-25 | Boehringer Ingelheim Animal Health Usa Inc | Antiparasitære og pesticid-isoxazolinforbindelser |
| CN104610110A (zh) * | 2014-03-12 | 2015-05-13 | 广东东阳光药业有限公司 | 一种制备4-取代硫代苯甲酰胺衍生物的方法 |
| BR112016023898A8 (pt) | 2014-04-17 | 2021-03-30 | Basf Se | uso de compostos malononitrila para proteger animais de parasitas |
| CA2949511A1 (en) | 2014-05-19 | 2015-11-26 | Merial, Inc. | Anthelmintic compounds |
| WO2016069983A1 (en) | 2014-10-31 | 2016-05-06 | Merial, Inc. | Parasiticidal composition comprising fipronil |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| CN107835818B (zh) | 2015-05-20 | 2022-04-29 | 勃林格殷格翰动物保健美国公司 | 驱虫缩酚酸肽化合物 |
| UY40429A (es) | 2016-02-24 | 2023-10-13 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| AU2017344097A1 (en) | 2016-10-14 | 2019-05-02 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| EP3541789A1 (en) | 2016-11-16 | 2019-09-25 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| MX2020001724A (es) | 2017-08-14 | 2020-07-29 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas. |
| US12269822B2 (en) | 2018-07-09 | 2025-04-08 | Boehringer Ingelheim Animal Health USA Inc. | Anthelminthic heterocyclic compounds |
| WO2020112374A1 (en) | 2018-11-20 | 2020-06-04 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| KR102281492B1 (ko) * | 2018-12-24 | 2021-07-26 | 동인당제약 주식회사 | 세벨라머 함유 경구투여용 현탁제 조성물 및 그 제조방법 |
| MX2021011302A (es) | 2019-03-19 | 2022-01-19 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de aza-benzotiofeno y aza-benzofurano como antihelminticos. |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| CN111781291A (zh) * | 2020-06-23 | 2020-10-16 | 广西壮族自治区水产科学研究院 | 一种水中13种大环内酯类抗生素的高分辨质谱检测方法 |
| CN116897044A (zh) | 2020-12-21 | 2023-10-17 | 勃林格殷格翰动物保健有限公司 | 包含异噁唑啉化合物的杀寄生虫环 |
| US12258193B2 (en) | 2022-02-17 | 2025-03-25 | Boehringer Ingelheim Vetmedica Gmbh | Method and system for providing a fluid product mailer |
| CN117837424A (zh) * | 2024-02-04 | 2024-04-09 | 黄淮学院 | 一种控制农作物灰飞虱的方法 |
| WO2025257633A1 (en) | 2024-06-12 | 2025-12-18 | Boehringer Ingelheim Vetmedica Gmbh | Long-acting castor oil-containing injectable formulations and methods of use thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6289076B1 (en) | 1997-05-06 | 2001-09-11 | Sumitomo Heavy Industries, Ltd. | Transmission system for synchrotron radiation light |
| US6239077B1 (en) | 1998-05-01 | 2001-05-29 | Nihon Nohyaku Co., Ltd. | Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof |
| WO2002050052A1 (en) | 2000-12-20 | 2002-06-27 | Syngenta Participations Ag | N-acyl aminoacetonitriles having pesticidal properties |
| NZ526538A (en) | 2000-12-20 | 2005-12-23 | Novartis Ag | Anti-endoparasitic amidoacetonitrils |
| AR035531A1 (es) | 2001-01-22 | 2004-06-02 | Novartis Ag | Composicion para el control de plagas endoparasiticas en ganados y animales domesticos, un metodo para su control y el uso de dicha composicion para la preparacion de medicamentos |
| MXPA03010404A (es) | 2001-05-15 | 2004-03-09 | Novartis Ag | Benzamidoacetonitrilos y su uso como antiparasitarios. |
| AR036054A1 (es) | 2001-06-15 | 2004-08-04 | Novartis Ag | Uso de compuestos de aminoacetonitrilo para el control de plagas, una composicion y un proceso para dicho control y una composicion farmaceutica contra parasitos |
| NZ531634A (en) | 2001-10-04 | 2005-10-28 | Novartis Ag | Cyanoacetyl compounds |
| JP2005531489A (ja) | 2001-10-04 | 2005-10-20 | ノバルティス アクチエンゲゼルシャフト | 駆虫薬としてのカルボニルオキシ−シアノメチル化合物 |
| TW200300140A (en) | 2001-11-14 | 2003-05-16 | Novartis Ag | Organic compounds |
| TWI261053B (en) | 2001-12-06 | 2006-09-01 | Novartis Ag | Amidoacetonitrile compounds, their preparation, compositions and use as pesticides |
| AR038156A1 (es) | 2002-01-21 | 2004-12-29 | Novartis Ag | Compuestos de amidoacetonitrilo, proceso para su preparacion, composicion para controlar los parasitos, y uso de estos compuestos para preparar una composicion farmaceutica |
| AR039020A1 (es) | 2002-03-21 | 2005-02-02 | Novartis Ag | Compuestos de aminoacetonitrilo |
| TW200400004A (en) | 2002-05-22 | 2004-01-01 | Novartis Ag | Organic compounds |
| TW200400931A (en) | 2002-05-22 | 2004-01-16 | Novartis Ag | Organic compounds |
| AR039961A1 (es) | 2002-06-06 | 2005-03-09 | Novartis Ag | Derivados de amidoacetonitrilo y su uso como pesticida |
| AR040149A1 (es) | 2002-06-07 | 2005-03-16 | Novartis Ag | Compuestos de aminoacetonitrilo, un proceso para su preparacion, composicion, y uso del compuesto |
| GB0214117D0 (en) | 2002-06-19 | 2002-07-31 | Syngenta Participations Ag | N-sulphonylaminoacetonitriles having pesticidal properties |
| TW200400932A (en) | 2002-06-19 | 2004-01-16 | Novartis Ag | Organic compounds |
| AR042420A1 (es) | 2002-09-11 | 2005-06-22 | Novartis Ag | Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica |
| GB0402677D0 (en) | 2003-11-06 | 2004-03-10 | Novartis Ag | Organic compounds |
| AR046757A1 (es) | 2003-12-10 | 2005-12-21 | Novartis Ag | Amidoacetonitrilos utiles como pesticidas |
| AR049391A1 (es) | 2004-06-10 | 2006-07-26 | Novartis Ag | Derivados de aminoacetonitrilo y su uso para controlar parasitos en animales de sangre caliente |
| WO2006043654A1 (ja) | 2004-10-22 | 2006-04-27 | Nihon Nohyaku Co., Ltd. | アセトニトリル誘導体及び有害生物防除剤並びにその使用方法 |
| EP1812385B1 (en) | 2004-11-09 | 2012-07-18 | Novartis AG | Process for the preparation of enantiomers of amidoacetonitrile compounds from their racemates |
| EP1910278A1 (en) | 2005-07-25 | 2008-04-16 | Novartis AG | Amidonitrile compounds |
| WO2008062005A1 (en) | 2006-11-24 | 2008-05-29 | Novartis Ag | The use of aminoacetonitril compounds in the control of endoparasites in warm- blood animals. |
| DE602007006690D1 (de) | 2006-12-01 | 2010-07-01 | Syngenta Participations Ag | N-cyanoalkylanthranilamide als insektizide |
| CN101578804A (zh) | 2007-02-05 | 2009-11-11 | 诺基亚公司 | 用于提供确认信令的方法和装置 |
| KR20110098012A (ko) | 2007-02-09 | 2011-08-31 | 화이자 리미티드 | 구충제 |
| ES2597083T3 (es) * | 2007-05-15 | 2017-01-13 | Merial, Inc. | Compuestos de ariloazol-2-il cianoetilamino, procedimiento de fabricación y procedimiento de utilización de los mismos |
-
2009
- 2009-10-20 KR KR1020167036242A patent/KR101782308B1/ko active Active
- 2009-10-20 MX MX2011004217A patent/MX2011004217A/es active IP Right Grant
- 2009-10-20 BR BRPI0920145A patent/BRPI0920145B8/pt active IP Right Grant
- 2009-10-20 EP EP09744007.7A patent/EP2358687B9/en active Active
- 2009-10-20 AU AU2009307736A patent/AU2009307736B2/en active Active
- 2009-10-20 CA CA2741186A patent/CA2741186C/en active Active
- 2009-10-20 CN CN200980148694.0A patent/CN102239151B/zh active Active
- 2009-10-20 US US12/582,486 patent/US7964621B2/en active Active
- 2009-10-20 EA EA201100666A patent/EA026649B1/ru not_active IP Right Cessation
- 2009-10-20 KR KR1020117011425A patent/KR101782311B1/ko active Active
- 2009-10-20 NZ NZ592382A patent/NZ592382A/xx unknown
- 2009-10-20 ES ES09744007T patent/ES2393965T3/es active Active
- 2009-10-20 JP JP2011533272A patent/JP5614853B2/ja active Active
- 2009-10-20 WO PCT/US2009/061337 patent/WO2010048191A1/en not_active Ceased
-
2011
- 2011-04-13 US US13/086,161 patent/US8314146B2/en active Active
- 2011-04-21 CL CL2011000917A patent/CL2011000917A1/es unknown
- 2011-04-21 ZA ZA2011/03033A patent/ZA201103033B/en unknown