CY1112410T1 - (1-ΑΖΑ-ΔΙΚΥΚΛΟ[3.3.1]ΕΝΝΕ-4-ΥΛ)-[5-(1Η-ΙΝΔΟΛ-5-ΥΛ)-ΕΤΕΡΟΑΡΥΛ]-ΑΜΙΝΕΣ ΩΣ ΧΟΛΙΝΕΡΓΙΚΟΙ ΣΥΝΔΕΤΕΣ ΤΟΥ Ν-ΑChR ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΨΥΧΩΤΙΚΩΝ ΚΑΙ ΝΕΥΡΟΕΚΦΥΛIΣΤΙΚΩΝ ΔΙΑΤΑΡΑΧΩΝ - Google Patents

(1-ΑΖΑ-ΔΙΚΥΚΛΟ[3.3.1]ΕΝΝΕ-4-ΥΛ)-[5-(1Η-ΙΝΔΟΛ-5-ΥΛ)-ΕΤΕΡΟΑΡΥΛ]-ΑΜΙΝΕΣ ΩΣ ΧΟΛΙΝΕΡΓΙΚΟΙ ΣΥΝΔΕΤΕΣ ΤΟΥ Ν-ΑChR ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΨΥΧΩΤΙΚΩΝ ΚΑΙ ΝΕΥΡΟΕΚΦΥΛIΣΤΙΚΩΝ ΔΙΑΤΑΡΑΧΩΝ

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Publication number
CY1112410T1
CY1112410T1 CY20121100091T CY121100091T CY1112410T1 CY 1112410 T1 CY1112410 T1 CY 1112410T1 CY 20121100091 T CY20121100091 T CY 20121100091T CY 121100091 T CY121100091 T CY 121100091T CY 1112410 T1 CY1112410 T1 CY 1112410T1
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CY
Cyprus
Prior art keywords
achr
dycycol
eteroaryl
enne
indol
Prior art date
Application number
CY20121100091T
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English (en)
Inventor
Mathias Frederiksen
Dominik Feuerbach
Konstanze Hurth
Manuel Koller
Bernard Lucien Roy
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Novartis Ag
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Publication of CY1112410T1 publication Critical patent/CY1112410T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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Abstract

Η παρούσα εφεύρεση σχετίζεται με ενώσεις του χημικού τύπου (Ι), όπου το n αντιπροσωπεύει τα 0, 1, 2, 3, 4 ή 5, το R αντιπροσωπεύει ανεξάρτητα μεταξύ τους υδροξυλ, κυανο, νιτρο, αλογόνο, αλκυλ, αλκοξυ, αλκυλκαρβονυλ, αλκοξυκαρβονυλ, αλκυλαμίνη, διαλκυλαμίνη, αλκυλκαρβονυλαμίνη, αλκυλκαρβαμιδικό, το Υ αντιπροσωπεύει μια από τις ακόλουθες ομάδες: (Ια) σε μορφή ελεύθερης βάσης ή σε μορφή άλατος προσθήκης οξέος, με διαδικασίες για την παρασκευή τους, με φαρμακευτικές συνθέσεις που τις περιέχουν και με τη χρήση τους στην παρασκευή ενός φαρμάκου για τη θεραπεία και / ή την καθυστέρηση της εξέλιξης ψυχωτικών και νευροεκφυλιστικών διαταραχών.
CY20121100091T 2005-12-16 2012-01-26 (1-ΑΖΑ-ΔΙΚΥΚΛΟ[3.3.1]ΕΝΝΕ-4-ΥΛ)-[5-(1Η-ΙΝΔΟΛ-5-ΥΛ)-ΕΤΕΡΟΑΡΥΛ]-ΑΜΙΝΕΣ ΩΣ ΧΟΛΙΝΕΡΓΙΚΟΙ ΣΥΝΔΕΤΕΣ ΤΟΥ Ν-ΑChR ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΨΥΧΩΤΙΚΩΝ ΚΑΙ ΝΕΥΡΟΕΚΦΥΛIΣΤΙΚΩΝ ΔΙΑΤΑΡΑΧΩΝ CY1112410T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0525673.0A GB0525673D0 (en) 2005-12-16 2005-12-16 Organic compounds
EP06840977A EP1966208B1 (en) 2005-12-16 2006-12-14 (1-AZA-BICYCLO[3.3.1]NON-4-YL)-[5-(1H-INDOL-5-YL)-HETEROARYL]-AMINES AS CHOLINERGIC LIGANDS OF THE N-AChR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISORDERS

Publications (1)

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CY1112410T1 true CY1112410T1 (el) 2015-12-09

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ID=35736291

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CY20121100091T CY1112410T1 (el) 2005-12-16 2012-01-26 (1-ΑΖΑ-ΔΙΚΥΚΛΟ[3.3.1]ΕΝΝΕ-4-ΥΛ)-[5-(1Η-ΙΝΔΟΛ-5-ΥΛ)-ΕΤΕΡΟΑΡΥΛ]-ΑΜΙΝΕΣ ΩΣ ΧΟΛΙΝΕΡΓΙΚΟΙ ΣΥΝΔΕΤΕΣ ΤΟΥ Ν-ΑChR ΓΙΑ ΤΗ ΘΕΡΑΠΕΙΑ ΨΥΧΩΤΙΚΩΝ ΚΑΙ ΝΕΥΡΟΕΚΦΥΛIΣΤΙΚΩΝ ΔΙΑΤΑΡΑΧΩΝ

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US (3) US7713977B2 (el)
EP (2) EP2354141A1 (el)
JP (1) JP4995203B2 (el)
KR (4) KR20110015704A (el)
CN (1) CN101305003B (el)
AT (1) ATE531716T1 (el)
AU (1) AU2006326257B2 (el)
BR (1) BRPI0620003A2 (el)
CA (1) CA2632893C (el)
CR (1) CR9965A (el)
CY (1) CY1112410T1 (el)
DK (1) DK1966208T3 (el)
EC (1) ECSP088486A (el)
ES (1) ES2376647T3 (el)
GB (1) GB0525673D0 (el)
GT (1) GT200800096A (el)
HK (1) HK1121443A1 (el)
HR (1) HRP20120071T1 (el)
IL (1) IL191054A (el)
MA (1) MA30025B1 (el)
MY (1) MY147369A (el)
NO (1) NO20083145L (el)
NZ (1) NZ568269A (el)
PL (1) PL1966208T3 (el)
PT (1) PT1966208E (el)
RU (1) RU2440350C2 (el)
SI (1) SI1966208T1 (el)
TN (1) TNSN08257A1 (el)
UA (1) UA94923C2 (el)
WO (1) WO2007068475A1 (el)
ZA (1) ZA200803408B (el)

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JPS6262265A (ja) * 1985-09-13 1987-03-18 Hitachi Ltd 復水器自動検査補修システム
GB0220581D0 (en) * 2002-09-04 2002-10-09 Novartis Ag Organic Compound
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) * 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
WO2010056710A1 (en) * 2008-11-11 2010-05-20 Biovista, Inc. Compositions and methods for treating eye diseases
WO2011009890A2 (en) 2009-07-23 2011-01-27 Novartis Ag Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
EA201391091A1 (ru) * 2011-01-27 2013-12-30 Новартис Аг Применение активаторов никотиновых ацетилхолиновых рецепторов альфа-7
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