BRPI0514248A - compostos orgánicos - Google Patents

compostos orgánicos

Info

Publication number
BRPI0514248A
BRPI0514248A BRPI0514248-2A BRPI0514248A BRPI0514248A BR PI0514248 A BRPI0514248 A BR PI0514248A BR PI0514248 A BRPI0514248 A BR PI0514248A BR PI0514248 A BRPI0514248 A BR PI0514248A
Authority
BR
Brazil
Prior art keywords
compounds
organic compounds
inflammatory
condition
ccr
Prior art date
Application number
BRPI0514248-2A
Other languages
English (en)
Inventor
Darren Mark Legrand
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0514248A publication Critical patent/BRPI0514248A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPOSTOS ORGáNICOS. A presente invenção refere-se aos compostos de fórmula I na forma livre ou de sal, na qual Ar, X , Y e T têm os significados indicados no relatório, são úteis para o tratamento de uma condição mediada pelo CCR-3, particularmente uma condição inflamatória ou alérgica tal como uma doença inflamatória ou obstrutiva das vias aéreas. São também descritas as composições farmacêuticas que contêm os compostos e os processos de preparação dos compostos.
BRPI0514248-2A 2004-08-10 2005-08-09 compostos orgánicos BRPI0514248A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0417801.8A GB0417801D0 (en) 2004-08-10 2004-08-10 Organic compounds
PCT/EP2005/008654 WO2006015854A2 (en) 2004-08-10 2005-08-09 Azetidine derivatives as ccr-3 receptor antagonists

Publications (1)

Publication Number Publication Date
BRPI0514248A true BRPI0514248A (pt) 2008-06-03

Family

ID=33017254

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514248-2A BRPI0514248A (pt) 2004-08-10 2005-08-09 compostos orgánicos

Country Status (17)

Country Link
US (1) US7691841B2 (pt)
EP (1) EP1781606B1 (pt)
JP (1) JP2008509185A (pt)
KR (1) KR20070045242A (pt)
CN (1) CN101175722B (pt)
AT (1) ATE438620T1 (pt)
AU (1) AU2005270308B2 (pt)
BR (1) BRPI0514248A (pt)
CA (1) CA2572748A1 (pt)
DE (1) DE602005015866D1 (pt)
ES (1) ES2330125T3 (pt)
GB (1) GB0417801D0 (pt)
MX (1) MX2007001646A (pt)
PL (1) PL1781606T3 (pt)
PT (1) PT1781606E (pt)
RU (1) RU2007108657A (pt)
WO (1) WO2006015854A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2934265B1 (fr) * 2008-07-23 2010-07-30 Sanofi Aventis Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique
ES2539161T3 (es) * 2009-04-16 2015-06-26 Janssen Pharmaceutica Nv Antagonistas 4-azetidinil-1-heteroaril-ciclohexano de CCR2
EP2419418B1 (en) * 2009-04-17 2015-04-15 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9609374D0 (en) 1996-05-03 1996-07-10 Merck Sharp & Dohme Therapeutic agents
US7576117B1 (en) * 1999-08-04 2009-08-18 Teijin Limited Cyclic amine CCR3 antagonist
GB0117387D0 (en) 2001-07-17 2001-09-05 Novartis Ag Organic compounds
JP2003155285A (ja) * 2001-11-19 2003-05-27 Toray Ind Inc 環状含窒素誘導体
TW200800167A (en) * 2002-03-15 2008-01-01 Novartis Ag Organic compounds
WO2004050024A2 (en) * 2002-11-27 2004-06-17 Incyte Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
WO2004055016A1 (en) * 2002-12-13 2004-07-01 Smithkline Beecham Corporation Pyrrolidine and azetidine compounds as ccr5 antagonists
CA2534550A1 (en) * 2003-09-15 2005-03-24 Novartis Ag 1, 3-disubstituted azetidine derivatives for use as ccr-3 receptor antagonists in the treatment of inflammatory and allergic diseases

Also Published As

Publication number Publication date
AU2005270308B2 (en) 2009-10-22
MX2007001646A (es) 2007-04-10
GB0417801D0 (en) 2004-09-15
US7691841B2 (en) 2010-04-06
DE602005015866D1 (de) 2009-09-17
EP1781606B1 (en) 2009-08-05
WO2006015854A2 (en) 2006-02-16
WO2006015854A3 (en) 2007-08-30
ES2330125T3 (es) 2009-12-04
PL1781606T3 (pl) 2010-01-29
ATE438620T1 (de) 2009-08-15
EP1781606A2 (en) 2007-05-09
AU2005270308A1 (en) 2006-02-16
CN101175722B (zh) 2010-11-24
RU2007108657A (ru) 2008-09-20
CA2572748A1 (en) 2006-02-16
US20070259848A1 (en) 2007-11-08
CN101175722A (zh) 2008-05-07
JP2008509185A (ja) 2008-03-27
KR20070045242A (ko) 2007-05-02
PT1781606E (pt) 2009-10-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.