MA30025B1 - (1-aza-bicyclo[3.3.1]non-4- yl)-[5-(1h-indol-5- yl)-heteroaryl]-amines en tant que ligands cholinergiques du n-achr dans le traitement de troubles psychotiques et neurodegeneratifs - Google Patents

(1-aza-bicyclo[3.3.1]non-4- yl)-[5-(1h-indol-5- yl)-heteroaryl]-amines en tant que ligands cholinergiques du n-achr dans le traitement de troubles psychotiques et neurodegeneratifs

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Publication number
MA30025B1
MA30025B1 MA30997A MA30997A MA30025B1 MA 30025 B1 MA30025 B1 MA 30025B1 MA 30997 A MA30997 A MA 30997A MA 30997 A MA30997 A MA 30997A MA 30025 B1 MA30025 B1 MA 30025B1
Authority
MA
Morocco
Prior art keywords
achr
indol
aza
bicyclo
neurodegenerative
Prior art date
Application number
MA30997A
Other languages
English (en)
Inventor
Mathias Frederiksen
Dominik Feuerbach
Konstanze Hurth
Manuel Koller
Bernard Lucien Roy
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA30025B1 publication Critical patent/MA30025B1/fr

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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Abstract

La présente invention concerne des composés de formule (I): dans laquelle : n représente 0, 1, 2, 3, 4 ou 5, R représente, indépendamment les uns des autres, des groupes hydroxyle, cyano, nitro, un halogène, un groupe alkyle, alkoxy alkylcarbonyle, alkoxycarbonyle, alkylamine, dialkylamine, alkylcarbonylamine, alkylcarbamate; Y représente l'un des groupes suivants : sous forme de base libre ou de sel d'addition d'acide, des procédés pour leur préparation, des compositions pharmaceutiques les contenant, et leur utilisation dans la fabrication d'un médicament pour le traitement et/ou le retardement de la progression d'affections psychotiques et neurodégénératives.
MA30997A 2005-12-16 2008-06-03 (1-aza-bicyclo[3.3.1]non-4- yl)-[5-(1h-indol-5- yl)-heteroaryl]-amines en tant que ligands cholinergiques du n-achr dans le traitement de troubles psychotiques et neurodegeneratifs MA30025B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0525673.0A GB0525673D0 (en) 2005-12-16 2005-12-16 Organic compounds

Publications (1)

Publication Number Publication Date
MA30025B1 true MA30025B1 (fr) 2008-12-01

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MA30997A MA30025B1 (fr) 2005-12-16 2008-06-03 (1-aza-bicyclo[3.3.1]non-4- yl)-[5-(1h-indol-5- yl)-heteroaryl]-amines en tant que ligands cholinergiques du n-achr dans le traitement de troubles psychotiques et neurodegeneratifs

Country Status (31)

Country Link
US (3) US7713977B2 (fr)
EP (2) EP1966208B1 (fr)
JP (1) JP4995203B2 (fr)
KR (4) KR20140097598A (fr)
CN (1) CN101305003B (fr)
AT (1) ATE531716T1 (fr)
AU (1) AU2006326257B2 (fr)
BR (1) BRPI0620003A2 (fr)
CA (1) CA2632893C (fr)
CR (1) CR9965A (fr)
CY (1) CY1112410T1 (fr)
DK (1) DK1966208T3 (fr)
EC (1) ECSP088486A (fr)
ES (1) ES2376647T3 (fr)
GB (1) GB0525673D0 (fr)
GT (1) GT200800096A (fr)
HK (1) HK1121443A1 (fr)
HR (1) HRP20120071T1 (fr)
IL (1) IL191054A (fr)
MA (1) MA30025B1 (fr)
MY (1) MY147369A (fr)
NO (1) NO20083145L (fr)
NZ (1) NZ568269A (fr)
PL (1) PL1966208T3 (fr)
PT (1) PT1966208E (fr)
RU (1) RU2440350C2 (fr)
SI (1) SI1966208T1 (fr)
TN (1) TNSN08257A1 (fr)
UA (1) UA94923C2 (fr)
WO (1) WO2007068475A1 (fr)
ZA (1) ZA200803408B (fr)

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JP2014503568A (ja) 2011-01-27 2014-02-13 ノバルティス アーゲー ニコチン酸アセチルコリン受容体α７活性化因子の使用
CN103561740A (zh) 2011-03-18 2014-02-05 诺瓦提斯公司 用于帕金森病中多巴胺诱导的运动障碍的α7烟碱性乙酰胆碱受体活化剂和mGluR5拮抗剂的组合
EA034964B1 (ru) 2011-10-20 2020-04-13 Новартис Аг Биомаркеры, имеющие прогностическое значение в отношении ответа на лечение активатором альфа 7 никотиновых ацетилхолиновых рецепторов
CA2894384C (fr) 2012-12-11 2018-03-06 Novartis Ag Biomarqueur de prediction de la sensibilite a un traitement par un activateur du recepteur alpha 7 nicotinique de l'acetylcholine
JP6338223B2 (ja) 2013-01-15 2018-06-06 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アゴニストの使用
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IL191054A0 (en) 2008-12-29
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