HRP20120071T1 - (1-AZA-BICIKLO[3.3.1]NON-4-IL)-[5-(1H-INDOL-5-IL)-HETEROARIL]-AMINI KAO KOLINERGIČKI LIGANDI OD N-AChR ZA LIJEČENJE PSIHOTIČKIH I NEURODEGENERATIVNIH POREMEĆAJA - Google Patents
(1-AZA-BICIKLO[3.3.1]NON-4-IL)-[5-(1H-INDOL-5-IL)-HETEROARIL]-AMINI KAO KOLINERGIČKI LIGANDI OD N-AChR ZA LIJEČENJE PSIHOTIČKIH I NEURODEGENERATIVNIH POREMEĆAJA Download PDFInfo
- Publication number
- HRP20120071T1 HRP20120071T1 HR20120071T HRP20120071T HRP20120071T1 HR P20120071 T1 HRP20120071 T1 HR P20120071T1 HR 20120071 T HR20120071 T HR 20120071T HR P20120071 T HRP20120071 T HR P20120071T HR P20120071 T1 HRP20120071 T1 HR P20120071T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- image
- acid addition
- free base
- Prior art date
Links
- 208000028017 Psychotic disease Diseases 0.000 title claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 title claims 3
- 230000001713 cholinergic effect Effects 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 35
- 150000003839 salts Chemical group 0.000 claims abstract 12
- 239000002253 acid Substances 0.000 claims abstract 8
- 239000012458 free base Substances 0.000 claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 5
- 125000004702 alkoxy alkyl carbonyl group Chemical group 0.000 claims abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract 2
- 150000003973 alkyl amines Chemical class 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 2
- 125000005265 dialkylamine group Chemical group 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- -1 5-indolyl Chemical group 0.000 claims 3
- 238000004296 chiral HPLC Methods 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 1
- 229910052796 boron Inorganic materials 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- AIDS & HIV (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0525673.0A GB0525673D0 (en) | 2005-12-16 | 2005-12-16 | Organic compounds |
PCT/EP2006/012022 WO2007068475A1 (fr) | 2005-12-16 | 2006-12-14 | (1-aza-bicyclo[3.3.1]non-4-yl)-[5-(1h-indol-5-yl)-hétéroaryl]-amines en tant que ligands cholinergiques du n-achr dans le traitement de troubles psychotiques et neurodégénératifs |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20120071T1 true HRP20120071T1 (hr) | 2012-02-29 |
Family
ID=35736291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20120071T HRP20120071T1 (hr) | 2005-12-16 | 2012-01-23 | (1-AZA-BICIKLO[3.3.1]NON-4-IL)-[5-(1H-INDOL-5-IL)-HETEROARIL]-AMINI KAO KOLINERGIČKI LIGANDI OD N-AChR ZA LIJEČENJE PSIHOTIČKIH I NEURODEGENERATIVNIH POREMEĆAJA |
Country Status (31)
Country | Link |
---|---|
US (3) | US7713977B2 (fr) |
EP (2) | EP1966208B1 (fr) |
JP (1) | JP4995203B2 (fr) |
KR (4) | KR20110015704A (fr) |
CN (1) | CN101305003B (fr) |
AT (1) | ATE531716T1 (fr) |
AU (1) | AU2006326257B2 (fr) |
BR (1) | BRPI0620003A2 (fr) |
CA (1) | CA2632893C (fr) |
CR (1) | CR9965A (fr) |
CY (1) | CY1112410T1 (fr) |
DK (1) | DK1966208T3 (fr) |
EC (1) | ECSP088486A (fr) |
ES (1) | ES2376647T3 (fr) |
GB (1) | GB0525673D0 (fr) |
GT (1) | GT200800096A (fr) |
HK (1) | HK1121443A1 (fr) |
HR (1) | HRP20120071T1 (fr) |
IL (1) | IL191054A (fr) |
MA (1) | MA30025B1 (fr) |
MY (1) | MY147369A (fr) |
NO (1) | NO20083145L (fr) |
NZ (1) | NZ568269A (fr) |
PL (1) | PL1966208T3 (fr) |
PT (1) | PT1966208E (fr) |
RU (1) | RU2440350C2 (fr) |
SI (1) | SI1966208T1 (fr) |
TN (1) | TNSN08257A1 (fr) |
UA (1) | UA94923C2 (fr) |
WO (1) | WO2007068475A1 (fr) |
ZA (1) | ZA200803408B (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6262265A (ja) * | 1985-09-13 | 1987-03-18 | Hitachi Ltd | 復水器自動検査補修システム |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
PE20060437A1 (es) * | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
WO2010056710A1 (fr) * | 2008-11-11 | 2010-05-20 | Biovista, Inc. | Compositions et procédés pour traiter des maladies ophtalmiques |
EP2959902A1 (fr) * | 2009-07-23 | 2015-12-30 | Novartis AG | Utilisation de dérivés d'azabicycloalkyle pour la prévention ou le traitement de l'ataxie |
TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α7活化劑之用途 |
KR20140003580A (ko) * | 2011-01-27 | 2014-01-09 | 노파르티스 아게 | 니코틴성 아세틸콜린 수용체 알파 7 활성화제의 용도 |
CA2830458A1 (fr) | 2011-03-18 | 2012-09-27 | Novartis Ag | Combinaisons d'activateurs des recepteurs nicotiniques a l'acetylcholine alpha 7 et d'antagonistes des mglur5 destinees a etre utilisees dans la dyskinesie induite par la dopaminedans la maladie de parkinson |
BR112014007485B1 (pt) | 2011-10-20 | 2022-05-31 | Novartis Ag | Métodos para prever responsividade terapêutica de um indivíduo a tratamento com um ativador do receptor de acetilcolina nicotínico alfa 7, e usos do referido ativador |
NZ709067A (en) | 2012-12-11 | 2016-08-26 | Novartis Ag | Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment |
CN105246485B (zh) * | 2013-01-15 | 2019-03-15 | 诺华有限公司 | α7烟碱型乙酰胆碱受体激动剂的应用 |
MX2015009155A (es) | 2013-01-15 | 2016-03-04 | Novartis Ag | Uso de agonistas del receptor nicotinico de acetilcolina alfa 7. |
BR112015016994A8 (pt) * | 2013-01-15 | 2018-01-23 | Novartis Ag | uso de agonistas do receptor alfa 7 nicotínico de acetilcolina |
US20150313884A1 (en) | 2013-01-15 | 2015-11-05 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
Family Cites Families (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB281309A (en) | 1926-11-27 | 1928-03-29 | Inventia Patent Verwert Ges | Improvements in or relating to brushing machines having replaceable brush members |
US3310553A (en) | 1962-09-25 | 1967-03-21 | Pfizer & Co C | Alkylated thioxathenesulfonamides |
US3539573A (en) | 1967-03-22 | 1970-11-10 | Jean Schmutz | 11-basic substituted dibenzodiazepines and dibenzothiazepines |
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2005
- 2005-12-16 GB GBGB0525673.0A patent/GB0525673D0/en not_active Ceased
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- 2006-12-14 KR KR1020117002824A patent/KR20110015704A/ko not_active Application Discontinuation
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- 2006-12-14 AT AT06840977T patent/ATE531716T1/de active
- 2006-12-14 SI SI200631235T patent/SI1966208T1/sl unknown
- 2006-12-14 DK DK06840977.0T patent/DK1966208T3/da active
- 2006-12-14 KR KR1020087014269A patent/KR20080068129A/ko not_active Application Discontinuation
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- 2006-12-14 ES ES06840977T patent/ES2376647T3/es active Active
- 2006-12-14 WO PCT/EP2006/012022 patent/WO2007068475A1/fr active Application Filing
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- 2006-12-14 EP EP06840977A patent/EP1966208B1/fr active Active
- 2006-12-14 KR KR1020147020450A patent/KR20140097598A/ko not_active Application Discontinuation
- 2006-12-14 AU AU2006326257A patent/AU2006326257B2/en not_active Ceased
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- 2006-12-14 RU RU2008128568/04A patent/RU2440350C2/ru not_active IP Right Cessation
- 2006-12-14 EP EP11162280A patent/EP2354141A1/fr not_active Withdrawn
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