PL1966208T3 - (1-Aza-bicyklo[3.3.1]non-4-ylo)-[5-(1H-indol-5-ilo)-heteroarylo}-aminy jako ligandy cholinergiczne receptorów n-AChR do leczenia zaburzeń psychotycznych i neurodegeneracyjnych - Google Patents
(1-Aza-bicyklo[3.3.1]non-4-ylo)-[5-(1H-indol-5-ilo)-heteroarylo}-aminy jako ligandy cholinergiczne receptorów n-AChR do leczenia zaburzeń psychotycznych i neurodegeneracyjnychInfo
- Publication number
- PL1966208T3 PL1966208T3 PL06840977T PL06840977T PL1966208T3 PL 1966208 T3 PL1966208 T3 PL 1966208T3 PL 06840977 T PL06840977 T PL 06840977T PL 06840977 T PL06840977 T PL 06840977T PL 1966208 T3 PL1966208 T3 PL 1966208T3
- Authority
- PL
- Poland
- Prior art keywords
- achr
- psychotic
- indol
- aza
- bicyclo
- Prior art date
Links
- 230000001713 cholinergic effect Effects 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 208000028017 Psychotic disease Diseases 0.000 title 1
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004702 alkoxy alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005265 dialkylamine group Chemical group 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0525673.0A GB0525673D0 (en) | 2005-12-16 | 2005-12-16 | Organic compounds |
| PCT/EP2006/012022 WO2007068475A1 (en) | 2005-12-16 | 2006-12-14 | (1-aza-bicyclo[3.3.1] n0n-4-yl)-[5-(ih-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-achr for the treatment of psychotic and neurodegenerative disorders |
| EP06840977A EP1966208B1 (en) | 2005-12-16 | 2006-12-14 | (1-AZA-BICYCLO[3.3.1]NON-4-YL)-[5-(1H-INDOL-5-YL)-HETEROARYL]-AMINES AS CHOLINERGIC LIGANDS OF THE N-AChR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISORDERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1966208T3 true PL1966208T3 (pl) | 2012-04-30 |
Family
ID=35736291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06840977T PL1966208T3 (pl) | 2005-12-16 | 2006-12-14 | (1-Aza-bicyklo[3.3.1]non-4-ylo)-[5-(1H-indol-5-ilo)-heteroarylo}-aminy jako ligandy cholinergiczne receptorów n-AChR do leczenia zaburzeń psychotycznych i neurodegeneracyjnych |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US7713977B2 (pl) |
| EP (2) | EP2354141A1 (pl) |
| JP (1) | JP4995203B2 (pl) |
| KR (4) | KR101443003B1 (pl) |
| CN (1) | CN101305003B (pl) |
| AT (1) | ATE531716T1 (pl) |
| AU (1) | AU2006326257B2 (pl) |
| BR (1) | BRPI0620003A2 (pl) |
| CA (1) | CA2632893C (pl) |
| CR (1) | CR9965A (pl) |
| CY (1) | CY1112410T1 (pl) |
| DK (1) | DK1966208T3 (pl) |
| EC (1) | ECSP088486A (pl) |
| ES (1) | ES2376647T3 (pl) |
| GB (1) | GB0525673D0 (pl) |
| GT (1) | GT200800096A (pl) |
| HR (1) | HRP20120071T1 (pl) |
| IL (1) | IL191054A (pl) |
| MA (1) | MA30025B1 (pl) |
| MY (1) | MY147369A (pl) |
| NO (1) | NO20083145L (pl) |
| NZ (1) | NZ568269A (pl) |
| PL (1) | PL1966208T3 (pl) |
| PT (1) | PT1966208E (pl) |
| RU (1) | RU2440350C2 (pl) |
| SI (1) | SI1966208T1 (pl) |
| TN (1) | TNSN08257A1 (pl) |
| UA (1) | UA94923C2 (pl) |
| WO (1) | WO2007068475A1 (pl) |
| ZA (1) | ZA200803408B (pl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6262265A (ja) * | 1985-09-13 | 1987-03-18 | Hitachi Ltd | 復水器自動検査補修システム |
| GB0220581D0 (en) * | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| AR049401A1 (es) | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) * | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| WO2010056710A1 (en) * | 2008-11-11 | 2010-05-20 | Biovista, Inc. | Compositions and methods for treating eye diseases |
| EP2456438A2 (en) * | 2009-07-23 | 2012-05-30 | Novartis AG | Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| EP2667862A1 (en) | 2011-01-27 | 2013-12-04 | Novartis AG | Use of nicotinic acetylcholine receptor alpha 7 activators |
| WO2012127393A1 (en) | 2011-03-18 | 2012-09-27 | Novartis Ag | COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE |
| IN2014CN03647A (pl) | 2011-10-20 | 2015-10-09 | Novartis Ag | |
| KR20180014854A (ko) | 2012-12-11 | 2018-02-09 | 노파르티스 아게 | 알파 7 니코틴성 아세틸콜린 수용체 활성화제 치료에 대한 반응성의 예측 바이오마커 |
| US20150313884A1 (en) | 2013-01-15 | 2015-11-05 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
| MX378251B (es) | 2013-01-15 | 2025-03-10 | Novartis Ag | Uso de agonistas del receptor nicotinico de acetilcolina alfa 7. |
| KR101879919B1 (ko) * | 2013-01-15 | 2018-07-18 | 노파르티스 아게 | 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도 |
| BR112015016994A8 (pt) | 2013-01-15 | 2018-01-23 | Novartis Ag | uso de agonistas do receptor alfa 7 nicotínico de acetilcolina |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB281309A (en) | 1926-11-27 | 1928-03-29 | Inventia Patent Verwert Ges | Improvements in or relating to brushing machines having replaceable brush members |
| US3310553A (en) | 1962-09-25 | 1967-03-21 | Pfizer & Co C | Alkylated thioxathenesulfonamides |
| US3539573A (en) | 1967-03-22 | 1970-11-10 | Jean Schmutz | 11-basic substituted dibenzodiazepines and dibenzothiazepines |
| BE759371A (fr) | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
| DE2139107A1 (de) | 1971-08-04 | 1973-02-15 | Merck Patent Gmbh | Heterocyclisch substituierte adenosinverbindungen |
| GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| US4536518A (en) | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| ZA848275B (en) | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
| US4605652A (en) | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
| ES2053451T3 (es) | 1986-01-07 | 1994-08-01 | Beecham Group Plc | Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles. |
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