DK1966208T3 - (1-Aza-bicyclo[3.3.1]non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-aminer som cholinergiske ligander af nAChR til behandling af psykotiske og neurodegenerative lidelser - Google Patents

(1-Aza-bicyclo[3.3.1]non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-aminer som cholinergiske ligander af nAChR til behandling af psykotiske og neurodegenerative lidelser

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Publication number
DK1966208T3
DK1966208T3 DK06840977.0T DK06840977T DK1966208T3 DK 1966208 T3 DK1966208 T3 DK 1966208T3 DK 06840977 T DK06840977 T DK 06840977T DK 1966208 T3 DK1966208 T3 DK 1966208T3
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Prior art keywords
nachr
psychotic
indol
aza
bicyclo
Prior art date
Application number
DK06840977.0T
Other languages
English (en)
Inventor
Mathias Frederiksen
Dominik Feuerbach
Konstanze Hurth
Manuel Koller
Bernard Lucien Roy
Original Assignee
Novartis Ag
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Publication date
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Publication of DK1966208T3 publication Critical patent/DK1966208T3/da

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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DK06840977.0T 2005-12-16 2006-12-14 (1-Aza-bicyclo[3.3.1]non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-aminer som cholinergiske ligander af nAChR til behandling af psykotiske og neurodegenerative lidelser DK1966208T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0525673.0A GB0525673D0 (en) 2005-12-16 2005-12-16 Organic compounds
PCT/EP2006/012022 WO2007068475A1 (en) 2005-12-16 2006-12-14 (1-aza-bicyclo[3.3.1] n0n-4-yl)-[5-(ih-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-achr for the treatment of psychotic and neurodegenerative disorders

Publications (1)

Publication Number Publication Date
DK1966208T3 true DK1966208T3 (da) 2012-02-13

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DK06840977.0T DK1966208T3 (da) 2005-12-16 2006-12-14 (1-Aza-bicyclo[3.3.1]non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-aminer som cholinergiske ligander af nAChR til behandling af psykotiske og neurodegenerative lidelser

Country Status (31)

Country Link
US (3) US7713977B2 (da)
EP (2) EP2354141A1 (da)
JP (1) JP4995203B2 (da)
KR (4) KR20110015704A (da)
CN (1) CN101305003B (da)
AT (1) ATE531716T1 (da)
AU (1) AU2006326257B2 (da)
BR (1) BRPI0620003A2 (da)
CA (1) CA2632893C (da)
CR (1) CR9965A (da)
CY (1) CY1112410T1 (da)
DK (1) DK1966208T3 (da)
EC (1) ECSP088486A (da)
ES (1) ES2376647T3 (da)
GB (1) GB0525673D0 (da)
GT (1) GT200800096A (da)
HK (1) HK1121443A1 (da)
HR (1) HRP20120071T1 (da)
IL (1) IL191054A (da)
MA (1) MA30025B1 (da)
MY (1) MY147369A (da)
NO (1) NO20083145L (da)
NZ (1) NZ568269A (da)
PL (1) PL1966208T3 (da)
PT (1) PT1966208E (da)
RU (1) RU2440350C2 (da)
SI (1) SI1966208T1 (da)
TN (1) TNSN08257A1 (da)
UA (1) UA94923C2 (da)
WO (1) WO2007068475A1 (da)
ZA (1) ZA200803408B (da)

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GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) * 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
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JP2012533601A (ja) * 2009-07-23 2012-12-27 ノバルティス アーゲー 運動失調症の処置または予防のための、アザビシクロアルキル誘導体またはピロリジン−２−オン誘導体の使用
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
EA201391091A1 (ru) 2011-01-27 2013-12-30 Новартис Аг Применение активаторов никотиновых ацетилхолиновых рецепторов альфа-7
WO2012127393A1 (en) 2011-03-18 2012-09-27 Novartis Ag COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE
CN103930112B (zh) 2011-10-20 2018-11-09 诺华股份有限公司 预测对α7烟碱型乙酰胆碱受体激活剂疗法的响应的生物标志物
WO2014091388A2 (en) 2012-12-11 2014-06-19 Novartis Ag Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
EP2945626B1 (en) * 2013-01-15 2018-09-12 Novartis AG Use of alpha 7 nicotinic receptor agonists for the treatment of narcolepsy
KR101879920B1 (ko) 2013-01-15 2018-07-18 노파르티스 아게 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
ES2865736T3 (es) 2013-01-15 2021-10-15 Novartis Ag Uso de agonistas del receptor de acetilcolina nicotínico alfa 7

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