AR071789A1 - Heterociclos nitrogenados inhibidores de quinasas jnk, composiciones farmaceuticas que los contienen, proceso de preparacion, y uso de los mismos en el tratamiento de enfermedades neurologicas e inflamatorias, entre otras. - Google Patents
Heterociclos nitrogenados inhibidores de quinasas jnk, composiciones farmaceuticas que los contienen, proceso de preparacion, y uso de los mismos en el tratamiento de enfermedades neurologicas e inflamatorias, entre otras.Info
- Publication number
- AR071789A1 AR071789A1 ARP090101735A ARP090101735A AR071789A1 AR 071789 A1 AR071789 A1 AR 071789A1 AR P090101735 A ARP090101735 A AR P090101735A AR P090101735 A ARP090101735 A AR P090101735A AR 071789 A1 AR071789 A1 AR 071789A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- haloalkyl
- alkyl
- alkoxy
- hydroxy
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos y composiciones aqu¡ descriptos son utiles para modular la actividad de las JNK y tratar enfermedades asociadas con la actividad de las JNK. Se describen metodos y formulaciones para inhibir las JNK y tratar trastornos mediados por las JNK y similares con los compuestos, y procesos para la obtencion de dichos compuestos y para la fabricacion de las correspondientes composiciones aqu¡ descriptas. Reivindicacion 1: Un compuesto de la formula 1 o una sal farmaceuticamente aceptable del mismo, en la que cada uno de R1 y R2 es con independencia H o alquilo inferior; o R1 y R2 juntos forman un anillo cicloalquilo opcionalmente sustituido por uno o m s R2'; R2' es alquilo inferior, hidroxi, halogeno, amino, alcoxi inferior, hidroxialquilo inferior o haloalquilo inferior; R3 es H o N(R4)(R5); R4 es H, alquilo inferior o C(=O)OR4'; R4' es H o alquilo inferior; R5 es H o alquilo inferior; o R2 y R3 juntos forman un anillo heteroc¡clico o heteroarilo, opcionalmente sustituido por uno o m s R2'; Q es CH o N; Z1 es (CH2)u; u es el numero 0 o 1; Z2 es (CH2)v; v es el numero 0 o 1; X1 es alquilo inferior, alcoxi inferior, haloalquilo inferior o hidroxi; m es el numero 0, 1 o 2; X2 es alquilo inferior, alcoxi inferior o haloalquilo inferior; n es el numero 0 o 1; X3 es alquilo inferior, alcoxi inferior o haloalquilo inferior; p es el numero 0 o 1; X4 es alquilo inferior, alcoxi inferior, haloalquilo inferior, hidroxi, hidroxilalquilo inferior o halogeno; q es el numero 0, 1 o 2; X5 es alquilo inferior, alcoxi inferior, haloalquilo inferior, hidroxi, hidroxilalquilo inferior o halogeno; r es el numero 0, 1 o 2; Y1 es CH(Y1'); Y1' es H o alquilo inferior; Y2 es H o Y2'; Y2' es alquilo inferior, N(Y2'')2, haloalquilo inferior o heteroalquilo inferior; o Y1' e Y2' juntos forman un anillo heteroc¡clico; y cada Y2 es con independencia H, alquilo inferior, cicloalquilo inferior, fenilo o heterocicloalquilo inferior; o los dos Y2 juntos forman un anillo heteroc¡clico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5389608P | 2008-05-16 | 2008-05-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR071789A1 true AR071789A1 (es) | 2010-07-14 |
Family
ID=40937466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101735A AR071789A1 (es) | 2008-05-16 | 2009-05-14 | Heterociclos nitrogenados inhibidores de quinasas jnk, composiciones farmaceuticas que los contienen, proceso de preparacion, y uso de los mismos en el tratamiento de enfermedades neurologicas e inflamatorias, entre otras. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8183254B2 (es) |
EP (1) | EP2283009B1 (es) |
JP (1) | JP5329648B2 (es) |
KR (1) | KR101368079B1 (es) |
CN (1) | CN102015689B (es) |
AR (1) | AR071789A1 (es) |
AU (1) | AU2009248233A1 (es) |
BR (1) | BRPI0912564A2 (es) |
CA (1) | CA2722158A1 (es) |
CL (1) | CL2009001192A1 (es) |
ES (1) | ES2392788T3 (es) |
IL (1) | IL208916A0 (es) |
MX (1) | MX2010012249A (es) |
PE (1) | PE20091968A1 (es) |
RU (1) | RU2504545C2 (es) |
TW (1) | TW200948804A (es) |
WO (1) | WO2009138340A1 (es) |
ZA (1) | ZA201007178B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2012013589A (es) * | 2010-06-04 | 2012-12-17 | Hoffmann La Roche | Derivados de 2-amino pirimidina utiles como inhibidores de cinasas del extremo n-terminal de c-jun (jnk). |
RU2012155144A (ru) * | 2010-06-04 | 2014-07-20 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы jnk |
DK3234110T3 (da) | 2014-12-18 | 2024-05-13 | Harvard College | FREMGANGSMÅDER TIL GENERERING AF STAMCELLE-AFLEDTE ß-CELLER OG ANVENDELSER DERAF |
CN106810536A (zh) * | 2015-11-30 | 2017-06-09 | 甘李药业股份有限公司 | 一种蛋白激酶抑制剂及其制备方法和医药用途 |
WO2017204626A1 (en) | 2016-05-24 | 2017-11-30 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Combination therapy - combined map2k4/map3k1 and mek/erk inhibition |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5636900A (en) * | 1999-06-30 | 2001-01-31 | Merck & Co., Inc. | Src kinase inhibitor compounds |
UA78035C2 (en) * | 2002-04-25 | 2007-02-15 | Applied Research Systems | Piperazine benzothiazole for treatment of cerebral ischemic disorders or cns disorders |
WO2006038001A1 (en) * | 2004-10-06 | 2006-04-13 | Celltech R & D Limited | Aminopyrimidine derivatives as jnk inhibitors |
GB0500492D0 (en) * | 2005-01-11 | 2005-02-16 | Cyclacel Ltd | Compound |
BRPI0717035B8 (pt) * | 2006-09-08 | 2021-05-25 | Hoffmann La Roche | moduladores de benzotriazol cinase |
RU2493155C2 (ru) * | 2006-12-08 | 2013-09-20 | Ф.Хоффманн-Ля Рош Аг | Замещенные пиримидины и их применение в качестве модуляторов jnk |
-
2009
- 2009-05-06 JP JP2011508866A patent/JP5329648B2/ja not_active Expired - Fee Related
- 2009-05-06 BR BRPI0912564A patent/BRPI0912564A2/pt not_active IP Right Cessation
- 2009-05-06 CA CA2722158A patent/CA2722158A1/en not_active Abandoned
- 2009-05-06 RU RU2010151475/04A patent/RU2504545C2/ru not_active IP Right Cessation
- 2009-05-06 AU AU2009248233A patent/AU2009248233A1/en not_active Abandoned
- 2009-05-06 EP EP09745673A patent/EP2283009B1/en not_active Not-in-force
- 2009-05-06 WO PCT/EP2009/055443 patent/WO2009138340A1/en active Application Filing
- 2009-05-06 CN CN200980116401.0A patent/CN102015689B/zh not_active Expired - Fee Related
- 2009-05-06 KR KR1020107025625A patent/KR101368079B1/ko not_active IP Right Cessation
- 2009-05-06 ES ES09745673T patent/ES2392788T3/es active Active
- 2009-05-06 MX MX2010012249A patent/MX2010012249A/es active IP Right Grant
- 2009-05-12 PE PE2009000646A patent/PE20091968A1/es not_active Application Discontinuation
- 2009-05-13 TW TW098115896A patent/TW200948804A/zh unknown
- 2009-05-14 AR ARP090101735A patent/AR071789A1/es unknown
- 2009-05-14 US US12/454,210 patent/US8183254B2/en not_active Expired - Fee Related
- 2009-05-15 CL CL2009001192A patent/CL2009001192A1/es unknown
-
2010
- 2010-10-07 ZA ZA2010/07178A patent/ZA201007178B/en unknown
- 2010-10-25 IL IL208916A patent/IL208916A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL208916A0 (en) | 2011-01-31 |
CN102015689A (zh) | 2011-04-13 |
RU2010151475A (ru) | 2012-06-27 |
CN102015689B (zh) | 2014-01-08 |
KR101368079B1 (ko) | 2014-03-14 |
US8183254B2 (en) | 2012-05-22 |
PE20091968A1 (es) | 2010-01-15 |
MX2010012249A (es) | 2010-12-06 |
ES2392788T3 (es) | 2012-12-13 |
EP2283009A1 (en) | 2011-02-16 |
RU2504545C2 (ru) | 2014-01-20 |
WO2009138340A1 (en) | 2009-11-19 |
AU2009248233A1 (en) | 2009-11-19 |
CA2722158A1 (en) | 2009-11-19 |
BRPI0912564A2 (pt) | 2019-09-24 |
ZA201007178B (en) | 2013-03-27 |
TW200948804A (en) | 2009-12-01 |
US20090318484A1 (en) | 2009-12-24 |
JP5329648B2 (ja) | 2013-10-30 |
KR20100137567A (ko) | 2010-12-30 |
EP2283009B1 (en) | 2012-08-29 |
CL2009001192A1 (es) | 2010-08-13 |
JP2011520824A (ja) | 2011-07-21 |
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