CR9965A - (1-aza-biciclo[3.3.3.1]-non-4-il)-[1h-indol-5-il)-heteroaril]-amina como ligandos colinergicos del n-achr para el tratamiento de trastornos psicoticos y neurodegenerativos - Google Patents

(1-aza-biciclo[3.3.3.1]-non-4-il)-[1h-indol-5-il)-heteroaril]-amina como ligandos colinergicos del n-achr para el tratamiento de trastornos psicoticos y neurodegenerativos

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Publication number
CR9965A
CR9965A CR9965A CR9965A CR9965A CR 9965 A CR9965 A CR 9965A CR 9965 A CR9965 A CR 9965A CR 9965 A CR9965 A CR 9965A CR 9965 A CR9965 A CR 9965A
Authority
CR
Costa Rica
Prior art keywords
achr
colinergic
heteroaril
amina
psychotic
Prior art date
Application number
CR9965A
Other languages
English (en)
Inventor
Frederiksen Mathias
Feuerbach Dominik
Hurth Konstanze
Koller Manuel
Lucien Roy Bernard
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CR9965A publication Critical patent/CR9965A/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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Abstract

La presente invencion se refiere a compuestos de la Formula (I) en donde n representa 0, 1, 2, 3, 4 o 5, R representa independientemente uno del otro, hidroxilo, ciano, nitro, halogeno, alquilo, alcoxi-alquil-carbonilo, alco-carbonilo, alquil-amina, dialquil-amina, alquil-carbonil-amina, alquil-carbamato, Y representa uno de los siguientes grups: (Ia): en forma de base libre o de sal de adicion de acido, a procesos para su produccion, a composicones farmaceuticas que los comprenden, y a su uso en la fabricacion de un medicamento que los comprende.
CR9965A 2005-12-16 2008-05-09 (1-aza-biciclo[3.3.3.1]-non-4-il)-[1h-indol-5-il)-heteroaril]-amina como ligandos colinergicos del n-achr para el tratamiento de trastornos psicoticos y neurodegenerativos CR9965A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0525673.0A GB0525673D0 (en) 2005-12-16 2005-12-16 Organic compounds

Publications (1)

Publication Number Publication Date
CR9965A true CR9965A (es) 2008-08-25

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ID=35736291

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Application Number Title Priority Date Filing Date
CR9965A CR9965A (es) 2005-12-16 2008-05-09 (1-aza-biciclo[3.3.3.1]-non-4-il)-[1h-indol-5-il)-heteroaril]-amina como ligandos colinergicos del n-achr para el tratamiento de trastornos psicoticos y neurodegenerativos

Country Status (31)

Country Link
US (3) US7713977B2 (es)
EP (2) EP1966208B1 (es)
JP (1) JP4995203B2 (es)
KR (4) KR20140097598A (es)
CN (1) CN101305003B (es)
AT (1) ATE531716T1 (es)
AU (1) AU2006326257B2 (es)
BR (1) BRPI0620003A2 (es)
CA (1) CA2632893C (es)
CR (1) CR9965A (es)
CY (1) CY1112410T1 (es)
DK (1) DK1966208T3 (es)
EC (1) ECSP088486A (es)
ES (1) ES2376647T3 (es)
GB (1) GB0525673D0 (es)
GT (1) GT200800096A (es)
HK (1) HK1121443A1 (es)
HR (1) HRP20120071T1 (es)
IL (1) IL191054A (es)
MA (1) MA30025B1 (es)
MY (1) MY147369A (es)
NO (1) NO20083145L (es)
NZ (1) NZ568269A (es)
PL (1) PL1966208T3 (es)
PT (1) PT1966208E (es)
RU (1) RU2440350C2 (es)
SI (1) SI1966208T1 (es)
TN (1) TNSN08257A1 (es)
UA (1) UA94923C2 (es)
WO (1) WO2007068475A1 (es)
ZA (1) ZA200803408B (es)

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GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) * 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) * 2005-12-16 2006-01-25 Novartis Ag Organic compounds
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CN102573842A (zh) * 2009-07-23 2012-07-11 诺瓦提斯公司 氮杂双环烷基衍生物或吡咯烷-2-酮衍生物的用途
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
MX2013008704A (es) * 2011-01-27 2013-08-21 Novartis Ag Uso de activadores del receptor de acetil-colina nicotinico alfa-7.
MX2013010698A (es) 2011-03-18 2014-02-17 Novartis Ag Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson.
AU2012324458B2 (en) 2011-10-20 2016-05-19 Novartis Ag Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
EP2931315B1 (en) 2012-12-11 2017-11-29 Novartis AG Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
ES2883232T3 (es) 2013-01-15 2021-12-07 Novartis Ag Uso de agonistas del receptor nicotínico de acetilcolina alfa 7
JP6137336B2 (ja) * 2013-01-15 2017-05-31 ノバルティス アーゲー ナルコレプシーの処置のためのアルファ７ニコチン性受容体アゴニストの使用
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
KR101879919B1 (ko) 2013-01-15 2018-07-18 노파르티스 아게 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도

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