HRP20120071T1 - (1-AZA-BICIKLO[3.3.1]NON-4-IL)-[5-(1H-INDOL-5-IL)-HETEROARIL]-AMINI KAO KOLINERGIČKI LIGANDI OD N-AChR ZA LIJEČENJE PSIHOTIČKIH I NEURODEGENERATIVNIH POREMEĆAJA - Google Patents
(1-AZA-BICIKLO[3.3.1]NON-4-IL)-[5-(1H-INDOL-5-IL)-HETEROARIL]-AMINI KAO KOLINERGIČKI LIGANDI OD N-AChR ZA LIJEČENJE PSIHOTIČKIH I NEURODEGENERATIVNIH POREMEĆAJA Download PDFInfo
- Publication number
- HRP20120071T1 HRP20120071T1 HR20120071T HRP20120071T HRP20120071T1 HR P20120071 T1 HRP20120071 T1 HR P20120071T1 HR 20120071 T HR20120071 T HR 20120071T HR P20120071 T HRP20120071 T HR P20120071T HR P20120071 T1 HRP20120071 T1 HR P20120071T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- image
- acid addition
- free base
- Prior art date
Links
- 208000028017 Psychotic disease Diseases 0.000 title claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 title claims 3
- 230000001713 cholinergic effect Effects 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 35
- 150000003839 salts Chemical group 0.000 claims abstract 12
- 239000002253 acid Substances 0.000 claims abstract 8
- 239000012458 free base Substances 0.000 claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 5
- 125000004702 alkoxy alkyl carbonyl group Chemical group 0.000 claims abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract 2
- 150000003973 alkyl amines Chemical class 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 2
- 125000005265 dialkylamine group Chemical group 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- -1 5-indolyl Chemical group 0.000 claims 3
- 238000004296 chiral HPLC Methods 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 1
- 229910052796 boron Inorganic materials 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0525673.0A GB0525673D0 (en) | 2005-12-16 | 2005-12-16 | Organic compounds |
| PCT/EP2006/012022 WO2007068475A1 (en) | 2005-12-16 | 2006-12-14 | (1-aza-bicyclo[3.3.1] n0n-4-yl)-[5-(ih-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-achr for the treatment of psychotic and neurodegenerative disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120071T1 true HRP20120071T1 (hr) | 2012-02-29 |
Family
ID=35736291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120071T HRP20120071T1 (hr) | 2005-12-16 | 2012-01-23 | (1-AZA-BICIKLO[3.3.1]NON-4-IL)-[5-(1H-INDOL-5-IL)-HETEROARIL]-AMINI KAO KOLINERGIČKI LIGANDI OD N-AChR ZA LIJEČENJE PSIHOTIČKIH I NEURODEGENERATIVNIH POREMEĆAJA |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US7713977B2 (es) |
| EP (2) | EP1966208B1 (es) |
| JP (1) | JP4995203B2 (es) |
| KR (4) | KR101443003B1 (es) |
| CN (1) | CN101305003B (es) |
| AT (1) | ATE531716T1 (es) |
| AU (1) | AU2006326257B2 (es) |
| BR (1) | BRPI0620003A2 (es) |
| CA (1) | CA2632893C (es) |
| CR (1) | CR9965A (es) |
| CY (1) | CY1112410T1 (es) |
| DK (1) | DK1966208T3 (es) |
| EC (1) | ECSP088486A (es) |
| ES (1) | ES2376647T3 (es) |
| GB (1) | GB0525673D0 (es) |
| GT (1) | GT200800096A (es) |
| HK (1) | HK1121443A1 (es) |
| HR (1) | HRP20120071T1 (es) |
| IL (1) | IL191054A (es) |
| MA (1) | MA30025B1 (es) |
| MY (1) | MY147369A (es) |
| NO (1) | NO20083145L (es) |
| NZ (1) | NZ568269A (es) |
| PL (1) | PL1966208T3 (es) |
| PT (1) | PT1966208E (es) |
| RU (1) | RU2440350C2 (es) |
| SI (1) | SI1966208T1 (es) |
| TN (1) | TNSN08257A1 (es) |
| UA (1) | UA94923C2 (es) |
| WO (1) | WO2007068475A1 (es) |
| ZA (1) | ZA200803408B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6262265A (ja) * | 1985-09-13 | 1987-03-18 | Hitachi Ltd | 復水器自動検査補修システム |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| AR049401A1 (es) | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| GB0521508D0 (en) * | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| WO2010056710A1 (en) * | 2008-11-11 | 2010-05-20 | Biovista, Inc. | Compositions and methods for treating eye diseases |
| US20120157464A1 (en) * | 2009-07-23 | 2012-06-21 | Novartis Ag | Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives for the treatment or prevention of ataxia |
| TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α７活化劑之用途 |
| MX2013008704A (es) * | 2011-01-27 | 2013-08-21 | Novartis Ag | Uso de activadores del receptor de acetil-colina nicotinico alfa-7. |
| KR20140018286A (ko) | 2011-03-18 | 2014-02-12 | 노파르티스 아게 | 파킨슨병에서의 도파민 유발 이상운동증에서 사용하기 위한 알파 7 니코틴성 아세틸콜린 수용체 활성화제 및 mGluR5 길항제의 조합물 |
| JP6162705B2 (ja) | 2011-10-20 | 2017-07-12 | ノバルティス アーゲー | アルファ７ニコチン性アセチルコリン受容体活性化剤による処置に対する応答性を予測するバイオマーカー |
| AU2013356914B2 (en) | 2012-12-11 | 2017-01-05 | Novartis Ag | Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment |
| US20150313884A1 (en) | 2013-01-15 | 2015-11-05 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
| KR101879920B1 (ko) | 2013-01-15 | 2018-07-18 | 노파르티스 아게 | 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도 |
| EP2945626B1 (en) | 2013-01-15 | 2018-09-12 | Novartis AG | Use of alpha 7 nicotinic receptor agonists for the treatment of narcolepsy |
| BR112015016992A8 (pt) * | 2013-01-15 | 2018-01-23 | Novartis Ag | uso de agonistas do receptor alfa 7 nicotínico de acetilcolina |
Family Cites Families (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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