WO2010007318A3 - NOUVEAUX DERIVES IMIDAZO[1,2-a]PYRIMIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET - Google Patents

NOUVEAUX DERIVES IMIDAZO[1,2-a]PYRIMIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET Download PDF

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Publication number
WO2010007318A3
WO2010007318A3 PCT/FR2009/051408 FR2009051408W WO2010007318A3 WO 2010007318 A3 WO2010007318 A3 WO 2010007318A3 FR 2009051408 W FR2009051408 W FR 2009051408W WO 2010007318 A3 WO2010007318 A3 WO 2010007318A3
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WO
WIPO (PCT)
Prior art keywords
imidazo
production
application
pharmaceutical compositions
met inhibitors
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Application number
PCT/FR2009/051408
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English (en)
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WO2010007318A2 (fr
Inventor
Eric Bacque
Dominique Damour
Conception Nemececk
Patrick Nemececk
Laurent Schio
Sylvie Wentzler
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Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40352183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2010007318(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP09737062A priority Critical patent/EP2318414A2/fr
Priority to MX2011000670A priority patent/MX2011000670A/es
Priority to CA2730964A priority patent/CA2730964A1/fr
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Priority to CN200980136540XA priority patent/CN102159577A/zh
Priority to BRPI0915920-7A priority patent/BRPI0915920A2/pt
Priority to JP2011517980A priority patent/JP2011528339A/ja
Priority to EA201170224A priority patent/EA201170224A1/ru
Priority to AU2009272518A priority patent/AU2009272518A1/en
Publication of WO2010007318A2 publication Critical patent/WO2010007318A2/fr
Publication of WO2010007318A3 publication Critical patent/WO2010007318A3/fr
Priority to TNP2010000619A priority patent/TN2010000619A1/fr
Priority to US13/007,830 priority patent/US20110263593A1/en
Priority to ZA2011/00428A priority patent/ZA201100428B/en
Priority to IL210708A priority patent/IL210708A0/en
Priority to MA33618A priority patent/MA32564B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne les nouveaux produits de formule (I): dans laquelle : n = 0,1 ou 2; X représente H, HaI ou alk; R représente H, NH2, NHaIk, N(alk)2; Ra représente H; HaI; -O-cycloalkyle; -O-alkyle, -O-aryle; -O-hétéroaryle; - NRd(cycloalkyle); -NRd(alkyle); -NRd(aryle); -NRd(hétéroaryle); alkyle; cycloalkyle; hétérocycloalkyle; aryle ou hétéroaryle; tous éventuellement substitués; Rb représente H, Rc, -COORc-CO-Rc ou -CO-NRcRd; avec Rc représente alkyle, cycloalkyle, hétérocycloalkyle, aryle et hétéroaryle, tous éventuellement substitués; Rd représente H, alk ou cycloalkyle; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments notamment comme inhibiteurs de MET.
PCT/FR2009/051408 2008-07-18 2009-07-16 NOUVEAUX DERIVES IMIDAZO[1,2-a]PYRIMIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET WO2010007318A2 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
AU2009272518A AU2009272518A1 (en) 2008-07-18 2009-07-16 Imidazo [1, 2-a] pyrimidine derivatives method for the production thereof application thereof as medicaments pharmaceutical compositions and use thereof as MET inhibitors
BRPI0915920-7A BRPI0915920A2 (pt) 2008-07-18 2009-07-16 derivados imidazo [1,2-a]pirimidina, o respectivo processo de preparo, a respectiva aplicação a título de medicamentos, composições farmacêuticas e nova utilização notadamente com inibidores de met
MX2011000670A MX2011000670A (es) 2008-07-18 2009-07-16 Nuevos derivados de imidazo [1, 2-a] pirimidina, su procedimiento de preparación, su uso como medicamentos, composiciones farmacéuticas y nuevo uso particularmente como inhibidores de met.
CA2730964A CA2730964A1 (fr) 2008-07-18 2009-07-16 Nouveaux derives imidazo[1,2-a]pyrimidine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
EA201170224A EA201170224A1 (ru) 2008-07-18 2009-07-16 Новые производные имидазо[1,2-a]пиримидинов, способ их получения, их применение в качестве лекарственных средств, фармацевтические композиции и новое применение, в частности, в качестве ингибиторов мет
CN200980136540XA CN102159577A (zh) 2008-07-18 2009-07-16 咪唑并[1,2-a]嘧啶衍生物，其制备方法，其作为药物、药物组合物的应用以及作为MET抑制剂的用途
JP2011517980A JP2011528339A (ja) 2008-07-18 2009-07-16 イミダゾ［１，２−ａ］ピリミジン誘導体、この調製方法、薬剤としてのこの適用、医薬組成物、およびＭＥＴ阻害剤としてのこの使用
EP09737062A EP2318414A2 (fr) 2008-07-18 2009-07-16 Derives imidazo [1,2-a] pyrimidine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et utilisation comme inhibiteurs de met
TNP2010000619A TN2010000619A1 (fr) 2009-07-16 2010-12-29 NOUVEAUX DERIVES IMIDAZO [1,2-a] PYRIMIDINE LEUR PROCEDE DE PREPARATION LEUR APPLICATION A TITRE DE MEDICAMENTS COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET
IL210708A IL210708A0 (en) 2008-07-18 2011-01-17 Imidazo [1,2-a]pyrimidine derivatives method for the production thereof application thereof as medicaments pharmaceutical compositions and use thereof as met inhibitors
ZA2011/00428A ZA201100428B (en) 2008-07-18 2011-01-17 Imidazo [1,2-a]pyrimidine derivatives method for the production thereof application thereof as medicaments pharmaceutical compositions and use thereof as met inhibitors
US13/007,830 US20110263593A1 (en) 2008-07-18 2011-01-17 NOVEL IMIDAZO[1,2-a]PYRIMIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE, IN PARTICULAR AS MET INHIBITORS
MA33618A MA32564B1 (fr) 2008-07-18 2011-02-15 NOUVEAUX DERIVES IMIDAZO[1,2-a]PYRIMIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0804086 2008-07-18
FR0804086A FR2933982A1 (fr) 2008-07-18 2008-07-18 Nouveaux derives imidazo°1,2-a!pyrimidine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/007,830 Continuation US20110263593A1 (en) 2008-07-18 2011-01-17 NOVEL IMIDAZO[1,2-a]PYRIMIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE, IN PARTICULAR AS MET INHIBITORS

Publications (2)

Publication Number Publication Date
WO2010007318A2 WO2010007318A2 (fr) 2010-01-21
WO2010007318A3 true WO2010007318A3 (fr) 2010-04-08

Family

ID=40352183

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2009/051408 WO2010007318A2 (fr) 2008-07-18 2009-07-16 NOUVEAUX DERIVES IMIDAZO[1,2-a]PYRIMIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET

Country Status (26)

Country Link
US (1) US20110263593A1 (fr)
EP (1) EP2318414A2 (fr)
JP (1) JP2011528339A (fr)
KR (1) KR20110043680A (fr)
CN (1) CN102159577A (fr)
AR (1) AR072820A1 (fr)
AU (1) AU2009272518A1 (fr)
BR (1) BRPI0915920A2 (fr)
CA (1) CA2730964A1 (fr)
CL (1) CL2011000118A1 (fr)
CO (1) CO6341634A2 (fr)
CR (1) CR20110031A (fr)
DO (1) DOP2011000019A (fr)
EA (1) EA201170224A1 (fr)
EC (1) ECSP11010765A (fr)
FR (1) FR2933982A1 (fr)
IL (1) IL210708A0 (fr)
MA (1) MA32564B1 (fr)
MX (1) MX2011000670A (fr)
NI (1) NI201100020A (fr)
PE (1) PE20110584A1 (fr)
SV (1) SV2011003811A (fr)
TW (1) TW201011025A (fr)
UY (1) UY31998A (fr)
WO (1) WO2010007318A2 (fr)
ZA (1) ZA201100428B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
WO2011121223A1 (fr) 2010-03-30 2011-10-06 Sanofi-Aventis Derives de 6-(alkyl- ou cycloalkyl-triazolopyridazine-sulfanyl) benzothiazoles: preparation, application comme medicaments et utilisation comme inhibiteurs de met
CN102796103A (zh) * 2011-05-23 2012-11-28 南京英派药业有限公司 6-（芳基甲酰）咪唑并[1,2-a]嘧啶和6-（芳基甲酰）[1,2,4]三唑并[4,3-a]嘧啶作为Hedgehog抑制剂及其应用
WO2016089648A1 (fr) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Inhibiteurs de bach1 en combinaison avec des activateurs de nrf2 et compositions pharmaceutiques les contenant
JP7304855B2 (ja) 2017-11-14 2023-07-07 ザ チルドレンズ メディカル センター コーポレーション 新規イミダゾピリミジン化合物およびそれらの使用
JP7382316B2 (ja) 2017-11-14 2023-11-16 ザ チルドレンズ メディカル センター コーポレーション ヒト免疫応答をモジュレートするためのイミダゾピリミジンの使用
CA3129665A1 (fr) 2019-03-21 2020-09-24 Onxeo Molecule dbait associee a un inhibiteur de kinase pour le traitement du cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785157A (en) * 1952-11-05 1957-03-12 Eastman Kodak Co Benzothiazoleazoaniline compounds
US6528510B1 (en) * 1998-09-11 2003-03-04 Warner-Lambert Company HIV protease inhibitors
US20030153568A1 (en) * 2000-02-07 2003-08-14 Basf Aktiengesellschaft Ludwigshafen, Germany Benzothiazole derivatives
WO2006038001A1 (fr) * 2004-10-06 2006-04-13 Celltech R & D Limited Derives d’aminopyrimidine en tant qu’inhibiteurs de la jnk
EP1674466A1 (fr) * 2004-12-27 2006-06-28 4Sc Ag Derives benzazoles 2,5- et 2-6-disubstitues utiles comme des inhibiteurs de la proteine kinase
WO2008064157A1 (fr) * 2006-11-22 2008-05-29 Incyte Corporation Imidazotriazines et imidazopyrimidines utilisées en tant qu'inhibiteurs de kinases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2294117A1 (fr) * 1997-07-03 1999-01-14 Dupont Pharmaceuticals Company Imidazopyrimidines et imidazopyridines utiles pour traiter des troubles neurologiques
EP1711495A2 (fr) * 2004-01-23 2006-10-18 Amgen Inc. Quinolines, chinazolines, pyridines et pyrimidines et leur utilsation dans le traitement d'inflammation, angiogenèse et le cancer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785157A (en) * 1952-11-05 1957-03-12 Eastman Kodak Co Benzothiazoleazoaniline compounds
US6528510B1 (en) * 1998-09-11 2003-03-04 Warner-Lambert Company HIV protease inhibitors
US20030153568A1 (en) * 2000-02-07 2003-08-14 Basf Aktiengesellschaft Ludwigshafen, Germany Benzothiazole derivatives
WO2006038001A1 (fr) * 2004-10-06 2006-04-13 Celltech R & D Limited Derives d’aminopyrimidine en tant qu’inhibiteurs de la jnk
EP1674466A1 (fr) * 2004-12-27 2006-06-28 4Sc Ag Derives benzazoles 2,5- et 2-6-disubstitues utiles comme des inhibiteurs de la proteine kinase
WO2008064157A1 (fr) * 2006-11-22 2008-05-29 Incyte Corporation Imidazotriazines et imidazopyrimidines utilisées en tant qu'inhibiteurs de kinases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PAPKE K ET AL: "On the rhodanation of halogen substituted anilines. 24. On the organic rhodan compounds", DIE PHARMAZIE, GOVI VERLAG PHARMAZEUTISCHER VERLAG GMBH, ESCHBORN, DE, vol. 22, no. 6, 1 May 1967 (1967-05-01), pages 229 - 233, XP009128816, ISSN: 0031-7144 *
VARA PRASAD J V N ET AL: "Thiocyanation of alkylanilines. A simple and efficient synthesis of thiosulfonates containing 2-aminobenzothiazole", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 41, no. 21, 1 May 2000 (2000-05-01), pages 4065 - 4068, XP004204495, ISSN: 0040-4039 *

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JP2011528339A (ja) 2011-11-17
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IL210708A0 (en) 2011-03-31
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