WO2006117211A3 - Derives d'uree, procedes pour leur fabrication et utilisations de ces derives - Google Patents

Derives d'uree, procedes pour leur fabrication et utilisations de ces derives Download PDF

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Publication number
WO2006117211A3
WO2006117211A3 PCT/EP2006/004166 EP2006004166W WO2006117211A3 WO 2006117211 A3 WO2006117211 A3 WO 2006117211A3 EP 2006004166 W EP2006004166 W EP 2006004166W WO 2006117211 A3 WO2006117211 A3 WO 2006117211A3
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WO
WIPO (PCT)
Prior art keywords
manufacture
urea derivatives
derivatives methods
methods
medicaments
Prior art date
Application number
PCT/EP2006/004166
Other languages
English (en)
Other versions
WO2006117211A2 (fr
Inventor
Pierre Deprez
Helene Jary
Taoues Temal
Original Assignee
Proskelia Sas
Pierre Deprez
Helene Jary
Taoues Temal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002605008A priority Critical patent/CA2605008A1/fr
Priority to AU2006243328A priority patent/AU2006243328B2/en
Priority to US11/919,537 priority patent/US8247412B2/en
Priority to PL06724709T priority patent/PL1874765T3/pl
Priority to BRPI0611025A priority patent/BRPI0611025A2/pt
Priority to ES06724709T priority patent/ES2384052T3/es
Priority to EA200702375A priority patent/EA200702375A1/ru
Priority to JP2008508167A priority patent/JP4995189B2/ja
Application filed by Proskelia Sas, Pierre Deprez, Helene Jary, Taoues Temal filed Critical Proskelia Sas
Priority to AT06724709T priority patent/ATE548368T1/de
Priority to EP06724709A priority patent/EP1874765B1/fr
Priority to DK06724709.8T priority patent/DK1874765T3/da
Publication of WO2006117211A2 publication Critical patent/WO2006117211A2/fr
Publication of WO2006117211A3 publication Critical patent/WO2006117211A3/fr
Priority to IL186854A priority patent/IL186854A0/en
Priority to NO20076145A priority patent/NO20076145L/no
Priority to HRP20120424TT priority patent/HRP20120424T1/hr
Priority to US13/535,198 priority patent/US20120283255A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treating Waste Gases (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (I), dans laquelle R1, R'1, R2, R'2, R3, Y et G sont tels que définis dans la description, un procédé pour leur préparation, leur utilisation sous forme de médicaments et des compositions pharmaceutiques les contenant.
PCT/EP2006/004166 2005-04-29 2006-04-24 Derives d'uree, procedes pour leur fabrication et utilisations de ces derives WO2006117211A2 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
AT06724709T ATE548368T1 (de) 2005-04-29 2006-04-24 Harnstoffderivate, verfahren zu ihrer herstellung und ihre anwendungen
AU2006243328A AU2006243328B2 (en) 2005-04-29 2006-04-24 Urea derivatives methods for their manufacture and uses thereof
EP06724709A EP1874765B1 (fr) 2005-04-29 2006-04-24 Derives d'uree, procedes pour leur fabrication et utilisations de ces derives
BRPI0611025A BRPI0611025A2 (pt) 2005-04-29 2006-04-24 composto, uso de um composto, e, composição farmacêuticamente aceitável
ES06724709T ES2384052T3 (es) 2005-04-29 2006-04-24 Derivados de urea, métodos para su fabricación y usos de los mismos
EA200702375A EA200702375A1 (ru) 2005-04-29 2006-04-24 Производные мочевины, способы их получения и применения
JP2008508167A JP4995189B2 (ja) 2005-04-29 2006-04-24 尿素誘導体、その製造方法、およびその使用
CA002605008A CA2605008A1 (fr) 2005-04-29 2006-04-24 Derives d'uree, procedes pour leur fabrication et utilisations de ces derives
US11/919,537 US8247412B2 (en) 2005-04-29 2006-04-24 Urea derivatives methods for their manufacture and uses thereof
PL06724709T PL1874765T3 (pl) 2005-04-29 2006-04-24 Pochodne mocznika, sposoby ich otrzymywania i zastosowanie
DK06724709.8T DK1874765T3 (da) 2005-04-29 2006-04-24 Ureaderivater, fremgangsmåder til fremstilling af disse og anvendelser deraf
IL186854A IL186854A0 (en) 2005-04-29 2007-10-23 Urea derivatives and pharmaceutical compositions containing the same
NO20076145A NO20076145L (no) 2005-04-29 2007-11-28 Ureadeviater, fremgangsmater for deres fremstilling og anvendelse derav
HRP20120424TT HRP20120424T1 (hr) 2005-04-29 2012-05-17 Derivati ureje, postupci za njihovu proizvodnju i njihova uporaba
US13/535,198 US20120283255A1 (en) 2005-04-29 2012-06-27 Urea derivatives, methods for their manufacture, and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0504360 2005-04-29
FR0504360A FR2885129B1 (fr) 2005-04-29 2005-04-29 Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/535,198 Division US20120283255A1 (en) 2005-04-29 2012-06-27 Urea derivatives, methods for their manufacture, and uses therefor

Publications (2)

Publication Number Publication Date
WO2006117211A2 WO2006117211A2 (fr) 2006-11-09
WO2006117211A3 true WO2006117211A3 (fr) 2007-01-11

Family

ID=35311522

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/004166 WO2006117211A2 (fr) 2005-04-29 2006-04-24 Derives d'uree, procedes pour leur fabrication et utilisations de ces derives

Country Status (25)

Country Link
US (2) US8247412B2 (fr)
EP (2) EP1874765B1 (fr)
JP (1) JP4995189B2 (fr)
KR (1) KR20080003380A (fr)
CN (1) CN101238120A (fr)
AR (1) AR056991A1 (fr)
AT (1) ATE548368T1 (fr)
AU (1) AU2006243328B2 (fr)
BR (1) BRPI0611025A2 (fr)
CA (1) CA2605008A1 (fr)
CR (1) CR9469A (fr)
CY (1) CY1112960T1 (fr)
DK (1) DK1874765T3 (fr)
EA (1) EA200702375A1 (fr)
ES (1) ES2384052T3 (fr)
FR (1) FR2885129B1 (fr)
HR (1) HRP20120424T1 (fr)
IL (1) IL186854A0 (fr)
NO (1) NO20076145L (fr)
PL (1) PL1874765T3 (fr)
PT (1) PT1874765E (fr)
TW (1) TW200714598A (fr)
UY (1) UY29510A1 (fr)
WO (1) WO2006117211A2 (fr)
ZA (1) ZA200708871B (fr)

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FR2885129B1 (fr) 2005-04-29 2007-06-15 Proskelia Sas Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
US7875609B2 (en) 2005-11-25 2011-01-25 Galapagos Sasu Urea derivatives, processes for their preparation, their use as medicaments, and pharmaceutical compositions containing them
CA2648939C (fr) * 2006-04-20 2014-07-08 Amgen Inc. Formules d'emulsions stables
GB0613674D0 (en) * 2006-07-10 2006-08-16 Proskelia Sas Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
AU2008233088B2 (en) 2007-03-30 2013-09-26 Amgen Inc. Calcimimetic compounds for use in the treatment of bowel disorders
EP2156846B1 (fr) * 2007-05-08 2014-08-13 Ajinomoto Co., Inc. Agent prophylactique ou thérapeutique contre la diarrhée
JP5504484B2 (ja) * 2007-07-10 2014-05-28 アムジエン・インコーポレーテツド ウレア誘導体および関連ジアミン、これらの製造方法および使用
WO2010104882A1 (fr) 2009-03-10 2010-09-16 Amgen Inc. Procédés de modulation de la motilité des spermatozoïdes
WO2013138753A1 (fr) 2012-03-16 2013-09-19 Fox Chase Chemical Diversity Center, Inc. Promédicaments de riluzole et leur méthode d'utilisation
US9663529B2 (en) 2013-07-02 2017-05-30 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
TW201506024A (zh) 2013-07-02 2015-02-16 必治妥美雅史谷比公司 作為有效ｒｏｃｋ抑制劑的三環甲醯胺衍生物
CN107567438B (zh) * 2015-03-03 2021-06-29 拜尔哈文制药股份有限公司 利鲁唑前药及其用途
CN106946851B (zh) * 2017-03-14 2019-11-12 牡丹江医学院 一种用于预防和治疗肾结石的药物

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WO2001000576A1 (fr) * 1999-06-29 2001-01-04 Ortho-Mcneil Pharmaceutical, Inc. Uree-peptoides de type indole et indazole utilises en tant qu'antagonistes du recepteur de thrombine
WO2002059102A2 (fr) * 2001-01-26 2002-08-01 Aventis Pharma S.A. Derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et utilisation

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JP4995189B2 (ja) 2012-08-08
ATE548368T1 (de) 2012-03-15
FR2885129B1 (fr) 2007-06-15
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AU2006243328A1 (en) 2006-11-09
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BRPI0611025A2 (pt) 2016-11-16
WO2006117211A2 (fr) 2006-11-09
JP2008539186A (ja) 2008-11-13
FR2885129A1 (fr) 2006-11-03
KR20080003380A (ko) 2008-01-07
US8247412B2 (en) 2012-08-21
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US20100240889A1 (en) 2010-09-23
CA2605008A1 (fr) 2006-11-09
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AR056991A1 (es) 2007-11-07
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