DE3854932T2 - Am Brückenkopf substituierte Azabicyclenderivate - Google Patents
Am Brückenkopf substituierte AzabicyclenderivateInfo
- Publication number
- DE3854932T2 DE3854932T2 DE3854932T DE3854932T DE3854932T2 DE 3854932 T2 DE3854932 T2 DE 3854932T2 DE 3854932 T DE3854932 T DE 3854932T DE 3854932 T DE3854932 T DE 3854932T DE 3854932 T2 DE3854932 T2 DE 3854932T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- chem
- alkyl
- nitrogen
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Recording Measured Values (AREA)
- Luminescent Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878709025A GB8709025D0 (en) | 1987-04-15 | 1987-04-15 | Compounds |
GB878729809A GB8729809D0 (en) | 1987-12-22 | 1987-12-22 | Novel compounds |
GB888804224A GB8804224D0 (en) | 1988-02-24 | 1988-02-24 | Novel compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3854932D1 DE3854932D1 (de) | 1996-03-07 |
DE3854932T2 true DE3854932T2 (de) | 1996-06-13 |
Family
ID=27263387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3854932T Expired - Fee Related DE3854932T2 (de) | 1987-04-15 | 1988-04-13 | Am Brückenkopf substituierte Azabicyclenderivate |
Country Status (8)
Country | Link |
---|---|
US (2) | US4971975A (de) |
EP (1) | EP0287356B1 (de) |
JP (1) | JP2651695B2 (de) |
AT (1) | ATE133415T1 (de) |
AU (1) | AU614513B2 (de) |
DE (1) | DE3854932T2 (de) |
DK (1) | DK202388A (de) |
NZ (1) | NZ224237A (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
DE3877470T2 (de) * | 1987-09-10 | 1993-06-24 | Merck Sharp & Dohme | Oxazole und thiazole zur behandlung seniler demenz. |
EP0322182A3 (de) * | 1987-12-22 | 1992-01-02 | Beecham Group Plc | Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
NZ227684A (en) * | 1988-01-30 | 1991-07-26 | Merck Sharp & Dohme | Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions |
GB8808926D0 (en) * | 1988-04-15 | 1988-05-18 | Beecham Group Plc | Novel compounds |
EP0338723B1 (de) * | 1988-04-15 | 1993-08-04 | Beecham Group Plc | Chemische Verbindungen |
EP0363085A3 (de) | 1988-10-03 | 1991-03-27 | Beecham Group Plc | Chemische Verbindungen |
CA2000041A1 (en) * | 1988-10-13 | 1990-04-13 | Barry S. Orlek | Compounds |
ES2219636T3 (es) * | 1989-04-13 | 2004-12-01 | Beecham Group P.L.C. | Nuevos compuestos. |
EP0402056A3 (de) * | 1989-06-06 | 1991-09-04 | Beecham Group p.l.c. | Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
GB8917957D0 (en) * | 1989-08-05 | 1989-09-20 | Beecham Group Plc | Novel compounds |
US5157160A (en) * | 1989-08-16 | 1992-10-20 | Beecham Group P.L.C. | Certain 5-substituted-1-azabicyclo[3.1.1]heptanes and their pharmaceutical use |
DE69030695T2 (de) * | 1989-08-16 | 1998-01-08 | Beecham Group Plc | Azabicyclische Verbindungen |
DE69026197T2 (de) * | 1989-10-07 | 1997-01-09 | Beecham Group Plc | Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
YU84791A (sh) * | 1990-05-19 | 1994-06-10 | Boehringer Ingelheim Kg. | Biciklicni 1-aza-cikloalkalni |
AU8436291A (en) * | 1990-08-24 | 1992-03-17 | Beecham Group Plc | Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them |
GB9019095D0 (en) * | 1990-09-01 | 1990-10-17 | Beecham Group Plc | Novel compounds |
CA2093823A1 (en) * | 1990-10-12 | 1992-04-13 | Steven M. Bromidge | 1,2,5,6-tetrahydropyridine oxime derivatives |
WO1993008191A1 (en) * | 1991-10-15 | 1993-04-29 | Warner-Lambert Company | Azabicyclo oxime and amine cholinergic agents and methods of treatment |
SE9201478D0 (sv) * | 1992-05-11 | 1992-05-11 | Kabi Pharmacia Ab | Heteroaromatic quinuclidinenes, their use and preparation |
US5679693A (en) * | 1992-09-30 | 1997-10-21 | Sanofi | 1-azoniabicyclo 2.2.1!heptanes, method of preparing them and pharmaceutical compositions in which they are present |
AU6010594A (en) * | 1993-02-12 | 1994-08-29 | Sankyo Company Limited | Isoxazoleoxy derivative |
GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
US5733912A (en) * | 1997-02-19 | 1998-03-31 | Abbott Laboratories | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission |
US6875774B2 (en) | 2002-08-06 | 2005-04-05 | The University Of North Carolina | Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
EP1928437A2 (de) * | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenese mittels muscarinrezeptormodulation |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
EP2068872A1 (de) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Kombinationen mit einem 4-acylaminopyridin-derivat |
RU2441868C2 (ru) | 2007-02-09 | 2012-02-10 | Астеллас Фарма Инк. | Аза-кольцевое соединение с внутренним мостиком |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3661918A (en) * | 1968-10-17 | 1972-05-09 | Exxon Research Engineering Co | Process for the preparation of bicyclic amines |
JPS56156283A (en) * | 1980-05-07 | 1981-12-02 | Suntory Ltd | 8-substituted pyrrolitidine and its quaternary ammonium salt |
JPH0633286B2 (ja) * | 1985-01-14 | 1994-05-02 | エーザイ株式会社 | セフエム誘導体 |
US4771051A (en) * | 1985-05-17 | 1988-09-13 | A/S Ferrosan | 3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments |
EP0235878A3 (de) * | 1986-01-16 | 1989-06-14 | Beecham Group Plc | Neue Verbindungen |
GB8630896D0 (en) | 1986-12-24 | 1987-02-04 | Merck Sharp & Dohme | Oxadiazoles |
GB8607713D0 (en) | 1986-03-27 | 1986-04-30 | Merck Sharpe & Dohme Ltd | Oxadiazoles |
NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
GB8615784D0 (en) | 1986-06-27 | 1986-08-06 | Beecham Group Plc | Compounds |
GB8622380D0 (en) | 1986-09-17 | 1986-10-22 | Beecham Group Plc | Compounds |
DE3789039T2 (de) * | 1986-06-27 | 1994-06-09 | Beecham Group Plc | Verbrückte bicyclische N-heterocyclische Verbindungen. |
GB8615785D0 (en) * | 1986-06-27 | 1986-08-06 | Beecham Group Plc | Compounds |
GB8721342D0 (en) | 1987-09-10 | 1987-10-14 | Merk Sharp & Dohme Ltd | Therapeutic agents |
GB8817311D0 (en) | 1988-07-20 | 1988-08-24 | Merck Sharp & Dohme | Therapeutic agents |
GB8801758D0 (en) | 1988-01-27 | 1988-02-24 | Merck Sharp & Dohme | Therapeutic agents |
GB8812145D0 (en) | 1988-05-23 | 1988-06-29 | Merck Sharp & Dohme | Therapeutic agents |
NZ225999A (en) * | 1987-09-10 | 1992-04-28 | Merck Sharp & Dohme | Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions |
GB8801759D0 (en) | 1988-01-27 | 1988-02-24 | Merck Sharp & Dohme | Therapeutic agents |
DE3877470T2 (de) * | 1987-09-10 | 1993-06-24 | Merck Sharp & Dohme | Oxazole und thiazole zur behandlung seniler demenz. |
GB8721343D0 (en) | 1987-09-10 | 1987-10-14 | Merk Sharp & Dohme Ltd | Therapeutic agents |
-
1988
- 1988-04-13 DK DK202388A patent/DK202388A/da not_active Application Discontinuation
- 1988-04-13 AT AT88303334T patent/ATE133415T1/de not_active IP Right Cessation
- 1988-04-13 DE DE3854932T patent/DE3854932T2/de not_active Expired - Fee Related
- 1988-04-13 EP EP88303334A patent/EP0287356B1/de not_active Expired - Lifetime
- 1988-04-13 AU AU14557/88A patent/AU614513B2/en not_active Ceased
- 1988-04-13 NZ NZ224237A patent/NZ224237A/en unknown
- 1988-04-14 JP JP63090466A patent/JP2651695B2/ja not_active Expired - Lifetime
- 1988-04-15 US US07/182,139 patent/US4971975A/en not_active Expired - Fee Related
-
1990
- 1990-09-21 US US07/573,641 patent/US5132316A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2651695B2 (ja) | 1997-09-10 |
US4971975A (en) | 1990-11-20 |
AU1455788A (en) | 1988-10-27 |
EP0287356A3 (en) | 1989-09-20 |
JPS63290878A (ja) | 1988-11-28 |
AU614513B2 (en) | 1991-09-05 |
DE3854932D1 (de) | 1996-03-07 |
US5132316A (en) | 1992-07-21 |
EP0287356B1 (de) | 1996-01-24 |
NZ224237A (en) | 1991-04-26 |
DK202388D0 (da) | 1988-04-13 |
EP0287356A2 (de) | 1988-10-19 |
DK202388A (da) | 1988-10-16 |
ATE133415T1 (de) | 1996-02-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3854932T2 (de) | Am Brückenkopf substituierte Azabicyclenderivate | |
DE69207017T2 (de) | Benzamide | |
ATE98634T1 (de) | Acryloylsubstituierte pyrrol-derivate. | |
DK504889A (da) | N-heterocykliske forbindelser | |
AU2508888A (en) | New Peroxycarboxilyc amine derivatives | |
ES2098866T3 (es) | Oligodesoxirribonucleotidos modificados, su preparacion y su utilizacion terapeutica. | |
GB8917957D0 (en) | Novel compounds | |
AU639493B2 (en) | Azabicyclo compounds | |
DE69030695D1 (de) | Azabicyclische Verbindungen | |
DE69024713D1 (de) | Pyrrolo(2,1-b)thiazol-Derivate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |