CA2741186C - Thioamide compounds, method of making and method of using thereof - Google Patents
Thioamide compounds, method of making and method of using thereof Download PDFInfo
- Publication number
- CA2741186C CA2741186C CA2741186A CA2741186A CA2741186C CA 2741186 C CA2741186 C CA 2741186C CA 2741186 A CA2741186 A CA 2741186A CA 2741186 A CA2741186 A CA 2741186A CA 2741186 C CA2741186 C CA 2741186C
- Authority
- CA
- Canada
- Prior art keywords
- halo
- alkyl
- alkoxy
- alkylthio
- alkylcarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10711408P | 2008-10-21 | 2008-10-21 | |
| US61/107,114 | 2008-10-21 | ||
| PCT/US2009/061337 WO2010048191A1 (en) | 2008-10-21 | 2009-10-20 | Thioamide compounds, method of making and method of using thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2741186A1 CA2741186A1 (en) | 2010-04-29 |
| CA2741186C true CA2741186C (en) | 2016-07-19 |
Family
ID=41404569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2741186A Active CA2741186C (en) | 2008-10-21 | 2009-10-20 | Thioamide compounds, method of making and method of using thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7964621B2 (enExample) |
| EP (1) | EP2358687B9 (enExample) |
| JP (1) | JP5614853B2 (enExample) |
| KR (2) | KR101782308B1 (enExample) |
| CN (1) | CN102239151B (enExample) |
| AU (1) | AU2009307736B2 (enExample) |
| BR (1) | BRPI0920145B8 (enExample) |
| CA (1) | CA2741186C (enExample) |
| CL (1) | CL2011000917A1 (enExample) |
| EA (1) | EA026649B1 (enExample) |
| ES (1) | ES2393965T3 (enExample) |
| MX (1) | MX2011004217A (enExample) |
| NZ (1) | NZ592382A (enExample) |
| WO (1) | WO2010048191A1 (enExample) |
| ZA (1) | ZA201103033B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH669977A5 (enExample) | 1986-02-27 | 1989-04-28 | Bbc Brown Boveri & Cie | |
| WO2012020568A1 (ja) * | 2010-08-10 | 2012-02-16 | 川崎重工業株式会社 | 原動機システム及び船舶 |
| PT3172964T (pt) | 2011-09-12 | 2020-11-30 | Boehringer Ingelheim Animal Health Usa Inc | Composições parasiticidas compreendendo um agente ativo de isoxazolina, método e utilizações das mesmas |
| CN104168900A (zh) | 2012-02-06 | 2014-11-26 | 梅里亚有限公司 | 包含全身性地起作用的活性剂的杀寄生虫口服兽用组合物、方法及其用途 |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| CA2891926A1 (en) | 2012-11-20 | 2014-05-30 | Merial, Inc. | Anthelmintic compounds and compositions and method of using thereof |
| CN103073487B (zh) * | 2013-01-15 | 2014-11-19 | 西华大学 | N-双取代硫代乙酰胺类化合物的合成方法 |
| AR094961A1 (es) | 2013-03-15 | 2015-09-09 | Lilly Co Eli | 1-hidroxi-benzooxaboroles como agentes antiparasitarios |
| CN105873925B (zh) | 2013-11-01 | 2019-09-10 | 勃林格殷格翰动物保健美国公司 | 抗寄生物的和杀虫的异噁唑啉化合物 |
| CN104610110A (zh) * | 2014-03-12 | 2015-05-13 | 广东东阳光药业有限公司 | 一种制备4-取代硫代苯甲酰胺衍生物的方法 |
| ES2765405T3 (es) | 2014-04-17 | 2020-06-09 | Boehringer Ingelheim Animal Health Usa Inc | Utilización de compuestos de malononitrilo para proteger animales de parásitos |
| MX375153B (es) | 2014-05-19 | 2025-03-06 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelminticos. |
| US10864193B2 (en) | 2014-10-31 | 2020-12-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising fipronil at high concentrations |
| PY1609250A (es) | 2015-02-26 | 2018-03-01 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| CN107835818B (zh) | 2015-05-20 | 2022-04-29 | 勃林格殷格翰动物保健美国公司 | 驱虫缩酚酸肽化合物 |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| CN110381738B (zh) | 2016-10-14 | 2021-07-16 | 勃林格殷格翰动物保健美国公司 | 农药的和杀寄生物的乙烯基异噁唑啉化合物 |
| EP3541789A1 (en) | 2016-11-16 | 2019-09-25 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| ES2944616T3 (es) | 2017-08-14 | 2023-06-22 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas |
| MX2021000293A (es) | 2018-07-09 | 2021-07-15 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos antihelminticos. |
| EP3883648A1 (en) | 2018-11-20 | 2021-09-29 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| KR102281492B1 (ko) * | 2018-12-24 | 2021-07-26 | 동인당제약 주식회사 | 세벨라머 함유 경구투여용 현탁제 조성물 및 그 제조방법 |
| JP7637630B2 (ja) | 2019-03-19 | 2025-02-28 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物 |
| PH12022553222A1 (en) | 2020-05-29 | 2024-02-12 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic heterocyclic compounds |
| CN111781291A (zh) * | 2020-06-23 | 2020-10-16 | 广西壮族自治区水产科学研究院 | 一种水中13种大环内酯类抗生素的高分辨质谱检测方法 |
| JP2024504208A (ja) | 2020-12-21 | 2024-01-30 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | イソオキサゾリン化合物を含む殺寄生虫首輪 |
| JP7857414B2 (ja) | 2022-02-17 | 2026-05-12 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 流体製品メーラーを提供する方法及びシステム |
| CN117837424A (zh) * | 2024-02-04 | 2024-04-09 | 黄淮学院 | 一种控制农作物灰飞虱的方法 |
| WO2025257633A1 (en) | 2024-06-12 | 2025-12-18 | Boehringer Ingelheim Vetmedica Gmbh | Long-acting castor oil-containing injectable formulations and methods of use thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6289076B1 (en) | 1997-05-06 | 2001-09-11 | Sumitomo Heavy Industries, Ltd. | Transmission system for synchrotron radiation light |
| US6239077B1 (en) | 1998-05-01 | 2001-05-29 | Nihon Nohyaku Co., Ltd. | Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof |
| AR035523A1 (es) * | 2000-12-20 | 2004-06-02 | Novartis Ag | Uso de compuestos de aminoacetonitrilo para combatir animales daninos endoparasitarios en animales utiles y domesticos de sangre caliente |
| WO2002050052A1 (en) | 2000-12-20 | 2002-06-27 | Syngenta Participations Ag | N-acyl aminoacetonitriles having pesticidal properties |
| AR035531A1 (es) | 2001-01-22 | 2004-06-02 | Novartis Ag | Composicion para el control de plagas endoparasiticas en ganados y animales domesticos, un metodo para su control y el uso de dicha composicion para la preparacion de medicamentos |
| RU2284990C2 (ru) | 2001-05-15 | 2006-10-10 | Новартис Аг | Производные бензамидоацетонитрила, способ их получения, содержащая их композиция для борьбы с нематодами и их применение |
| TWI236341B (en) | 2001-06-15 | 2005-07-21 | Novartis Ag | Aminoacetonitrile compounds for use in the control of endoparasites |
| US20040242913A1 (en) | 2001-10-04 | 2004-12-02 | Pierre Ducray | Organic compounds |
| JP2005531489A (ja) | 2001-10-04 | 2005-10-20 | ノバルティス アクチエンゲゼルシャフト | 駆虫薬としてのカルボニルオキシ−シアノメチル化合物 |
| TW200300140A (en) | 2001-11-14 | 2003-05-16 | Novartis Ag | Organic compounds |
| AR037746A1 (es) | 2001-12-06 | 2004-12-01 | Novartis Ag | Compuestos derivados de amidoacetonitrilo, un procedimiento para su preparacion, un procedimiento para la preparacion de compuestos intermediarios, una composicion para combatir parasitos, un procedimiento para combatir dichos parasitos, y el empleo de dichos derivados para la preparacion de una com |
| AR038156A1 (es) | 2002-01-21 | 2004-12-29 | Novartis Ag | Compuestos de amidoacetonitrilo, proceso para su preparacion, composicion para controlar los parasitos, y uso de estos compuestos para preparar una composicion farmaceutica |
| AR039020A1 (es) | 2002-03-21 | 2005-02-02 | Novartis Ag | Compuestos de aminoacetonitrilo |
| TW200400931A (en) | 2002-05-22 | 2004-01-16 | Novartis Ag | Organic compounds |
| TW200400004A (en) | 2002-05-22 | 2004-01-01 | Novartis Ag | Organic compounds |
| AR039961A1 (es) | 2002-06-06 | 2005-03-09 | Novartis Ag | Derivados de amidoacetonitrilo y su uso como pesticida |
| TW200406386A (en) | 2002-06-07 | 2004-05-01 | Novartis Ag | Organic compounds |
| TW200400932A (en) | 2002-06-19 | 2004-01-16 | Novartis Ag | Organic compounds |
| GB0214117D0 (en) | 2002-06-19 | 2002-07-31 | Syngenta Participations Ag | N-sulphonylaminoacetonitriles having pesticidal properties |
| AR042420A1 (es) * | 2002-09-11 | 2005-06-22 | Novartis Ag | Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica |
| GB0402677D0 (en) | 2003-11-06 | 2004-03-10 | Novartis Ag | Organic compounds |
| AR046757A1 (es) | 2003-12-10 | 2005-12-21 | Novartis Ag | Amidoacetonitrilos utiles como pesticidas |
| AR049391A1 (es) | 2004-06-10 | 2006-07-26 | Novartis Ag | Derivados de aminoacetonitrilo y su uso para controlar parasitos en animales de sangre caliente |
| WO2006043654A1 (ja) | 2004-10-22 | 2006-04-27 | Nihon Nohyaku Co., Ltd. | アセトニトリル誘導体及び有害生物防除剤並びにその使用方法 |
| JP5112074B2 (ja) | 2004-11-09 | 2013-01-09 | ノバルティス アーゲー | アミドアセトニトリル化合物のラセミ体からのアミドアセトニトリル化合物の鏡像異性体の調製方法 |
| US20080227863A1 (en) | 2005-07-25 | 2008-09-18 | Novartis Ag | Organic Compounds |
| WO2008062005A1 (en) | 2006-11-24 | 2008-05-29 | Novartis Ag | The use of aminoacetonitril compounds in the control of endoparasites in warm- blood animals. |
| EP2099785B1 (en) | 2006-12-01 | 2010-05-19 | Syngeta Participations AG | N-cyanoalkylanthranilamides as insecticides |
| CN101578804A (zh) | 2007-02-05 | 2009-11-11 | 诺基亚公司 | 用于提供确认信令的方法和装置 |
| KR20110098012A (ko) | 2007-02-09 | 2011-08-31 | 화이자 리미티드 | 구충제 |
| PL3088384T3 (pl) * | 2007-05-15 | 2019-06-28 | Merial, Inc. | Związki aryloazol-2-ilo-cyjanoetyloaminowe, sposób ich wytwarzania oraz sposób ich stosowania |
-
2009
- 2009-10-20 CA CA2741186A patent/CA2741186C/en active Active
- 2009-10-20 MX MX2011004217A patent/MX2011004217A/es active IP Right Grant
- 2009-10-20 KR KR1020167036242A patent/KR101782308B1/ko active Active
- 2009-10-20 KR KR1020117011425A patent/KR101782311B1/ko active Active
- 2009-10-20 CN CN200980148694.0A patent/CN102239151B/zh active Active
- 2009-10-20 EP EP09744007.7A patent/EP2358687B9/en active Active
- 2009-10-20 BR BRPI0920145A patent/BRPI0920145B8/pt active IP Right Grant
- 2009-10-20 US US12/582,486 patent/US7964621B2/en active Active
- 2009-10-20 EA EA201100666A patent/EA026649B1/ru not_active IP Right Cessation
- 2009-10-20 AU AU2009307736A patent/AU2009307736B2/en active Active
- 2009-10-20 JP JP2011533272A patent/JP5614853B2/ja active Active
- 2009-10-20 NZ NZ592382A patent/NZ592382A/xx unknown
- 2009-10-20 WO PCT/US2009/061337 patent/WO2010048191A1/en not_active Ceased
- 2009-10-20 ES ES09744007T patent/ES2393965T3/es active Active
-
2011
- 2011-04-13 US US13/086,161 patent/US8314146B2/en active Active
- 2011-04-21 CL CL2011000917A patent/CL2011000917A1/es unknown
- 2011-04-21 ZA ZA2011/03033A patent/ZA201103033B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR101782308B1 (ko) | 2017-09-27 |
| WO2010048191A1 (en) | 2010-04-29 |
| MX2011004217A (es) | 2011-06-20 |
| KR20170003704A (ko) | 2017-01-09 |
| CA2741186A1 (en) | 2010-04-29 |
| BRPI0920145B1 (pt) | 2021-03-30 |
| US8314146B2 (en) | 2012-11-20 |
| US20100130565A1 (en) | 2010-05-27 |
| EA026649B1 (ru) | 2017-05-31 |
| EP2358687A1 (en) | 2011-08-24 |
| EA201100666A1 (ru) | 2011-12-30 |
| JP2012506441A (ja) | 2012-03-15 |
| JP5614853B2 (ja) | 2014-10-29 |
| CN102239151A (zh) | 2011-11-09 |
| BRPI0920145B8 (pt) | 2021-05-25 |
| AU2009307736B2 (en) | 2015-02-05 |
| US20110190231A1 (en) | 2011-08-04 |
| AU2009307736A1 (en) | 2010-04-29 |
| EP2358687B9 (en) | 2013-04-17 |
| KR20110071140A (ko) | 2011-06-28 |
| CL2011000917A1 (es) | 2011-09-16 |
| ES2393965T3 (es) | 2013-01-03 |
| ZA201103033B (en) | 2012-02-29 |
| CN102239151B (zh) | 2014-07-02 |
| EP2358687B1 (en) | 2012-09-19 |
| NZ592382A (en) | 2013-03-28 |
| US7964621B2 (en) | 2011-06-21 |
| KR101782311B1 (ko) | 2017-09-27 |
| ES2393965T9 (es) | 2013-07-19 |
| BRPI0920145A2 (pt) | 2017-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2358687B9 (en) | Thioamide compounds, method of making and method of using thereof | |
| CA2784141C (en) | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles | |
| CA2656617C (en) | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | |
| AU2012203942B2 (en) | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | |
| AU2014265124A1 (en) | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles | |
| AU2015200249A1 (en) | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140930 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 16TH ANNIV.) - STANDARD Year of fee payment: 16 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20251007 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251007 |