PE20090487A1 - Compuestos heterociclos como inhibidores de lta4h - Google Patents

Compuestos heterociclos como inhibidores de lta4h

Info

Publication number
PE20090487A1
PE20090487A1 PE2008000325A PE2008000325A PE20090487A1 PE 20090487 A1 PE20090487 A1 PE 20090487A1 PE 2008000325 A PE2008000325 A PE 2008000325A PE 2008000325 A PE2008000325 A PE 2008000325A PE 20090487 A1 PE20090487 A1 PE 20090487A1
Authority
PE
Peru
Prior art keywords
compounds
phenoxy
etoxy
benzoxazole
lta4h
Prior art date
Application number
PE2008000325A
Other languages
English (en)
Inventor
William T Barchuk
Paul J Dunford
James P Edwards
Anne M Fourie
Lars Karlsson
Joanne M Quan
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39686382&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090487(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20090487A1 publication Critical patent/PE20090487A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

REFERIDA A COMPUESTOS DERIVADOS DE FORMULA (I) DONDE X ES S, N O NR5, DONDE R5 ES H O CH3; Y ES O O CH2; Z ES O O UN ENLACE; W ES CH2 O CHR1-CH2, DONDE R1 ES OH O H; R4 ES H, OCH3, Cl, F, Br, I, OH, NH2, CN, CF3 O CH3; R6 ES H O F; R2 Y R3 SON INDEPENDIENTEMENTE H, ALQUIL(C1-C7), CICLOALQUENILO(C5-C7), CICLOAQUIL(C3-C7) OPCIONALMENTE BENZOFUSIONADO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-[4-(2-PIRROLIDIIN-1-IL-ETOXI)-FENOXI]-BENZOXAZOL; {3-[4-(BENZOXAZOL-2-ILOXI)-FENOXI]-PROPIL}-DIMETIL-AMINA; 2-[4-(2-AZEPAN-1-IL-ETOXI)-FENOXI]-BENZOXAZOL, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDRORES DE LA ENZIMA LEUCOTRIENO A4 HIDROLASA (LTA4H) SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS A LA INFLAMACION
PE2008000325A 2007-02-14 2008-02-14 Compuestos heterociclos como inhibidores de lta4h PE20090487A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88985107P 2007-02-14 2007-02-14

Publications (1)

Publication Number Publication Date
PE20090487A1 true PE20090487A1 (es) 2009-05-16

Family

ID=39686382

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000325A PE20090487A1 (es) 2007-02-14 2008-02-14 Compuestos heterociclos como inhibidores de lta4h

Country Status (7)

Country Link
US (1) US20080194630A1 (es)
AR (1) AR065355A1 (es)
CL (1) CL2008000468A1 (es)
PE (1) PE20090487A1 (es)
TW (1) TW200906396A (es)
UY (1) UY30918A1 (es)
WO (1) WO2008100564A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0412345A (pt) * 2003-07-28 2006-10-03 Janssen Pharmaceutica Nv derivados de benzimidazol, benzotiazol e benzoxazol e seu uso como moduladores de lta4h
DK2268646T3 (da) * 2008-04-11 2013-11-18 Janssen Pharmaceutica Nv Thiazolopyridin-2-yloxy-phenyl og thiazolopyrazin-2-yloxy-phenyl-aminer som modulatorer af leukotrien-a4-hydrolase
KR20110077015A (ko) * 2008-10-27 2011-07-06 가부시키가이샤 에무스사이엔스 페닐기 함유 시클로헥실아민 유도체 및 중추 신경 장해를 수반하는 질환의 치료약
RU2011137454A (ru) * 2009-02-10 2013-03-20 Эбботт Лэборетриз Агонисты и антагонисты s1p5-рецепторов и способы их применения
CN102459251B (zh) * 2009-05-14 2015-05-20 詹森药业有限公司 作为白三烯a4水解酶的调节剂的具有两个稠合双环杂芳基部分的化合物
CN103483209A (zh) * 2013-09-13 2014-01-01 陕西嘉禾植物化工有限责任公司 一种大麦碱的合成方法
LT3083564T (lt) 2013-12-20 2018-09-25 Novartis Ag Heteroarilo butano rūgšties dariniai, kaip lta4h inhibitoriai
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
MX2018009809A (es) 2016-02-11 2018-09-10 Bayer Cropscience Ag 2-oximidazolilcarboxamidas sustituidas como plaguicidas.
BR112021013637A2 (pt) 2019-01-11 2021-09-14 Naegis Pharmaceuticals Inc. Inibidores da síntese de leucotrieno
CN113683491A (zh) * 2021-09-01 2021-11-23 王传良 一种4-(2-溴乙基)苯酚的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873346A (en) * 1985-09-20 1989-10-10 The Upjohn Company Substituted benzothiazoles, benzimidazoles, and benzoxazoles
DK171349B1 (da) * 1986-11-14 1996-09-16 Hoffmann La Roche Tetrahydronaphthalenderivater, fremgangsmåde til fremstilling deraf, lægemidler indeholdende forbindelserne samt anvendelse af forbindelserne til fremstilling af lægemidler
IT1240598B (it) * 1990-03-13 1993-12-17 Mini Ricerca Scient Tecnolog Derivati amminici ad azione antifungina
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
BRPI0412345A (pt) * 2003-07-28 2006-10-03 Janssen Pharmaceutica Nv derivados de benzimidazol, benzotiazol e benzoxazol e seu uso como moduladores de lta4h
JP4991693B2 (ja) * 2005-03-16 2012-08-01 メダ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 呼吸器疾患の治療のための抗コリン作用薬及びロイコトリエン受容体アンタゴニストの組み合わせ剤

Also Published As

Publication number Publication date
US20080194630A1 (en) 2008-08-14
AR065355A1 (es) 2009-06-03
WO2008100564A1 (en) 2008-08-21
TW200906396A (en) 2009-02-16
UY30918A1 (es) 2008-09-02
CL2008000468A1 (es) 2008-08-22

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