CN108752217B - 一种度鲁特韦关键中间体2,4-二氟苄胺的合成方法 - Google Patents
一种度鲁特韦关键中间体2,4-二氟苄胺的合成方法 Download PDFInfo
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- CN108752217B CN108752217B CN201810790781.7A CN201810790781A CN108752217B CN 108752217 B CN108752217 B CN 108752217B CN 201810790781 A CN201810790781 A CN 201810790781A CN 108752217 B CN108752217 B CN 108752217B
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- difluorobenzene
- difluorobenzylamine
- dolutegravir
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
- C07C209/26—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with hydrogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
- C07C209/28—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with other reducing agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/49—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with carbon monoxide
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CN201810790781.7A CN108752217B (zh) | 2018-07-18 | 2018-07-18 | 一种度鲁特韦关键中间体2,4-二氟苄胺的合成方法 |
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CN201810790781.7A CN108752217B (zh) | 2018-07-18 | 2018-07-18 | 一种度鲁特韦关键中间体2,4-二氟苄胺的合成方法 |
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CN108752217A CN108752217A (zh) | 2018-11-06 |
CN108752217B true CN108752217B (zh) | 2021-08-06 |
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CN201810790781.7A Active CN108752217B (zh) | 2018-07-18 | 2018-07-18 | 一种度鲁特韦关键中间体2,4-二氟苄胺的合成方法 |
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Families Citing this family (2)
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CN109896963A (zh) * | 2019-03-04 | 2019-06-18 | 东南大学 | 一种4-甲氨基对二甲苯环二体的合成方法 |
CN112374997A (zh) * | 2020-11-17 | 2021-02-19 | 江西国化实业有限公司 | 一种2,4-二氟苄胺及其中间体的制备工艺 |
Family Cites Families (4)
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CN1721386A (zh) * | 2004-07-13 | 2006-01-18 | 上海康文医药中间体有限公司 | 用茶条槭制备2.3.4-三羟基苯甲醛的方法 |
ES2825198T3 (es) * | 2007-05-15 | 2021-05-14 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de ariloazol-2-il cianoetilamino, procedimiento de fabricación y procedimiento de utilización de los mismos |
CN102311352B (zh) * | 2011-07-11 | 2013-10-16 | 上海应用技术学院 | 一种2-甲氧基-4-甲基苄胺的合成方法 |
CN105017026B (zh) * | 2015-07-02 | 2017-10-10 | 南京杰运医药科技有限公司 | 2,4‑二氟苯甲胺的合成方法 |
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Address after: Huangjiao Yantou, Yongquan Town, Linhai City, Taizhou City, Zhejiang Province Patentee after: Zhejiang Shaxing Technology Co.,Ltd. Address before: Huangjiao Yantou, Yongquan Town, Linhai City, Taizhou City, Zhejiang Province Patentee before: ZHEJIANG SHAXING TECHNOLOGY Co.,Ltd. |
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Application publication date: 20181106 Assignee: Zhejiang Shaxing Bohai Technology Co.,Ltd. Assignor: Zhejiang Shaxing Technology Co.,Ltd. Contract record no.: X2023330000338 Denomination of invention: A synthesis method of 2,4-difluorobenzylamine, a key intermediate of Dulutevir Granted publication date: 20210806 License type: Common License Record date: 20230613 |
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