JP2010525881A - 被検体の検知または経皮的薬物送達のための皮膚透過装置 - Google Patents
被検体の検知または経皮的薬物送達のための皮膚透過装置 Download PDFInfo
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- JP2010525881A JP2010525881A JP2010506530A JP2010506530A JP2010525881A JP 2010525881 A JP2010525881 A JP 2010525881A JP 2010506530 A JP2010506530 A JP 2010506530A JP 2010506530 A JP2010506530 A JP 2010506530A JP 2010525881 A JP2010525881 A JP 2010525881A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/328—Applying electric currents by contact electrodes alternating or intermittent currents for improving the appearance of the skin, e.g. facial toning or wrinkle treatment
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
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- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
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- Optics & Photonics (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Plasma & Fusion (AREA)
- Electromagnetism (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Electrotherapy Devices (AREA)
- Medicinal Preparation (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Surgical Instruments (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91455207P | 2007-04-27 | 2007-04-27 | |
| PCT/US2008/061623 WO2008134545A1 (en) | 2007-04-27 | 2008-04-25 | Skin permeation device for analyte sensing or transdermal drug delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013002319A Division JP5827632B2 (ja) | 2007-04-27 | 2013-01-10 | 被検体の検知または経皮的薬物送達のための皮膚透過装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010525881A true JP2010525881A (ja) | 2010-07-29 |
| JP2010525881A5 JP2010525881A5 (cg-RX-API-DMAC7.html) | 2011-06-16 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506530A Withdrawn JP2010525881A (ja) | 2007-04-27 | 2008-04-25 | 被検体の検知または経皮的薬物送達のための皮膚透過装置 |
| JP2013002319A Expired - Fee Related JP5827632B2 (ja) | 2007-04-27 | 2013-01-10 | 被検体の検知または経皮的薬物送達のための皮膚透過装置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013002319A Expired - Fee Related JP5827632B2 (ja) | 2007-04-27 | 2013-01-10 | 被検体の検知または経皮的薬物送達のための皮膚透過装置 |
Country Status (23)
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US9125979B2 (en) | 2007-10-25 | 2015-09-08 | Proteus Digital Health, Inc. | Fluid transfer port information system |
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| CN102946798A (zh) | 2010-02-01 | 2013-02-27 | 普罗秋斯数字健康公司 | 数据采集系统 |
| BR122021014110B1 (pt) | 2010-05-08 | 2022-05-31 | The Regents Of The University Of California | Aparelho e scanner para detecção de umidade subepidérmica (sem) a partir de local externo à pele de paciente e método para monitorar a formação de úlceras de pressão em local alvo na pele de paciente |
| EP2600901B1 (en) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| MX2013003681A (es) | 2010-10-01 | 2013-11-20 | Moderna Therapeutics Inc | Ácidos nucleicos manipulados y métodos de uso de los mismos. |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US9143126B2 (en) | 2011-09-22 | 2015-09-22 | Ford Global Technologies, Llc | Proximity switch having lockout control for controlling movable panel |
| US9428535B2 (en) | 2011-10-03 | 2016-08-30 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| US10112556B2 (en) | 2011-11-03 | 2018-10-30 | Ford Global Technologies, Llc | Proximity switch having wrong touch adaptive learning and method |
| JP6078550B2 (ja) * | 2011-11-24 | 2017-02-08 | シネロン メディカル リミテッド | 皮膚加熱エネルギーによる個人用皮膚治療のための装置 |
| SMT202200355T1 (it) | 2011-12-16 | 2022-11-18 | Modernatx Inc | Composizioni di mrna modificato |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| EP2834260A4 (en) | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9287864B2 (en) | 2012-04-11 | 2016-03-15 | Ford Global Technologies, Llc | Proximity switch assembly and calibration method therefor |
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| US9219472B2 (en) | 2012-04-11 | 2015-12-22 | Ford Global Technologies, Llc | Proximity switch assembly and activation method using rate monitoring |
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| US9559688B2 (en) | 2012-04-11 | 2017-01-31 | Ford Global Technologies, Llc | Proximity switch assembly having pliable surface and depression |
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| US9337832B2 (en) | 2012-06-06 | 2016-05-10 | Ford Global Technologies, Llc | Proximity switch and method of adjusting sensitivity therefor |
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| US9186490B2 (en) * | 2012-06-26 | 2015-11-17 | Franklin J. Chang | Skin treatment device |
| US20130345661A1 (en) * | 2012-06-26 | 2013-12-26 | Franklin J. Chang | Skin Treatment Device |
| US10842670B2 (en) * | 2012-08-22 | 2020-11-24 | Johnson & Johnson Vision Care, Inc. | Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices |
| WO2014045300A2 (en) * | 2012-09-03 | 2014-03-27 | Fdc Limited | "topical drug delivery system" |
| US8922340B2 (en) | 2012-09-11 | 2014-12-30 | Ford Global Technologies, Llc | Proximity switch based door latch release |
| EP2922554B1 (en) | 2012-11-26 | 2022-02-23 | ModernaTX, Inc. | Terminally modified rna |
| EP3434774A1 (en) | 2013-01-17 | 2019-01-30 | ModernaTX, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
| EP2964114B1 (en) * | 2013-03-04 | 2016-08-03 | Koninklijke Philips N.V. | A microdermabrasion device |
| WO2014159813A1 (en) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| US9311204B2 (en) | 2013-03-13 | 2016-04-12 | Ford Global Technologies, Llc | Proximity interface development system having replicator and method |
| US10820860B2 (en) | 2013-03-14 | 2020-11-03 | One Drop Biosensor Technologies, Llc | On-body microsensor for biomonitoring |
| WO2014152717A2 (en) | 2013-03-14 | 2014-09-25 | Sano Intelligence, Inc. | On-body microsensor for biomonitoring |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10052257B2 (en) | 2013-06-13 | 2018-08-21 | Dyansys, Inc. | Method and apparatus for stimulative electrotherapy |
| CN105592789B (zh) * | 2013-06-13 | 2019-07-19 | 迪彦希斯有限公司 | 用于自主神经系统敏感点测试的方法和装置 |
| US10130275B2 (en) | 2013-06-13 | 2018-11-20 | Dyansys, Inc. | Method and apparatus for autonomic nervous system sensitivity-point testing |
| PL3019619T3 (pl) | 2013-07-11 | 2022-01-10 | Modernatx, Inc. | Kompozycje zawierające syntetyczne polinkleotydy kodujące białka powiązane z crispr i syntetyczne sgrna oraz sposoby ich stosowania |
| CA2923029A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| CN103550795B (zh) * | 2013-10-24 | 2015-04-22 | 苏州格林泰克科技有限公司 | 一种电极磨砂导电胶及其制备方法 |
| US10595754B2 (en) | 2014-03-13 | 2020-03-24 | Sano Intelligence, Inc. | System for monitoring body chemistry |
| US20150257687A1 (en) | 2014-03-13 | 2015-09-17 | Sano Intelligence, Inc. | System for monitoring body chemistry |
| US20170204152A1 (en) | 2014-07-16 | 2017-07-20 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| GB201415611D0 (en) | 2014-09-03 | 2014-10-15 | Univ Strathclyde | Apparatus for topical application of material |
| US10038443B2 (en) | 2014-10-20 | 2018-07-31 | Ford Global Technologies, Llc | Directional proximity switch assembly |
| US10856790B2 (en) | 2015-01-09 | 2020-12-08 | Exhalix Llc | Transdermal sampling strip and method for analyzing transdermally emitted gases |
| US10252044B2 (en) | 2015-02-27 | 2019-04-09 | Robert T. Bock Consultancy, Llc | Ultrasonic method and device for cosmetic applications |
| US9654103B2 (en) | 2015-03-18 | 2017-05-16 | Ford Global Technologies, Llc | Proximity switch assembly having haptic feedback and method |
| CA2982249C (en) | 2015-04-24 | 2019-12-31 | Bruin Biometrics, Llc | Apparatus and methods for determining damaged tissue using sub-epidermal moisture measurements |
| US20180360344A1 (en) * | 2017-06-19 | 2018-12-20 | Bruin Biometrics, Llc | Apparatus and methods for determining damaged tissue using sub-epidermal moisture measurements |
| US9548733B2 (en) | 2015-05-20 | 2017-01-17 | Ford Global Technologies, Llc | Proximity sensor assembly having interleaved electrode configuration |
| WO2017021585A1 (en) | 2015-08-04 | 2017-02-09 | Helsingin Yliopisto | Device and method for localized delivery and extraction of material |
| FR3043333B1 (fr) * | 2015-11-06 | 2017-12-22 | Seb Sa | Dispositif d'application d'un produit a distribuer sur la peau d'un utilisateur par iontophorese comprenant des moyens de mesure d'absence de produit et procede correspondant |
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| AU2016381186B2 (en) | 2015-12-30 | 2022-01-20 | Inovio Pharmaceuticals, Inc. | Electroporation device with detachable needle array with lock-out system |
| CN106236087A (zh) * | 2016-08-31 | 2016-12-21 | 苏州格林泰克科技有限公司 | 一种无胶生物电电极及电极辅助装置 |
| WO2018117926A1 (en) * | 2016-12-23 | 2018-06-28 | Atlasbalans Ab | A handheld machine adapted for administration of anti-inflammatory compounds into a body |
| RU184518U1 (ru) * | 2017-01-27 | 2018-10-30 | Виктор Филиппович Агафонников | Электростимулятор желудочно-кишечного тракта с эндогенным ионофорезом ванадия |
| KR20230003447A (ko) | 2017-02-03 | 2023-01-05 | 브루인 바이오메트릭스, 엘엘씨 | 당뇨병성 족부 궤양에 대한 감수성의 측정 |
| CA3042093A1 (en) | 2017-02-03 | 2018-08-09 | Bruin Biometrics, Llc | Measurement of tissue viability |
| BR112019008564A2 (pt) | 2017-02-03 | 2019-09-10 | Bruin Biometrics Llc | aparelhos para avaliar pré-eclâmpsia, hipovolemia e síndrome compartimental, e métodos para detectar pré-eclâmpsia, hipovolemia e síndrome compartimental |
| CN107014877B (zh) * | 2017-05-27 | 2023-06-20 | 北京怡唐生物科技有限公司 | 一种动态连续血糖监测系统 |
| BR112020009672A2 (pt) | 2017-11-16 | 2020-10-13 | Bruin Biometrics, Llc | método para avaliar um paciente e método para gerenciar tratamento de um paciente |
| DK3749181T3 (da) | 2018-02-09 | 2024-04-29 | Bruin Biometrics Llc | Detektering af vævsbeskadigelse |
| US20190247117A1 (en) * | 2018-02-15 | 2019-08-15 | Neuwave Medical, Inc. | Energy delivery devices and related systems and methods thereof |
| CN109011130A (zh) * | 2018-05-29 | 2018-12-18 | 上海大学 | 一种基于纳米针的经皮光电驱动离子药物输送装置 |
| CN117596814A (zh) | 2018-10-11 | 2024-02-23 | 布鲁恩生物有限责任公司 | 具有一次性元件的装置 |
| US11324414B2 (en) * | 2018-11-28 | 2022-05-10 | Vine Medical, LLC | Devices, systems and methods for controlling a spring force exerted on a sensor for obtaining bio-conductance readings using a linear actuator |
| CN113316417B (zh) * | 2018-12-21 | 2024-05-31 | 费森尤斯医疗保健控股公司 | 使用生物阻抗的皮肤钠测量 |
| US11642075B2 (en) | 2021-02-03 | 2023-05-09 | Bruin Biometrics, Llc | Methods of treating deep and early-stage pressure induced tissue damage |
| USD988882S1 (en) | 2021-04-21 | 2023-06-13 | Informed Data Systems Inc. | Sensor assembly |
| USD1076079S1 (en) | 2021-04-21 | 2025-05-20 | One Health Biosensing Inc. | Applicator assembly |
| USD1086030S1 (en) | 2021-04-21 | 2025-07-29 | One Health Biosensing Inc. | Charging station |
| US20230293886A1 (en) * | 2022-02-18 | 2023-09-21 | Nse Products, Inc. | Microcurrent-based skin treatment and pretreatment techniques |
| WO2025244305A1 (ko) * | 2024-05-20 | 2025-11-27 | 주식회사 제이시스메디칼 | 고주파 출력 장치 |
| US12485280B1 (en) | 2024-07-15 | 2025-12-02 | Tav-Tech Ltd | Unitary enhanced jet spray dermal treatment handpiece |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62270144A (ja) * | 1986-03-03 | 1987-11-24 | 久光製薬株式会社 | 経皮投薬用皮膚損傷装置 |
| JPH02224752A (ja) * | 1989-02-28 | 1990-09-06 | Advance Co Ltd | イオントフォレーゼ用デバイス |
| US20040059282A1 (en) * | 2002-09-25 | 2004-03-25 | Flock Stephen T. | Microsurgical tissue treatment system |
| JP2005296629A (ja) * | 2004-02-24 | 2005-10-27 | Mattioli Engineering Ltd | 皮膚吸収を高めるため、および経皮薬剤投与のための方法および装置 |
| WO2006045149A1 (en) * | 2004-10-28 | 2006-05-04 | Ronald Allan Greenberg | A method and apparatus for abrading the skin using a vibrating dermabrasion apparatus |
| JP2006192285A (ja) * | 1995-08-29 | 2006-07-27 | Spectrx Inc | 薬物送達および鑑視適用のためのヒト皮膚の微細穿孔 |
Family Cites Families (231)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005A (en) * | 1845-04-22 | Improvement in the manufacture of indurated rubber fabrics | ||
| US498271A (en) | 1893-05-30 | Caster | ||
| US2887112A (en) | 1957-08-15 | 1959-05-19 | Sanborn Company | Pad for skin preparation for electrocardiography and the like |
| US3508540A (en) | 1967-02-14 | 1970-04-28 | Us Navy | Apparatus for direct measurement of skin conductance |
| US3551554A (en) | 1968-08-16 | 1970-12-29 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active agents with dmso |
| US3711606A (en) | 1970-09-02 | 1973-01-16 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active steroidal agents with dmso |
| US3711602A (en) | 1970-10-30 | 1973-01-16 | Crown Zellerbach Corp | Compositions for topical application for enhancing tissue penetration of physiologically active agents with dmso |
| US3834374A (en) | 1972-04-06 | 1974-09-10 | M Ensanian | Diagnostic electrical scanning |
| US4002221A (en) | 1972-09-19 | 1977-01-11 | Gilbert Buchalter | Method of transmitting ultrasonic impulses to surface using transducer coupling agent |
| US3828769A (en) | 1973-02-28 | 1974-08-13 | H Mettler | Method and apparatus for ultrasonic treatment of lower tissues simultaneous with heating of subcutaneous, outer muscle and lower tissues |
| US3980077A (en) | 1975-02-20 | 1976-09-14 | Carletta M. Neeley | Method for aiding diagnostic scanning of the body of a patient |
| US4020830A (en) | 1975-03-12 | 1977-05-03 | The University Of Utah | Selective chemical sensitive FET transducers |
| US4144317A (en) | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
| US4027664A (en) | 1975-11-17 | 1977-06-07 | Baxter Travenol Laboratories, Inc. | Diagnostic electrode assembly with a skin preparation surface |
| US4144646A (en) | 1975-12-05 | 1979-03-20 | Lion Hamigaki Kabushiki Kaisha | Torsional ultrasonic vibrators |
| US4127125A (en) | 1975-12-22 | 1978-11-28 | Lion Hamigaki Kabushiki Kaisha | Devices for transmitting ultrasonic waves to teeth |
| CA1083040A (en) | 1976-02-09 | 1980-08-05 | Mostafa Fahim | Topical application of medication by ultrasound with coupling agent |
| US4309989A (en) | 1976-02-09 | 1982-01-12 | The Curators Of The University Of Missouri | Topical application of medication by ultrasound with coupling agent |
| DE2756460A1 (de) | 1977-12-17 | 1979-06-21 | Fraunhofer Ges Forschung | Verfahren zur lokal begrenzten applikation von therpeutika durch die oberflaeche von lebenden koerpern oder koerperorganen |
| US4176664A (en) | 1978-03-13 | 1979-12-04 | Stanley Kalish | Impregnated bandage |
| US4280494A (en) | 1979-06-26 | 1981-07-28 | Cosgrove Robert J Jun | System for automatic feedback-controlled administration of drugs |
| US4249531A (en) | 1979-07-05 | 1981-02-10 | Alza Corporation | Bioerodible system for delivering drug manufactured from poly(carboxylic acid) |
| US4274419A (en) * | 1979-10-19 | 1981-06-23 | Quinton Instrument Co. | Skin preparation device and method used in the application of medical electrodes |
| CA1165240A (en) | 1980-07-09 | 1984-04-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
| US4372296A (en) | 1980-11-26 | 1983-02-08 | Fahim Mostafa S | Treatment of acne and skin disorders and compositions therefor |
| US4457748A (en) | 1982-01-11 | 1984-07-03 | Medtronic, Inc. | Non-invasive diagnosis method |
| US4622031A (en) | 1983-08-18 | 1986-11-11 | Drug Delivery Systems Inc. | Indicator for electrophoretic transcutaneous drug delivery device |
| US4537776A (en) | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
| US4538612A (en) | 1983-08-29 | 1985-09-03 | Ndm Corporation | Skin preparation method and product |
| US4563184A (en) | 1983-10-17 | 1986-01-07 | Bernard Korol | Synthetic resin wound dressing and method of treatment using same |
| US4557943A (en) | 1983-10-31 | 1985-12-10 | Advanced Semiconductor Materials America, Inc. | Metal-silicide deposition using plasma-enhanced chemical vapor deposition |
| US4646725A (en) | 1983-11-16 | 1987-03-03 | Manoutchehr Moasser | Method for treating herpes lesions and other infectious skin conditions |
| US4605670A (en) | 1984-02-01 | 1986-08-12 | Nitto Electric Industrial Co., Ltd. | Method for percutaneously administering metoclopramide |
| DK8601218A (cg-RX-API-DMAC7.html) | 1984-07-18 | 1986-03-17 | ||
| US4732153A (en) | 1984-07-18 | 1988-03-22 | Michael Phillips | Transdermal dosimeter |
| US4657543A (en) | 1984-07-23 | 1987-04-14 | Massachusetts Institute Of Technology | Ultrasonically modulated polymeric devices for delivering compositions |
| US4834978A (en) | 1984-10-01 | 1989-05-30 | Biotek, Inc. | Method of transdermal drug delivery |
| US4702732A (en) | 1984-12-24 | 1987-10-27 | Trustees Of Boston University | Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands |
| JPS6218446A (ja) * | 1985-07-08 | 1987-01-27 | Bridgestone Corp | 分散性改良カ−ボンブラツクを配合したゴム組成物 |
| US4698058A (en) | 1985-10-15 | 1987-10-06 | Albert R. Greenfeld | Ultrasonic self-cleaning catheter system for indwelling drains and medication supply |
| US4683242A (en) | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
| US4775361A (en) | 1986-04-10 | 1988-10-04 | The General Hospital Corporation | Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport |
| US4769022A (en) | 1986-05-02 | 1988-09-06 | Minnesota Mining And Manufacturing Company | Cleansing pad |
| DE246341T1 (de) | 1986-05-20 | 1989-03-30 | Massachusetts Institute Of Technology, Cambridge, Mass. | Bioerodierbare erzeugnisse zur verwendung als implantate oder prothese mit einem voraussehbaren resorbierungsgrad. |
| GB8612861D0 (en) | 1986-05-27 | 1986-07-02 | Cambridge Life Sciences | Immobilised enzyme biosensors |
| US4981779A (en) | 1986-06-26 | 1991-01-01 | Becton, Dickinson And Company | Apparatus for monitoring glucose |
| US4948587A (en) | 1986-07-08 | 1990-08-14 | Massachusetts Institute Of Technology | Ultrasound enhancement of transbuccal drug delivery |
| US4767402A (en) | 1986-07-08 | 1988-08-30 | Massachusetts Institute Of Technology | Ultrasound enhancement of transdermal drug delivery |
| JPS6336172A (ja) | 1986-07-29 | 1988-02-16 | Toshiba Corp | 超音波カプラ |
| US4778457A (en) | 1986-11-06 | 1988-10-18 | York Kenneth K | Disposable applicator |
| US4863970A (en) | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
| US4786277A (en) | 1986-11-21 | 1988-11-22 | Trustees Of Boston University | Electrodes, electrode assemblies, methods, and systems for tissue stimulation |
| JPS63132889A (ja) | 1986-11-21 | 1988-06-04 | Tanabe Seiyaku Co Ltd | キナゾリノン誘導体 |
| JPS63135179A (ja) | 1986-11-26 | 1988-06-07 | 立花 俊郎 | 薬物の経皮投与具 |
| US5001051A (en) | 1986-12-12 | 1991-03-19 | Regents Of The University Of California | Dose critical in-vivo detection of anti-cancer drug levels in blood |
| US5006342A (en) | 1986-12-22 | 1991-04-09 | Cygnus Corporation | Resilient transdermal drug delivery device |
| EP0278599A3 (en) | 1987-02-02 | 1988-12-07 | Seiko Epson Corporation | Photographic transfer type image forming apparatus |
| US4773806A (en) | 1987-04-03 | 1988-09-27 | Beaulieu Burl R | Agricultural vehicle for transporting and feeding hay |
| US4787888A (en) | 1987-06-01 | 1988-11-29 | University Of Connecticut | Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a) |
| US4821733A (en) | 1987-08-18 | 1989-04-18 | Dermal Systems International | Transdermal detection system |
| US4820720A (en) | 1987-08-24 | 1989-04-11 | Alza Corporation | Transdermal drug composition with dual permeation enhancers |
| AU614092B2 (en) | 1987-09-11 | 1991-08-22 | Paul Max Grinwald | Improved method and apparatus for enhanced drug permeation of skin |
| JPH01140054A (ja) | 1987-11-26 | 1989-06-01 | Nec Corp | グルコースセンサ |
| WO1989006555A1 (en) | 1988-01-21 | 1989-07-27 | Massachusetts Institute Of Technology | Transport of molecules across tissue using electroporation |
| JP2907342B2 (ja) | 1988-01-29 | 1999-06-21 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | イオン滲透非侵襲的サンプリングまたは送出装置 |
| US5362307A (en) | 1989-01-24 | 1994-11-08 | The Regents Of The University Of California | Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance |
| US4866050A (en) | 1988-04-27 | 1989-09-12 | Ben Amoz Daniel | Ultrasonic transdermal application of steroid compositions |
| US5078144A (en) | 1988-08-19 | 1992-01-07 | Olympus Optical Co. Ltd. | System for applying ultrasonic waves and a treatment instrument to a body part |
| US5076273A (en) | 1988-09-08 | 1991-12-31 | Sudor Partners | Method and apparatus for determination of chemical species in body fluid |
| EP0363504A1 (en) | 1988-10-10 | 1990-04-18 | Dräger Nederland B.V. | Method of providing a substrate with a layer comprising a polyvinylbased hydrogel and a biochemically active material |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5250419A (en) | 1988-12-16 | 1993-10-05 | L'oreal | Method for the direct measurement of at least one chemical parameter of skin using a biosensor |
| US5086229A (en) | 1989-01-19 | 1992-02-04 | Futrex, Inc. | Non-invasive measurement of blood glucose |
| US4933062A (en) | 1989-03-07 | 1990-06-12 | University Of Connecticut | Modified composite electrodes with renewable surface for electrochemical applications and method of making same |
| US4953552A (en) | 1989-04-21 | 1990-09-04 | Demarzo Arthur P | Blood glucose monitoring system |
| US5118404A (en) | 1989-04-28 | 1992-06-02 | Nec Corporation | Enzyme electrode and a method of determining concentration of an analyte in a sample solution |
| KR920700014A (ko) | 1989-06-02 | 1992-02-19 | 테오도르 에이취. 스탠리 | 비침입적인 혈중 글루코오스의 검사 장치 및 방법 |
| US5139023A (en) | 1989-06-02 | 1992-08-18 | Theratech Inc. | Apparatus and method for noninvasive blood glucose monitoring |
| US5120544A (en) | 1989-06-19 | 1992-06-09 | Henley International, Inc. | Crosslinked hydrogel and method for making same |
| US5069908A (en) | 1989-06-19 | 1991-12-03 | Henley International, Inc. | Crosslinked hydrogel and method for making same |
| US4986271A (en) | 1989-07-19 | 1991-01-22 | The University Of New Mexico | Vivo refillable glucose sensor |
| US5050604A (en) | 1989-10-16 | 1991-09-24 | Israel Reshef | Apparatus and method for monitoring the health condition of a subject |
| US5140985A (en) | 1989-12-11 | 1992-08-25 | Schroeder Jon M | Noninvasive blood glucose measuring device |
| US5036861A (en) | 1990-01-11 | 1991-08-06 | Sembrowich Walter L | Method and apparatus for non-invasively monitoring plasma glucose levels |
| US5179189A (en) | 1990-01-19 | 1993-01-12 | Nova Pharmaceutical Corporation | Fatty acid terminated polyanhydrides |
| US5016615A (en) | 1990-02-20 | 1991-05-21 | Riverside Research Institute | Local application of medication with ultrasound |
| US5231975A (en) | 1990-02-23 | 1993-08-03 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
| US5115805A (en) | 1990-02-23 | 1992-05-26 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
| CA2196746A1 (en) | 1990-02-23 | 1991-08-24 | The Regents Of The University Of California | Ultrasound-enhanced delivery of materials through the skin |
| US5165407A (en) | 1990-04-19 | 1992-11-24 | The University Of Kansas | Implantable glucose sensor |
| US5161532A (en) | 1990-04-19 | 1992-11-10 | Teknekron Sensor Development Corporation | Integral interstitial fluid sensor |
| US5119819A (en) | 1990-05-02 | 1992-06-09 | Miles Inc. | Method and apparatus for non-invasive monitoring of blood glucose |
| WO1991019529A1 (en) | 1990-06-15 | 1991-12-26 | Cortrak Medical, Inc. | Drug delivery apparatus and method |
| US5197946A (en) | 1990-06-27 | 1993-03-30 | Shunro Tachibana | Injection instrument with ultrasonic oscillating element |
| US5236410A (en) | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
| WO1992006701A1 (en) | 1990-10-18 | 1992-04-30 | Huffstutler, M., Conrad, Jr. | Preparation of concentrated fluid symphytum extracts, therapeutic forms and methods of use |
| JP2646848B2 (ja) | 1990-11-30 | 1997-08-27 | 日本電気株式会社 | グルコースセンサの測定方法 |
| ES2176189T3 (es) | 1991-02-01 | 2002-12-01 | Massachusetts Inst Technology | Mezlas de polimeros biodegradables para uso medicamentosos. |
| AU1442592A (en) | 1991-02-20 | 1992-09-15 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
| US5135753A (en) | 1991-03-12 | 1992-08-04 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| DE69215722T3 (de) | 1991-03-22 | 2001-03-08 | Katsuro Tachibana | Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen |
| JP2684871B2 (ja) | 1991-05-16 | 1997-12-03 | 日本電気株式会社 | 体液成分測定方法および測定装置 |
| JP3181071B2 (ja) | 1991-06-28 | 2001-07-03 | 俊郎 立花 | 血液処理装置 |
| US5171215A (en) | 1991-08-22 | 1992-12-15 | Flanagan Dennis F | Endermic method and apparatus |
| US5178448A (en) | 1991-09-13 | 1993-01-12 | Donnelly Corporation | Rearview mirror with lighting assembly |
| US5215520A (en) | 1991-09-17 | 1993-06-01 | Centre Internationale De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) | Method for delivering an active substance topically or percutaneously |
| CA2123487A1 (en) | 1991-11-12 | 1993-05-27 | Adrian S. Fox | Adhesive hydrogels having extended use lives and process for the preparation of same |
| US5697882A (en) * | 1992-01-07 | 1997-12-16 | Arthrocare Corporation | System and method for electrosurgical cutting and ablation |
| US5470582A (en) | 1992-02-07 | 1995-11-28 | Syntex (U.S.A.) Inc. | Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles |
| US5165418B1 (en) | 1992-03-02 | 1999-12-14 | Nikola I Tankovich | Blood sampling device and method using a laser |
| US5405614A (en) | 1992-04-08 | 1995-04-11 | International Medical Associates, Inc. | Electronic transdermal drug delivery system |
| NL9200731A (nl) | 1992-04-22 | 1993-11-16 | Jacob Korf | Werkwijze en inrichting voor het niet-invasief bewaken van de concentratie van stoffen in bloed. |
| US5964723A (en) | 1992-06-19 | 1999-10-12 | Augustine Medical, Inc. | Normothermic tissue heating wound covering |
| US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
| US5230344A (en) | 1992-07-31 | 1993-07-27 | Intelligent Hearing Systems Corp. | Evoked potential processing system with spectral averaging, adaptive averaging, two dimensional filters, electrode configuration and method therefor |
| JPH0670987A (ja) | 1992-08-28 | 1994-03-15 | Katsuro Tachibana | 薬物投与・体液採取ユニット及び装置 |
| US5421816A (en) | 1992-10-14 | 1995-06-06 | Endodermic Medical Technologies Company | Ultrasonic transdermal drug delivery system |
| US5643252A (en) | 1992-10-28 | 1997-07-01 | Venisect, Inc. | Laser perforator |
| US6315772B1 (en) | 1993-09-24 | 2001-11-13 | Transmedica International, Inc. | Laser assisted pharmaceutical delivery and fluid removal |
| US5633234A (en) | 1993-01-22 | 1997-05-27 | The Johns Hopkins University | Lysosomal targeting of immunogens |
| US5364838A (en) | 1993-01-29 | 1994-11-15 | Miris Medical Corporation | Method of administration of insulin |
| US5386837A (en) | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
| US5267985A (en) | 1993-02-11 | 1993-12-07 | Trancell, Inc. | Drug delivery by multiple frequency phonophoresis |
| CA2114968A1 (en) | 1993-02-25 | 1994-08-26 | John Wille | Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity |
| US5667487A (en) | 1993-04-07 | 1997-09-16 | Henley; Julian L. | Ionosonic drug delivery apparatus |
| AU7107394A (en) | 1993-07-16 | 1995-02-13 | Cygnus Therapeutic Systems | Noninvasive glucose monitor |
| US5413550A (en) | 1993-07-21 | 1995-05-09 | Pti, Inc. | Ultrasound therapy system with automatic dose control |
| US5415629A (en) | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
| US5582184A (en) | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
| DE69322968T2 (de) | 1993-10-22 | 1999-07-08 | Rijksuniversiteit Te Groningen, Groningen | Verfahren und Vorrichtung zur kontinuierlichen Überwachung eines Anolytpegels |
| US5445611A (en) | 1993-12-08 | 1995-08-29 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal delivery with ultrasound and chemical enhancers |
| US5885211A (en) | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
| US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
| US5458140A (en) | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
| US5443080A (en) | 1993-12-22 | 1995-08-22 | Americate Transtech, Inc. | Integrated system for biological fluid constituent analysis |
| EP0766578B1 (en) | 1994-06-24 | 2000-10-04 | Cygnus, Inc. | Iontophoretic sampling device |
| US5771890A (en) | 1994-06-24 | 1998-06-30 | Cygnus, Inc. | Device and method for sampling of substances using alternating polarity |
| US5429735A (en) | 1994-06-27 | 1995-07-04 | Miles Inc. | Method of making and amperometric electrodes |
| JP3170172B2 (ja) | 1995-03-30 | 2001-05-28 | ティーディーケイ株式会社 | チップ部品供給装置及び該装置に用いるチップ部品供給ケース |
| US5569198A (en) | 1995-01-23 | 1996-10-29 | Cortrak Medical Inc. | Microporous catheter |
| US5626554A (en) | 1995-02-21 | 1997-05-06 | Exogen, Inc. | Gel containment structure |
| US5573778A (en) | 1995-03-17 | 1996-11-12 | Adhesives Research, Inc. | Drug flux enhancer-tolerant pressure sensitive adhesive composition |
| US5646221A (en) | 1995-03-31 | 1997-07-08 | Kowa Co., Ltd. | Adhesive base material |
| US6041252A (en) | 1995-06-07 | 2000-03-21 | Ichor Medical Systems Inc. | Drug delivery system and method |
| AU706662B2 (en) | 1995-07-12 | 1999-06-17 | Cygnus, Inc. | Hydrogel patch |
| US5947921A (en) | 1995-12-18 | 1999-09-07 | Massachusetts Institute Of Technology | Chemical and physical enhancers and ultrasound for transdermal drug delivery |
| US6002961A (en) | 1995-07-25 | 1999-12-14 | Massachusetts Institute Of Technology | Transdermal protein delivery using low-frequency sonophoresis |
| AU725269B2 (en) | 1995-07-25 | 2000-10-12 | Massachusetts Institute Of Technology | Enhanced transdermal transport using ultrasound |
| EP0847775B1 (en) | 1995-08-31 | 2004-10-27 | Hisamitsu Pharmaceutical Co. Inc. | Iontophoresis device and method of current control therefor |
| US5906830A (en) | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| US5989409A (en) | 1995-09-11 | 1999-11-23 | Cygnus, Inc. | Method for glucose sensing |
| US5735273A (en) | 1995-09-12 | 1998-04-07 | Cygnus, Inc. | Chemical signal-impermeable mask |
| US5902603A (en) | 1995-09-14 | 1999-05-11 | Cygnus, Inc. | Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use |
| US5833647A (en) | 1995-10-10 | 1998-11-10 | The Penn State Research Foundation | Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery |
| US5618275A (en) | 1995-10-27 | 1997-04-08 | Sonex International Corporation | Ultrasonic method and apparatus for cosmetic and dermatological applications |
| AU1081097A (en) | 1995-11-24 | 1997-06-11 | Ekos Corporation | Hemostasis material and apparatus |
| EP0812150A4 (en) | 1995-12-28 | 1999-03-10 | Cygnus Therapeutic Systems | CONTINUOUS CONTROL OF A PHYSIOLOGICAL ANALYTE |
| US6032060A (en) | 1996-01-25 | 2000-02-29 | 3M Innovative Properties Company | Method for conditioning skin and an electrode by passing electrical energy |
| ES2247621T3 (es) | 1996-02-15 | 2006-03-01 | Biosense Webster, Inc. | Sonda de excavacion. |
| US6009343A (en) | 1996-02-23 | 1999-12-28 | Abbott Laboratories | Enhanced transdermal transport of fluid using vacuum |
| US5895362A (en) | 1996-02-23 | 1999-04-20 | Abbott Laboratories | Transdermal transport using ultrasonic standing waves |
| US5655539A (en) | 1996-02-26 | 1997-08-12 | Abbott Laboratories | Method for conducting an ultrasound procedure using an ultrasound transmissive pad |
| US5656016A (en) | 1996-03-18 | 1997-08-12 | Abbott Laboratories | Sonophoretic drug delivery system |
| US6234990B1 (en) | 1996-06-28 | 2001-05-22 | Sontra Medical, Inc. | Ultrasound enhancement of transdermal transport |
| US6024717A (en) | 1996-10-24 | 2000-02-15 | Vibrx, Inc. | Apparatus and method for sonically enhanced drug delivery |
| WO1998020331A1 (en) | 1996-11-07 | 1998-05-14 | Cambridge Sensors Limited | Electrodes and their use in assays |
| US6063039A (en) | 1996-12-06 | 2000-05-16 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
| WO1998028037A1 (en) | 1996-12-20 | 1998-07-02 | Alza Corporation | Device and method for enhancing transdermal agent flux |
| US5913833A (en) | 1997-02-07 | 1999-06-22 | Abbott Laboratories | Method and apparatus for obtaining biological fluids |
| US6139718A (en) | 1997-03-25 | 2000-10-31 | Cygnus, Inc. | Electrode with improved signal to noise ratio |
| US5961451A (en) | 1997-04-07 | 1999-10-05 | Motorola, Inc. | Noninvasive apparatus having a retaining member to retain a removable biosensor |
| US6546378B1 (en) | 1997-04-24 | 2003-04-08 | Bright Ideas, L.L.C. | Signal interpretation engine |
| US5851438A (en) | 1997-08-29 | 1998-12-22 | E. I. Du Pont De Nemours And Company | Thick film compositions for making medical electrodes |
| US6126619A (en) | 1997-09-02 | 2000-10-03 | Transon Llc | Multiple transducer assembly and method for coupling ultrasound energy to a body |
| US6503198B1 (en) | 1997-09-11 | 2003-01-07 | Jack L. Aronowtiz | Noninvasive transdermal systems for detecting an analyte obtained from or underneath skin and methods |
| JP2002500075A (ja) | 1998-01-08 | 2002-01-08 | ソントラ メディカル， インコーポレイテッド | 超音波伝達で増強される経皮輸送 |
| US8287483B2 (en) | 1998-01-08 | 2012-10-16 | Echo Therapeutics, Inc. | Method and apparatus for enhancement of transdermal transport |
| US7066884B2 (en) | 1998-01-08 | 2006-06-27 | Sontra Medical, Inc. | System, method, and device for non-invasive body fluid sampling and analysis |
| US7273458B2 (en) | 1998-01-12 | 2007-09-25 | Georgia Tech Research Corporation | Method of applying acoustic energy effective to alter transport or cell viability |
| US20020055702A1 (en) | 1998-02-10 | 2002-05-09 | Anthony Atala | Ultrasound-mediated drug delivery |
| JP3594794B2 (ja) | 1998-03-24 | 2004-12-02 | 独立行政法人 科学技術振興機構 | ナノ秒時間ゲート分光診断装置 |
| US6398753B2 (en) | 1998-04-03 | 2002-06-04 | Mcdaniel David H. | Ultrasound enhancement of percutaneous drug absorption |
| BR9912339A (pt) | 1998-07-21 | 2001-04-17 | Spectrx Inc | Dispositivo coletor e sensor de fluido para colocação sobre pelo menos uma abertura artificial realizada em uma membrana biológica para medir uma caracterìstica de um fluido biológico e processos de monitorar uma caracterìstica de um fluido biológico recolhido de pelo menos uma abertura artificial em um tecido e de manter uma vazão de um fluido biológico através de um dispositivo que continuamente recolhe e mede uma caracterìstica de um fluido biológico. |
| US6535753B1 (en) | 1998-08-20 | 2003-03-18 | Microsense International, Llc | Micro-invasive method for painless detection of analytes in extra-cellular space |
| JP2002524120A (ja) | 1998-09-04 | 2002-08-06 | パウダージェクト リサーチ リミテッド | 粒子送達法を使用するモニタリング方法 |
| US6468229B1 (en) | 1998-10-20 | 2002-10-22 | Abbott Laboratories | Apparatus and method for the collection of interstitial fluids |
| JP2000126182A (ja) | 1998-10-27 | 2000-05-09 | Mitani Sangyo Co Ltd | 腫瘍診断方法 |
| US6148232A (en) | 1998-11-09 | 2000-11-14 | Elecsys Ltd. | Transdermal drug delivery and analyte extraction |
| US20040171980A1 (en) | 1998-12-18 | 2004-09-02 | Sontra Medical, Inc. | Method and apparatus for enhancement of transdermal transport |
| EP1139880A4 (en) | 1998-12-18 | 2005-08-17 | Sontra Medical Inc | METHOD AND APPARATUS FOR PRODUCING HOMOGENEOUS CAVITATION FOR TRANSDERMAL TRANSPORT |
| CA2355184A1 (en) | 1998-12-18 | 2000-06-22 | Sontra Medical, Inc. | Methods and apparatus for enhancement of transdermal transport |
| US6477410B1 (en) * | 2000-05-31 | 2002-11-05 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
| JP4210386B2 (ja) | 1999-03-30 | 2009-01-14 | テルモ株式会社 | 体腔内超音波診断装置 |
| US6920455B1 (en) * | 1999-05-19 | 2005-07-19 | Sun Microsystems, Inc. | Mechanism and method for managing service-specified data in a profile service |
| WO2001003638A1 (en) * | 1999-07-12 | 2001-01-18 | Dermispa Group, Inc. | Massage and toning device and method of use |
| US6645184B1 (en) * | 1999-08-09 | 2003-11-11 | Brian D. Zelickson | Tape stripping system and method |
| US7133717B2 (en) * | 1999-08-25 | 2006-11-07 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery and diagnostic sampling |
| US6251083B1 (en) | 1999-09-07 | 2001-06-26 | Amira Medical | Interstitial fluid methods and devices for determination of an analyte in the body |
| AU781149B2 (en) | 2000-03-17 | 2005-05-05 | Echo Therapeutics, Inc. | System, method, and device for non-invasive body fluid sampling and analysis |
| JP2001286569A (ja) * | 2000-04-05 | 2001-10-16 | Polytronics Ltd | 経皮投薬装置 |
| US6540675B2 (en) | 2000-06-27 | 2003-04-01 | Rosedale Medical, Inc. | Analyte monitor |
| US7664484B2 (en) * | 2000-09-07 | 2010-02-16 | Tangoe, Inc. | Pooling groups of wireless communication users |
| US6487447B1 (en) | 2000-10-17 | 2002-11-26 | Ultra-Sonic Technologies, L.L.C. | Method and apparatus for in-vivo transdermal and/or intradermal delivery of drugs by sonoporation |
| EP2085109A3 (en) * | 2000-10-26 | 2009-09-02 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
| US7180855B1 (en) * | 2001-04-19 | 2007-02-20 | At&T Corp. | Service interface for QoS-driven HPNA networks |
| US7027408B2 (en) * | 2001-03-05 | 2006-04-11 | Qwest Communications International, Inc | Method and system for dynamic service profile integration by a service controller |
| US7496401B2 (en) | 2001-04-06 | 2009-02-24 | Mattioli Engineering Ltd | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
| WO2003039620A2 (en) * | 2001-05-17 | 2003-05-15 | Transpharma Medical Ltd. | Integrated transdermal drug delivery system |
| US7158792B1 (en) * | 2001-09-20 | 2007-01-02 | Sprint Communications Company L.P. | Selecting a wireless link in a public wireless communication network |
| US7882029B2 (en) * | 2001-10-16 | 2011-02-01 | Hewlett-Packard Development Company, L.P. | Centralized billing credit system utilizing a predetermined unit of usage |
| US6795727B2 (en) * | 2001-10-17 | 2004-09-21 | Pedro Giammarusti | Devices and methods for promoting transcutaneous movement of substances |
| US6887239B2 (en) | 2002-04-17 | 2005-05-03 | Sontra Medical Inc. | Preparation for transmission and reception of electrical signals |
| AU2003225128A1 (en) | 2002-04-24 | 2003-11-10 | Stephen T. Flock | Feedback control device for transcutaneous drug delivery and uses therefor |
| US7166086B2 (en) * | 2002-08-29 | 2007-01-23 | Becton, Dickinson And Company | Substance delivery via a rotating microabrading surface |
| US7324447B1 (en) * | 2002-09-30 | 2008-01-29 | Packeteer, Inc. | Methods, apparatuses and systems facilitating concurrent classification and control of tunneled and non-tunneled network traffic |
| US7221929B2 (en) * | 2002-10-12 | 2007-05-22 | Lg Electronics Inc. | Handling charging information in interworking structure of mobile communication and wireless local area networks |
| US6998985B2 (en) * | 2003-03-05 | 2006-02-14 | Dmatek, Ltd. | Monitoring and tracking network |
| US7668903B2 (en) * | 2003-07-07 | 2010-02-23 | Xerox Corporation | Method and apparatus for dynamically delivering service profiles to clients |
| US7873705B2 (en) * | 2004-03-12 | 2011-01-18 | Flash Networks Ltd. | System and method for identifying content service within content server |
| US7292159B2 (en) * | 2004-07-14 | 2007-11-06 | Spectrum Tracking Systems, Inc. | Method and system for providing tracking services to locate an asset |
| US20060100567A1 (en) | 2004-07-30 | 2006-05-11 | Rocky Mountain Biosystems, Inc | Microsurgical tissue treatment system |
| US8224414B2 (en) | 2004-10-28 | 2012-07-17 | Echo Therapeutics, Inc. | System and method for analyte sampling and analysis with hydrogel |
| US8156128B2 (en) * | 2005-09-14 | 2012-04-10 | Jumptap, Inc. | Contextual mobile content placement on a mobile communication facility |
| JP2009509194A (ja) * | 2005-09-20 | 2009-03-05 | ケンライト，デビッド，ノリス | 近接応答ディスプレイ材料用装置及び方法 |
| US20070093243A1 (en) * | 2005-10-25 | 2007-04-26 | Vivek Kapadekar | Device management system |
| US9636035B2 (en) * | 2005-12-14 | 2017-05-02 | Scibase Ab | Medical apparatus for determination of biological conditions using impedance measurements |
| US7720505B2 (en) * | 2006-03-07 | 2010-05-18 | Marvell World Trade Ltd. | Personal lifestyle device |
| US8064391B2 (en) * | 2006-08-22 | 2011-11-22 | Embarq Holdings Company, Llc | System and method for monitoring and optimizing network performance to a wireless device |
| US7941184B2 (en) * | 2006-11-10 | 2011-05-10 | Dell Products L.P. | Methods and systems for managing and/or tracking use of subscriber identity module components |
| US8612320B2 (en) * | 2006-12-14 | 2013-12-17 | Corelogic Solutions, Llc | Method and apparatus for detecting fraudulent loans |
| JP5995060B2 (ja) | 2012-05-18 | 2016-09-21 | 日本精機株式会社 | 車両用表示装置 |
-
2008
- 2008-04-25 HR HR20110396T patent/HRP20110396T1/hr unknown
- 2008-04-25 MX MX2009011581A patent/MX2009011581A/es active IP Right Grant
- 2008-04-25 KR KR1020097024792A patent/KR101211252B1/ko not_active Expired - Fee Related
- 2008-04-25 AU AU2008245585A patent/AU2008245585B2/en not_active Ceased
- 2008-04-25 RU RU2009143880/14A patent/RU2435616C2/ru not_active IP Right Cessation
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- 2008-04-25 NZ NZ580997A patent/NZ580997A/en not_active IP Right Cessation
- 2008-04-25 SI SI200830257T patent/SI2152358T1/sl unknown
- 2008-04-25 JP JP2010506530A patent/JP2010525881A/ja not_active Withdrawn
- 2008-04-25 CN CN200880020556.XA patent/CN101707872B/zh not_active Expired - Fee Related
- 2008-04-25 US US12/110,034 patent/US8386027B2/en not_active Expired - Fee Related
- 2008-04-25 DE DE602008005299T patent/DE602008005299D1/de active Active
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- 2009-10-22 IL IL201699A patent/IL201699A/en not_active IP Right Cessation
- 2009-11-23 ZA ZA200908281A patent/ZA200908281B/xx unknown
-
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- 2011-06-02 CY CY20111100534T patent/CY1112035T1/el unknown
-
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- 2013-01-10 JP JP2013002319A patent/JP5827632B2/ja not_active Expired - Fee Related
- 2013-01-22 US US13/746,673 patent/US9572527B2/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62270144A (ja) * | 1986-03-03 | 1987-11-24 | 久光製薬株式会社 | 経皮投薬用皮膚損傷装置 |
| JPH02224752A (ja) * | 1989-02-28 | 1990-09-06 | Advance Co Ltd | イオントフォレーゼ用デバイス |
| JP2006192285A (ja) * | 1995-08-29 | 2006-07-27 | Spectrx Inc | 薬物送達および鑑視適用のためのヒト皮膚の微細穿孔 |
| US20040059282A1 (en) * | 2002-09-25 | 2004-03-25 | Flock Stephen T. | Microsurgical tissue treatment system |
| JP2005296629A (ja) * | 2004-02-24 | 2005-10-27 | Mattioli Engineering Ltd | 皮膚吸収を高めるため、および経皮薬剤投与のための方法および装置 |
| WO2006045149A1 (en) * | 2004-10-28 | 2006-05-04 | Ronald Allan Greenberg | A method and apparatus for abrading the skin using a vibrating dermabrasion apparatus |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021121621A (ja) * | 2010-12-06 | 2021-08-26 | フォリカ, インコーポレイテッドFollica, Inc. | 禿頭症を治療するため、および毛髪の成長を促進するための方法 |
| JP2024079800A (ja) * | 2010-12-06 | 2024-06-11 | フォリカ，インコーポレイテッド | 禿頭症を治療するため、および毛髪の成長を促進するための方法 |
| JP2017511234A (ja) * | 2014-03-21 | 2017-04-20 | ロレアル | 音波とイオントフォレーゼを組み合わせたスキンケア機器 |
| JP2017513683A (ja) * | 2014-04-21 | 2017-06-01 | チャン, フランクリン, ジェイ.CHANG, Franklin, J. | 経皮送達の装置と方法 |
| JP2018537222A (ja) * | 2015-12-15 | 2018-12-20 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 表面処理装置及び方法 |
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