HRP20110396T1 - Uređaj za detektiranje analita ili transdermalno oslobađanje lijeka prodorom kroz kožu - Google Patents

Uređaj za detektiranje analita ili transdermalno oslobađanje lijeka prodorom kroz kožu Download PDF

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HRP20110396T1
HRP20110396T1 HR20110396T HRP20110396T HRP20110396T1 HR P20110396 T1 HRP20110396 T1 HR P20110396T1 HR 20110396 T HR20110396 T HR 20110396T HR P20110396 T HRP20110396 T HR P20110396T HR P20110396 T1 HRP20110396 T1 HR P20110396T1
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Croatia
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abrasive head
control mechanism
feedback control
tissue site
source electrode
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HR20110396T
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English (en)
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Chuang Han
P. Eslava Juan
P. Hurley James
Ghosh Debashis
Krystyniak Keith
C. Kellogg Scott
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Echo Therapeutics
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Publication of HRP20110396T1 publication Critical patent/HRP20110396T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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    • A61B17/54—Chiropodists' instruments, e.g. pedicure
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    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
    • A—HUMAN NECESSITIES
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    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
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    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
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    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
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    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
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    • A—HUMAN NECESSITIES
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
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    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
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    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
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    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
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    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
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    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
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    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
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    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/328—Applying electric currents by contact electrodes alternating or intermittent currents for improving the appearance of the skin, e.g. facial toning or wrinkle treatment

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  • Health & Medical Sciences (AREA)
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  • Otolaryngology (AREA)
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  • Dermatology (AREA)
  • Plasma & Fusion (AREA)
  • Electromagnetism (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Electrotherapy Devices (AREA)
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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Surgical Instruments (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Uređaj za kontroliranu abraziju (10) naznačen time što obuhvaća ručni aplikator (12), abrazivnu glavu (20), kontrolni mehanizam na bazi povratne sprege (feedback mehanizam) (30), elektrodu izvora (42), povratnu elektrodu (42), elektromotor (50), pri čemu se elektroda izvora (42) nalazi u abrazivnoj glavi (50). Patent sadrži još 14 patentnih zahtjeva.

Claims (15)

1. Uređaj za kontroliranu abraziju (10) naznačen time što obuhvaća ručni aplikator (12), abrazivnu glavu (20), kontrolni mehanizam na bazi povratne sprege (feedback mehanizam) (30), elektrodu izvora (42), povratnu elektrodu (42), elektromotor (50), pri čemu se elektroda izvora (42) nalazi u abrazivnoj glavi (50).
2. Uređaj prema zahtjevu 1, naznačen time što kontrolni mehanizam povratne sprege (30) predstavlja interni kontrolni mehanizam povratne sprege.
3. Uređaj prema zahtjevu 1, naznačen time što kontrolni mehanizam povratne sprege (30) predstavlja eksterni kontrolni mehanizam povratne sprege.
4. Uređaj prema zahtjevu 3, naznačen time što se povratna elektroda (44) nalazi na proksimalnom kraju ručnog aplikatora (12), i što povratna elektroda okružuje abrazivnu glavu (20).
5. Uređaj za kontroliranu abraziju (10) naznačen time što obuhvaća ručni aplikator (12), abrazivnu glavu (20), eksterni kontrolni mehanizam povratne sprege (30), elektrodu izvora (42), povratnu elektrodu (42), pozicijski prsten (60), elektromotor (50), pri čemu se elektroda izvora (42) nalazi unutar pozicionog prstena (60).
6. Uređaj prema bilo kojem od zahtjeva od 1 do 5, naznačen time što abrazivna glava (20) sadrži tekućinu za vlaženje.
7. Uređaj prema bilo kojem od zahtjeva od 1 i 3 do 5, naznačen time što abrazivna glava (20) sadrži materijal odabran iz skupine koja obuhvaća provodljive i neprovodljive materijale.
8. Uređaj prema zahtjevu 7, koji se poziva na bilo koji od zahtjeva 1, 3 ili 4, naznačen time što abrazivna glava (20) sadrži provodljivi materijal, i gdje je abrazivna glava (20) elektroda izvora (42).
9. Uređaj prema zahtjevu 8, naznačen time što provodljivi materijal uključuje perforacije (22A, 22B).
10. Uređaj prema bilo kojem od zahtjeva od 1 do 9, naznačen time što abrazivna glava (20) predstavlja abrazivnu glavu za jednokratnu upotrebu, i prema kojem uređaj također obuhvaća i čašicu (27), koja pokriva abrazivnu glavu (20).
11. Uređaj za kontroliranu abraziju prema zahtjevu 5, naznačen time što je povratna elektroda (44) smještena izvan ručnog aplikatora (12).
12. Uređaj prema zahtjevu 1, naznačen time što uključuje mehanizam za mjerenje električnih parametara tkivnog mjesta protokom struje između elektrode izvora (42) i povratne elektrode (44).
13. Uređaj prema zahtjevu 12, naznačen time što je električni parametar izabran iz skupine koja obuhvaća vrijednost jačine struje, promjenu vrijednosti struje tijekom određenog vremenskog perioda, trenutnu brzinu promjene vrijednosti jačine struje, vrijednost impedanse na tkivnom mestu, promjenu vrijednosti impedanse na tkivnom mestu tijekom određenog vremenskog perioda, razliku između vrijednosti impedanse na tkivnom mestu i referentnom tkivnom mestu.
14. Uređaj prema zahtjevu 13, naznačen time što uključuje mehanizam za isključivanje motora (50) u trenutku kada vrijednost analiziranog elektro-parametra postane suštinski jednaka, ili premaši predefiniranu vrijednost.
15. Uređaj prema zahtjevu 1, naznačen time što uključuje mehanizme (30, 42, 44) za mjerenje električnih parametara tkivnog mesta u kontinuitetu tijekom cijelog trajanja postupka primjene abrazivne glave (20) na tkivno mesto.
HR20110396T 2007-04-27 2011-05-27 Uređaj za detektiranje analita ili transdermalno oslobađanje lijeka prodorom kroz kožu HRP20110396T1 (hr)

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Application Number Priority Date Filing Date Title
US91455207P 2007-04-27 2007-04-27
PCT/US2008/061623 WO2008134545A1 (en) 2007-04-27 2008-04-25 Skin permeation device for analyte sensing or transdermal drug delivery

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US (2) US8386027B2 (hr)
EP (1) EP2152358B1 (hr)
JP (2) JP2010525881A (hr)
KR (1) KR101211252B1 (hr)
CN (1) CN101707872B (hr)
AT (1) ATE499967T1 (hr)
AU (1) AU2008245585B2 (hr)
BR (1) BRPI0810969A2 (hr)
CA (1) CA2685423C (hr)
CY (1) CY1112035T1 (hr)
DE (1) DE602008005299D1 (hr)
DK (1) DK2152358T3 (hr)
ES (1) ES2387419T3 (hr)
HK (1) HK1140709A1 (hr)
HR (1) HRP20110396T1 (hr)
IL (1) IL201699A (hr)
MX (1) MX2009011581A (hr)
NZ (1) NZ580997A (hr)
PL (1) PL2152358T3 (hr)
PT (1) PT2152358E (hr)
RU (1) RU2435616C2 (hr)
SI (1) SI2152358T1 (hr)
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