JP2010519181A5 - - Google Patents
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- Publication number
- JP2010519181A5 JP2010519181A5 JP2009548468A JP2009548468A JP2010519181A5 JP 2010519181 A5 JP2010519181 A5 JP 2010519181A5 JP 2009548468 A JP2009548468 A JP 2009548468A JP 2009548468 A JP2009548468 A JP 2009548468A JP 2010519181 A5 JP2010519181 A5 JP 2010519181A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- amino
- alkyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88799407P | 2007-02-02 | 2007-02-02 | |
| US60/887,994 | 2007-02-02 | ||
| US1231007P | 2007-12-07 | 2007-12-07 | |
| US61/012,310 | 2007-12-07 | ||
| PCT/US2008/052778 WO2008097835A2 (en) | 2007-02-02 | 2008-02-01 | Compositions and methods for the treatment of metabolic disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014005460A Division JP5878937B2 (ja) | 2007-02-02 | 2014-01-15 | 代謝障害を処置するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519181A JP2010519181A (ja) | 2010-06-03 |
| JP2010519181A5 true JP2010519181A5 (enExample) | 2012-03-08 |
| JP5461197B2 JP5461197B2 (ja) | 2014-04-02 |
Family
ID=39682342
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548468A Expired - Fee Related JP5461197B2 (ja) | 2007-02-02 | 2008-02-01 | 代謝障害を処置するための組成物および方法 |
| JP2014005460A Expired - Fee Related JP5878937B2 (ja) | 2007-02-02 | 2014-01-15 | 代謝障害を処置するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014005460A Expired - Fee Related JP5878937B2 (ja) | 2007-02-02 | 2014-01-15 | 代謝障害を処置するための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8207196B2 (enExample) |
| EP (1) | EP2120580B1 (enExample) |
| JP (2) | JP5461197B2 (enExample) |
| CN (1) | CN101674730B (enExample) |
| AU (1) | AU2008214095B2 (enExample) |
| CA (1) | CA2677264C (enExample) |
| WO (1) | WO2008097835A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9233941B2 (en) * | 2007-02-02 | 2016-01-12 | Baylor College Of Medicine | Methods and compositions for the treatment of body weight related disorders |
| AU2008214095B2 (en) * | 2007-02-02 | 2014-07-10 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| US9212179B2 (en) * | 2007-02-02 | 2015-12-15 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| US9187485B2 (en) * | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
| WO2009094224A1 (en) | 2008-01-25 | 2009-07-30 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| CA2750935A1 (en) | 2009-01-30 | 2010-08-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and their use as pi3k inhibitors |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| EP3159331A1 (en) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
| WO2012021611A1 (en) | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| PH12013500274A1 (en) | 2010-08-11 | 2013-03-04 | Millennium Pharm Inc | Heteroaryls and uses thereof |
| JP2013533318A (ja) | 2010-08-11 | 2013-08-22 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | ヘテロアリールおよびその使用 |
| EP2616441B1 (en) | 2010-09-17 | 2019-08-07 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| EP2625294A4 (en) * | 2010-10-07 | 2014-03-26 | Univ Columbia | PROCESS FOR TREATING TUMORS WITH A P53 MUTATION |
| CA2814688A1 (en) | 2010-10-13 | 2012-04-19 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US8691184B2 (en) * | 2011-01-25 | 2014-04-08 | The Regents Of The University Of Michigan | Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013110007A1 (en) * | 2012-01-18 | 2013-07-25 | The Trustees Of Columbia University In The City Of New York | USE OF FATOSTATIN FOR TREATING CANCER HAVING A p53 MUTATION |
| WO2014004054A1 (en) | 2012-06-25 | 2014-01-03 | Thomas Jefferson University | Compositions and methods for treating cancer with aberrant lipogenic signaling |
| US20140275178A1 (en) * | 2013-03-13 | 2014-09-18 | Musc Foundation For Research Development | Thiazole compounds, compositions and methods for treatment of degenerative diseases and disorders |
| KR20160067841A (ko) * | 2013-08-28 | 2016-06-14 | 메디베이션 테크놀로지즈, 인크. | 헤테로사이클릭 화합물 및 사용 방법 |
| WO2015031710A1 (en) * | 2013-08-29 | 2015-03-05 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic and body weight related disorders |
| RU2016136091A (ru) | 2014-02-14 | 2018-03-19 | Дзе Юниверсити Оф Бритиш Коламбиа | Соединения, воздействующие на днк-связывающий домен (dbd) андрогенового рецептора человека, в качестве терапевтических средств, а также способы их применения |
| US9873689B2 (en) | 2014-11-07 | 2018-01-23 | Fgh Biotech, Inc. | Synthesis of fatostatin based polycyclic compounds |
| WO2016105491A1 (en) * | 2014-12-23 | 2016-06-30 | Fgh Biotech | Compositions of fatostatin based heterocyclic compounds and uses thereof |
| EP3259256B1 (en) * | 2015-02-17 | 2022-03-09 | Beijing Erai Therapeutics Co., Ltd. | Compounds and methods for inducing browning of white adipose tissue |
| CA2977539A1 (en) | 2015-03-04 | 2016-09-09 | Medivation Technologies, Inc. | Sterol regulatory element-binding proteins (srebps) inhibitors |
| CA2978627A1 (en) | 2015-03-04 | 2016-09-09 | Medivation Technologies, Inc. | Srebp blockers for use in treating liver fibrosis, elevated cholesterol and insulin resistance |
| WO2016191864A1 (en) * | 2015-05-29 | 2016-12-08 | Changiz Taghibiglou | Polypeptides and antibodies to treat skin conditions associated with overproduction of sebum |
| CA3008395A1 (en) * | 2015-11-06 | 2017-05-11 | The Children's Hospital Of Philadelphia | Compositions and methods for the treatment of fatty acid metabolism disorders |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US20230346721A1 (en) | 2018-04-18 | 2023-11-02 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US12521378B2 (en) | 2016-04-19 | 2026-01-13 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| WO2017190086A1 (en) | 2016-04-29 | 2017-11-02 | Fgh Biotech, Inc. | Di-substituted pyrazole compounds for the treatment of diseases |
| WO2018049080A1 (en) * | 2016-09-07 | 2018-03-15 | Fgh Biotech, Inc. | Di-substituted pyrazole compounds for the treatment of diseases |
| KR101869308B1 (ko) * | 2017-02-28 | 2018-06-20 | 대구가톨릭대학교산학협력단 | Srebp-1 디코이 올리고디옥시뉴클레오티드 및 이를 유효성분으로 함유하는 지방간 질환의 예방 또는 치료용 약학 조성물 |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| JP2021512160A (ja) | 2018-01-29 | 2021-05-13 | カピュラス セラピューティクス リミテッド ライアビリティ カンパニー | 6員の中央環を含むsrebp阻害剤 |
| WO2020132700A1 (en) * | 2018-12-21 | 2020-06-25 | Fgh Biotech Inc. | Methods of using inhibitors of srebp in combination with niclosamide and analogs thereof |
| CN113631163A (zh) * | 2019-01-28 | 2021-11-09 | 卡普勒斯疗法有限责任公司 | 包括噻吩中心环的srebp抑制剂 |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| WO2021035031A1 (en) * | 2019-08-21 | 2021-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibitors of phospholipid synthesis and methods of use |
| EP4096659A4 (en) * | 2020-01-27 | 2023-10-18 | Capulus Therapeutics, LLC | Srebp inhibitors comprising a thiophene central ring |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| EP4531871A2 (en) * | 2022-05-25 | 2025-04-09 | Amgen Inc. | Rnai constructs for inhibiting scap expression and methods of use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4791200A (en) * | 1987-06-22 | 1988-12-13 | Ortho Pharmaceutical Corporation | 2-substituted-4-aryl-substituted thiazoles |
| US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
| DE69132006T2 (de) | 1990-11-30 | 2000-08-03 | Otsuka Pharmaceutical Co., Ltd. | Thiazolederivate als inhibitoren von aktivem sauerstoff |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| JPH04282326A (ja) * | 1991-03-08 | 1992-10-07 | Yuki Gosei Kogyo Co Ltd | 非対称な三環系化合物の製造法 |
| JPH06508371A (ja) | 1991-06-21 | 1994-09-22 | ユニバーシティー オブ シンシナティ | 経口投与できる治療用タンパク質及びその製法 |
| US5756353A (en) | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
| ES2105262T3 (es) | 1992-05-18 | 1997-10-16 | Minnesota Mining & Mfg | Dispositivo de suministro de farmaco a traves de las mucosas. |
| US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| WO1994022846A1 (en) * | 1993-03-30 | 1994-10-13 | Pfizer Inc. | Compounds enhancing antitumor activity of other cytotoxic agents |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
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| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| MY128323A (en) | 1996-09-30 | 2007-01-31 | Otsuka Pharma Co Ltd | Thiazole derivatives for inhibition of cytokine production and of cell adhesion |
| JPH1179993A (ja) | 1997-09-05 | 1999-03-23 | Sumitomo Pharmaceut Co Ltd | 免疫抑制剤 |
| JPH11186479A (ja) | 1997-12-22 | 1999-07-09 | Toyo Commun Equip Co Ltd | 放熱板付き表面実装部品 |
| JP2000080086A (ja) * | 1998-07-01 | 2000-03-21 | Takeda Chem Ind Ltd | レチノイド関連受容体機能調節剤 |
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| KR100838447B1 (ko) * | 2001-02-21 | 2008-06-16 | 아스트라제네카 아베 | 헤테로폴리시클릭 화합물 및 대사향성 글루타메이트수용체 길항제로서의 그의 용도 |
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| CA2630920A1 (en) * | 2005-11-22 | 2007-05-31 | University Of South Florida | Inhibition of cell proliferation |
| AU2008214095B2 (en) * | 2007-02-02 | 2014-07-10 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| EP2764052B1 (en) * | 2011-10-04 | 2018-07-18 | Dow Silicones Corporation | Iron(iii) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts |
-
2008
- 2008-02-01 AU AU2008214095A patent/AU2008214095B2/en not_active Ceased
- 2008-02-01 CA CA2677264A patent/CA2677264C/en active Active
- 2008-02-01 CN CN200880008035.2A patent/CN101674730B/zh not_active Expired - Fee Related
- 2008-02-01 EP EP08728809.8A patent/EP2120580B1/en active Active
- 2008-02-01 WO PCT/US2008/052778 patent/WO2008097835A2/en not_active Ceased
- 2008-02-01 JP JP2009548468A patent/JP5461197B2/ja not_active Expired - Fee Related
- 2008-02-01 US US12/024,530 patent/US8207196B2/en active Active
-
2012
- 2012-05-31 US US13/484,685 patent/US8778976B2/en active Active
- 2012-05-31 US US13/484,702 patent/US8927578B2/en active Active
-
2014
- 2014-01-15 JP JP2014005460A patent/JP5878937B2/ja not_active Expired - Fee Related
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