JP2010533185A5 - - Google Patents
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- Publication number
- JP2010533185A5 JP2010533185A5 JP2010516062A JP2010516062A JP2010533185A5 JP 2010533185 A5 JP2010533185 A5 JP 2010533185A5 JP 2010516062 A JP2010516062 A JP 2010516062A JP 2010516062 A JP2010516062 A JP 2010516062A JP 2010533185 A5 JP2010533185 A5 JP 2010533185A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- diphenylpropyl
- thiazol
- amino
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 dimethylene group Chemical group 0.000 claims 51
- 150000001875 compounds Chemical class 0.000 claims 29
- 150000003839 salts Chemical class 0.000 claims 27
- 125000001424 substituent group Chemical group 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 125000003282 alkyl amino group Chemical group 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 125000004663 dialkyl amino group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 7
- 125000004442 acylamino group Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 239000004202 carbamide Substances 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000004414 alkyl thio group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 150000001408 amides Chemical class 0.000 claims 5
- 125000003277 amino group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 229910052801 chlorine Inorganic materials 0.000 claims 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims 5
- 125000004122 cyclic group Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 210000000557 podocyte Anatomy 0.000 claims 5
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 5
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 150000003457 sulfones Chemical class 0.000 claims 4
- 150000003462 sulfoxides Chemical class 0.000 claims 4
- 125000004001 thioalkyl group Chemical group 0.000 claims 4
- 125000003172 aldehyde group Chemical group 0.000 claims 3
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 3
- 125000005422 alkyl sulfonamido group Chemical group 0.000 claims 3
- 125000004422 alkyl sulphonamide group Chemical group 0.000 claims 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 3
- ZACUJFIIPRZJOC-UHFFFAOYSA-N 3-[[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]carbamoyl-(3,3-diphenylpropyl)amino]benzoic acid Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C=C(C=CC=2)C(O)=O)=N1 ZACUJFIIPRZJOC-UHFFFAOYSA-N 0.000 claims 2
- NIIRFCZAPMBUDM-UHFFFAOYSA-N 4-[1,3-benzothiazol-2-ylcarbamoyl(3,3-diphenylpropyl)amino]cyclohexane-1-carboxylic acid Chemical compound C1CC(C(=O)O)CCC1N(C(=O)NC=1SC2=CC=CC=C2N=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 NIIRFCZAPMBUDM-UHFFFAOYSA-N 0.000 claims 2
- UWWRMJBSKOKEMQ-UHFFFAOYSA-N 4-[[5-chloro-4-(4-methylsulfonylphenyl)-1,3-thiazol-2-yl]carbamoyl-(3,3-diphenylpropyl)amino]cyclohexane-1-carboxylic acid Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCC(CC2)C(O)=O)=N1 UWWRMJBSKOKEMQ-UHFFFAOYSA-N 0.000 claims 2
- HZLAPSDQTJOIED-UHFFFAOYSA-N 4-[[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]carbamoyl-(3,3-diphenylpropyl)amino]cyclohexane-1-carboxylic acid Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCC(CC2)C(O)=O)=N1 HZLAPSDQTJOIED-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 229920001774 Perfluoroether Polymers 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 2
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 2
- 125000001769 aryl amino group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000004986 diarylamino group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000000262 haloalkenyl group Chemical group 0.000 claims 2
- 125000000232 haloalkynyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000005020 hydroxyalkenyl group Chemical group 0.000 claims 2
- 125000005016 hydroxyalkynyl group Chemical group 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 1
- 125000004530 1,2,4-triazinyl group Chemical group N1=NC(=NC=C1)* 0.000 claims 1
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 1
- 125000004520 1,3,4-thiadiazolyl group Chemical group 0.000 claims 1
- 125000003363 1,3,5-triazinyl group Chemical group N1=C(N=CN=C1)* 0.000 claims 1
- ZKOIQFRAZPGWTR-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-(2-pyrazin-2-ylethyl)-3-[3-[4-(triazol-1-yl)phenyl]-1,2,4-thiadiazol-5-yl]urea Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCN(CCC=1N=CC=NC=1)C(=O)NC(SN=1)=NC=1C(C=C1)=CC=C1N1C=CN=N1 ZKOIQFRAZPGWTR-UHFFFAOYSA-N 0.000 claims 1
- QMZYFIWRVMLSPX-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)-3-([1,3]thiazolo[4,5-c]pyridin-2-yl)urea Chemical compound N=1C2=CN=CC=C2SC=1NC(=O)N(CCC=1N=CC=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 QMZYFIWRVMLSPX-UHFFFAOYSA-N 0.000 claims 1
- OSWRCTIFDUIICT-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)-3-([1,3]thiazolo[5,4-b]pyridin-2-yl)urea Chemical compound N=1C2=CC=CN=C2SC=1NC(=O)N(CCC=1N=CC=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 OSWRCTIFDUIICT-UHFFFAOYSA-N 0.000 claims 1
- PMLAWBYQPXMQAJ-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)-3-[3-[4-(triazol-1-yl)phenyl]-1,2,4-thiadiazol-5-yl]urea Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCN(CCC=1N=CC=CC=1)C(=O)NC(SN=1)=NC=1C(C=C1)=CC=C1N1C=CN=N1 PMLAWBYQPXMQAJ-UHFFFAOYSA-N 0.000 claims 1
- VUUDDBJKIJUUPE-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-(2-pyrimidin-2-ylethyl)-3-[3-[4-(triazol-1-yl)phenyl]-1,2,4-thiadiazol-5-yl]urea Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCN(CCC=1N=CC=CN=1)C(=O)NC(SN=1)=NC=1C(C=C1)=CC=C1N1C=CN=N1 VUUDDBJKIJUUPE-UHFFFAOYSA-N 0.000 claims 1
- HRGAURTYKULADY-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-methyl-3-(4-phenyl-1,3-thiazol-2-yl)urea Chemical compound N=1C(C=2C=CC=CC=2)=CSC=1NC(=O)N(C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 HRGAURTYKULADY-UHFFFAOYSA-N 0.000 claims 1
- AZIFEQTWSIFKJM-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-(3-methoxyphenyl)-1-(2-methylpropyl)urea Chemical compound COC1=CC=CC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC(C)C)=C1 AZIFEQTWSIFKJM-UHFFFAOYSA-N 0.000 claims 1
- JVTDCDIEQLAMHX-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-(4-methylsulfonylphenyl)-1,2,4-thiadiazol-5-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=NC=2)=N1 JVTDCDIEQLAMHX-UHFFFAOYSA-N 0.000 claims 1
- LHHZQKSJWYYWSL-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-(4-methylsulfonylphenyl)-1,2,4-thiadiazol-5-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=N1 LHHZQKSJWYYWSL-UHFFFAOYSA-N 0.000 claims 1
- LTKVZIMSURZVED-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=NC=2)=N1 LTKVZIMSURZVED-UHFFFAOYSA-N 0.000 claims 1
- AGHZLKBRHCZXRK-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=N1 AGHZLKBRHCZXRK-UHFFFAOYSA-N 0.000 claims 1
- SOFOCHPFTUZMAA-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyrimidin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CN=2)=N1 SOFOCHPFTUZMAA-UHFFFAOYSA-N 0.000 claims 1
- ZMONVHVKFIGNJS-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-[2-(oxan-4-yl)ethyl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCOCC2)=N1 ZMONVHVKFIGNJS-UHFFFAOYSA-N 0.000 claims 1
- YYBJMBSGAOJYGN-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-propan-2-ylurea Chemical compound N=1C(C=2C=CC(NS(C)(=O)=O)=CC=2)=NSC=1NC(=O)N(C(C)C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 YYBJMBSGAOJYGN-UHFFFAOYSA-N 0.000 claims 1
- RJESAVXJLXLTFB-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[4-(4-methylsulfonylphenyl)-1,3-thiazol-2-yl]-1-(2-piperidin-4-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCNCC2)=N1 RJESAVXJLXLTFB-UHFFFAOYSA-N 0.000 claims 1
- OALHLQSZEVEJCB-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(2-piperidin-3-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=CSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CNCCC2)=N1 OALHLQSZEVEJCB-UHFFFAOYSA-N 0.000 claims 1
- OLWYWDJFVLIKHG-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(2-piperidin-4-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=CSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCNCC2)=N1 OLWYWDJFVLIKHG-UHFFFAOYSA-N 0.000 claims 1
- IHVWNPFIECNCBW-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[5-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-3-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=NS1 IHVWNPFIECNCBW-UHFFFAOYSA-N 0.000 claims 1
- AOKNTQVNBDYBGY-UHFFFAOYSA-N 1-[2-(5-chloropyridin-2-yl)ethyl]-3-[5-chloro-4-[4-(triazol-1-yl)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)urea Chemical compound N=1C(C=2C=CC(=CC=2)N2N=NC=C2)=C(Cl)SC=1NC(=O)N(CCC=1N=CC(Cl)=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 AOKNTQVNBDYBGY-UHFFFAOYSA-N 0.000 claims 1
- ADGAPAYEXWEBQW-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-1-cyclopropyl-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)C2CC2)=N1 ADGAPAYEXWEBQW-UHFFFAOYSA-N 0.000 claims 1
- NNBWJPWNZZBQFV-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-(4-methylsulfonylphenyl)-1,2,4-thiadiazol-5-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=NC=2)=N1 NNBWJPWNZZBQFV-UHFFFAOYSA-N 0.000 claims 1
- DCPKYHGPQRGTLX-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-(4-methylsulfonylphenyl)-1,2,4-thiadiazol-5-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CC=2)=N1 DCPKYHGPQRGTLX-UHFFFAOYSA-N 0.000 claims 1
- QQTJMZKEZXQPBS-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=NC=2)=N1 QQTJMZKEZXQPBS-UHFFFAOYSA-N 0.000 claims 1
- UMZJLTDGXPEGDJ-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CC=2)=N1 UMZJLTDGXPEGDJ-UHFFFAOYSA-N 0.000 claims 1
- HZKBZYFAJXFCMW-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyrimidin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CN=2)=N1 HZKBZYFAJXFCMW-UHFFFAOYSA-N 0.000 claims 1
- AWNQPDHDOBCWMK-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-[2-(oxan-4-yl)ethyl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC2CCOCC2)=N1 AWNQPDHDOBCWMK-UHFFFAOYSA-N 0.000 claims 1
- AVWKENNMYYMCLO-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[4-[4-(tert-butylsulfamoyl)phenyl]-5-chloro-1,3-thiazol-2-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)NC(C)(C)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CC=2)=N1 AVWKENNMYYMCLO-UHFFFAOYSA-N 0.000 claims 1
- KBMOQDVILAOWKD-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-3-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CC=2)=NS1 KBMOQDVILAOWKD-UHFFFAOYSA-N 0.000 claims 1
- UPGIWZDMEIGHPY-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-chloro-4-(4-methylsulfonylphenyl)-1,3-thiazol-2-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=NC=2)=N1 UPGIWZDMEIGHPY-UHFFFAOYSA-N 0.000 claims 1
- RPMBXBLTTFHWLJ-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-chloro-4-(4-sulfamoylphenyl)-1,3-thiazol-2-yl]-1-cyclopropylurea Chemical compound C1=CC(S(=O)(=O)N)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)C2CC2)=N1 RPMBXBLTTFHWLJ-UHFFFAOYSA-N 0.000 claims 1
- ZCCSRANATLOSRH-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=NC=2)=N1 ZCCSRANATLOSRH-UHFFFAOYSA-N 0.000 claims 1
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- VOYBSYONWFLLDY-UHFFFAOYSA-N 3-[5-chloro-4-(6-chloropyridin-3-yl)-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-piperidin-4-ylurea Chemical compound N=1C(C=2C=NC(Cl)=CC=2)=C(Cl)SC=1NC(=O)N(C1CCNCC1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 VOYBSYONWFLLDY-UHFFFAOYSA-N 0.000 claims 1
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- IKKIITPFLMQBPQ-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-fluorophenyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C(=CC=CC=2)F)=N1 IKKIITPFLMQBPQ-UHFFFAOYSA-N 0.000 claims 1
- JEOCZTFYUDFTEJ-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-piperidin-3-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CNCCC2)=N1 JEOCZTFYUDFTEJ-UHFFFAOYSA-N 0.000 claims 1
- XWGOOSGNHLDFRD-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-piperidin-4-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCNCC2)=N1 XWGOOSGNHLDFRD-UHFFFAOYSA-N 0.000 claims 1
- DTCQUUCXPLURAX-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=NC=2)=N1 DTCQUUCXPLURAX-UHFFFAOYSA-N 0.000 claims 1
- MXGKZYXCFFJDIO-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=N1 MXGKZYXCFFJDIO-UHFFFAOYSA-N 0.000 claims 1
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- FKGGGBNUSFSCNO-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(thian-4-yl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCSCC2)=N1 FKGGGBNUSFSCNO-UHFFFAOYSA-N 0.000 claims 1
- FKJOGWVEBMXGNE-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[2-(2-fluorophenyl)ethyl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2C(=CC=CC=2)F)=N1 FKJOGWVEBMXGNE-UHFFFAOYSA-N 0.000 claims 1
- YLAICAYFOQYUFU-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[2-(2-methoxyphenyl)ethyl]urea Chemical compound COC1=CC=CC=C1CCN(C(=O)NC=1SC(Cl)=C(N=1)C=1C=CC(NS(C)(=O)=O)=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 YLAICAYFOQYUFU-UHFFFAOYSA-N 0.000 claims 1
- XOIWSMWLQCUVMM-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[2-(4-fluorophenyl)ethyl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2C=CC(F)=CC=2)=N1 XOIWSMWLQCUVMM-UHFFFAOYSA-N 0.000 claims 1
- HMWKDYDNYFKDQW-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[2-(4-methoxyphenyl)ethyl]urea Chemical compound C1=CC(OC)=CC=C1CCN(C(=O)NC=1SC(Cl)=C(N=1)C=1C=CC(NS(C)(=O)=O)=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 HMWKDYDNYFKDQW-UHFFFAOYSA-N 0.000 claims 1
- UKTKLARTYMMLTC-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[4-(2-hydroxyethyl)phenyl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C=CC(CCO)=CC=2)=N1 UKTKLARTYMMLTC-UHFFFAOYSA-N 0.000 claims 1
- PJADPCCRORXZQD-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-methylurea Chemical compound N=1C(C=2C=CC(NS(C)(=O)=O)=CC=2)=C(Cl)SC=1NC(=O)N(C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 PJADPCCRORXZQD-UHFFFAOYSA-N 0.000 claims 1
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95905807P | 2007-07-10 | 2007-07-10 | |
| US60/959,058 | 2007-07-10 | ||
| PCT/US2008/008508 WO2009009122A2 (en) | 2007-07-10 | 2008-07-10 | Derivatives of urea and related diamines, methods for their manufacture, and uses therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533185A JP2010533185A (ja) | 2010-10-21 |
| JP2010533185A5 true JP2010533185A5 (enExample) | 2011-04-21 |
| JP5504484B2 JP5504484B2 (ja) | 2014-05-28 |
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| JP2010516062A Expired - Fee Related JP5504484B2 (ja) | 2007-07-10 | 2008-07-10 | ウレア誘導体および関連ジアミン、これらの製造方法および使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8324396B2 (enExample) |
| EP (1) | EP2176247A2 (enExample) |
| JP (1) | JP5504484B2 (enExample) |
| AU (1) | AU2008275595B2 (enExample) |
| CA (1) | CA2692598A1 (enExample) |
| WO (1) | WO2009009122A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2885129B1 (fr) | 2005-04-29 | 2007-06-15 | Proskelia Sas | Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation. |
| WO2007060026A1 (en) | 2005-11-25 | 2007-05-31 | Galapagos Sas | Urea derivatives useful as calcium receptor modulators |
| ES2499015T3 (es) * | 2007-05-08 | 2014-09-26 | Ajinomoto Co., Inc. | Agente profiláctico o terapéutico para la diarrea |
| WO2013138753A1 (en) | 2012-03-16 | 2013-09-19 | Fox Chase Chemical Diversity Center, Inc. | Prodrugs of riluzole and their method of use |
| CN102701992B (zh) * | 2012-07-03 | 2014-01-15 | 重庆医科大学 | 一种抗肿瘤化合物及其药学上可接受的盐、及制备方法和应用 |
| CN103992236B (zh) * | 2014-04-29 | 2016-05-18 | 于非 | 一种新型靶向性抗肿瘤药物及其制备方法与应用 |
| AU2021303146A1 (en) * | 2020-06-29 | 2023-02-02 | Bacainn Biotherapeutics, Ltd. | Probenecid compounds for the treatment of inflammasome-mediated lung disease |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58109464A (ja) | 1981-12-23 | 1983-06-29 | Nippon Paint Co Ltd | アミノ酸化合物、その製法ならびに触媒 |
| IL67417A (en) * | 1982-01-26 | 1989-10-31 | American Cyanamid Co | Antiatherosclerotic substituted ureas,process for their preparation and pharmaceutical compositions containing them |
| US4994465A (en) * | 1989-02-17 | 1991-02-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds |
| US5153226A (en) | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| US6011068A (en) | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6031003A (en) | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| JPH0841006A (ja) | 1994-08-05 | 1996-02-13 | Nisshin Flour Milling Co Ltd | ジウレア誘導体 |
| WO1996012697A2 (en) | 1994-10-21 | 1996-05-02 | Nps Pharmaceuticals, Inc. | Calcium receptor-active compounds |
| JPH10195037A (ja) | 1996-02-15 | 1998-07-28 | Tanabe Seiyaku Co Ltd | フェノール誘導体 |
| JPH11139969A (ja) | 1997-08-07 | 1999-05-25 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| US6365617B1 (en) | 1999-06-29 | 2002-04-02 | Ortho-Mcneil Pharmaceutical, Inc. | Indole and indazole urea-peptoids as thrombin receptor antagonists |
| FR2820136A1 (fr) | 2001-01-26 | 2002-08-02 | Aventis Pharma Sa | Nouveaux derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
| FR2885129B1 (fr) * | 2005-04-29 | 2007-06-15 | Proskelia Sas | Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation. |
| WO2007060026A1 (en) | 2005-11-25 | 2007-05-31 | Galapagos Sas | Urea derivatives useful as calcium receptor modulators |
| GB0613674D0 (en) | 2006-07-10 | 2006-08-16 | Proskelia Sas | Derivatives of urea and related diamines, methods for their manufacture, and uses therefor |
-
2008
- 2008-07-10 EP EP08780119A patent/EP2176247A2/en not_active Withdrawn
- 2008-07-10 WO PCT/US2008/008508 patent/WO2009009122A2/en not_active Ceased
- 2008-07-10 JP JP2010516062A patent/JP5504484B2/ja not_active Expired - Fee Related
- 2008-07-10 AU AU2008275595A patent/AU2008275595B2/en not_active Ceased
- 2008-07-10 CA CA 2692598 patent/CA2692598A1/en not_active Abandoned
- 2008-07-10 US US12/218,228 patent/US8324396B2/en active Active
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