JP5504484B2 - ウレア誘導体および関連ジアミン、これらの製造方法および使用 - Google Patents

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Publication number

JP5504484B2

JP5504484B2 JP2010516062A JP2010516062A JP5504484B2 JP 5504484 B2 JP5504484 B2 JP 5504484B2 JP 2010516062 A JP2010516062 A JP 2010516062A JP 2010516062 A JP2010516062 A JP 2010516062A JP 5504484 B2 JP5504484 B2 JP 5504484B2

Authority

JP

Japan

Prior art keywords

phenyl

diphenylpropyl

thiazol

chloro

amino

Prior art date

2007-07-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 238000000034 method Methods 0.000 title description 251
• 150000004985 diamines Chemical class 0.000 title description 2
• 150000003672 ureas Chemical class 0.000 title description 2
• -1 1- (3,3-diphenylpropyl) -1-isopropyl-3- (4- (4- (methylsulfonamido) phenyl) thiazol-2-yl) urea 1- (3,3-diphenylpropyl) -3- (4- (4- (methylsulfonamido) phenyl) thiazol-2-yl) -1-propylurea Chemical compound 0.000 claims description 270
• 150000001875 compounds Chemical class 0.000 claims description 230
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 92
• 239000004202 carbamide Substances 0.000 claims description 46
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 41
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 32
• 150000003839 salts Chemical class 0.000 claims description 32
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 23
• HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims description 21
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 16
• 150000001408 amides Chemical class 0.000 claims description 15
• ZACUJFIIPRZJOC-UHFFFAOYSA-N 3-[[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]carbamoyl-(3,3-diphenylpropyl)amino]benzoic acid Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C=C(C=CC=2)C(O)=O)=N1 ZACUJFIIPRZJOC-UHFFFAOYSA-N 0.000 claims description 13
• NPGCSDOTXJJGOK-UHFFFAOYSA-N 3-[5-chloro-4-[4-(hydroxymethyl)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-propan-2-ylurea Chemical compound N=1C(C=2C=CC(CO)=CC=2)=C(Cl)SC=1NC(=O)N(C(C)C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 NPGCSDOTXJJGOK-UHFFFAOYSA-N 0.000 claims description 6
• PJADPCCRORXZQD-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-methylurea Chemical compound N=1C(C=2C=CC(NS(C)(=O)=O)=CC=2)=C(Cl)SC=1NC(=O)N(C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 PJADPCCRORXZQD-UHFFFAOYSA-N 0.000 claims description 6
• 239000005711 Benzoic acid Substances 0.000 claims description 6
• 235000010233 benzoic acid Nutrition 0.000 claims description 6
• USLNXSDONWYRFN-UHFFFAOYSA-N 2-[4-[[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]carbamoyl-(3,3-diphenylpropyl)amino]phenyl]acetic acid Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C=CC(CC(O)=O)=CC=2)=N1 USLNXSDONWYRFN-UHFFFAOYSA-N 0.000 claims description 5
• NIIRFCZAPMBUDM-UHFFFAOYSA-N 4-[1,3-benzothiazol-2-ylcarbamoyl(3,3-diphenylpropyl)amino]cyclohexane-1-carboxylic acid Chemical compound C1CC(C(=O)O)CCC1N(C(=O)NC=1SC2=CC=CC=C2N=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 NIIRFCZAPMBUDM-UHFFFAOYSA-N 0.000 claims description 5
• HRGAURTYKULADY-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-methyl-3-(4-phenyl-1,3-thiazol-2-yl)urea Chemical compound N=1C(C=2C=CC=CC=2)=CSC=1NC(=O)N(C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 HRGAURTYKULADY-UHFFFAOYSA-N 0.000 claims description 4
• OALHLQSZEVEJCB-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(2-piperidin-3-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=CSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CNCCC2)=N1 OALHLQSZEVEJCB-UHFFFAOYSA-N 0.000 claims description 4
• OLQKRTSHJBUICH-UHFFFAOYSA-N 1-cyclopropyl-1-(3,3-diphenylpropyl)-3-[4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=CSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CC2)=N1 OLQKRTSHJBUICH-UHFFFAOYSA-N 0.000 claims description 4
• FTRZIZTVCSCBFP-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-1-(3,3-diphenylpropyl)-1-methylurea Chemical compound N=1C2=CC=CC=C2SC=1NC(=O)N(C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 FTRZIZTVCSCBFP-UHFFFAOYSA-N 0.000 claims description 4
• UUIUELBLXNNIMF-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-1-(3,3-diphenylpropyl)-1-propylurea Chemical compound N=1C2=CC=CC=C2SC=1NC(=O)N(CCC)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 UUIUELBLXNNIMF-UHFFFAOYSA-N 0.000 claims description 4
• CNIUALCPWIVVDR-UHFFFAOYSA-N 3-[5-chloro-4-(4-sulfamoylphenyl)-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[2-(oxan-4-yl)ethyl]urea Chemical compound C1=CC(S(=O)(=O)N)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCOCC2)=N1 CNIUALCPWIVVDR-UHFFFAOYSA-N 0.000 claims description 4
• XUFRZYADNMCTKR-UHFFFAOYSA-N 3-[5-chloro-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-piperidin-4-ylurea Chemical compound C1=NC(C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCNCC2)=N1 XUFRZYADNMCTKR-UHFFFAOYSA-N 0.000 claims description 4
• DOYBEVPHIOZZNR-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(2-cyanoethyl)-1-(3,3-diphenylpropyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC#N)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)=N1 DOYBEVPHIOZZNR-UHFFFAOYSA-N 0.000 claims description 4
• XOIWSMWLQCUVMM-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[2-(4-fluorophenyl)ethyl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2C=CC(F)=CC=2)=N1 XOIWSMWLQCUVMM-UHFFFAOYSA-N 0.000 claims description 4
• HMWKDYDNYFKDQW-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[2-(4-methoxyphenyl)ethyl]urea Chemical compound C1=CC(OC)=CC=C1CCN(C(=O)NC=1SC(Cl)=C(N=1)C=1C=CC(NS(C)(=O)=O)=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 HMWKDYDNYFKDQW-UHFFFAOYSA-N 0.000 claims description 4
• IJIZOZXAWNFVDF-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-propan-2-ylurea Chemical compound N=1C(C=2C=CC(NS(C)(=O)=O)=CC=2)=C(Cl)SC=1NC(=O)N(C(C)C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 IJIZOZXAWNFVDF-UHFFFAOYSA-N 0.000 claims description 4
• UWWRMJBSKOKEMQ-UHFFFAOYSA-N 4-[[5-chloro-4-(4-methylsulfonylphenyl)-1,3-thiazol-2-yl]carbamoyl-(3,3-diphenylpropyl)amino]cyclohexane-1-carboxylic acid Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCC(CC2)C(O)=O)=N1 UWWRMJBSKOKEMQ-UHFFFAOYSA-N 0.000 claims description 4
• HZLAPSDQTJOIED-UHFFFAOYSA-N 4-[[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]carbamoyl-(3,3-diphenylpropyl)amino]cyclohexane-1-carboxylic acid Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCC(CC2)C(O)=O)=N1 HZLAPSDQTJOIED-UHFFFAOYSA-N 0.000 claims description 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
• BOMBPAKGWZYNAC-UHFFFAOYSA-N methyl 3-[[2-cyclohexylethyl(3,3-diphenylpropyl)carbamoyl]amino]benzoate Chemical compound COC(=O)C1=CC=CC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCCCC2)=C1 BOMBPAKGWZYNAC-UHFFFAOYSA-N 0.000 claims description 4
• CXXMOYDDXQAZNI-UHFFFAOYSA-N methyl 3-[[benzyl(3,3-diphenylpropyl)carbamoyl]amino]benzoate Chemical compound COC(=O)C1=CC=CC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC=2C=CC=CC=2)=C1 CXXMOYDDXQAZNI-UHFFFAOYSA-N 0.000 claims description 4
• OGPYGYAIRQEKOU-UHFFFAOYSA-N n-[4-[3-[[3,3-diphenylpropyl(2-pyridin-2-ylethyl)carbamoyl]amino]-1,2,4-thiadiazol-5-yl]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1C1=NC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=NS1 OGPYGYAIRQEKOU-UHFFFAOYSA-N 0.000 claims description 4
• 230000007935 neutral effect Effects 0.000 claims description 4
• RJESAVXJLXLTFB-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[4-(4-methylsulfonylphenyl)-1,3-thiazol-2-yl]-1-(2-piperidin-4-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCNCC2)=N1 RJESAVXJLXLTFB-UHFFFAOYSA-N 0.000 claims description 3
• OLWYWDJFVLIKHG-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(2-piperidin-4-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=CSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCNCC2)=N1 OLWYWDJFVLIKHG-UHFFFAOYSA-N 0.000 claims description 3
• RPMBXBLTTFHWLJ-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-chloro-4-(4-sulfamoylphenyl)-1,3-thiazol-2-yl]-1-cyclopropylurea Chemical compound C1=CC(S(=O)(=O)N)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)C2CC2)=N1 RPMBXBLTTFHWLJ-UHFFFAOYSA-N 0.000 claims description 3
• QHPAQLMKTKIWKR-UHFFFAOYSA-N 1-benzyl-3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC=2C=CC=CC=2)=N1 QHPAQLMKTKIWKR-UHFFFAOYSA-N 0.000 claims description 3
• AITMPYIQNVYIBL-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-1-(3,3-diphenylpropyl)-1-propan-2-ylurea Chemical compound N=1C2=CC=CC=C2SC=1NC(=O)N(C(C)C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 AITMPYIQNVYIBL-UHFFFAOYSA-N 0.000 claims description 3
• HCBGMTOJOIWJMF-UHFFFAOYSA-N 3-[1,3-benzothiazol-2-ylcarbamoyl(3,3-diphenylpropyl)amino]cyclopentane-1-carboxylic acid Chemical compound C1C(C(=O)O)CCC1N(C(=O)NC=1SC2=CC=CC=C2N=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 HCBGMTOJOIWJMF-UHFFFAOYSA-N 0.000 claims description 3
• VTALQYIVQZDWRR-UHFFFAOYSA-N 3-[5-chloro-4-(4-methylsulfonylphenyl)-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-piperidin-4-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCNCC2)=N1 VTALQYIVQZDWRR-UHFFFAOYSA-N 0.000 claims description 3
• GTQRPYUBSCNURT-UHFFFAOYSA-N 3-[5-chloro-4-(4-sulfamoylphenyl)-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)N)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=N1 GTQRPYUBSCNURT-UHFFFAOYSA-N 0.000 claims description 3
• JEOCZTFYUDFTEJ-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-piperidin-3-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CNCCC2)=N1 JEOCZTFYUDFTEJ-UHFFFAOYSA-N 0.000 claims description 3
• MXGKZYXCFFJDIO-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=N1 MXGKZYXCFFJDIO-UHFFFAOYSA-N 0.000 claims description 3
• FVMWKCAAGYSODJ-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-pyridin-3-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2C=NC=CC=2)=N1 FVMWKCAAGYSODJ-UHFFFAOYSA-N 0.000 claims description 3
• OVMAMDGPCNDIKV-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-pyridin-4-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2C=CN=CC=2)=N1 OVMAMDGPCNDIKV-UHFFFAOYSA-N 0.000 claims description 3
• UMIIJVFNCZOMCB-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(3-phenylpropyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCCC=2C=CC=CC=2)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)=N1 UMIIJVFNCZOMCB-UHFFFAOYSA-N 0.000 claims description 3
• MAYWFBUXGLYLNU-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(oxan-4-yl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCOCC2)=N1 MAYWFBUXGLYLNU-UHFFFAOYSA-N 0.000 claims description 3
• UKTKLARTYMMLTC-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[4-(2-hydroxyethyl)phenyl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C=CC(CCO)=CC=2)=N1 UKTKLARTYMMLTC-UHFFFAOYSA-N 0.000 claims description 3
• OKARARGFKYNAOK-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-cyclohexyl-1-(3,3-diphenylpropyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCCCC2)=N1 OKARARGFKYNAOK-UHFFFAOYSA-N 0.000 claims description 3
• LBEAGSHXLDXIEU-UHFFFAOYSA-N 3-[5-chloro-4-[4-(morpholin-4-ylmethyl)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(oxan-4-yl)urea Chemical compound N=1C(C=2C=CC(CN3CCOCC3)=CC=2)=C(Cl)SC=1NC(=O)N(C1CCOCC1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 LBEAGSHXLDXIEU-UHFFFAOYSA-N 0.000 claims description 3
• REJFZUMCCNNDJH-UHFFFAOYSA-N 3-[5-chloro-4-[4-(morpholin-4-ylmethyl)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-propan-2-ylurea Chemical compound N=1C(C=2C=CC(CN3CCOCC3)=CC=2)=C(Cl)SC=1NC(=O)N(C(C)C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 REJFZUMCCNNDJH-UHFFFAOYSA-N 0.000 claims description 3
• WOPQNHSLIVELFV-UHFFFAOYSA-N 3-[5-chloro-4-[4-(piperazin-1-ylmethyl)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-propan-2-ylurea Chemical compound N=1C(C=2C=CC(CN3CCNCC3)=CC=2)=C(Cl)SC=1NC(=O)N(C(C)C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 WOPQNHSLIVELFV-UHFFFAOYSA-N 0.000 claims description 3
• RKGNVZZXERDKIJ-UHFFFAOYSA-N 3-[5-chloro-4-[4-(triazol-1-yl)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)urea Chemical compound N=1C(C=2C=CC(=CC=2)N2N=NC=C2)=C(Cl)SC=1NC(=O)N(CCC=1N=CC=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 RKGNVZZXERDKIJ-UHFFFAOYSA-N 0.000 claims description 3
• YNGLWJYHGXXLQM-UHFFFAOYSA-N 3-[[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]carbamoyl-(3,3-diphenylpropyl)amino]-n-methylbenzamide Chemical compound CNC(=O)C1=CC=CC(N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C(=O)NC=2SC(Cl)=C(N=2)C=2C=CC(NS(C)(=O)=O)=CC=2)=C1 YNGLWJYHGXXLQM-UHFFFAOYSA-N 0.000 claims description 3
• FPQGJGUPIGMVBZ-UHFFFAOYSA-N ClC1=C(N=C(S1)NC(NC(C)(C1=CC=CC=C1)CCC(C1=CC=CC=C1)C1=CC=CC=C1)=O)C1=CC=C(C=C1)NS(=O)(=O)C Chemical compound ClC1=C(N=C(S1)NC(NC(C)(C1=CC=CC=C1)CCC(C1=CC=CC=C1)C1=CC=CC=C1)=O)C1=CC=C(C=C1)NS(=O)(=O)C FPQGJGUPIGMVBZ-UHFFFAOYSA-N 0.000 claims description 3
• QMZYFIWRVMLSPX-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)-3-([1,3]thiazolo[4,5-c]pyridin-2-yl)urea Chemical compound N=1C2=CN=CC=C2SC=1NC(=O)N(CCC=1N=CC=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 QMZYFIWRVMLSPX-UHFFFAOYSA-N 0.000 claims description 2
• OSWRCTIFDUIICT-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)-3-([1,3]thiazolo[5,4-b]pyridin-2-yl)urea Chemical compound N=1C2=CC=CN=C2SC=1NC(=O)N(CCC=1N=CC=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 OSWRCTIFDUIICT-UHFFFAOYSA-N 0.000 claims description 2
• PMLAWBYQPXMQAJ-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)-3-[3-[4-(triazol-1-yl)phenyl]-1,2,4-thiadiazol-5-yl]urea Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCN(CCC=1N=CC=CC=1)C(=O)NC(SN=1)=NC=1C(C=C1)=CC=C1N1C=CN=N1 PMLAWBYQPXMQAJ-UHFFFAOYSA-N 0.000 claims description 2
• VUUDDBJKIJUUPE-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-1-(2-pyrimidin-2-ylethyl)-3-[3-[4-(triazol-1-yl)phenyl]-1,2,4-thiadiazol-5-yl]urea Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCN(CCC=1N=CC=CN=1)C(=O)NC(SN=1)=NC=1C(C=C1)=CC=C1N1C=CN=N1 VUUDDBJKIJUUPE-UHFFFAOYSA-N 0.000 claims description 2
• JVTDCDIEQLAMHX-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-(4-methylsulfonylphenyl)-1,2,4-thiadiazol-5-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=NC=2)=N1 JVTDCDIEQLAMHX-UHFFFAOYSA-N 0.000 claims description 2
• LHHZQKSJWYYWSL-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-(4-methylsulfonylphenyl)-1,2,4-thiadiazol-5-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=N1 LHHZQKSJWYYWSL-UHFFFAOYSA-N 0.000 claims description 2
• LTKVZIMSURZVED-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=NC=2)=N1 LTKVZIMSURZVED-UHFFFAOYSA-N 0.000 claims description 2
• AGHZLKBRHCZXRK-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=N1 AGHZLKBRHCZXRK-UHFFFAOYSA-N 0.000 claims description 2
• SOFOCHPFTUZMAA-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyrimidin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CN=2)=N1 SOFOCHPFTUZMAA-UHFFFAOYSA-N 0.000 claims description 2
• ZMONVHVKFIGNJS-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-[2-(oxan-4-yl)ethyl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCOCC2)=N1 ZMONVHVKFIGNJS-UHFFFAOYSA-N 0.000 claims description 2
• YYBJMBSGAOJYGN-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-propan-2-ylurea Chemical compound N=1C(C=2C=CC(NS(C)(=O)=O)=CC=2)=NSC=1NC(=O)N(C(C)C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 YYBJMBSGAOJYGN-UHFFFAOYSA-N 0.000 claims description 2
• IHVWNPFIECNCBW-UHFFFAOYSA-N 1-(3,3-diphenylpropyl)-3-[5-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-3-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=NS1 IHVWNPFIECNCBW-UHFFFAOYSA-N 0.000 claims description 2
• AOKNTQVNBDYBGY-UHFFFAOYSA-N 1-[2-(5-chloropyridin-2-yl)ethyl]-3-[5-chloro-4-[4-(triazol-1-yl)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)urea Chemical compound N=1C(C=2C=CC(=CC=2)N2N=NC=C2)=C(Cl)SC=1NC(=O)N(CCC=1N=CC(Cl)=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 AOKNTQVNBDYBGY-UHFFFAOYSA-N 0.000 claims description 2
• NNBWJPWNZZBQFV-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-(4-methylsulfonylphenyl)-1,2,4-thiadiazol-5-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=NC=2)=N1 NNBWJPWNZZBQFV-UHFFFAOYSA-N 0.000 claims description 2
• DCPKYHGPQRGTLX-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-(4-methylsulfonylphenyl)-1,2,4-thiadiazol-5-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CC=2)=N1 DCPKYHGPQRGTLX-UHFFFAOYSA-N 0.000 claims description 2
• QQTJMZKEZXQPBS-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=NC=2)=N1 QQTJMZKEZXQPBS-UHFFFAOYSA-N 0.000 claims description 2
• UMZJLTDGXPEGDJ-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CC=2)=N1 UMZJLTDGXPEGDJ-UHFFFAOYSA-N 0.000 claims description 2
• HZKBZYFAJXFCMW-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-(2-pyrimidin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CN=2)=N1 HZKBZYFAJXFCMW-UHFFFAOYSA-N 0.000 claims description 2
• AWNQPDHDOBCWMK-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[3-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-5-yl]-1-[2-(oxan-4-yl)ethyl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NSC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC2CCOCC2)=N1 AWNQPDHDOBCWMK-UHFFFAOYSA-N 0.000 claims description 2
• AVWKENNMYYMCLO-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[4-[4-(tert-butylsulfamoyl)phenyl]-5-chloro-1,3-thiazol-2-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)NC(C)(C)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CC=2)=N1 AVWKENNMYYMCLO-UHFFFAOYSA-N 0.000 claims description 2
• KBMOQDVILAOWKD-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-[4-(methanesulfonamido)phenyl]-1,2,4-thiadiazol-3-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=NC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CC=2)=NS1 KBMOQDVILAOWKD-UHFFFAOYSA-N 0.000 claims description 2
• UPGIWZDMEIGHPY-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-chloro-4-(4-methylsulfonylphenyl)-1,3-thiazol-2-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=NC=2)=N1 UPGIWZDMEIGHPY-UHFFFAOYSA-N 0.000 claims description 2
• ZCCSRANATLOSRH-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=NC=2)=N1 ZCCSRANATLOSRH-UHFFFAOYSA-N 0.000 claims description 2
• OUHTTZJXZXNTHX-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CC=2)=N1 OUHTTZJXZXNTHX-UHFFFAOYSA-N 0.000 claims description 2
• QQUZTLOUQPDQIC-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(2-pyrimidin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CCC=2N=CC=CN=2)=N1 QQUZTLOUQPDQIC-UHFFFAOYSA-N 0.000 claims description 2
• DEGKBUOTALGDGP-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-chloro-4-[4-(triazol-1-yl)phenyl]-1,3-thiazol-2-yl]-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCN(C(=O)NC=1SC(Cl)=C(N=1)C=1C=CC(=CC=1)N1N=NC=C1)CCC1=CN=CC=N1 DEGKBUOTALGDGP-UHFFFAOYSA-N 0.000 claims description 2
• VPBHSEJELGTXFC-UHFFFAOYSA-N 1-[3,3-bis(4-fluorophenyl)propyl]-3-[5-chloro-4-[4-(triazol-1-yl)phenyl]-1,3-thiazol-2-yl]-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCN(C(=O)NC=1SC(Cl)=C(N=1)C=1C=CC(=CC=1)N1N=NC=C1)CCC1=CC=CC=N1 VPBHSEJELGTXFC-UHFFFAOYSA-N 0.000 claims description 2
• SIXMVCGISJKPCD-UHFFFAOYSA-N 2-[4-[[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]carbamoyl-(3,3-diphenylpropyl)amino]phenyl]-n-methylacetamide Chemical compound C1=CC(CC(=O)NC)=CC=C1N(C(=O)NC=1SC(Cl)=C(N=1)C=1C=CC(NS(C)(=O)=O)=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 SIXMVCGISJKPCD-UHFFFAOYSA-N 0.000 claims description 2
• PASUWTQDRZBHLI-UHFFFAOYSA-N 2-[[1,3-benzothiazol-2-ylcarbamoyl(3,3-diphenylpropyl)amino]methyl]cyclopropane-1-carboxylic acid Chemical compound OC(=O)C1CC1CN(C(=O)NC=1SC2=CC=CC=C2N=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 PASUWTQDRZBHLI-UHFFFAOYSA-N 0.000 claims description 2
• QVZTWZBKQPGCOV-UHFFFAOYSA-N 3-[4-[4-(tert-butylsulfamoyl)phenyl]-5-chloro-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-pyridin-2-ylethyl)urea Chemical compound C1=CC(S(=O)(=O)NC(C)(C)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CC=2)=N1 QVZTWZBKQPGCOV-UHFFFAOYSA-N 0.000 claims description 2
• ZPGQVHHQYPSBSU-UHFFFAOYSA-N 3-[5-chloro-4-(2-oxo-1,3-dihydroindol-5-yl)-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(oxan-4-yl)urea Chemical compound N=1C(C=2C=C3CC(=O)NC3=CC=2)=C(Cl)SC=1NC(=O)N(C1CCOCC1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 ZPGQVHHQYPSBSU-UHFFFAOYSA-N 0.000 claims description 2
• RRZODLBCXANRGT-UHFFFAOYSA-N 3-[5-chloro-4-(2-oxo-1,3-dihydroindol-5-yl)-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-propan-2-ylurea Chemical compound N=1C(C=2C=C3CC(=O)NC3=CC=2)=C(Cl)SC=1NC(=O)N(C(C)C)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 RRZODLBCXANRGT-UHFFFAOYSA-N 0.000 claims description 2
• YWIQJZPZRPMHBF-UHFFFAOYSA-N 3-[5-chloro-4-(4-methylsulfonylphenyl)-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(oxan-4-yl)urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCOCC2)=N1 YWIQJZPZRPMHBF-UHFFFAOYSA-N 0.000 claims description 2
• PONYVAMMQPFMOL-UHFFFAOYSA-N 3-[5-chloro-4-(4-methylsulfonylphenyl)-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[2-(oxan-4-yl)ethyl]urea Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCOCC2)=N1 PONYVAMMQPFMOL-UHFFFAOYSA-N 0.000 claims description 2
• VOYBSYONWFLLDY-UHFFFAOYSA-N 3-[5-chloro-4-(6-chloropyridin-3-yl)-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-piperidin-4-ylurea Chemical compound N=1C(C=2C=NC(Cl)=CC=2)=C(Cl)SC=1NC(=O)N(C1CCNCC1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 VOYBSYONWFLLDY-UHFFFAOYSA-N 0.000 claims description 2
• IKKIITPFLMQBPQ-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-fluorophenyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C(=CC=CC=2)F)=N1 IKKIITPFLMQBPQ-UHFFFAOYSA-N 0.000 claims description 2
• XWGOOSGNHLDFRD-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-piperidin-4-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC2CCNCC2)=N1 XWGOOSGNHLDFRD-UHFFFAOYSA-N 0.000 claims description 2
• DTCQUUCXPLURAX-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-pyrazin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=NC=2)=N1 DTCQUUCXPLURAX-UHFFFAOYSA-N 0.000 claims description 2
• OEKLCVUTIHEXNR-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(2-pyrimidin-2-ylethyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2N=CC=CN=2)=N1 OEKLCVUTIHEXNR-UHFFFAOYSA-N 0.000 claims description 2
• SRFHFBZWBFEFPO-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(3-fluorophenyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C=C(F)C=CC=2)=N1 SRFHFBZWBFEFPO-UHFFFAOYSA-N 0.000 claims description 2
• QVALIFYIOOJTDC-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(4-fluorophenyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C=CC(F)=CC=2)=N1 QVALIFYIOOJTDC-UHFFFAOYSA-N 0.000 claims description 2
• MQPZMBOPZKPPQU-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(4-hydroxycyclohexyl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCC(O)CC2)=N1 MQPZMBOPZKPPQU-UHFFFAOYSA-N 0.000 claims description 2
• FKGGGBNUSFSCNO-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-(thian-4-yl)urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C2CCSCC2)=N1 FKGGGBNUSFSCNO-UHFFFAOYSA-N 0.000 claims description 2
• FKJOGWVEBMXGNE-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[2-(2-fluorophenyl)ethyl]urea Chemical compound C1=CC(NS(=O)(=O)C)=CC=C1C1=C(Cl)SC(NC(=O)N(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCC=2C(=CC=CC=2)F)=N1 FKJOGWVEBMXGNE-UHFFFAOYSA-N 0.000 claims description 2
• YLAICAYFOQYUFU-UHFFFAOYSA-N 3-[5-chloro-4-[4-(methanesulfonamido)phenyl]-1,3-thiazol-2-yl]-1-(3,3-diphenylpropyl)-1-[2-(2-methoxyphenyl)ethyl]urea Chemical compound COC1=CC=CC=C1CCN(C(=O)NC=1SC(Cl)=C(N=1)C=1C=CC(NS(C)(=O)=O)=CC=1)CCC(C=1C=CC=CC=1)C1=CC=CC=C1 YLAICAYFOQYUFU-UHFFFAOYSA-N 0.000 claims description 2
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