AU2008275595B2 - Derivatives of urea and related diamines, methods for their manufacture, and uses therefor - Google Patents

Derivatives of urea and related diamines, methods for their manufacture, and uses therefor Download PDF

Info

Publication number
AU2008275595B2
AU2008275595B2 AU2008275595A AU2008275595A AU2008275595B2 AU 2008275595 B2 AU2008275595 B2 AU 2008275595B2 AU 2008275595 A AU2008275595 A AU 2008275595A AU 2008275595 A AU2008275595 A AU 2008275595A AU 2008275595 B2 AU2008275595 B2 AU 2008275595B2
Authority
AU
Australia
Prior art keywords
phenyl
diphenylpropyl
thiazol
chloro
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008275595A
Other languages
English (en)
Other versions
AU2008275595A1 (en
Inventor
Pierre Deprez
Christopher Fotsch
Paul Harrington
Sarah Lively
Kanaka Pattabiraman
David St. Jean
Taoues Temal-Laib
Paul Wehn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AU2008275595A1 publication Critical patent/AU2008275595A1/en
Application granted granted Critical
Publication of AU2008275595B2 publication Critical patent/AU2008275595B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2008275595A 2007-07-10 2008-07-10 Derivatives of urea and related diamines, methods for their manufacture, and uses therefor Ceased AU2008275595B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95905807P 2007-07-10 2007-07-10
US60/959,058 2007-07-10
PCT/US2008/008508 WO2009009122A2 (en) 2007-07-10 2008-07-10 Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

Publications (2)

Publication Number Publication Date
AU2008275595A1 AU2008275595A1 (en) 2009-01-15
AU2008275595B2 true AU2008275595B2 (en) 2013-11-14

Family

ID=39884677

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008275595A Ceased AU2008275595B2 (en) 2007-07-10 2008-07-10 Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

Country Status (6)

Country Link
US (1) US8324396B2 (enExample)
EP (1) EP2176247A2 (enExample)
JP (1) JP5504484B2 (enExample)
AU (1) AU2008275595B2 (enExample)
CA (1) CA2692598A1 (enExample)
WO (1) WO2009009122A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2885129B1 (fr) * 2005-04-29 2007-06-15 Proskelia Sas Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
US7875609B2 (en) 2005-11-25 2011-01-25 Galapagos Sasu Urea derivatives, processes for their preparation, their use as medicaments, and pharmaceutical compositions containing them
ES2499015T3 (es) * 2007-05-08 2014-09-26 Ajinomoto Co., Inc. Agente profiláctico o terapéutico para la diarrea
US9725427B2 (en) 2012-03-16 2017-08-08 Biohaven Pharmaceutical Holding Company Limited Prodrugs of riluzole and their method of use
CN102701992B (zh) * 2012-07-03 2014-01-15 重庆医科大学 一种抗肿瘤化合物及其药学上可接受的盐、及制备方法和应用
CN103992236B (zh) * 2014-04-29 2016-05-18 于非 一种新型靶向性抗肿瘤药物及其制备方法与应用
CN115989219B (zh) 2020-06-29 2026-02-13 贝凯恩生物医疗技术有限公司 用于治疗炎症小体介导的肺部疾病的丙磺舒化合物
CN119569720B (zh) * 2024-12-03 2026-07-17 深圳智微通科技有限公司 4-(4-氯噻吩-2-基)-5-(4-环己基哌嗪-1-基)噻唑-2-胺的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3247581A1 (de) * 1982-01-26 1983-08-04 American Cyanamid Co., Wayne, N.J. Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen
US4994465A (en) * 1989-02-17 1991-02-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds
FR2820136A1 (fr) * 2001-01-26 2002-08-02 Aventis Pharma Sa Nouveaux derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58109464A (ja) 1981-12-23 1983-06-29 Nippon Paint Co Ltd アミノ酸化合物、その製法ならびに触媒
US5153226A (en) 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) * 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
JPH0841006A (ja) 1994-08-05 1996-02-13 Nisshin Flour Milling Co Ltd ジウレア誘導体
EP1275635A1 (en) * 1994-10-21 2003-01-15 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
JPH10195037A (ja) 1996-02-15 1998-07-28 Tanabe Seiyaku Co Ltd フェノール誘導体
JPH11139969A (ja) 1997-08-07 1999-05-25 Tanabe Seiyaku Co Ltd 医薬組成物
US6365617B1 (en) 1999-06-29 2002-04-02 Ortho-Mcneil Pharmaceutical, Inc. Indole and indazole urea-peptoids as thrombin receptor antagonists
FR2885129B1 (fr) * 2005-04-29 2007-06-15 Proskelia Sas Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
US7875609B2 (en) * 2005-11-25 2011-01-25 Galapagos Sasu Urea derivatives, processes for their preparation, their use as medicaments, and pharmaceutical compositions containing them
GB0613674D0 (en) 2006-07-10 2006-08-16 Proskelia Sas Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3247581A1 (de) * 1982-01-26 1983-08-04 American Cyanamid Co., Wayne, N.J. Antiatherosklerotisch wirkende, substituierte harnstoff- und thioharnstoffverbindungen
US4994465A (en) * 1989-02-17 1991-02-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds
FR2820136A1 (fr) * 2001-01-26 2002-08-02 Aventis Pharma Sa Nouveaux derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEVRIES, V. et al, "Potential Antiatherosclerotic Agents. 6. Hypocholesterolemic Trisubstituted Urea Analogues." Journal of Medicinal Chemistry, 1989, 32(10), 2318-2325. *
EIDEN, F. et al, "Beitrag zur Analyse von Calciumantagonisten I. Fendilin und Prenylamin." Deutsche Apotheker Zeitung, 1983, 123(20), 958-962. *
ESTEVES-SOUZA, A. et al, "Synthesis, Cytotoxicity, and DNA-topoisomerase Inhibitory Activity of New Asymmetric Ureas and Thioureas." Bioorganic and Medicinal Chemistry, 2006, 14(2), 492-499. *
PURCHASE, T. et al, "Inhibitors of Acyl-CoA:Cholesterol Acyltransferase: Novel Trisubstituted Ureas as Hypocholesterolemic Agents." Bioorganic and Medicinal Chemistry, 1997, 5(4), 739-747. *

Also Published As

Publication number Publication date
AU2008275595A1 (en) 2009-01-15
US20090054463A1 (en) 2009-02-26
JP2010533185A (ja) 2010-10-21
WO2009009122A3 (en) 2009-06-25
JP5504484B2 (ja) 2014-05-28
WO2009009122A2 (en) 2009-01-15
US8324396B2 (en) 2012-12-04
EP2176247A2 (en) 2010-04-21
CA2692598A1 (en) 2009-01-15

Similar Documents

Publication Publication Date Title
AU2004222792B2 (en) Selective NPY (Y5) antagonists
US8324396B2 (en) Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
US7678815B2 (en) Thiazole-4-carboxyamide derivatives
ES2249059T3 (es) Nuevos compuestos de bifenilo y analogos de bifenilo como antagonista de integrina.
AU2005205201B2 (en) Thiazole derivatives and use thereof
CA2396257A1 (en) Novel compounds and compositions as protease inhibitors
CA2515215A1 (en) Vanilloid receptor ligands and their use in treatments
CA2620179A1 (en) Inhibitors of voltage-gated sodium channels
AU2007271918A1 (en) Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
WO2006011631A2 (en) Thiazole derivatives having vap-1 inhibitory activity
US6686381B2 (en) Thiazole derivatives
AU2003253364B2 (en) Thiazole derivatives
AU2006331656B2 (en) Calcium channel antagonists
PT95317A (pt) Processo para a obtencao de um novo composto tiazol destinado
AU2006243328A1 (en) Urea derivatives methods for their manufacture and uses thereof
AU2006316705A1 (en) Urea derivatives useful as calcium receptor modulators
US6989379B1 (en) Selective NPY (Y5) antagonists
US20090203692A1 (en) Novel chemical compounds
WO1992016526A1 (en) Thiazole derivatives
AU2012204095A1 (en) Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1
JP2007015999A (ja) イミノチアゾール化合物の製造方法
MXPA06007934A (en) Thiazole derivatives and use thereof

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired