AU2008214095B2 - Compositions and methods for the treatment of metabolic disorders - Google Patents
Compositions and methods for the treatment of metabolic disorders Download PDFInfo
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- AU2008214095B2 AU2008214095B2 AU2008214095A AU2008214095A AU2008214095B2 AU 2008214095 B2 AU2008214095 B2 AU 2008214095B2 AU 2008214095 A AU2008214095 A AU 2008214095A AU 2008214095 A AU2008214095 A AU 2008214095A AU 2008214095 B2 AU2008214095 B2 AU 2008214095B2
- Authority
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- Australia
- Prior art keywords
- thiazol
- propylpyridin
- fatostatin
- propylpyridine
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 208000030159 metabolic disease Diseases 0.000 title claims abstract description 44
- 239000000203 mixture Substances 0.000 title claims description 78
- 238000000034 method Methods 0.000 title claims description 55
- 238000011282 treatment Methods 0.000 title abstract description 40
- 150000001875 compounds Chemical class 0.000 claims abstract description 68
- 208000008589 Obesity Diseases 0.000 claims abstract description 26
- 235000020824 obesity Nutrition 0.000 claims abstract description 26
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 19
- 108010020396 Sterol Regulatory Element Binding Proteins Proteins 0.000 claims description 125
- 102000009822 Sterol Regulatory Element Binding Proteins Human genes 0.000 claims description 123
- 108010074436 Sterol Regulatory Element Binding Protein 1 Proteins 0.000 claims description 74
- 102100026839 Sterol regulatory element-binding protein 1 Human genes 0.000 claims description 73
- -1 p-toluenesulfonyl Chemical group 0.000 claims description 60
- 125000003118 aryl group Chemical group 0.000 claims description 29
- 108010074438 Sterol Regulatory Element Binding Protein 2 Proteins 0.000 claims description 23
- 102100026841 Sterol regulatory element-binding protein 2 Human genes 0.000 claims description 23
- 208000010706 fatty liver disease Diseases 0.000 claims description 23
- 208000004930 Fatty Liver Diseases 0.000 claims description 22
- 206010019708 Hepatic steatosis Diseases 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 22
- 231100000240 steatosis hepatitis Toxicity 0.000 claims description 22
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 20
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- VYYMYRPKZDHXOO-UHFFFAOYSA-N 4-(2,4-difluorophenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole Chemical compound C1=NC(CCC)=CC(C=2SC=C(N=2)C=2C(=CC(F)=CC=2)F)=C1 VYYMYRPKZDHXOO-UHFFFAOYSA-N 0.000 claims description 9
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Classifications
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
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| US61/012,310 | 2007-12-07 | ||
| PCT/US2008/052778 WO2008097835A2 (en) | 2007-02-02 | 2008-02-01 | Compositions and methods for the treatment of metabolic disorders |
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| US9212179B2 (en) * | 2007-02-02 | 2015-12-15 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| CA2677264C (en) * | 2007-02-02 | 2021-11-30 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| US9233941B2 (en) * | 2007-02-02 | 2016-01-12 | Baylor College Of Medicine | Methods and compositions for the treatment of body weight related disorders |
| US9029411B2 (en) | 2008-01-25 | 2015-05-12 | Millennium Pharmaceuticals, Inc. | Thiophenes and uses thereof |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| US9139589B2 (en) | 2009-01-30 | 2015-09-22 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| EP3159331A1 (en) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| MA34797B1 (fr) | 2010-08-11 | 2014-01-02 | Millennium Pharm Inc | Hétéroaryles et leurs utilisations |
| JP2013533318A (ja) | 2010-08-11 | 2013-08-22 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | ヘテロアリールおよびその使用 |
| US9062038B2 (en) | 2010-08-11 | 2015-06-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| AU2011303597A1 (en) * | 2010-09-17 | 2013-04-11 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| WO2012048303A2 (en) * | 2010-10-07 | 2012-04-12 | Columbia University | METHOD FOR TREATING CANCER HARBORING A p53 MUTATION |
| PH12013500723A1 (en) | 2010-10-13 | 2017-08-23 | Millennium Pharm Inc | Heteroaryls and uses thereof |
| KR101762724B1 (ko) * | 2011-01-25 | 2017-07-28 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | Bcl-2/bcl-xl 억제제 및 이를 이용한 치료 방법 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013110007A1 (en) * | 2012-01-18 | 2013-07-25 | The Trustees Of Columbia University In The City Of New York | USE OF FATOSTATIN FOR TREATING CANCER HAVING A p53 MUTATION |
| JP6228198B2 (ja) | 2012-06-25 | 2017-11-08 | トーマス・ジェファーソン・ユニバーシティＴｈｏｍａｓ Ｊｅｆｆｅｒｓｏｎ Ｕｎｉｖｅｒｓｉｔｙ | 異常な脂質生合成シグナル伝達を有するがんを処置するための組成物および方法 |
| US20140275178A1 (en) * | 2013-03-13 | 2014-09-18 | Musc Foundation For Research Development | Thiazole compounds, compositions and methods for treatment of degenerative diseases and disorders |
| DK3038622T3 (en) * | 2013-08-28 | 2018-07-16 | Medivation Tech Llc | HETEROCYCLIC RELATIONS AND PROCEDURES FOR USE |
| CN107074839A (zh) * | 2013-08-29 | 2017-08-18 | 贝勒医学院 | 用于治疗代谢和体重相关的病症的组合物和方法 |
| KR20160115999A (ko) * | 2014-02-14 | 2016-10-06 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 치료제로서의 인간 안드로겐 수용체 dna-결합 도메인(dbd) 화합물 및 그의 사용 방법 |
| US9873689B2 (en) | 2014-11-07 | 2018-01-23 | Fgh Biotech, Inc. | Synthesis of fatostatin based polycyclic compounds |
| WO2016105491A1 (en) * | 2014-12-23 | 2016-06-30 | Fgh Biotech | Compositions of fatostatin based heterocyclic compounds and uses thereof |
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| US8778976B2 (en) | 2014-07-15 |
| US8927578B2 (en) | 2015-01-06 |
| CA2677264A1 (en) | 2008-08-14 |
| JP2014088431A (ja) | 2014-05-15 |
| US8207196B2 (en) | 2012-06-26 |
| WO2008097835A3 (en) | 2008-10-30 |
| CN101674730B (zh) | 2014-09-10 |
| US20090131475A1 (en) | 2009-05-21 |
| JP2010519181A (ja) | 2010-06-03 |
| US20130005768A1 (en) | 2013-01-03 |
| EP2120580B1 (en) | 2017-12-27 |
| US20130012538A1 (en) | 2013-01-10 |
| JP5878937B2 (ja) | 2016-03-08 |
| EP2120580A4 (en) | 2011-09-28 |
| CN101674730A (zh) | 2010-03-17 |
| EP2120580A2 (en) | 2009-11-25 |
| JP5461197B2 (ja) | 2014-04-02 |
| CA2677264C (en) | 2021-11-30 |
| AU2008214095A1 (en) | 2008-08-14 |
| WO2008097835A2 (en) | 2008-08-14 |
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