EP4096659A4 - Srebp inhibitors comprising a thiophene central ring - Google Patents

Srebp inhibitors comprising a thiophene central ring Download PDF

Info

Publication number
EP4096659A4
EP4096659A4 EP21748420.3A EP21748420A EP4096659A4 EP 4096659 A4 EP4096659 A4 EP 4096659A4 EP 21748420 A EP21748420 A EP 21748420A EP 4096659 A4 EP4096659 A4 EP 4096659A4
Authority
EP
European Patent Office
Prior art keywords
thiophene
central ring
srebp
inhibitors
srebp inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP21748420.3A
Other languages
German (de)
French (fr)
Other versions
EP4096659A1 (en
Inventor
Michael John Green
Barry Patrick Hart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Capulus Therapeutics LLC
Original Assignee
Capulus Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Capulus Therapeutics LLC filed Critical Capulus Therapeutics LLC
Publication of EP4096659A1 publication Critical patent/EP4096659A1/en
Publication of EP4096659A4 publication Critical patent/EP4096659A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP21748420.3A 2020-01-27 2021-01-26 Srebp inhibitors comprising a thiophene central ring Withdrawn EP4096659A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062966358P 2020-01-27 2020-01-27
US202063056410P 2020-07-24 2020-07-24
PCT/US2021/015101 WO2021154735A1 (en) 2020-01-27 2021-01-26 Srebp inhibitors comprising a thiophene central ring

Publications (2)

Publication Number Publication Date
EP4096659A1 EP4096659A1 (en) 2022-12-07
EP4096659A4 true EP4096659A4 (en) 2023-10-18

Family

ID=77079187

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21748420.3A Withdrawn EP4096659A4 (en) 2020-01-27 2021-01-26 Srebp inhibitors comprising a thiophene central ring

Country Status (2)

Country Link
EP (1) EP4096659A4 (en)
WO (1) WO2021154735A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024089216A1 (en) 2022-10-27 2024-05-02 Syngenta Crop Protection Ag Novel sulfur-containing heteroaryl carboxamide compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015031710A1 (en) * 2013-08-29 2015-03-05 Baylor College Of Medicine Compositions and methods for the treatment of metabolic and body weight related disorders
WO2017190086A1 (en) * 2016-04-29 2017-11-02 Fgh Biotech, Inc. Di-substituted pyrazole compounds for the treatment of diseases
WO2018049080A1 (en) * 2016-09-07 2018-03-15 Fgh Biotech, Inc. Di-substituted pyrazole compounds for the treatment of diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101674730B (en) * 2007-02-02 2014-09-10 贝勒医学院 Compositions and methods for the treatment of metabolic disorders
WO2015031650A1 (en) * 2013-08-28 2015-03-05 Sarvajit Chakravarty Heterocyclic compounds and methods of use
EP3265457A1 (en) * 2015-03-04 2018-01-10 Medivation Technologies LLC Sterol regulatory element-binding proteins (srebps) inhibitors
CA2978627A1 (en) * 2015-03-04 2016-09-09 Medivation Technologies, Inc. Srebp blockers for use in treating liver fibrosis, elevated cholesterol and insulin resistance

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015031710A1 (en) * 2013-08-29 2015-03-05 Baylor College Of Medicine Compositions and methods for the treatment of metabolic and body weight related disorders
WO2017190086A1 (en) * 2016-04-29 2017-11-02 Fgh Biotech, Inc. Di-substituted pyrazole compounds for the treatment of diseases
WO2018049080A1 (en) * 2016-09-07 2018-03-15 Fgh Biotech, Inc. Di-substituted pyrazole compounds for the treatment of diseases

Also Published As

Publication number Publication date
WO2021154735A1 (en) 2021-08-05
EP4096659A1 (en) 2022-12-07

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