EP4096659A4 - Inhibiteurs de srebp comprenant un noyau central de thiophène - Google Patents
Inhibiteurs de srebp comprenant un noyau central de thiophène Download PDFInfo
- Publication number
- EP4096659A4 EP4096659A4 EP21748420.3A EP21748420A EP4096659A4 EP 4096659 A4 EP4096659 A4 EP 4096659A4 EP 21748420 A EP21748420 A EP 21748420A EP 4096659 A4 EP4096659 A4 EP 4096659A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- thiophene
- central ring
- srebp
- inhibitors
- srebp inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- 229930192474 thiophene Natural products 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062966358P | 2020-01-27 | 2020-01-27 | |
US202063056410P | 2020-07-24 | 2020-07-24 | |
PCT/US2021/015101 WO2021154735A1 (fr) | 2020-01-27 | 2021-01-26 | Inhibiteurs de srebp comprenant un noyau central de thiophène |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4096659A1 EP4096659A1 (fr) | 2022-12-07 |
EP4096659A4 true EP4096659A4 (fr) | 2023-10-18 |
Family
ID=77079187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21748420.3A Pending EP4096659A4 (fr) | 2020-01-27 | 2021-01-26 | Inhibiteurs de srebp comprenant un noyau central de thiophène |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP4096659A4 (fr) |
WO (1) | WO2021154735A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024089216A1 (fr) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Nouveaux composés hétéroaryl-carboxamides contenant du soufre |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015031710A1 (fr) * | 2013-08-29 | 2015-03-05 | Baylor College Of Medicine | Compositions et procédés de traitement de troubles métaboliques et troubles associés au poids corporel |
WO2017190086A1 (fr) * | 2016-04-29 | 2017-11-02 | Fgh Biotech, Inc. | Composés de pyrazole di-substitués pour le traitement de maladies |
WO2018049080A1 (fr) * | 2016-09-07 | 2018-03-15 | Fgh Biotech, Inc. | Composés de pyrazole di-substitués pour le traitement de maladies |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5461197B2 (ja) * | 2007-02-02 | 2014-04-02 | ベイラー カレッジ オブ メディスン | 代謝障害を処置するための組成物および方法 |
JP2017506618A (ja) * | 2013-08-28 | 2017-03-09 | メディベイション テクノロジーズ, インコーポレイテッド | 複素環式化合物および使用方法 |
JP2018507235A (ja) * | 2015-03-04 | 2018-03-15 | メディベイション テクノロジーズ エルエルシー | ステロール調節エレメント結合タンパク質(srebp)阻害剤 |
JP2018507234A (ja) * | 2015-03-04 | 2018-03-15 | メディベイション テクノロジーズ エルエルシー | 肝臓線維症、コレステロールの上昇およびインスリン抵抗性を処置する際における使用のためのsrebp遮断薬 |
-
2021
- 2021-01-26 WO PCT/US2021/015101 patent/WO2021154735A1/fr unknown
- 2021-01-26 EP EP21748420.3A patent/EP4096659A4/fr active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015031710A1 (fr) * | 2013-08-29 | 2015-03-05 | Baylor College Of Medicine | Compositions et procédés de traitement de troubles métaboliques et troubles associés au poids corporel |
WO2017190086A1 (fr) * | 2016-04-29 | 2017-11-02 | Fgh Biotech, Inc. | Composés de pyrazole di-substitués pour le traitement de maladies |
WO2018049080A1 (fr) * | 2016-09-07 | 2018-03-15 | Fgh Biotech, Inc. | Composés de pyrazole di-substitués pour le traitement de maladies |
Also Published As
Publication number | Publication date |
---|---|
EP4096659A1 (fr) | 2022-12-07 |
WO2021154735A1 (fr) | 2021-08-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20220802 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: A61K0031442700 Ipc: C07D0409040000 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20230914 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/4436 20060101ALI20230908BHEP Ipc: A61K 31/436 20060101ALI20230908BHEP Ipc: A61P 3/06 20060101ALI20230908BHEP Ipc: A61P 1/16 20060101ALI20230908BHEP Ipc: C07D 491/056 20060101ALI20230908BHEP Ipc: C07D 409/04 20060101AFI20230908BHEP |