JP2010516259A5 - - Google Patents
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- JP2010516259A5 JP2010516259A5 JP2009546581A JP2009546581A JP2010516259A5 JP 2010516259 A5 JP2010516259 A5 JP 2010516259A5 JP 2009546581 A JP2009546581 A JP 2009546581A JP 2009546581 A JP2009546581 A JP 2009546581A JP 2010516259 A5 JP2010516259 A5 JP 2010516259A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer stem
- stem cells
- human cancer
- human
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 70
- 201000011510 cancer Diseases 0.000 claims description 66
- 210000000130 stem cell Anatomy 0.000 claims description 53
- 238000000034 method Methods 0.000 claims description 17
- 230000018109 developmental process Effects 0.000 claims description 6
- 235000015097 nutrients Nutrition 0.000 claims description 6
- 229940030156 cell vaccine Drugs 0.000 claims description 5
- 238000004166 bioassay Methods 0.000 claims description 4
- 239000002458 cell surface marker Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 230000002163 immunogen Effects 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000010255 intramuscular injection Methods 0.000 claims description 2
- 239000007927 intramuscular injection Substances 0.000 claims description 2
- 230000002601 intratumoral effect Effects 0.000 claims description 2
- 238000010253 intravenous injection Methods 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 230000000144 pharmacologic effect Effects 0.000 claims description 2
- 230000009758 senescence Effects 0.000 claims description 2
- 238000010254 subcutaneous injection Methods 0.000 claims description 2
- 239000007929 subcutaneous injection Substances 0.000 claims description 2
- 238000011282 treatment Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88149707P | 2007-01-22 | 2007-01-22 | |
| US90718007P | 2007-03-23 | 2007-03-23 | |
| US92424707P | 2007-05-04 | 2007-05-04 | |
| US95071407P | 2007-07-19 | 2007-07-19 | |
| US97261307P | 2007-09-14 | 2007-09-14 | |
| PCT/US2008/051730 WO2008091908A2 (en) | 2007-01-22 | 2008-01-22 | Human cancer stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516259A JP2010516259A (ja) | 2010-05-20 |
| JP2010516259A5 true JP2010516259A5 (https=) | 2010-12-24 |
Family
ID=39641454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546581A Pending JP2010516259A (ja) | 2007-01-22 | 2008-01-22 | ヒトがん幹細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8309354B2 (https=) |
| EP (1) | EP2109668A4 (https=) |
| JP (1) | JP2010516259A (https=) |
| KR (1) | KR101523698B1 (https=) |
| CN (1) | CN101855339A (https=) |
| AU (1) | AU2008207945A1 (https=) |
| CA (1) | CA2675521C (https=) |
| IL (1) | IL199836A (https=) |
| WO (1) | WO2008091908A2 (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101523698B1 (ko) | 2007-01-22 | 2015-05-29 | 마크로제닉스 웨스트 인코퍼레이티드 | 사람 암 줄기세포 |
| CN102203290B (zh) | 2008-10-27 | 2015-05-06 | 北海道公立大学法人札幌医科大学 | 肿瘤干细胞分子标记 |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011078301A1 (ja) | 2009-12-25 | 2011-06-30 | ファーマロジカルズ・リサーチ プライベート リミテッド | Nog樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法 |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| JP5998060B2 (ja) | 2010-03-04 | 2016-09-28 | マクロジェニクス，インコーポレーテッド | Ｂ７−ｈ３と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用 |
| WO2011129348A1 (ja) * | 2010-04-13 | 2011-10-20 | 株式会社Ｒｅｉメディカル | 癌組織由来細胞塊または癌細胞凝集塊から得られる癌治療用組成物およびそれを用いた免疫療法剤の製造方法ならびに免疫療法効果評価方法 |
| EP2596119B8 (en) | 2010-07-23 | 2021-06-02 | Astellas Institute for Regenerative Medicine | Methods for detection of rare subpopulations of cells and highly purified compositions of cells |
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| CA2810016A1 (en) * | 2010-09-03 | 2012-03-08 | Stem Centrx, Inc. | Novel modulators and methods of use |
| US9778264B2 (en) | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
| JP6230789B2 (ja) * | 2010-10-06 | 2017-11-15 | 中外製薬株式会社 | 癌幹細胞集団及びその作製方法 |
| WO2012118547A1 (en) | 2010-12-08 | 2012-09-07 | Stem Centrx, Inc. | Novel modulators and methods of use |
| KR101182549B1 (ko) * | 2010-12-16 | 2012-09-12 | 엘지이노텍 주식회사 | 3차원 입체 카메라 모듈 |
| SA112330278B1 (ar) | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
| ES2586599T3 (es) * | 2011-03-24 | 2016-10-17 | The Rogosin Institute | Ensayo para cribar compuestos que disminuyen selectivamente el número de células madre de cáncer |
| DK2714733T3 (da) | 2011-05-21 | 2019-05-06 | Macrogenics Inc | Cd3-bindende molekyler, der er i stand til at binde til human og ikke-human cd3 |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| JP6077997B2 (ja) * | 2011-09-07 | 2017-02-08 | 中外製薬株式会社 | 癌幹細胞の分離 |
| US20140302511A1 (en) | 2011-10-28 | 2014-10-09 | Pharmalogicals Research Pte. Ltd. | Cancer stem cell-specific molecule |
| US10247731B2 (en) | 2012-02-22 | 2019-04-02 | Verik Bio, Inc. | System for immunotherapy targeting tumor propagation and progression |
| CA2865415C (en) | 2012-02-24 | 2022-06-21 | Stem Centrx, Inc. | Anti sez6 antibodies and methods of use |
| PE20190658A1 (es) | 2012-02-24 | 2019-05-08 | Abbvie Stemcentrx Llc | Moduladores y metodos de empleo novedosos |
| JP6090735B2 (ja) * | 2012-03-02 | 2017-03-08 | 国立大学法人山口大学 | 消化器系がん幹細胞を培養するための無血清培地、及びそれを用いた消化器系がん幹細胞の増殖方法 |
| CA3223380A1 (en) * | 2012-03-19 | 2013-09-26 | Stemline Therapeutics, Inc. | Methods for treating and monitoring the status of cancer |
| DK3536334T3 (da) | 2012-05-16 | 2021-09-13 | Stemline Therapeutics Inc | Cancer stamcelle målrettede cancer vacciner |
| WO2014165101A1 (en) * | 2013-03-13 | 2014-10-09 | California Stem Cell, Inc. | Individualized high purity colon carcinoma stem cells, methods and use of the same |
| BR112015019909A2 (pt) | 2013-02-22 | 2017-08-29 | Abbvie Stemcentrx Llc | Conjugados anticorpo-fármaco, composição farmacêutica, usos dos mesmos, e kit |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| TWI659210B (zh) * | 2013-08-12 | 2019-05-11 | Minerva Biotechnologies Corporation | 加強腫瘤生長的方法 |
| AU2014312215B2 (en) | 2013-08-28 | 2020-02-27 | Abbvie Stemcentrx Llc | Site-specific antibody conjugation methods and compositions |
| AU2014312310A1 (en) | 2013-08-28 | 2016-04-07 | Abbvie Stemcentrx Llc | Novel SEZ6 modulators and methods of use |
| US9782476B2 (en) | 2013-09-06 | 2017-10-10 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
| PE20160870A1 (es) | 2013-11-06 | 2016-09-09 | Abbvie Stemcentrx Llc | Anticuerpos anti-claudina novedosos y metodos de uso |
| PE20160993A1 (es) | 2013-12-12 | 2016-10-14 | Abbvie Stemcentrx Llc | Nuevos anticuerpos anti-dpep3 y metodos de uso |
| PE20161209A1 (es) | 2014-02-21 | 2016-11-10 | Abbvie Stemcentrx Llc | Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti-dll3) y medicamentos para usarse en el tratamiento contra melanoma |
| KR20170003720A (ko) | 2014-05-27 | 2017-01-09 | 아카데미아 시니카 | 항-ｃｄ20 글리코항체 및 이의 용도 |
| CA2950423A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| KR102512592B1 (ko) | 2014-05-27 | 2023-03-21 | 아카데미아 시니카 | 항-ｈｅｒ2 글리코항체 및 이의 용도 |
| CN106714829A (zh) | 2014-05-28 | 2017-05-24 | 中央研究院 | 抗TNF‑α醣抗体及其用途 |
| CN106537148B (zh) * | 2014-06-25 | 2019-10-11 | 泰尔哈绍梅尔医学研究基础设施和服务有限公司 | 癌症干细胞的鉴定及其用于诊断和治疗的用途 |
| US20170191034A1 (en) * | 2014-09-04 | 2017-07-06 | Agency For Science Technology And Research | A method to up-regulate cancer stem cell markers for the generation of antigen specific cytotoxic effector t cells |
| TW201617368A (zh) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗ｍｆｉ２抗體及使用方法 |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| JP2018510844A (ja) * | 2015-01-24 | 2018-04-19 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | がんマーカーおよびその使用方法 |
| SG11201706024YA (en) | 2015-01-26 | 2017-08-30 | Macrogenics Inc | Multivalent molecules comprising dr5-binding domains |
| KR20160109356A (ko) | 2015-03-11 | 2016-09-21 | 이화여자대학교 산학협력단 | 자가 면역 질환 예방 또는 치료용 조성물 |
| KR20160109358A (ko) | 2015-03-11 | 2016-09-21 | 이화여자대학교 산학협력단 | 면역 질환 예방 또는 치료용 조성물 |
| KR102036029B1 (ko) | 2015-03-11 | 2019-10-24 | 이화여자대학교 산학협력단 | 골수 부전 예방 또는 치료용 조성물 |
| JP6161828B2 (ja) * | 2015-04-20 | 2017-07-12 | 国立大学法人 岡山大学 | がんの非ヒトモデル動物及びその作製方法、がん幹細胞及びその製造方法 |
| EP3208331A1 (en) * | 2016-02-17 | 2017-08-23 | PromoCell bioscience alive GmbH Biomedizinische Produkte | Chemically defined medium for the culture of cancer stem cell (csc) containing cell populations |
| TWI781098B (zh) | 2016-04-15 | 2022-10-21 | 美商宏觀基因股份有限公司 | 新穎的ｂ７-ｈ３-結合分子、其抗體藥物綴合物及其使用方法 |
| EP3454864A4 (en) | 2016-04-21 | 2021-01-13 | Abbvie Stemcentrx LLC | Novel anti-bmpr1b antibodies and methods of use |
| EP3500594A4 (en) | 2016-08-22 | 2020-03-11 | Cho Pharma Inc. | ANTIBODIES, BINDING FRAGMENTS AND METHOD FOR USE |
| GB201700952D0 (en) * | 2017-01-19 | 2017-03-08 | Univ Cape Town | In vitro propagation of primary cancer cells |
| CN107904206A (zh) * | 2017-11-17 | 2018-04-13 | 张家港澳洋医院有限公司 | 一种脂多糖诱导肿瘤细胞生成肿瘤干细胞的用途和方法 |
| AU2019284405B2 (en) * | 2018-06-13 | 2025-08-21 | Genex Health Co.,Ltd | Colorectal cancer solid tumour primary cell and colorectal cancer ascitic fluid primary tumour cell culturing method, and matching reagent |
| KR102089476B1 (ko) | 2018-07-11 | 2020-03-16 | 이화여자대학교 산학협력단 | 피부 염증 질환 예방 또는 치료용 조성물 |
| KR102130493B1 (ko) | 2018-07-11 | 2020-07-06 | 이화여자대학교 산학협력단 | 건선 예방 또는 치료용 조성물 |
| CN109652377B (zh) * | 2019-01-15 | 2023-03-28 | 广州医科大学 | 一种肺癌干细胞的制备方法及应用 |
| WO2021046186A1 (en) * | 2019-09-04 | 2021-03-11 | Vcell Therapeutics, Inc. | Vaccine for treatment of cancer and method of making by stress reprogramming |
| KR20190120141A (ko) | 2019-10-16 | 2019-10-23 | 이화여자대학교 산학협력단 | 골수 부전 예방 또는 치료용 조성물 |
| CN113069547B (zh) * | 2021-04-16 | 2023-01-24 | 同济大学附属第一妇婴保健院 | Bap1作为肿瘤治疗靶点在制备预防或治疗肿瘤药物中的应用 |
| CN113444690A (zh) * | 2021-07-29 | 2021-09-28 | 大连大学 | 一种基于三维培养体系的肿瘤细胞耐照射模型的建立方法 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US20050136066A1 (en) | 1996-06-12 | 2005-06-23 | Yajun Guo | Cellular vaccines and immunotherapeutics and methods for their preparation |
| US7348015B2 (en) | 1998-01-14 | 2008-03-25 | Morphogenesis, Inc. | Antigen modified cancer cell vaccines for cancer therapy |
| US6416999B1 (en) | 2000-04-07 | 2002-07-09 | Raven Biotechnologies, Inc. | Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof |
| US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| WO2003032814A2 (en) | 2001-10-16 | 2003-04-24 | Raven Biotechnologies, Inc. | Antibodies that bind to cancer-associated antigen cd46 and methods of use thereof |
| JP2005522483A (ja) | 2002-04-11 | 2005-07-28 | アルタレックス メディカル コーポレーション | 結合剤及び腫瘍細胞をターゲティングする際のそれらの使用 |
| MXPA04012664A (es) | 2002-06-19 | 2005-08-15 | Raven Biotechnologies Inc | Objetivo de superficie celular raag10 novedoso y una familia de anticuerpos que reconocen ese objetivo. |
| MXPA06003028A (es) | 2003-09-18 | 2006-06-23 | Raven Biotechnologies Inc | Medios de cultivo de celulas. |
| GB0406215D0 (en) | 2004-03-19 | 2004-04-21 | Procure Therapeutics Ltd | Prostate stem cell |
| KR101295139B1 (ko) | 2004-06-07 | 2013-08-12 | 레이븐 바이오테크놀로지스, 인코퍼레이티드 | 트랜스페린 리셉터 항체 |
| ITRM20040438A1 (it) | 2004-09-15 | 2004-12-15 | Univ Palermo | Metodo per la purificazione e l'amplificazione di cellule staminali tumorali. |
| CA3218940A1 (en) | 2004-11-12 | 2006-05-18 | Cambridge University Technical Services Ltd. | Methods and means related to cancer stem cells |
| US7687242B2 (en) | 2005-01-12 | 2010-03-30 | Raven Biotechnologies, Inc. | KID31 and antibodies that bind thereto |
| WO2006084078A2 (en) | 2005-02-02 | 2006-08-10 | Raven Biotechnologies, Inc. | Jam-3 and antibodies that bind thereto |
| AU2006210589B2 (en) | 2005-02-02 | 2011-12-08 | Macrogenics West, Inc. | ADAM-9 modulators |
| EP1846455A4 (en) | 2005-02-03 | 2010-02-17 | Raven Biotechnologies Inc | ANTIBODY TO THE ONKOSTATIN M RECEPTOR |
| BRPI0607450A2 (pt) | 2005-02-04 | 2009-09-01 | Raven Biotechnologies Inc | anticorpos que se ligam a epha2 e métodos para sua utilização |
| US20090012024A1 (en) | 2005-07-26 | 2009-01-08 | Procure Therapeutics Limited | Stem Cell Markers |
| US20070123448A1 (en) | 2005-11-23 | 2007-05-31 | The Hospital For Sick Children | Novel chemical entities affecting neuroblastoma tumor-initiating cells |
| WO2008039874A2 (en) | 2006-09-26 | 2008-04-03 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
| KR101523698B1 (ko) | 2007-01-22 | 2015-05-29 | 마크로제닉스 웨스트 인코퍼레이티드 | 사람 암 줄기세포 |
-
2008
- 2008-01-22 KR KR1020097017268A patent/KR101523698B1/ko not_active Expired - Fee Related
- 2008-01-22 CN CN200880009078A patent/CN101855339A/zh active Pending
- 2008-01-22 US US12/018,126 patent/US8309354B2/en not_active Expired - Fee Related
- 2008-01-22 JP JP2009546581A patent/JP2010516259A/ja active Pending
- 2008-01-22 CA CA2675521A patent/CA2675521C/en not_active Expired - Fee Related
- 2008-01-22 AU AU2008207945A patent/AU2008207945A1/en not_active Abandoned
- 2008-01-22 EP EP08728101A patent/EP2109668A4/en not_active Withdrawn
- 2008-01-22 WO PCT/US2008/051730 patent/WO2008091908A2/en not_active Ceased
-
2009
- 2009-07-13 IL IL199836A patent/IL199836A/en not_active IP Right Cessation
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