JP2010516259A - ヒトがん幹細胞 - Google Patents

ヒトがん幹細胞 Download PDF

Info

Publication number
JP2010516259A
JP2010516259A JP2009546581A JP2009546581A JP2010516259A JP 2010516259 A JP2010516259 A JP 2010516259A JP 2009546581 A JP2009546581 A JP 2009546581A JP 2009546581 A JP2009546581 A JP 2009546581A JP 2010516259 A JP2010516259 A JP 2010516259A
Authority
JP
Japan
Prior art keywords
cancer stem
stem cells
cells
cell
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009546581A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010516259A5 (https=
Inventor
ジェニー ピー. マサー
ペネロピ ロバーツ
Original Assignee
レイベン バイオテクノロジーズ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by レイベン バイオテクノロジーズ filed Critical レイベン バイオテクノロジーズ
Publication of JP2010516259A publication Critical patent/JP2010516259A/ja
Publication of JP2010516259A5 publication Critical patent/JP2010516259A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0693Tumour cells; Cancer cells
    • C12N5/0695Stem cells; Progenitor cells; Precursor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009546581A 2007-01-22 2008-01-22 ヒトがん幹細胞 Pending JP2010516259A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88149707P 2007-01-22 2007-01-22
US90718007P 2007-03-23 2007-03-23
US92424707P 2007-05-04 2007-05-04
US95071407P 2007-07-19 2007-07-19
US97261307P 2007-09-14 2007-09-14
PCT/US2008/051730 WO2008091908A2 (en) 2007-01-22 2008-01-22 Human cancer stem cells

Publications (2)

Publication Number Publication Date
JP2010516259A true JP2010516259A (ja) 2010-05-20
JP2010516259A5 JP2010516259A5 (https=) 2010-12-24

Family

ID=39641454

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009546581A Pending JP2010516259A (ja) 2007-01-22 2008-01-22 ヒトがん幹細胞

Country Status (9)

Country Link
US (1) US8309354B2 (https=)
EP (1) EP2109668A4 (https=)
JP (1) JP2010516259A (https=)
KR (1) KR101523698B1 (https=)
CN (1) CN101855339A (https=)
AU (1) AU2008207945A1 (https=)
CA (1) CA2675521C (https=)
IL (1) IL199836A (https=)
WO (1) WO2008091908A2 (https=)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012046797A1 (ja) * 2010-10-06 2012-04-12 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞集団及びその作製方法
JP2013208104A (ja) * 2012-03-02 2013-10-10 Yamaguchi Univ 消化器系がん幹細胞を培養するための無血清培地、及びそれを用いた消化器系がん幹細胞の増殖方法
JP2015518561A (ja) * 2012-03-19 2015-07-02 ステムライン セラピューティクス,インコーポレーテッド 癌の状態を治療及びモニタリングする方法
JPWO2016170938A1 (ja) * 2015-04-20 2017-04-27 国立大学法人 岡山大学 がんの非ヒトモデル動物及びその作製方法、がん幹細胞及びその製造方法
JP2017528114A (ja) * 2014-06-25 2017-09-28 テル ハショマー メディカル リサーチ インフラストラクチャー アンド サーヴィシーズ リミテッド がん幹細胞の同定ならびに診断および処置のためのその使用
US10018630B2 (en) 2011-09-07 2018-07-10 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
CN108699529A (zh) * 2016-02-17 2018-10-23 普乐思尔活性生物科学有限公司 用于培养含癌症干细胞(csc)的细胞群的化学成分确定的培养基
JP2019213551A (ja) * 2013-08-12 2019-12-19 ミネルバ バイオテクノロジーズ コーポレーション 腫瘍成長を増強する方法
US10934351B2 (en) 2011-10-28 2021-03-02 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell-specific molecule
JP2022511607A (ja) * 2018-06-13 2022-02-01 北京基石生命科技有限公司 結腸直腸癌固形腫瘍初代細胞及び結腸直腸腺癌腹水初代腫瘍細胞の培養方法およびキット
JP2022546578A (ja) * 2019-09-04 2022-11-04 ブイセル セラピューティックス,インコーポレイテッド 癌を処置するためのワクチンおよびストレスリプログラミングによるその作製方法
US11536713B2 (en) 2009-12-25 2022-12-27 Chugai Seiyaku Kabushiki Kaisha Method for searching and screening for target of anti-cancer agent using non-human animal model having NOG established cancer cell line transplanted therein

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101523698B1 (ko) 2007-01-22 2015-05-29 마크로제닉스 웨스트 인코퍼레이티드 사람 암 줄기세포
CN102203290B (zh) 2008-10-27 2015-05-06 北海道公立大学法人札幌医科大学 肿瘤干细胞分子标记
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
JP5998060B2 (ja) 2010-03-04 2016-09-28 マクロジェニクス,インコーポレーテッド B7−h3と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用
WO2011129348A1 (ja) * 2010-04-13 2011-10-20 株式会社Reiメディカル 癌組織由来細胞塊または癌細胞凝集塊から得られる癌治療用組成物およびそれを用いた免疫療法剤の製造方法ならびに免疫療法効果評価方法
EP2596119B8 (en) 2010-07-23 2021-06-02 Astellas Institute for Regenerative Medicine Methods for detection of rare subpopulations of cells and highly purified compositions of cells
WO2012019061A2 (en) 2010-08-05 2012-02-09 Stem Centrx, Inc. Novel effectors and methods of use
EP2611463A2 (en) 2010-09-03 2013-07-10 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
CA2810016A1 (en) * 2010-09-03 2012-03-08 Stem Centrx, Inc. Novel modulators and methods of use
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
WO2012118547A1 (en) 2010-12-08 2012-09-07 Stem Centrx, Inc. Novel modulators and methods of use
KR101182549B1 (ko) * 2010-12-16 2012-09-12 엘지이노텍 주식회사 3차원 입체 카메라 모듈
SA112330278B1 (ar) 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
ES2586599T3 (es) * 2011-03-24 2016-10-17 The Rogosin Institute Ensayo para cribar compuestos que disminuyen selectivamente el número de células madre de cáncer
DK2714733T3 (da) 2011-05-21 2019-05-06 Macrogenics Inc Cd3-bindende molekyler, der er i stand til at binde til human og ikke-human cd3
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
US10247731B2 (en) 2012-02-22 2019-04-02 Verik Bio, Inc. System for immunotherapy targeting tumor propagation and progression
CA2865415C (en) 2012-02-24 2022-06-21 Stem Centrx, Inc. Anti sez6 antibodies and methods of use
PE20190658A1 (es) 2012-02-24 2019-05-08 Abbvie Stemcentrx Llc Moduladores y metodos de empleo novedosos
DK3536334T3 (da) 2012-05-16 2021-09-13 Stemline Therapeutics Inc Cancer stamcelle målrettede cancer vacciner
WO2014165101A1 (en) * 2013-03-13 2014-10-09 California Stem Cell, Inc. Individualized high purity colon carcinoma stem cells, methods and use of the same
BR112015019909A2 (pt) 2013-02-22 2017-08-29 Abbvie Stemcentrx Llc Conjugados anticorpo-fármaco, composição farmacêutica, usos dos mesmos, e kit
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
AU2014312215B2 (en) 2013-08-28 2020-02-27 Abbvie Stemcentrx Llc Site-specific antibody conjugation methods and compositions
AU2014312310A1 (en) 2013-08-28 2016-04-07 Abbvie Stemcentrx Llc Novel SEZ6 modulators and methods of use
US9782476B2 (en) 2013-09-06 2017-10-10 Academia Sinica Human iNKT cell activation using glycolipids with altered glycosyl groups
PE20160870A1 (es) 2013-11-06 2016-09-09 Abbvie Stemcentrx Llc Anticuerpos anti-claudina novedosos y metodos de uso
PE20160993A1 (es) 2013-12-12 2016-10-14 Abbvie Stemcentrx Llc Nuevos anticuerpos anti-dpep3 y metodos de uso
PE20161209A1 (es) 2014-02-21 2016-11-10 Abbvie Stemcentrx Llc Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti-dll3) y medicamentos para usarse en el tratamiento contra melanoma
KR20170003720A (ko) 2014-05-27 2017-01-09 아카데미아 시니카 항-cd20 글리코항체 및 이의 용도
CA2950423A1 (en) 2014-05-27 2015-12-03 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
KR102512592B1 (ko) 2014-05-27 2023-03-21 아카데미아 시니카 항-her2 글리코항체 및 이의 용도
CN106714829A (zh) 2014-05-28 2017-05-24 中央研究院 抗TNF‑α醣抗体及其用途
US20170191034A1 (en) * 2014-09-04 2017-07-06 Agency For Science Technology And Research A method to up-regulate cancer stem cell markers for the generation of antigen specific cytotoxic effector t cells
TW201617368A (zh) 2014-09-05 2016-05-16 史坦森特瑞斯公司 新穎抗mfi2抗體及使用方法
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
JP2018510844A (ja) * 2015-01-24 2018-04-19 アカデミア シニカAcademia Sinica がんマーカーおよびその使用方法
SG11201706024YA (en) 2015-01-26 2017-08-30 Macrogenics Inc Multivalent molecules comprising dr5-binding domains
KR20160109356A (ko) 2015-03-11 2016-09-21 이화여자대학교 산학협력단 자가 면역 질환 예방 또는 치료용 조성물
KR20160109358A (ko) 2015-03-11 2016-09-21 이화여자대학교 산학협력단 면역 질환 예방 또는 치료용 조성물
KR102036029B1 (ko) 2015-03-11 2019-10-24 이화여자대학교 산학협력단 골수 부전 예방 또는 치료용 조성물
TWI781098B (zh) 2016-04-15 2022-10-21 美商宏觀基因股份有限公司 新穎的b7-h3-結合分子、其抗體藥物綴合物及其使用方法
EP3454864A4 (en) 2016-04-21 2021-01-13 Abbvie Stemcentrx LLC Novel anti-bmpr1b antibodies and methods of use
EP3500594A4 (en) 2016-08-22 2020-03-11 Cho Pharma Inc. ANTIBODIES, BINDING FRAGMENTS AND METHOD FOR USE
GB201700952D0 (en) * 2017-01-19 2017-03-08 Univ Cape Town In vitro propagation of primary cancer cells
CN107904206A (zh) * 2017-11-17 2018-04-13 张家港澳洋医院有限公司 一种脂多糖诱导肿瘤细胞生成肿瘤干细胞的用途和方法
KR102089476B1 (ko) 2018-07-11 2020-03-16 이화여자대학교 산학협력단 피부 염증 질환 예방 또는 치료용 조성물
KR102130493B1 (ko) 2018-07-11 2020-07-06 이화여자대학교 산학협력단 건선 예방 또는 치료용 조성물
CN109652377B (zh) * 2019-01-15 2023-03-28 广州医科大学 一种肺癌干细胞的制备方法及应用
KR20190120141A (ko) 2019-10-16 2019-10-23 이화여자대학교 산학협력단 골수 부전 예방 또는 치료용 조성물
CN113069547B (zh) * 2021-04-16 2023-01-24 同济大学附属第一妇婴保健院 Bap1作为肿瘤治疗靶点在制备预防或治疗肿瘤药物中的应用
CN113444690A (zh) * 2021-07-29 2021-09-28 大连大学 一种基于三维培养体系的肿瘤细胞耐照射模型的建立方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004527211A (ja) * 2000-08-03 2004-09-09 リージェンツ オブ ザ ユニバーシティ オブ ミシガン 充実腫瘍幹細胞の単離及び用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US20050136066A1 (en) 1996-06-12 2005-06-23 Yajun Guo Cellular vaccines and immunotherapeutics and methods for their preparation
US7348015B2 (en) 1998-01-14 2008-03-25 Morphogenesis, Inc. Antigen modified cancer cell vaccines for cancer therapy
US6416999B1 (en) 2000-04-07 2002-07-09 Raven Biotechnologies, Inc. Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof
US6436704B1 (en) 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
WO2003032814A2 (en) 2001-10-16 2003-04-24 Raven Biotechnologies, Inc. Antibodies that bind to cancer-associated antigen cd46 and methods of use thereof
JP2005522483A (ja) 2002-04-11 2005-07-28 アルタレックス メディカル コーポレーション 結合剤及び腫瘍細胞をターゲティングする際のそれらの使用
MXPA04012664A (es) 2002-06-19 2005-08-15 Raven Biotechnologies Inc Objetivo de superficie celular raag10 novedoso y una familia de anticuerpos que reconocen ese objetivo.
MXPA06003028A (es) 2003-09-18 2006-06-23 Raven Biotechnologies Inc Medios de cultivo de celulas.
GB0406215D0 (en) 2004-03-19 2004-04-21 Procure Therapeutics Ltd Prostate stem cell
KR101295139B1 (ko) 2004-06-07 2013-08-12 레이븐 바이오테크놀로지스, 인코퍼레이티드 트랜스페린 리셉터 항체
ITRM20040438A1 (it) 2004-09-15 2004-12-15 Univ Palermo Metodo per la purificazione e l'amplificazione di cellule staminali tumorali.
CA3218940A1 (en) 2004-11-12 2006-05-18 Cambridge University Technical Services Ltd. Methods and means related to cancer stem cells
US7687242B2 (en) 2005-01-12 2010-03-30 Raven Biotechnologies, Inc. KID31 and antibodies that bind thereto
WO2006084078A2 (en) 2005-02-02 2006-08-10 Raven Biotechnologies, Inc. Jam-3 and antibodies that bind thereto
AU2006210589B2 (en) 2005-02-02 2011-12-08 Macrogenics West, Inc. ADAM-9 modulators
EP1846455A4 (en) 2005-02-03 2010-02-17 Raven Biotechnologies Inc ANTIBODY TO THE ONKOSTATIN M RECEPTOR
BRPI0607450A2 (pt) 2005-02-04 2009-09-01 Raven Biotechnologies Inc anticorpos que se ligam a epha2 e métodos para sua utilização
US20090012024A1 (en) 2005-07-26 2009-01-08 Procure Therapeutics Limited Stem Cell Markers
US20070123448A1 (en) 2005-11-23 2007-05-31 The Hospital For Sick Children Novel chemical entities affecting neuroblastoma tumor-initiating cells
WO2008039874A2 (en) 2006-09-26 2008-04-03 Cedars-Sinai Medical Center Cancer stem cell antigen vaccines and methods
KR101523698B1 (ko) 2007-01-22 2015-05-29 마크로제닉스 웨스트 인코퍼레이티드 사람 암 줄기세포

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004527211A (ja) * 2000-08-03 2004-09-09 リージェンツ オブ ザ ユニバーシティ オブ ミシガン 充実腫瘍幹細胞の単離及び用途

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN6012063271; 'Proceedings of the National Academy of Sciences of USA' 2003, Vol.100, No.7, pp.3983-3988 *
JPN6012063273; 'Cancer Research' 2005, Vol.65, No.23, pp.10946-10951 *
JPN6012063275; 'Nature' 1994, Vol.367, pp.645-648 *
JPN6012063278; 'Nature Reviews Cancer' 2005, Vol.5, pp.311-321 *
JPN6012063281; 'Cancer Research' 2006, Vol.66, No.21, pp.10247-10252 *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11536713B2 (en) 2009-12-25 2022-12-27 Chugai Seiyaku Kabushiki Kaisha Method for searching and screening for target of anti-cancer agent using non-human animal model having NOG established cancer cell line transplanted therein
WO2012046797A1 (ja) * 2010-10-06 2012-04-12 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞集団及びその作製方法
CN103328626A (zh) * 2010-10-06 2013-09-25 药物研究私人有限公司 癌干细胞群及其制备方法
JPWO2012046797A1 (ja) * 2010-10-06 2014-02-24 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞集団及びその作製方法
CN103328626B (zh) * 2010-10-06 2017-02-08 中外制药株式会社 癌干细胞群及其制备方法
US11124773B2 (en) 2010-10-06 2021-09-21 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell population and method for production thereof
JP2018029583A (ja) * 2010-10-06 2018-03-01 中外製薬株式会社 癌幹細胞集団及びその作製方法
US11965180B2 (en) 2010-10-06 2024-04-23 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell population and method for production thereof
US10018630B2 (en) 2011-09-07 2018-07-10 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
US11858987B2 (en) 2011-10-28 2024-01-02 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell-specific molecule
US10934351B2 (en) 2011-10-28 2021-03-02 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell-specific molecule
JP2013208104A (ja) * 2012-03-02 2013-10-10 Yamaguchi Univ 消化器系がん幹細胞を培養するための無血清培地、及びそれを用いた消化器系がん幹細胞の増殖方法
JP2015518561A (ja) * 2012-03-19 2015-07-02 ステムライン セラピューティクス,インコーポレーテッド 癌の状態を治療及びモニタリングする方法
JP2019213551A (ja) * 2013-08-12 2019-12-19 ミネルバ バイオテクノロジーズ コーポレーション 腫瘍成長を増強する方法
JP2017528114A (ja) * 2014-06-25 2017-09-28 テル ハショマー メディカル リサーチ インフラストラクチャー アンド サーヴィシーズ リミテッド がん幹細胞の同定ならびに診断および処置のためのその使用
JP2017086091A (ja) * 2015-04-20 2017-05-25 国立大学法人 岡山大学 がんの非ヒトモデル動物及びその作製方法、がん幹細胞及びその製造方法
JPWO2016170938A1 (ja) * 2015-04-20 2017-04-27 国立大学法人 岡山大学 がんの非ヒトモデル動物及びその作製方法、がん幹細胞及びその製造方法
JP2019506878A (ja) * 2016-02-17 2019-03-14 プロモセル・バイオサイエンス・アライブ・ゲー・エム・ベー・ハー・ビオメディツィーニッシェ・プロドゥクテ がん幹細胞(csc)含有細胞集団の培養のための化学的に規定された培地
CN108699529B (zh) * 2016-02-17 2022-05-24 普乐思尔有限公司 用于培养含癌症干细胞(csc)的细胞群的化学成分确定的培养基
JP6990659B2 (ja) 2016-02-17 2022-01-12 プロモセル・ゲー・エム・ベー・ハー がん幹細胞(csc)含有細胞集団の培養のための化学的に規定された培地
CN108699529A (zh) * 2016-02-17 2018-10-23 普乐思尔活性生物科学有限公司 用于培养含癌症干细胞(csc)的细胞群的化学成分确定的培养基
JP2022511607A (ja) * 2018-06-13 2022-02-01 北京基石生命科技有限公司 結腸直腸癌固形腫瘍初代細胞及び結腸直腸腺癌腹水初代腫瘍細胞の培養方法およびキット
JP7507751B2 (ja) 2018-06-13 2024-06-28 北京基石生命科技有限公司 結腸直腸癌固形腫瘍初代細胞及び結腸直腸腺癌腹水初代腫瘍細胞の培養方法およびキット
JP2022546578A (ja) * 2019-09-04 2022-11-04 ブイセル セラピューティックス,インコーポレイテッド 癌を処置するためのワクチンおよびストレスリプログラミングによるその作製方法

Also Published As

Publication number Publication date
CN101855339A (zh) 2010-10-06
IL199836A0 (en) 2010-04-15
US8309354B2 (en) 2012-11-13
CA2675521C (en) 2016-04-26
EP2109668A2 (en) 2009-10-21
IL199836A (en) 2014-02-27
KR20100033471A (ko) 2010-03-30
AU2008207945A1 (en) 2008-07-31
WO2008091908A3 (en) 2009-12-30
KR101523698B1 (ko) 2015-05-29
CA2675521A1 (en) 2008-07-31
WO2008091908A2 (en) 2008-07-31
US20080175870A1 (en) 2008-07-24
EP2109668A4 (en) 2011-10-05

Similar Documents

Publication Publication Date Title
US8309354B2 (en) Human cancer stem cells
JP6207783B2 (ja) 抗原特異的t細胞の増殖のための方法
JP6630074B2 (ja) 新規に単離された細胞の治療組成物の操作および送達
EP2142210B1 (en) Cytotoxic anti-lag-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
US6805869B2 (en) Cellular vaccines and immunotherapeutics and methods for their preparation
WO2019024933A1 (zh) 靶向gpc3的car nk细胞
KR20110025812A (ko) 세포독성 효과인자의 프라이밍을 차단하고 조절성 cd8+ t 세포의 생성을 유도하는 항-cd8 항체
EP4426350A2 (en) Treatment of cancer with nk cells and multispecific engagers
TW202208616A (zh) 改良之腫瘤反應性t細胞的選擇
Chauvin et al. Killer dendritic cells link innate and adaptive immunity against established osteosarcoma in rats
US11701387B2 (en) Chimeric antigen receptor specific for BDCA2 antigen
WO2012064967A2 (en) Cancer cell-derived receptor activator of the nf-kb ligand drives bone and soft tissue metastases
Baek et al. Dendritic cell (DC) vaccine in mouse lung cancer minimal residual model; comparison of monocyte-derived DC vs. hematopoietic stem cell derived-DC
WO2011060205A1 (en) Methods, compositions, and assays for determining the effect of an immune cell on a cell from an infectious or neoplastic disease
AU2022246174A1 (en) Methods and compositions for t-cell coculture potency assays and use with cell therapy products
US20140030276A1 (en) Cancer immunopotentiating agent containing rankl antagonist
WO2025096638A2 (en) Genetically modified tumor infilitrating lymphocytes and methods of producing and using the same
Jæhger Preclinical Evaluation of Novel Drug Delivery Platforms for the Improvement of Adoptive T cell Therapy
JP2022544566A (ja) 不死化された筋芽細胞株及びその使用
US20210002611A1 (en) Improved alpha-beta t processed cell production method
Noda et al. Immunization with ASPH-loaded dendritic cells produces anti-tumor effects in a rat model of intrahepatic cholangiocarcinoma
Popple The tumour microenvironment influences antigen specific T cell transmigration
Gauldie et al. Dendritic Cells Derived from Murine Colonic

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101105

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101105

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20120117

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20120117

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121204

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130227

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130306

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130401

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130408

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130425

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130507

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130530

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20131010