JP2010513494A5 - - Google Patents
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- Publication number
- JP2010513494A5 JP2010513494A5 JP2009542841A JP2009542841A JP2010513494A5 JP 2010513494 A5 JP2010513494 A5 JP 2010513494A5 JP 2009542841 A JP2009542841 A JP 2009542841A JP 2009542841 A JP2009542841 A JP 2009542841A JP 2010513494 A5 JP2010513494 A5 JP 2010513494A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- solvate
- pharmaceutically acceptable
- nhso
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **[n]1c2c(*)c(*)c(CCCCC3)c3c2c(*)c1* Chemical compound **[n]1c2c(*)c(*)c(CCCCC3)c3c2c(*)c1* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87661306P | 2006-12-22 | 2006-12-22 | |
| US60/876,613 | 2006-12-22 | ||
| PCT/US2007/025765 WO2008082488A1 (en) | 2006-12-22 | 2007-12-17 | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013009837A Division JP2013100331A (ja) | 2006-12-22 | 2013-01-23 | Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 |
| JP2013009838A Division JP2013121970A (ja) | 2006-12-22 | 2013-01-23 | Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513494A JP2010513494A (ja) | 2010-04-30 |
| JP2010513494A5 true JP2010513494A5 (OSRAM) | 2013-03-14 |
| JP5211068B2 JP5211068B2 (ja) | 2013-06-12 |
Family
ID=39185892
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542841A Expired - Fee Related JP5211068B2 (ja) | 2006-12-22 | 2007-12-17 | Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 |
| JP2013009837A Pending JP2013100331A (ja) | 2006-12-22 | 2013-01-23 | Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 |
| JP2013009838A Pending JP2013121970A (ja) | 2006-12-22 | 2013-01-23 | Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013009837A Pending JP2013100331A (ja) | 2006-12-22 | 2013-01-23 | Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 |
| JP2013009838A Pending JP2013121970A (ja) | 2006-12-22 | 2013-01-23 | Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8546420B2 (OSRAM) |
| EP (1) | EP2064181A1 (OSRAM) |
| JP (3) | JP5211068B2 (OSRAM) |
| KR (1) | KR20090106539A (OSRAM) |
| CN (1) | CN101611002A (OSRAM) |
| AR (1) | AR064429A1 (OSRAM) |
| AU (1) | AU2007339386B8 (OSRAM) |
| CA (1) | CA2673254C (OSRAM) |
| CL (1) | CL2007003685A1 (OSRAM) |
| MX (1) | MX2009006878A (OSRAM) |
| PE (1) | PE20081567A1 (OSRAM) |
| TW (1) | TW200833662A (OSRAM) |
| WO (1) | WO2008082488A1 (OSRAM) |
| ZA (1) | ZA200904334B (OSRAM) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110104109A1 (en) * | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
| MX2009006877A (es) | 2006-12-22 | 2009-09-28 | Schering Corp | Derivados indolicos con anillo unido en las posiciones 5,6 y metodos de uso de los mismos. |
| CA2673254C (en) | 2006-12-22 | 2013-09-10 | Schering Corporation | 4,5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
| RU2009127855A (ru) | 2006-12-22 | 2011-01-27 | Шеринг Корпорейшн (US) | 4,5 циклоаннелированные производные индола для лечения или предотвращения вируса гепатита с (hcv) и родственных вирусных инфекций |
| CN101821252A (zh) * | 2007-08-29 | 2010-09-01 | 先灵公司 | 取代的吲哚衍生物及其使用方法 |
| PE20090994A1 (es) * | 2007-08-29 | 2009-08-03 | Schering Corp | Derivados de azaindol 2,3-sustituidos como agentes antivirales |
| WO2009064848A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
| WO2009064852A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
| CN102159579B (zh) * | 2008-06-13 | 2015-03-25 | 默沙东公司 | 三环吲哚衍生物及其使用方法 |
| ES2383273T3 (es) * | 2008-07-23 | 2012-06-19 | F. Hoffmann-La Roche Ag | Compuestos heterocíclicos antivíricos |
| SG172778A1 (en) | 2008-12-22 | 2011-08-29 | Hoffmann La Roche | Heterocyclic antiviral compounds |
| EP2435424B1 (en) | 2009-05-29 | 2015-01-21 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
| CA2782024A1 (en) | 2009-11-25 | 2011-06-03 | Schering Corporation | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
| WO2011087740A1 (en) | 2009-12-22 | 2011-07-21 | Schering Corporation | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases |
| CN102918049A (zh) | 2010-03-09 | 2013-02-06 | 默沙东公司 | 稠合三环甲硅烷基化合物及其用于治疗病毒性疾病的方法 |
| KR101213495B1 (ko) * | 2010-06-03 | 2013-01-14 | 삼성디스플레이 주식회사 | 유기 발광 소자 |
| US20140377223A1 (en) | 2010-07-26 | 2014-12-25 | Joseph A. Kozlowski | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
| JP2013540122A (ja) | 2010-09-29 | 2013-10-31 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合四環式化合物誘導体およびウィルス疾患治療のためのそれの使用方法 |
| WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| BR112013026345A2 (pt) | 2011-04-13 | 2019-04-24 | Merck Sharp & Dohe Corp. | composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv |
| WO2013033899A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases |
| WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
| WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
| EP2755981A4 (en) | 2011-09-14 | 2015-03-25 | Merck Sharp & Dohme | SILICULAR HETEROCYCLIC DERIVATIVES AND METHOD FOR THEIR USE FOR THE TREATMENT OF VIRUS DISEASES |
| WO2014059901A1 (en) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | 2'-cyano substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases |
| WO2014059902A1 (en) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | 2'-disubstituted substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases |
| AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
| RU2015123641A (ru) | 2012-11-19 | 2017-01-10 | Мерк Шарп И Доум Корп. | 2-алкинилзамещенные производные нуклеозидов, предназначенные для лечения вирусных заболеваний |
| WO2014204831A1 (en) | 2013-06-18 | 2014-12-24 | Merck Sharp & Dohme Corp. | Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| WO2014205592A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Heterocyclic compounds and methods of use thereof for treatment of hepatitis c |
| WO2014205593A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases |
| EP3063140A4 (en) | 2013-10-30 | 2017-11-08 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof |
| EP3455219A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| US10899788B2 (en) | 2016-06-20 | 2021-01-26 | Merck Sharp & Dohme Corp. | Cyclic phosphate substituted nucleoside compounds and methods of use thereof for the treatment of viral diseases |
| CN106619731B (zh) * | 2016-12-30 | 2020-06-12 | 昆明赛诺制药股份有限公司 | 一种治疗丙型肝炎的药物 |
| CN118440096A (zh) | 2017-06-20 | 2024-08-06 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE648639C (de) | 1935-05-19 | 1937-08-05 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von Dipyrrolen |
| US3632805A (en) | 1967-12-08 | 1972-01-04 | Sumitomo Chemical Co | Process for producing 1-aminoalkyl-benzodiazepine derivatives |
| AU575854B2 (en) | 1983-10-04 | 1988-08-11 | Shionogi & Co., Ltd. | 7beta-(carboxyalkenamido) cephalosporins |
| US5017380A (en) | 1986-07-02 | 1991-05-21 | Shionogi & Co., Ltd. | Gelatin hard capsule containing crystalline hydrate of oral cephalosporin |
| NZ220764A (en) | 1986-07-02 | 1989-09-27 | Shionogi & Co | Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions |
| CA2038925A1 (en) | 1990-03-26 | 1991-09-27 | Takashi Sohda | Indole derivatives, their production and use |
| JPH04149429A (ja) | 1990-10-12 | 1992-05-22 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー反転写真感光材料およびそれを用いた画像形成方法 |
| ZA939516B (en) * | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
| JPH0753558A (ja) * | 1993-08-10 | 1995-02-28 | Shionogi & Co Ltd | デュオカルマイシンsa及びその誘導体の製造法 |
| WO1995033752A1 (en) * | 1994-06-09 | 1995-12-14 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| WO1995033748A1 (en) * | 1994-06-09 | 1995-12-14 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| AU4514496A (en) * | 1994-12-13 | 1996-07-03 | Smithkline Beecham Corporation | Novel compounds |
| IT1278077B1 (it) | 1995-05-25 | 1997-11-17 | Angeletti P Ist Richerche Bio | Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal |
| GB9526495D0 (en) * | 1995-12-23 | 1996-02-28 | Knoll Ag | Therapeutic agents |
| US5922757A (en) | 1996-09-30 | 1999-07-13 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
| UA79749C2 (en) | 1996-10-18 | 2007-07-25 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
| GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
| IL134233A0 (en) | 1997-08-11 | 2001-04-30 | Boehringer Ingelheim Ca Ltd | Hepatitis c inhibitor peptide analogues |
| FR2768146B1 (fr) | 1997-09-05 | 2000-05-05 | Oreal | Nouveaux composes de la famille des indole-carboxyliques et leur utilisation |
| ES2317900T3 (es) | 2000-04-05 | 2009-05-01 | Schering Corporation | Inhibidores de serina proteasa ns3 macrociclicos del virus de la hepatitis c que comprenden fragmentos n-ciclicas p2. |
| PL358591A1 (en) | 2000-04-19 | 2004-08-09 | Schering Corporation | Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising alkyl and aryl alanine p2 moieties |
| AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
| AR034127A1 (es) | 2000-07-21 | 2004-02-04 | Schering Corp | Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento |
| CN1498224A (zh) | 2000-07-21 | 2004-05-19 | ���鹫˾ | 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 |
| WO2002008187A1 (en) | 2000-07-21 | 2002-01-31 | Schering Corporation | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus |
| AU2002211901A1 (en) | 2000-10-10 | 2002-04-22 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compositions containing such indoles and their use as PPAR-gamma binding agents |
| AU3659102A (en) | 2000-12-12 | 2002-06-24 | Schering Corp | Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus |
| JP2004518658A (ja) | 2000-12-18 | 2004-06-24 | イーライ・リリー・アンド・カンパニー | 新規なsPLA2インヒビター |
| ATE378328T1 (de) * | 2001-02-22 | 2007-11-15 | Univ London Pharmacy | Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| JP2003342276A (ja) * | 2002-05-24 | 2003-12-03 | Mitsui Chemicals Inc | ピロロキナゾリン誘導体及び農園芸用有害生物防除剤ならびにその使用方法 |
| EP1554271A1 (en) | 2002-10-15 | 2005-07-20 | Rigel Pharmaceuticals, Inc. | Substituted indoles and their use as hcv inhibitors |
| US20050075331A1 (en) | 2003-10-06 | 2005-04-07 | Pratt John K. | Anti-infective agents |
| AU2004242928B2 (en) | 2003-05-30 | 2011-03-10 | Gemin X Pharmaceuticals Canada Inc. | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases |
| GB0323845D0 (en) | 2003-10-10 | 2003-11-12 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
| WO2005047324A2 (en) | 2003-11-10 | 2005-05-26 | Schering Corp | Interleukin-10 antibodies |
| PL1730110T3 (pl) | 2004-02-27 | 2010-11-30 | Merck Sharp & Dohme | Siarkowe związki jako inhibitory proteazy serynowej NS3 wirusa zapalenia wątroby typu C |
| US20070219212A1 (en) | 2004-03-01 | 2007-09-20 | Condon Stephen M | Pyranouidole Derivatives and the Use Thereof for the Treatment of Hepatitis C Virus Infection or Disease |
| US20050249702A1 (en) | 2004-05-06 | 2005-11-10 | Schering Corporation | (1R,2S,5S)-N-[(1S)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide as inhibitor of hepatitis C virus NS3/NS4a serine protease |
| EP1604988A1 (en) | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals |
| WO2007084413A2 (en) | 2004-07-14 | 2007-07-26 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
| US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| BRPI0515596A (pt) | 2004-09-23 | 2008-07-29 | Wyeth Corp | composição farmacêutica usada para o tratamento e/ou prevenção de hcv, e, métodos de inibir rna polimerase ns5b de hepatite c de tratar ou prevenir infecção por hepatite c em um mamìfero |
| DE102004047272A1 (de) | 2004-09-24 | 2006-04-06 | Schering Ag | Inhibitoren der löslichen Adenylatzyklase |
| JP4149429B2 (ja) | 2004-10-26 | 2008-09-10 | 本田技研工業株式会社 | 車両の走行安全装置 |
| AU2005298403A1 (en) | 2004-10-26 | 2006-05-04 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Tetracyclic indole derivatives as antiviral agents |
| WO2006076529A1 (en) | 2005-01-14 | 2006-07-20 | Genelabs Technologies, Inc. | Indole derivatives for treating viral infections |
| US20110104109A1 (en) | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
| GB0518390D0 (en) | 2005-09-09 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| JP2009508966A (ja) | 2005-09-23 | 2009-03-05 | シェーリング コーポレイション | 治療薬としての縮合四環性mGluR1アンタゴニスト |
| WO2007084435A2 (en) | 2006-01-13 | 2007-07-26 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
| US20070274951A1 (en) | 2006-02-09 | 2007-11-29 | Xiao Tong | Combinations comprising HCV protease inhibitor(s) and HCV polymerase inhibitor(s), and methods of treatment related thereto |
| MX2009006877A (es) | 2006-12-22 | 2009-09-28 | Schering Corp | Derivados indolicos con anillo unido en las posiciones 5,6 y metodos de uso de los mismos. |
| RU2009127855A (ru) | 2006-12-22 | 2011-01-27 | Шеринг Корпорейшн (US) | 4,5 циклоаннелированные производные индола для лечения или предотвращения вируса гепатита с (hcv) и родственных вирусных инфекций |
| CA2673254C (en) | 2006-12-22 | 2013-09-10 | Schering Corporation | 4,5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
| PE20090994A1 (es) | 2007-08-29 | 2009-08-03 | Schering Corp | Derivados de azaindol 2,3-sustituidos como agentes antivirales |
| PE20090995A1 (es) | 2007-08-29 | 2009-08-03 | Schering Corp | Derivados indolicos 2,3-sustituidos como inhibidores del virus de la hepatitis c (vhc) |
| CN101821252A (zh) | 2007-08-29 | 2010-09-01 | 先灵公司 | 取代的吲哚衍生物及其使用方法 |
| WO2009064852A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
| WO2009064848A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
-
2007
- 2007-12-17 CA CA2673254A patent/CA2673254C/en not_active Expired - Fee Related
- 2007-12-17 KR KR1020097015272A patent/KR20090106539A/ko not_active Ceased
- 2007-12-17 MX MX2009006878A patent/MX2009006878A/es unknown
- 2007-12-17 JP JP2009542841A patent/JP5211068B2/ja not_active Expired - Fee Related
- 2007-12-17 WO PCT/US2007/025765 patent/WO2008082488A1/en not_active Ceased
- 2007-12-17 AU AU2007339386A patent/AU2007339386B8/en not_active Ceased
- 2007-12-17 US US12/519,728 patent/US8546420B2/en not_active Expired - Fee Related
- 2007-12-17 EP EP07863006A patent/EP2064181A1/en not_active Withdrawn
- 2007-12-17 CN CNA2007800517016A patent/CN101611002A/zh active Pending
- 2007-12-18 CL CL200703685A patent/CL2007003685A1/es unknown
- 2007-12-18 TW TW096148494A patent/TW200833662A/zh unknown
- 2007-12-18 AR ARP070105706A patent/AR064429A1/es not_active Application Discontinuation
-
2008
- 2008-01-02 PE PE2008000056A patent/PE20081567A1/es not_active Application Discontinuation
-
2009
- 2009-06-19 ZA ZA200904334A patent/ZA200904334B/xx unknown
-
2013
- 2013-01-23 JP JP2013009837A patent/JP2013100331A/ja active Pending
- 2013-01-23 JP JP2013009838A patent/JP2013121970A/ja active Pending
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