JP2010507565A5 - - Google Patents
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- Publication number
- JP2010507565A5 JP2010507565A5 JP2009518179A JP2009518179A JP2010507565A5 JP 2010507565 A5 JP2010507565 A5 JP 2010507565A5 JP 2009518179 A JP2009518179 A JP 2009518179A JP 2009518179 A JP2009518179 A JP 2009518179A JP 2010507565 A5 JP2010507565 A5 JP 2010507565A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- atom
- substituted
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006290536 | 2006-10-25 | ||
| JP2007021387 | 2007-01-31 | ||
| JP2007221911 | 2007-08-28 | ||
| PCT/JP2007/071169 WO2008050897A1 (en) | 2006-10-25 | 2007-10-24 | Metastin derivatives and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013004011A Division JP5686825B2 (ja) | 2006-10-25 | 2013-01-11 | メタスチン誘導体およびその用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010507565A JP2010507565A (ja) | 2010-03-11 |
| JP2010507565A5 true JP2010507565A5 (https=) | 2010-12-09 |
Family
ID=38925530
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518179A Pending JP2010507565A (ja) | 2006-10-25 | 2007-10-24 | メタスチン誘導体およびその用途 |
| JP2013004011A Expired - Fee Related JP5686825B2 (ja) | 2006-10-25 | 2013-01-11 | メタスチン誘導体およびその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013004011A Expired - Fee Related JP5686825B2 (ja) | 2006-10-25 | 2013-01-11 | メタスチン誘導体およびその用途 |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US8765909B2 (https=) |
| EP (1) | EP2081955B1 (https=) |
| JP (2) | JP2010507565A (https=) |
| KR (1) | KR101424306B1 (https=) |
| AR (1) | AR063367A1 (https=) |
| AU (1) | AU2007309969B2 (https=) |
| BR (1) | BRPI0717441B8 (https=) |
| CA (1) | CA2667537C (https=) |
| CL (1) | CL2007003053A1 (https=) |
| CR (1) | CR10799A (https=) |
| CY (1) | CY1116627T1 (https=) |
| DK (1) | DK2081955T3 (https=) |
| EC (1) | ECSP099279A (https=) |
| ES (1) | ES2539430T3 (https=) |
| GE (1) | GEP20125568B (https=) |
| HR (1) | HRP20150819T1 (https=) |
| HU (1) | HUE025291T2 (https=) |
| IL (1) | IL198046A (https=) |
| JO (1) | JO3048B1 (https=) |
| MA (1) | MA30887B1 (https=) |
| ME (1) | ME00786B (https=) |
| MX (1) | MX2009004148A (https=) |
| MY (1) | MY145975A (https=) |
| NO (1) | NO341584B1 (https=) |
| NZ (1) | NZ576375A (https=) |
| PE (1) | PE20081469A1 (https=) |
| PL (1) | PL2081955T3 (https=) |
| PT (1) | PT2081955E (https=) |
| RS (1) | RS54083B1 (https=) |
| SI (1) | SI2081955T1 (https=) |
| TN (1) | TN2009000140A1 (https=) |
| TW (1) | TWI404726B (https=) |
| WO (1) | WO2008050897A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1761680A (zh) | 2002-12-26 | 2006-04-19 | 武田药品工业株式会社 | 肿瘤迁移抑制素衍生物及其用途 |
| CA2571420A1 (en) | 2004-06-25 | 2006-01-05 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| AR058584A1 (es) | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| US20090099334A1 (en) * | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| WO2007125619A1 (ja) * | 2006-04-26 | 2007-11-08 | Kyoto University | Ｇｐｒ５４アゴニスト活性を有する新規化合物 |
| JO3048B1 (ar) | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| US8110639B2 (en) * | 2006-11-17 | 2012-02-07 | Solvay Advanced Polymers, L.L.C. | Transparent and flame retardant polysulfone compositions |
| EP2277900A4 (en) * | 2008-04-24 | 2011-08-03 | Takeda Pharmaceutical | METASTINE DERIVATIVE AND ITS USE |
| EP2275433B1 (en) * | 2008-04-30 | 2017-06-07 | Kyoto University | Metastin derivative and use thereof |
| LT2314609T (lt) * | 2008-07-30 | 2017-04-10 | Takeda Pharmaceutical Company Limited | Metastino darinys ir jo panaudojimas |
| WO2010137022A1 (en) * | 2009-05-27 | 2010-12-02 | Yeda Research And Development Co. Ltd | Gpr54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities |
| CA2802209C (en) * | 2010-06-25 | 2019-12-31 | Takeda Pharmaceutical Company Limited | Sustained-release formulation |
| EP2755690B1 (en) | 2011-08-04 | 2020-04-01 | Merck Sharp & Dohme B.V. | Kisspeptide-pentasaccharide conjugates |
| CN105263900B (zh) * | 2013-06-12 | 2020-09-22 | 默克专利股份公司 | 用于治疗关节病的羟基亚乙基衍生物 |
| US10220069B2 (en) * | 2014-01-22 | 2019-03-05 | The Johns Hopkins University | Compositions and methods for treating diabetes |
| JP6253146B2 (ja) * | 2014-02-04 | 2017-12-27 | 国立大学法人山口大学 | 新規なペプチド誘導体及びこれを含有する医薬 |
| CN107428803A (zh) * | 2015-02-08 | 2017-12-01 | 耶路撒冷希伯来大学伊萨姆研究发展有限公司 | 用于治疗恶性增殖性疾病的肽 |
| CN109206481B (zh) * | 2017-07-05 | 2023-08-18 | 尚华医药科技(江西)有限公司 | 一种肽类化合物、其应用及含其的组合物 |
| TWI795462B (zh) * | 2017-11-17 | 2023-03-11 | 日商鹽野義製藥股份有限公司 | 光安定性及溶出性優異的醫藥製劑 |
| US20230256051A1 (en) * | 2020-04-08 | 2023-08-17 | Rutgers, The State University Of New Jersey | Modified kisspeptin receptor agonists for fatty liver disease |
| WO2025217074A1 (en) * | 2024-04-08 | 2025-10-16 | Radionetics Oncology, Inc. | Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL74827A (en) | 1984-05-21 | 1989-06-30 | Salk Inst For Biological Studi | Peptides active as gnrh antagonists and pharmaceutical compositions containing them |
| MX9100717A (es) | 1990-08-24 | 1992-04-01 | Syntex Inc | Antagonistas de la bradiquinina |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| JPH09169735A (ja) | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | キノリン誘導体、その製造法および用途 |
| CN1200114A (zh) | 1995-10-19 | 1998-11-25 | 武田药品工业株式会社 | 作为gnrh拮抗剂的喹啉衍生物 |
| JP2000510453A (ja) | 1996-04-19 | 2000-08-15 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン遊離特性を有する化合物 |
| WO1998039448A2 (en) | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| JP4486187B2 (ja) | 1998-10-27 | 2010-06-23 | 武田薬品工業株式会社 | 新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド |
| US6528054B1 (en) | 1998-12-28 | 2003-03-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| PL353057A1 (en) | 1999-06-28 | 2003-10-06 | Basf Aktiengesellschaft | Method for preventing tumoral growth |
| US6638906B1 (en) | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
| CN1411509A (zh) * | 1999-12-17 | 2003-04-16 | 武田药品工业株式会社 | Kiss－1肽的制造方法 |
| JP2004526401A (ja) | 2000-03-29 | 2004-09-02 | コリクサ コーポレイション | 肺癌の治療および診断のための組成物および方法 |
| AU2001244609A1 (en) | 2000-03-30 | 2001-10-15 | Takeda Chemical Industries Ltd. | Novel protein, dna thereof and process for producing the same |
| US7834141B1 (en) | 2000-03-31 | 2010-11-16 | Theresa Siler-Khodr | Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy |
| RU2311920C2 (ru) | 2000-09-20 | 2007-12-10 | Корикса Корпорейшн | Композиции и способы для лечения и диагностики рака легких |
| JP2003026601A (ja) | 2000-11-29 | 2003-01-29 | Takeda Chem Ind Ltd | 医薬組成物およびその製造法 |
| JP2002320496A (ja) | 2001-02-26 | 2002-11-05 | Takeda Chem Ind Ltd | 新規マウス型ＫｉＳＳ−１レセプタータンパク質およびそのＤＮＡ |
| WO2002085399A1 (fr) | 2001-04-20 | 2002-10-31 | Takeda Chemical Industries, Ltd. | Preparations contenant un peptide |
| KR100599419B1 (ko) * | 2001-05-17 | 2006-07-10 | 가부시키가이샤 시마즈세이사쿠쇼 | 펩티드의 제조법 |
| US7112662B2 (en) | 2001-09-19 | 2006-09-26 | Takeda Pharmaceutical Company Limited | Anti-metasin antibodies and their methods of use |
| WO2003060125A1 (fr) | 2002-01-11 | 2003-07-24 | Takeda Chemical Industries, Ltd. | Procede de production du peptide kiss-1 |
| JP2003300906A (ja) | 2002-04-12 | 2003-10-21 | Daiichi Fine Chemical Co Ltd | がん転移抑制因子の安定化 |
| JPWO2004035089A1 (ja) | 2002-10-09 | 2006-02-09 | 協和醗酵工業株式会社 | ホルモン依存性癌の治療剤 |
| DE60327344D1 (de) | 2002-10-25 | 2009-06-04 | Takeda Pharmaceutical | Gpr54 'knock-out' säugetiere und screening-verfahren, die sie verwenden |
| JP4804714B2 (ja) | 2002-12-26 | 2011-11-02 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| CN1761680A (zh) | 2002-12-26 | 2006-04-19 | 武田药品工业株式会社 | 肿瘤迁移抑制素衍生物及其用途 |
| US6800611B2 (en) * | 2003-01-06 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Metastin derivatives and their use |
| KR100595364B1 (ko) | 2003-02-20 | 2006-07-03 | 재단법인 목암생명공학연구소 | Ｌｋ8 단백질을 유효성분으로 포함하는 항암제 |
| CA2518541C (en) | 2003-03-12 | 2013-05-21 | Takeda Pharmaceutical Company Limited | Gonadal function improving agents |
| EP1464652A1 (en) | 2003-04-02 | 2004-10-06 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases |
| US20050002935A1 (en) | 2003-04-17 | 2005-01-06 | Vincent Ling | Use of B7-H3 as an immunoregulatory agent |
| EP1618384A2 (en) | 2003-04-28 | 2006-01-25 | Wyeth | Methods utilising g-protein coupled receptor 54 |
| WO2004101747A2 (en) | 2003-05-07 | 2004-11-25 | The General Hospital Corporation | Identification and use of gpr54 and its ligands for reproductive disorders and contraception |
| EP1633702B1 (en) | 2003-05-30 | 2008-07-02 | Prozymex A/S | Protease inhibitors |
| EP1688498B1 (en) | 2003-11-03 | 2011-03-09 | Beijing Sunbio Biotech Co., Ltd. | A recombinant protein with cancer suppression action, its encoding gene and use |
| WO2005095973A2 (en) | 2004-03-25 | 2005-10-13 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 54 (gpr54) |
| JP2007533748A (ja) | 2004-04-23 | 2007-11-22 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 不妊症の処置のためのｇｐｃｒ５４リガンドの使用 |
| CA2571420A1 (en) | 2004-06-25 | 2006-01-05 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| WO2007084211A2 (en) | 2005-11-11 | 2007-07-26 | The General Hospital Corporation | Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| AR058584A1 (es) | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| US20090099334A1 (en) | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US20090093615A1 (en) | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| MX2008012055A (es) | 2006-03-20 | 2008-10-02 | Merck & Co Inc | Agonistas del receptor de neuromedina u y usos de los mismos. |
| US20100215637A1 (en) | 2006-03-28 | 2010-08-26 | Biopharmica Ltd | Agent for the Treatment of Hormone-Dependent Disorders and Uses Thereof |
| JO3048B1 (ar) | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| CA2701612A1 (en) | 2007-10-05 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Neuromedin u derivative |
| EP2277900A4 (en) | 2008-04-24 | 2011-08-03 | Takeda Pharmaceutical | METASTINE DERIVATIVE AND ITS USE |
| EP2340047A1 (en) | 2008-09-19 | 2011-07-06 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
-
2007
- 2007-10-23 JO JOP/2007/0448A patent/JO3048B1/ar active
- 2007-10-23 TW TW096139608A patent/TWI404726B/zh active
- 2007-10-24 CL CL200703053A patent/CL2007003053A1/es unknown
- 2007-10-24 BR BRPI0717441A patent/BRPI0717441B8/pt not_active IP Right Cessation
- 2007-10-24 EP EP20070830903 patent/EP2081955B1/en active Active
- 2007-10-24 DK DK07830903.6T patent/DK2081955T3/da active
- 2007-10-24 CA CA2667537A patent/CA2667537C/en active Active
- 2007-10-24 HU HUE07830903A patent/HUE025291T2/en unknown
- 2007-10-24 PL PL07830903T patent/PL2081955T3/pl unknown
- 2007-10-24 JP JP2009518179A patent/JP2010507565A/ja active Pending
- 2007-10-24 AR ARP070104699A patent/AR063367A1/es active IP Right Grant
- 2007-10-24 SI SI200731649T patent/SI2081955T1/sl unknown
- 2007-10-24 PE PE2007001444A patent/PE20081469A1/es active IP Right Grant
- 2007-10-24 WO PCT/JP2007/071169 patent/WO2008050897A1/en not_active Ceased
- 2007-10-24 PT PT78309036T patent/PT2081955E/pt unknown
- 2007-10-24 GE GEAP200711265A patent/GEP20125568B/en unknown
- 2007-10-24 ME MEP-2009-130A patent/ME00786B/me unknown
- 2007-10-24 MY MYPI20091689A patent/MY145975A/en unknown
- 2007-10-24 ES ES07830903.6T patent/ES2539430T3/es active Active
- 2007-10-24 NZ NZ576375A patent/NZ576375A/en not_active IP Right Cessation
- 2007-10-24 MX MX2009004148A patent/MX2009004148A/es active IP Right Grant
- 2007-10-24 RS RS20150413A patent/RS54083B1/sr unknown
- 2007-10-24 KR KR1020097010545A patent/KR101424306B1/ko active Active
- 2007-10-24 AU AU2007309969A patent/AU2007309969B2/en not_active Ceased
- 2007-10-24 US US12/446,142 patent/US8765909B2/en active Active
- 2007-10-24 HR HRP20150819TT patent/HRP20150819T1/hr unknown
- 2007-10-24 US US11/977,477 patent/US7786083B2/en active Active
-
2009
- 2009-04-06 IL IL198046A patent/IL198046A/en active IP Right Grant
- 2009-04-15 TN TNP2009000140A patent/TN2009000140A1/fr unknown
- 2009-04-16 NO NO20091487A patent/NO341584B1/no unknown
- 2009-04-23 EC EC2009009279A patent/ECSP099279A/es unknown
- 2009-05-13 MA MA31868A patent/MA30887B1/fr unknown
- 2009-05-15 CR CR10799A patent/CR10799A/es unknown
-
2013
- 2013-01-11 JP JP2013004011A patent/JP5686825B2/ja not_active Expired - Fee Related
-
2015
- 2015-07-29 CY CY20151100668T patent/CY1116627T1/el unknown
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