JP2009024028A5 - - Google Patents

Download PDF

Info

Publication number
JP2009024028A5
JP2009024028A5 JP2008245073A JP2008245073A JP2009024028A5 JP 2009024028 A5 JP2009024028 A5 JP 2009024028A5 JP 2008245073 A JP2008245073 A JP 2008245073A JP 2008245073 A JP2008245073 A JP 2008245073A JP 2009024028 A5 JP2009024028 A5 JP 2009024028A5
Authority
JP
Japan
Prior art keywords
trp
phe
arg
group
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008245073A
Other languages
English (en)
Japanese (ja)
Other versions
JP4654284B2 (ja
JP2009024028A (ja
Filing date
Publication date
Application filed filed Critical
Priority to JP2008245073A priority Critical patent/JP4654284B2/ja
Priority claimed from JP2008245073A external-priority patent/JP4654284B2/ja
Publication of JP2009024028A publication Critical patent/JP2009024028A/ja
Publication of JP2009024028A5 publication Critical patent/JP2009024028A5/ja
Application granted granted Critical
Publication of JP4654284B2 publication Critical patent/JP4654284B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2008245073A 2004-06-25 2008-09-25 メタスチン誘導体およびその用途 Expired - Fee Related JP4654284B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008245073A JP4654284B2 (ja) 2004-06-25 2008-09-25 メタスチン誘導体およびその用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004187671 2004-06-25
JP2004363311 2004-12-15
JP2008245073A JP4654284B2 (ja) 2004-06-25 2008-09-25 メタスチン誘導体およびその用途

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006554374A Division JP4346650B2 (ja) 2004-06-25 2005-06-23 メタスチン誘導体およびその用途

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009132363A Division JP2009227687A (ja) 2004-06-25 2009-06-01 メタスチン誘導体およびその用途

Publications (3)

Publication Number Publication Date
JP2009024028A JP2009024028A (ja) 2009-02-05
JP2009024028A5 true JP2009024028A5 (https=) 2009-03-19
JP4654284B2 JP4654284B2 (ja) 2011-03-16

Family

ID=34971534

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2006554374A Expired - Fee Related JP4346650B2 (ja) 2004-06-25 2005-06-23 メタスチン誘導体およびその用途
JP2008245073A Expired - Fee Related JP4654284B2 (ja) 2004-06-25 2008-09-25 メタスチン誘導体およびその用途
JP2009132363A Pending JP2009227687A (ja) 2004-06-25 2009-06-01 メタスチン誘導体およびその用途

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2006554374A Expired - Fee Related JP4346650B2 (ja) 2004-06-25 2005-06-23 メタスチン誘導体およびその用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009132363A Pending JP2009227687A (ja) 2004-06-25 2009-06-01 メタスチン誘導体およびその用途

Country Status (20)

Country Link
US (2) US7625869B2 (https=)
EP (2) EP2113513B1 (https=)
JP (3) JP4346650B2 (https=)
CN (2) CN101845091A (https=)
AR (1) AR049938A1 (https=)
AU (1) AU2005257484A1 (https=)
BR (1) BRPI0512397A (https=)
CA (1) CA2571420A1 (https=)
CL (1) CL2008003730A1 (https=)
CR (1) CR8828A (https=)
IL (1) IL179640A0 (https=)
MA (1) MA28903B1 (https=)
MX (1) MXPA06014206A (https=)
NO (1) NO20065957L (https=)
NZ (1) NZ552029A (https=)
PE (2) PE20060371A1 (https=)
RU (1) RU2006145886A (https=)
SG (1) SG153865A1 (https=)
TW (1) TW200607816A (https=)
WO (1) WO2006001499A2 (https=)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
CN1761680A (zh) 2002-12-26 2006-04-19 武田药品工业株式会社 肿瘤迁移抑制素衍生物及其用途
CA2518541C (en) 2003-03-12 2013-05-21 Takeda Pharmaceutical Company Limited Gonadal function improving agents
WO2005113147A2 (en) 2004-04-08 2005-12-01 Biomatrica, Inc. Integration of sample storage and sample management for life science
CA2571420A1 (en) 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
KR101644250B1 (ko) 2004-08-23 2016-07-29 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
CN104324362B (zh) 2005-09-14 2018-04-24 曼金德公司 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
AR058584A1 (es) 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
US8404643B2 (en) * 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
IN2015DN00888A (https=) 2006-02-22 2015-07-10 Mannkind Corp
WO2007125619A1 (ja) * 2006-04-26 2007-11-08 Kyoto University Ｇｐｒ５４アゴニスト活性を有する新規化合物
ITMI20061607A1 (it) 2006-08-09 2008-02-10 Maria Vincenza Carriero Peptidi con attivita farmacologica
JO3048B1 (ar) * 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
ZA200902452B (en) * 2006-10-25 2010-07-28 Takeda Pharmaceutical Metastin derivatives and use thereof
EP2277900A4 (en) 2008-04-24 2011-08-03 Takeda Pharmaceutical METASTINE DERIVATIVE AND ITS USE
EP2275433B1 (en) * 2008-04-30 2017-06-07 Kyoto University Metastin derivative and use thereof
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2929343T3 (es) 2008-06-13 2022-11-28 Mannkind Corp Inhalador de polvo seco accionado por aspiración para la administración de fármacos
KR101628410B1 (ko) 2008-06-20 2016-06-08 맨카인드 코포레이션 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
LT2314609T (lt) * 2008-07-30 2017-04-10 Takeda Pharmaceutical Company Limited Metastino darinys ir jo panaudojimas
JP2012513982A (ja) 2008-12-29 2012-06-21 武田薬品工業株式会社 癌の予防・治療剤
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010137022A1 (en) 2009-05-27 2010-12-02 Yeda Research And Development Co. Ltd Gpr54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities
CN102665690A (zh) 2009-12-22 2012-09-12 武田药品工业株式会社 缓释制剂
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
WO2012018639A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
EP2598660B1 (en) 2010-07-26 2017-03-15 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2755690B1 (en) 2011-08-04 2020-04-01 Merck Sharp & Dohme B.V. Kisspeptide-pentasaccharide conjugates
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
CN104350064A (zh) 2012-03-14 2015-02-11 耶达研究及发展有限公司 修饰的吻素肽和其用途
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
WO2014119753A1 (ja) * 2013-01-31 2014-08-07 学校法人 東京薬科大学 マイオスタチン阻害ペプチド
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
US10220069B2 (en) * 2014-01-22 2019-03-05 The Johns Hopkins University Compositions and methods for treating diabetes
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
ES2786373T3 (es) 2014-06-10 2020-10-09 Biomatrica Inc Estabilización de trombocitos a temperaturas ambiente
KR20250047404A (ko) 2015-12-08 2025-04-03 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
TWI778979B (zh) 2016-09-30 2022-10-01 瑞士商麥歐文科學有限公司 治療女性不孕症之方法
CN109206481B (zh) 2017-07-05 2023-08-18 尚华医药科技(江西)有限公司 一种肽类化合物、其应用及含其的组合物
CN108752233B (zh) * 2018-07-18 2020-10-16 河北师范大学 小分子凝胶因子、凝胶材料及制备方法和应用
US20230159450A1 (en) * 2020-05-08 2023-05-25 The Feinstein Institutes For Medical Research Dimers for use in synthesis of peptidomimetics
WO2025217074A1 (en) 2024-04-08 2025-10-16 Radionetics Oncology, Inc. Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
IL74827A (en) * 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
MX9100717A (es) * 1990-08-24 1992-04-01 Syntex Inc Antagonistas de la bradiquinina
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
CN1200114A (zh) 1995-10-19 1998-11-25 武田药品工业株式会社 作为gnrh拮抗剂的喹啉衍生物
JPH09169735A (ja) 1995-10-19 1997-06-30 Takeda Chem Ind Ltd キノリン誘導体、その製造法および用途
JP2000510453A (ja) 1996-04-19 2000-08-15 ノボ ノルディスク アクティーゼルスカブ 成長ホルモン遊離特性を有する化合物
WO1998039448A2 (en) 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 human secreted proteins
JP4486187B2 (ja) 1998-10-27 2010-06-23 武田薬品工業株式会社 新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド
US6528054B1 (en) 1998-12-28 2003-03-04 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
PL353057A1 (en) 1999-06-28 2003-10-06 Basf Aktiengesellschaft Method for preventing tumoral growth
US6638906B1 (en) 1999-12-13 2003-10-28 Nobex Corporation Amphiphilic polymers and polypeptide conjugates comprising same
JP2001231581A (ja) * 1999-12-17 2001-08-28 Takeda Chem Ind Ltd ＫｉＳＳ−１ペプチドの製造法
CN1411509A (zh) * 1999-12-17 2003-04-16 武田药品工业株式会社 Kiss－1肽的制造方法
JP2004526401A (ja) 2000-03-29 2004-09-02 コリクサ コーポレイション 肺癌の治療および診断のための組成物および方法
AU2001244609A1 (en) 2000-03-30 2001-10-15 Takeda Chemical Industries Ltd. Novel protein, dna thereof and process for producing the same
US7834141B1 (en) 2000-03-31 2010-11-16 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy
RU2311920C2 (ru) 2000-09-20 2007-12-10 Корикса Корпорейшн Композиции и способы для лечения и диагностики рака легких
JP2003026601A (ja) 2000-11-29 2003-01-29 Takeda Chem Ind Ltd 医薬組成物およびその製造法
JP2002320496A (ja) 2001-02-26 2002-11-05 Takeda Chem Ind Ltd 新規マウス型ＫｉＳＳ−１レセプタータンパク質およびそのＤＮＡ
WO2002085399A1 (fr) 2001-04-20 2002-10-31 Takeda Chemical Industries, Ltd. Preparations contenant un peptide
KR100599419B1 (ko) * 2001-05-17 2006-07-10 가부시키가이샤 시마즈세이사쿠쇼 펩티드의 제조법
US7112662B2 (en) * 2001-09-19 2006-09-26 Takeda Pharmaceutical Company Limited Anti-metasin antibodies and their methods of use
WO2003060125A1 (fr) 2002-01-11 2003-07-24 Takeda Chemical Industries, Ltd. Procede de production du peptide kiss-1
JP2003300906A (ja) 2002-04-12 2003-10-21 Daiichi Fine Chemical Co Ltd がん転移抑制因子の安定化
JPWO2004035089A1 (ja) * 2002-10-09 2006-02-09 協和醗酵工業株式会社 ホルモン依存性癌の治療剤
DE60327344D1 (de) 2002-10-25 2009-06-04 Takeda Pharmaceutical Gpr54 'knock-out' säugetiere und screening-verfahren, die sie verwenden
CN1761680A (zh) * 2002-12-26 2006-04-19 武田药品工业株式会社 肿瘤迁移抑制素衍生物及其用途
JP4804714B2 (ja) 2002-12-26 2011-11-02 武田薬品工業株式会社 メタスチン誘導体およびその用途
US6800611B2 (en) * 2003-01-06 2004-10-05 Takeda Chemical Industries, Ltd. Metastin derivatives and their use
KR100595364B1 (ko) 2003-02-20 2006-07-03 재단법인 목암생명공학연구소 Ｌｋ8 단백질을 유효성분으로 포함하는 항암제
CA2518541C (en) 2003-03-12 2013-05-21 Takeda Pharmaceutical Company Limited Gonadal function improving agents
EP1464652A1 (en) 2003-04-02 2004-10-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases
US20050002935A1 (en) 2003-04-17 2005-01-06 Vincent Ling Use of B7-H3 as an immunoregulatory agent
EP1618384A2 (en) 2003-04-28 2006-01-25 Wyeth Methods utilising g-protein coupled receptor 54
WO2004101747A2 (en) 2003-05-07 2004-11-25 The General Hospital Corporation Identification and use of gpr54 and its ligands for reproductive disorders and contraception
EP1633702B1 (en) 2003-05-30 2008-07-02 Prozymex A/S Protease inhibitors
EP1688498B1 (en) 2003-11-03 2011-03-09 Beijing Sunbio Biotech Co., Ltd. A recombinant protein with cancer suppression action, its encoding gene and use
RU2333221C2 (ru) 2003-11-03 2008-09-10 Бейцзин Санбио Байотек Ко., Лтд. Рекомбинантный белок, обладающий противораковым действием, кодирующий его ген и его применение
WO2005095973A2 (en) 2004-03-25 2005-10-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 54 (gpr54)
JP2007533748A (ja) 2004-04-23 2007-11-22 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症の処置のためのｇｐｃｒ５４リガンドの使用
CA2571420A1 (en) 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
WO2007084211A2 (en) 2005-11-11 2007-07-26 The General Hospital Corporation Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception
US8404643B2 (en) * 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
AR058584A1 (es) * 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
US20090099334A1 (en) * 2005-12-22 2009-04-16 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
MX2008012055A (es) 2006-03-20 2008-10-02 Merck & Co Inc Agonistas del receptor de neuromedina u y usos de los mismos.
US20100215637A1 (en) * 2006-03-28 2010-08-26 Biopharmica Ltd Agent for the Treatment of Hormone-Dependent Disorders and Uses Thereof
JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
CA2701612A1 (en) * 2007-10-05 2009-04-09 Takeda Pharmaceutical Company Limited Neuromedin u derivative
EP2277900A4 (en) 2008-04-24 2011-08-03 Takeda Pharmaceutical METASTINE DERIVATIVE AND ITS USE
EP2340047A1 (en) 2008-09-19 2011-07-06 Nektar Therapeutics Polymer conjugates of kiss1 peptides

Similar Documents

Publication Publication Date Title
JP2009024028A5 (https=)
JP2010507565A5 (https=)
RU2006145886A (ru) Производные метастина и их применение
JP5686825B2 (ja) メタスチン誘導体およびその用途
TWI250990B (en) Melanocortin receptor ligands
EP4592308A1 (en) Cyclic compound having selective kras inhibitory effect on hras and nras
TWI325003B (en) Ghrelin analogs
HU227640B1 (en) Kappa receptor opioid tetra peptides and pharmaceutical compositions comprising thereof
CN1254347A (zh) 甲状旁腺素的类似物
JP4653840B2 (ja) メタスチン誘導体およびその用途
JPWO2009131191A1 (ja) メタスチン誘導体およびその用途
TW200412995A (en) Peptide YY analogs
JP2012513982A (ja) 癌の予防・治療剤
WO2020230780A1 (ja) Ｒａｓ阻害ペプチド
JPH10502091A (ja) ＰＴＨまたはＰＴＨｒＰアンタゴニスト
CN110678550A (zh) 长效肾上腺髓质素衍生物
JP5698977B2 (ja) メタスチン誘導体およびその用途
JP2949129B2 (ja) 胃腸運動刺激活性を有するモチリン類似ポリペプチド
TW200410986A (en) Pharamaceutical comiposition comprising cyclic somatostatin analogs II
MX2011008776A (es) Analogos de neuropeptido y con por lo menos una substitucion de aminoacido sintetico.
JP6100699B2 (ja) 環状ｃｒｆアンタゴニストペプチド及びその薬学的に許容される塩
CN101528772B (zh) Metastin衍生物及其用途
EP0663834A1 (en) Growth hormone releasing peptides
MX2008012649A (es) Sustitutos de aminoacido para constructos peptidicos.
RU2454425C2 (ru) Производные метастина и их применение