BRPI0512397A - composto,produto farmacêutico, métodos para suprimir a metástase de cáncer ou o crescimento do cáncer, para prevenir ou tratar uma doença ou condição, para controlar a função placentária, para melhorar a função gonadal, para induzir ou estimular a ovulação, para promover a secreção do hormÈnio gonadotrópico ou promover a secreção do hormÈnio sexual, para suprimir a secreção do hormÈnio gonadotrópico ou suprimir a secreção do hormÈnio sexual, para infra regular hormÈnio gonadrotópico ou hormÈnio sexual, e a proteìna ot7t175 humana, e para realçar a estabilidade no sangue, uso do composto, e, agente para suprimir a secreção do hormÈnio gonadotrópico ou um agente para suprimir a secreção do hormÈnio sexual - Google Patents
composto,produto farmacêutico, métodos para suprimir a metástase de cáncer ou o crescimento do cáncer, para prevenir ou tratar uma doença ou condição, para controlar a função placentária, para melhorar a função gonadal, para induzir ou estimular a ovulação, para promover a secreção do hormÈnio gonadotrópico ou promover a secreção do hormÈnio sexual, para suprimir a secreção do hormÈnio gonadotrópico ou suprimir a secreção do hormÈnio sexual, para infra regular hormÈnio gonadrotópico ou hormÈnio sexual, e a proteìna ot7t175 humana, e para realçar a estabilidade no sangue, uso do composto, e, agente para suprimir a secreção do hormÈnio gonadotrópico ou um agente para suprimir a secreção do hormÈnio sexualInfo
- Publication number
- BRPI0512397A BRPI0512397A BRPI0512397-6A BRPI0512397A BRPI0512397A BR PI0512397 A BRPI0512397 A BR PI0512397A BR PI0512397 A BRPI0512397 A BR PI0512397A BR PI0512397 A BRPI0512397 A BR PI0512397A
- Authority
- BR
- Brazil
- Prior art keywords
- secretion
- suppressing
- hormone
- gonadotropic
- suppress
- Prior art date
Links
- 230000028327 secretion Effects 0.000 title abstract 10
- 230000001456 gonadotroph Effects 0.000 title abstract 7
- 239000003163 gonadal steroid hormone Substances 0.000 title abstract 6
- 239000005556 hormone Substances 0.000 title abstract 6
- 229940088597 hormone Drugs 0.000 title abstract 6
- 230000005907 cancer growth Effects 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 206010027476 Metastases Diseases 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 230000009401 metastasis Effects 0.000 title abstract 3
- 239000008280 blood Substances 0.000 title abstract 2
- 210000004369 blood Anatomy 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000002710 gonadal effect Effects 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 title 1
- 230000016087 ovulation Effects 0.000 title 1
- 230000003169 placental effect Effects 0.000 title 1
- 230000001737 promoting effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 6
- 230000001568 sexual effect Effects 0.000 abstract 3
- 102000013599 Kisspeptins Human genes 0.000 abstract 1
- 108010012048 Kisspeptins Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- KAHDONZOCXSKII-NJVVDGNHSA-N kisspeptin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)C1=CN=CN1 KAHDONZOCXSKII-NJVVDGNHSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004187671 | 2004-06-25 | ||
| JP2004363311 | 2004-12-15 | ||
| PCT/JP2005/012021 WO2006001499A2 (en) | 2004-06-25 | 2005-06-23 | Metastin derivatives and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0512397A true BRPI0512397A (pt) | 2008-03-04 |
Family
ID=34971534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0512397-6A BRPI0512397A (pt) | 2004-06-25 | 2005-06-23 | composto,produto farmacêutico, métodos para suprimir a metástase de cáncer ou o crescimento do cáncer, para prevenir ou tratar uma doença ou condição, para controlar a função placentária, para melhorar a função gonadal, para induzir ou estimular a ovulação, para promover a secreção do hormÈnio gonadotrópico ou promover a secreção do hormÈnio sexual, para suprimir a secreção do hormÈnio gonadotrópico ou suprimir a secreção do hormÈnio sexual, para infra regular hormÈnio gonadrotópico ou hormÈnio sexual, e a proteìna ot7t175 humana, e para realçar a estabilidade no sangue, uso do composto, e, agente para suprimir a secreção do hormÈnio gonadotrópico ou um agente para suprimir a secreção do hormÈnio sexual |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7625869B2 (https=) |
| EP (2) | EP2113513B1 (https=) |
| JP (3) | JP4346650B2 (https=) |
| CN (2) | CN101845091A (https=) |
| AR (1) | AR049938A1 (https=) |
| AU (1) | AU2005257484A1 (https=) |
| BR (1) | BRPI0512397A (https=) |
| CA (1) | CA2571420A1 (https=) |
| CL (1) | CL2008003730A1 (https=) |
| CR (1) | CR8828A (https=) |
| IL (1) | IL179640A0 (https=) |
| MA (1) | MA28903B1 (https=) |
| MX (1) | MXPA06014206A (https=) |
| NO (1) | NO20065957L (https=) |
| NZ (1) | NZ552029A (https=) |
| PE (2) | PE20060371A1 (https=) |
| RU (1) | RU2006145886A (https=) |
| SG (1) | SG153865A1 (https=) |
| TW (1) | TW200607816A (https=) |
| WO (1) | WO2006001499A2 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
| CN1761680A (zh) | 2002-12-26 | 2006-04-19 | 武田药品工业株式会社 | 肿瘤迁移抑制素衍生物及其用途 |
| CA2518541C (en) | 2003-03-12 | 2013-05-21 | Takeda Pharmaceutical Company Limited | Gonadal function improving agents |
| WO2005113147A2 (en) | 2004-04-08 | 2005-12-01 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| CA2571420A1 (en) | 2004-06-25 | 2006-01-05 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| CN104324362B (zh) | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
| US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| AR058584A1 (es) | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| US8404643B2 (en) * | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| IN2015DN00888A (https=) | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
| WO2007125619A1 (ja) * | 2006-04-26 | 2007-11-08 | Kyoto University | Ｇｐｒ５４アゴニスト活性を有する新規化合物 |
| ITMI20061607A1 (it) | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
| JO3048B1 (ar) * | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| ZA200902452B (en) * | 2006-10-25 | 2010-07-28 | Takeda Pharmaceutical | Metastin derivatives and use thereof |
| EP2277900A4 (en) | 2008-04-24 | 2011-08-03 | Takeda Pharmaceutical | METASTINE DERIVATIVE AND ITS USE |
| EP2275433B1 (en) * | 2008-04-30 | 2017-06-07 | Kyoto University | Metastin derivative and use thereof |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| ES2929343T3 (es) | 2008-06-13 | 2022-11-28 | Mannkind Corp | Inhalador de polvo seco accionado por aspiración para la administración de fármacos |
| KR101628410B1 (ko) | 2008-06-20 | 2016-06-08 | 맨카인드 코포레이션 | 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법 |
| LT2314609T (lt) * | 2008-07-30 | 2017-04-10 | Takeda Pharmaceutical Company Limited | Metastino darinys ir jo panaudojimas |
| JP2012513982A (ja) | 2008-12-29 | 2012-06-21 | 武田薬品工業株式会社 | 癌の予防・治療剤 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| WO2010137022A1 (en) | 2009-05-27 | 2010-12-02 | Yeda Research And Development Co. Ltd | Gpr54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities |
| CN102665690A (zh) | 2009-12-22 | 2012-09-12 | 武田药品工业株式会社 | 缓释制剂 |
| IL223742A (en) | 2010-06-21 | 2016-06-30 | Mannkind Corp | A dry powder inhaler and preparation for it |
| WO2012018639A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| EP2598660B1 (en) | 2010-07-26 | 2017-03-15 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| AU2012236150B2 (en) | 2011-04-01 | 2016-03-31 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
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- 2005-06-23 PE PE2005000728A patent/PE20060371A1/es not_active Application Discontinuation
- 2005-06-23 RU RU2006145886/04A patent/RU2006145886A/ru not_active Application Discontinuation
- 2005-06-23 NZ NZ552029A patent/NZ552029A/en not_active IP Right Cessation
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- 2005-06-23 EP EP09075257.7A patent/EP2113513B1/en not_active Expired - Lifetime
- 2005-06-23 AU AU2005257484A patent/AU2005257484A1/en not_active Abandoned
- 2005-06-23 BR BRPI0512397-6A patent/BRPI0512397A/pt not_active IP Right Cessation
- 2005-06-23 JP JP2006554374A patent/JP4346650B2/ja not_active Expired - Fee Related
- 2005-06-23 EP EP05755666A patent/EP1758932A2/en not_active Withdrawn
- 2005-06-23 MX MXPA06014206A patent/MXPA06014206A/es unknown
- 2005-06-23 WO PCT/JP2005/012021 patent/WO2006001499A2/en not_active Ceased
- 2005-06-23 PE PE2009000637A patent/PE20091567A1/es not_active Application Discontinuation
- 2005-06-23 US US11/630,698 patent/US7625869B2/en not_active Expired - Fee Related
- 2005-06-23 TW TW094120917A patent/TW200607816A/zh unknown
- 2005-06-23 CN CN200910225195A patent/CN101845091A/zh active Pending
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- 2005-06-23 CN CN200910225194A patent/CN101863971A/zh active Pending
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- 2006-12-22 CR CR8828A patent/CR8828A/es not_active Application Discontinuation
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2008
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- 2008-10-01 US US12/286,671 patent/US8778871B2/en active Active
- 2008-12-15 CL CL2008003730A patent/CL2008003730A1/es unknown
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| IL179640A0 (en) | 2007-05-15 |
| EP2113513A2 (en) | 2009-11-04 |
| SG153865A1 (en) | 2009-07-29 |
| JP4346650B2 (ja) | 2009-10-21 |
| WO2006001499A2 (en) | 2006-01-05 |
| AR049938A1 (es) | 2006-09-13 |
| JP2008506632A (ja) | 2008-03-06 |
| US8778871B2 (en) | 2014-07-15 |
| WO2006001499A3 (en) | 2006-03-02 |
| CA2571420A1 (en) | 2006-01-05 |
| MXPA06014206A (es) | 2007-02-14 |
| CN101863971A (zh) | 2010-10-20 |
| RU2006145886A (ru) | 2008-06-27 |
| EP2113513B1 (en) | 2016-05-18 |
| CN101845091A (zh) | 2010-09-29 |
| MA28903B1 (fr) | 2007-10-01 |
| US7625869B2 (en) | 2009-12-01 |
| NO20065957L (no) | 2007-01-25 |
| EP1758932A2 (en) | 2007-03-07 |
| US20080312155A1 (en) | 2008-12-18 |
| JP4654284B2 (ja) | 2011-03-16 |
| JP2009227687A (ja) | 2009-10-08 |
| CR8828A (es) | 2007-07-19 |
| TW200607816A (en) | 2006-03-01 |
| AU2005257484A1 (en) | 2006-01-05 |
| JP2009024028A (ja) | 2009-02-05 |
| PE20060371A1 (es) | 2006-06-15 |
| NZ552029A (en) | 2009-01-31 |
| US20090298765A1 (en) | 2009-12-03 |
| CL2008003730A1 (es) | 2009-05-04 |
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