|
US8133901B2
(en)
|
2006-12-01 |
2012-03-13 |
Actelion Pharmaceuticals Ltd. |
3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl) carbonylpiperidine derivatives as orexin receptor inhibitors
|
|
CL2007003827A1
(es)
*
|
2006-12-28 |
2008-09-26 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
|
|
CL2008000836A1
(es)
*
|
2007-03-26 |
2008-11-07 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras.
|
|
AU2008257411B2
(en)
|
2007-05-23 |
2012-04-26 |
Merck Sharp & Dohme Corp. |
Pyridyl piperidine orexin receptor antagonists
|
|
JP2010528007A
(ja)
*
|
2007-05-23 |
2010-08-19 |
メルク・シャープ・エンド・ドーム・コーポレイション |
シクロプロピルピロリジンオレキシン受容体アンタゴニスト
|
|
US8106215B2
(en)
|
2007-07-03 |
2012-01-31 |
Actelion Pharmaceuticals Ltd. |
3-aza-bicyclo[3.3.0]octane compounds
|
|
US8288429B2
(en)
*
|
2007-07-27 |
2012-10-16 |
Actelion Pharmaceuticals Ltd. |
2-aza-bicyclo[3.3.0]octane derivatives
|
|
AR067665A1
(es)
|
2007-07-27 |
2009-10-21 |
Actelion Pharmaceuticals Ltd |
Derivados de trans-3- aza-biciclo ( 3.1.0) hexano
|
|
WO2009016560A2
(en)
*
|
2007-07-27 |
2009-02-05 |
Actelion Pharmaceuticals Ltd |
Trans-3-aza-bicyclo[3.1.0]hexane derivatives
|
|
EP2025674A1
(de)
|
2007-08-15 |
2009-02-18 |
sanofi-aventis |
Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
US8288411B2
(en)
*
|
2007-09-24 |
2012-10-16 |
Actelion Pharmaceuticals Ltd. |
Pyrrolidines and piperidines as orexin receptor antagonists
|
|
WO2009104155A1
(en)
*
|
2008-02-21 |
2009-08-27 |
Actelion Pharmaceuticals Ltd |
2-aza-bicyclo[2.2.1]heptane derivatives
|
|
JP2011519849A
(ja)
*
|
2008-04-30 |
2011-07-14 |
アクテリオン ファーマシューティカルズ リミテッド |
ピペリジン及びピロリジン化合物
|
|
CN102164896A
(zh)
*
|
2008-10-14 |
2011-08-24 |
埃科特莱茵药品有限公司 |
苯乙基酰胺衍生物及其杂环类似物
|
|
UY32277A
(es)
*
|
2008-12-02 |
2010-05-31 |
Glaxo Group Ltd |
Derivados de n-{[1r,4s,6r)-3-(2-piridinilcarbonil)-3-azabiciclo[4.1.0-il}metil}-2heteroarilamina y uso de los mismos
|
|
CA2745420A1
(en)
|
2008-12-02 |
2010-06-10 |
Glaxo Group Limited |
N-{[(ir,4s,6r-3-(2-pyridinylcarbonyl)-3-azabicyclo [4.1.0] hept-4-yl] methyl}-2-heteroarylamine derivatives and uses thereof
|
|
GB0823467D0
(en)
|
2008-12-23 |
2009-01-28 |
Glaxo Group Ltd |
Novel Compounds
|
|
RU2011124709A
(ru)
*
|
2008-12-29 |
2013-02-10 |
Вандербилт Юниверсити |
ДВУЯДЕРНЫЕ ИНГИБИТОРЫ GlyT1 И СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
|
|
MX2011011127A
(es)
*
|
2009-04-24 |
2011-11-18 |
Glaxo Group Ltd |
3-azabiciclo[4.1.0] heptanos usados como antagonistas de orexina.
|
|
EP2275421A1
(en)
*
|
2009-07-15 |
2011-01-19 |
Rottapharm S.p.A. |
Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
|
|
WO2011023578A1
(en)
|
2009-08-24 |
2011-03-03 |
Glaxo Group Limited |
5-methyl-piperidine derivatives as orexin receptor antagonists for the treatment of sleep disorder
|
|
US20120149711A1
(en)
|
2009-08-24 |
2012-06-14 |
Glaxo Group Limited |
Piperidine derivatives used as orexin antagonists
|
|
US8653263B2
(en)
|
2009-10-23 |
2014-02-18 |
Janssen Pharmaceutica |
Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
|
|
BR112012010752B1
(pt)
*
|
2009-11-05 |
2021-07-20 |
University Of Notre Dame Du Lac |
Compostos imidazo[1,2-a]piridina
|
|
SG181502A1
(en)
*
|
2009-12-29 |
2012-07-30 |
Suven Life Sciences Ltd |
Alpha4beta2 neuronal nicotinic acetylcholine receptor ligands
|
|
EP2626350B1
(en)
*
|
2010-09-22 |
2015-04-15 |
Eisai R&D Management Co., Ltd. |
Cyclopropane compound
|
|
US9242970B2
(en)
*
|
2010-11-10 |
2016-01-26 |
Actelion Pharmaceuticals Ltd. |
Lactam derivatives useful as orexin receptor antagonists
|
|
WO2012089607A1
(en)
|
2010-12-28 |
2012-07-05 |
Glaxo Group Limited |
Novel compounds with a 3a-azabicyclo [4.1.0] heptane core acting on orexin receptors
|
|
WO2012089606A1
(en)
|
2010-12-28 |
2012-07-05 |
Glaxo Group Limited |
Azabicyclo [4.1.0] hept - 4 - yl derivatives as human orexin receptor antagonists
|
|
AR088352A1
(es)
|
2011-10-19 |
2014-05-28 |
Merck Sharp & Dohme |
Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
|
|
ES2672732T3
(es)
*
|
2012-02-07 |
2018-06-15 |
Eolas Therapeutics Inc. |
Prolinas/piperidinas sustituidas como antagonistas del receptor de orexina
|
|
US9440982B2
(en)
|
2012-02-07 |
2016-09-13 |
Eolas Therapeutics, Inc. |
Substituted prolines/piperidines as orexin receptor antagonists
|
|
ITMI20120424A1
(it)
*
|
2012-03-19 |
2013-09-20 |
Rottapharm Spa |
Composti chimici
|
|
MY169986A
(en)
*
|
2012-06-04 |
2019-06-19 |
Idorsia Pharmaceuticals Ltd |
Benzimidazole-proline derivatives
|
|
EP2875029B8
(en)
*
|
2012-07-18 |
2021-12-15 |
University of Notre Dame du Lac |
5,5-heteroaromatic anti-infective compounds
|
|
AR092955A1
(es)
|
2012-10-10 |
2015-05-06 |
Actelion Pharmaceuticals Ltd |
Antagonistas de receptores de orexina los cuales son derivados de [orto bi-(hetero-)aril]-[2-(meta bi-(hetero-)aril)-pirrolidin-1-il]-metanona
|
|
WO2014141065A1
(en)
|
2013-03-12 |
2014-09-18 |
Actelion Pharmaceuticals Ltd |
Azetidine amide derivatives as orexin receptor antagonists
|
|
DK3421458T3
(da)
|
2013-03-14 |
2020-12-14 |
Janssen Pharmaceutica Nv |
Benzo-fusionerede heterocykliske derivater som kan anvendes som agonister af gpr120
|
|
WO2015070253A1
(en)
*
|
2013-11-11 |
2015-05-14 |
Euthymics Bioscience, Inc. |
Novel methods
|
|
NZ721438A
(en)
|
2013-12-03 |
2021-12-24 |
Idorsia Pharmaceuticals Ltd |
Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists
|
|
UA119151C2
(uk)
|
2013-12-03 |
2019-05-10 |
Ідорсія Фармасьютікалз Лтд |
КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
|
|
JP6421185B2
(ja)
|
2013-12-04 |
2018-11-07 |
イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd |
ベンゾイミダゾール−プロリン誘導体の使用
|
|
UY36272A
(es)
|
2014-08-13 |
2016-02-29 |
Eolas Therapeutics Inc |
Difluoropirrolidinas como moduladores de los receptores de orexinas
|
|
WO2016063995A1
(en)
|
2014-10-23 |
2016-04-28 |
Eisai R&D Management Co., Ltd. |
Compositions and methods for treating insomnia
|
|
JP7055378B2
(ja)
|
2015-09-17 |
2022-04-18 |
ユニバーシティ・オブ・ノートル・ダム・デュ・ラック |
マイコバクテリア感染症に対して有用なベンジルアミン含有複素環化合物及び組成物
|
|
TWI710557B
(zh)
|
2016-02-12 |
2020-11-21 |
美商伊歐拉斯治療學公司 |
作為食慾素受體調節劑之經鹵素取代之六氫吡啶
|
|
BR112018067906A2
(pt)
|
2016-03-10 |
2019-01-29 |
Janssen Pharmaceutica Nv |
métodos de tratamento de depressão usando antagonistas do receptor de orexina-2
|
|
WO2017194548A1
(en)
|
2016-05-10 |
2017-11-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
|
|
PT3619199T
(pt)
|
2017-05-03 |
2021-10-01 |
Idorsia Pharmaceuticals Ltd |
Preparação de derivados de ácido 2-([1,2,3]triazol-2-il)- benzoico
|
|
WO2020007964A1
(en)
|
2018-07-05 |
2020-01-09 |
Idorsia Pharmaceuticals Ltd |
2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
|
|
WO2020007977A1
(en)
|
2018-07-06 |
2020-01-09 |
Idorsia Pharmaceuticals Ltd |
7-trifluoromethyl-[1,4]diazepan derivatives
|
|
WO2020099511A1
(en)
|
2018-11-14 |
2020-05-22 |
Idorsia Pharmaceuticals Ltd |
Benzimidazole-2-methyl-morpholine derivatives
|
|
CN116783182B
(zh)
*
|
2021-02-02 |
2025-08-29 |
南京明德新药研发有限公司 |
四氢吡咯并环化合物及其应用
|
|
TW202400149A
(zh)
|
2022-05-13 |
2024-01-01 |
瑞士商愛杜西亞製藥有限公司 |
經噻唑并芳基-甲基取代之環狀肼-n-甲醯胺衍生物
|
|
CN117126101A
(zh)
*
|
2023-08-28 |
2023-11-28 |
瑞博(杭州)医药科技有限公司 |
一种脯氨酸结构的盐酸盐中间体的高效制备方法
|
|
WO2025224168A1
(en)
|
2024-04-24 |
2025-10-30 |
Idorsia Pharmaceuticals Ltd |
Aryl sulfone and sulfanone derivatives as orexin receptor modulators
|