JP2010264253A5 - - Google Patents
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- Publication number
- JP2010264253A5 JP2010264253A5 JP2010134943A JP2010134943A JP2010264253A5 JP 2010264253 A5 JP2010264253 A5 JP 2010264253A5 JP 2010134943 A JP2010134943 A JP 2010134943A JP 2010134943 A JP2010134943 A JP 2010134943A JP 2010264253 A5 JP2010264253 A5 JP 2010264253A5
- Authority
- JP
- Japan
- Prior art keywords
- stent
- argatroban
- coating layer
- polymer
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011247 coating layer Substances 0.000 claims description 32
- 229920000642 polymer Polymers 0.000 claims description 25
- KXNPVXPOPUZYGB-XYVMCAHJSA-N argatroban Chemical group OC(=O)[C@H]1C[C@H](C)CCN1C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NC[C@H](C)C2 KXNPVXPOPUZYGB-XYVMCAHJSA-N 0.000 claims description 24
- 229960003856 argatroban Drugs 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 20
- 229920002988 biodegradable polymer Polymers 0.000 claims description 14
- 239000004621 biodegradable polymer Substances 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 13
- 206010072810 Vascular wall hypertrophy Diseases 0.000 claims description 7
- 239000003112 inhibitor Substances 0.000 claims description 7
- 239000010410 layer Substances 0.000 claims description 7
- XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 claims description 6
- VSKXVGWORBZZDY-UHFFFAOYSA-N 2-hydroxypropanoic acid;oxepan-2-one Chemical compound CC(O)C(O)=O.O=C1CCCCCO1 VSKXVGWORBZZDY-UHFFFAOYSA-N 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- GQLCSJBRVSWWDV-UHFFFAOYSA-N 2-hydroxyacetic acid oxepan-2-one Chemical compound OCC(O)=O.O=C1CCCCCO1 GQLCSJBRVSWWDV-UHFFFAOYSA-N 0.000 claims description 4
- 229920000954 Polyglycolide Polymers 0.000 claims description 4
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 3
- 239000004633 polyglycolic acid Substances 0.000 claims description 3
- 239000004626 polylactic acid Substances 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 5
- 239000012046 mixed solvent Substances 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 3
- 238000007654 immersion Methods 0.000 claims 3
- 239000002953 phosphate buffered saline Substances 0.000 claims 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 229910003460 diamond Inorganic materials 0.000 claims 2
- 239000010432 diamond Substances 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 239000007769 metal material Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 229910000861 Mg alloy Inorganic materials 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000007334 copolymerization reaction Methods 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- YYSFXUWWPNHNAZ-PKJQJFMNSA-N umirolimus Chemical compound C1[C@@H](OC)[C@H](OCCOCC)CC[C@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 YYSFXUWWPNHNAZ-PKJQJFMNSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 1
- 229950009819 zotarolimus Drugs 0.000 claims 1
- 230000009477 glass transition Effects 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 description 2
- HWBWPQJFPHMBHE-UHFFFAOYSA-N OCC(O)=O.O=C1OCCCO1 Chemical compound OCC(O)=O.O=C1OCCCO1 HWBWPQJFPHMBHE-UHFFFAOYSA-N 0.000 description 2
- 208000037976 chronic inflammation Diseases 0.000 description 2
- 230000006020 chronic inflammation Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 229920005570 flexible polymer Polymers 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920000117 poly(dioxanone) Polymers 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010134943A JP5369056B2 (ja) | 2007-09-04 | 2010-06-14 | 薬剤徐放性ステント |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007228788 | 2007-09-04 | ||
| JP2007228788 | 2007-09-04 | ||
| JP2010134943A JP5369056B2 (ja) | 2007-09-04 | 2010-06-14 | 薬剤徐放性ステント |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531112A Division JP5368991B2 (ja) | 2007-09-04 | 2008-09-03 | 薬剤徐放性ステント |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013021873A Division JP5636451B2 (ja) | 2007-09-04 | 2013-02-07 | 薬剤徐放性ステント |
| JP2013021872A Division JP5636450B2 (ja) | 2007-09-04 | 2013-02-07 | 薬剤徐放性ステント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010264253A JP2010264253A (ja) | 2010-11-25 |
| JP2010264253A5 true JP2010264253A5 (enExample) | 2011-10-20 |
| JP5369056B2 JP5369056B2 (ja) | 2013-12-18 |
Family
ID=40428619
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531112A Expired - Fee Related JP5368991B2 (ja) | 2007-09-04 | 2008-09-03 | 薬剤徐放性ステント |
| JP2010134943A Expired - Fee Related JP5369056B2 (ja) | 2007-09-04 | 2010-06-14 | 薬剤徐放性ステント |
| JP2013021872A Expired - Fee Related JP5636450B2 (ja) | 2007-09-04 | 2013-02-07 | 薬剤徐放性ステント |
| JP2013021873A Expired - Fee Related JP5636451B2 (ja) | 2007-09-04 | 2013-02-07 | 薬剤徐放性ステント |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531112A Expired - Fee Related JP5368991B2 (ja) | 2007-09-04 | 2008-09-03 | 薬剤徐放性ステント |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013021872A Expired - Fee Related JP5636450B2 (ja) | 2007-09-04 | 2013-02-07 | 薬剤徐放性ステント |
| JP2013021873A Expired - Fee Related JP5636451B2 (ja) | 2007-09-04 | 2013-02-07 | 薬剤徐放性ステント |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US8409272B2 (enExample) |
| EP (2) | EP2201966A4 (enExample) |
| JP (4) | JP5368991B2 (enExample) |
| KR (2) | KR20100085179A (enExample) |
| CN (2) | CN101940802B (enExample) |
| AU (1) | AU2010202640B2 (enExample) |
| WO (1) | WO2009031295A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100085179A (ko) | 2007-09-04 | 2010-07-28 | 가부시키가이샤 니혼 스텐토 테크놀로지 | 약제 서방성 스텐트 |
| JP5487122B2 (ja) | 2009-02-06 | 2014-05-07 | 学校法人慶應義塾 | 生体の管状器官に使用するステント |
| WO2010101072A1 (ja) | 2009-03-02 | 2010-09-10 | 株式会社日本ステントテクノロジー | 薬剤溶出性ステント |
| US8888840B2 (en) * | 2009-05-20 | 2014-11-18 | Boston Scientific Scimed, Inc. | Drug eluting medical implant |
| EP3858299B1 (en) * | 2009-05-20 | 2025-10-08 | Lyra Therapeutics, Inc. | Method of loading a self-expanding implant |
| US20110319987A1 (en) | 2009-05-20 | 2011-12-29 | Arsenal Medical | Medical implant |
| US9265633B2 (en) | 2009-05-20 | 2016-02-23 | 480 Biomedical, Inc. | Drug-eluting medical implants |
| US9309347B2 (en) | 2009-05-20 | 2016-04-12 | Biomedical, Inc. | Bioresorbable thermoset polyester/urethane elastomers |
| US8992601B2 (en) | 2009-05-20 | 2015-03-31 | 480 Biomedical, Inc. | Medical implants |
| US12213666B2 (en) * | 2010-09-30 | 2025-02-04 | Cilag Gmbh International | Tissue thickness compensator comprising layers |
| US10166128B2 (en) * | 2011-01-14 | 2019-01-01 | W. L. Gore & Associates. Inc. | Lattice |
| CN110075355A (zh) * | 2013-10-22 | 2019-08-02 | 康斯瓦维有限责任公司 | 用于抑制支架型心瓣膜或生物假体的狭窄、阻塞或钙化的方法 |
| JP2015154921A (ja) * | 2014-01-17 | 2015-08-27 | 株式会社日本ステントテクノロジー | 薬剤徐放性ステント |
| JP5695259B1 (ja) | 2014-02-19 | 2015-04-01 | 株式会社World Medish | 高柔軟性ステント |
| US10143779B2 (en) * | 2014-05-16 | 2018-12-04 | Terumo Kabushiki Kaisha | Method of inhibiting thickening of vascular intima |
| JP2016005533A (ja) * | 2014-05-30 | 2016-01-14 | 株式会社日本ステントテクノロジー | ステント |
| TWI721956B (zh) | 2014-10-28 | 2021-03-21 | 日商Jimro股份有限公司 | 藥劑溶出型支架 |
| JP2016163619A (ja) * | 2015-03-06 | 2016-09-08 | 株式会社日本ステントテクノロジー | 防食効果を利用したマグネシウムの分解速度制御 |
| JP2016165375A (ja) * | 2015-03-10 | 2016-09-15 | 株式会社日本ステントテクノロジー | 防食被覆層を有するステントの製造方法 |
| NZ773842A (en) * | 2015-03-16 | 2022-07-01 | Magic Leap Inc | Methods and systems for diagnosing and treating health ailments |
| WO2016163339A1 (ja) * | 2015-04-07 | 2016-10-13 | 二プロ株式会社 | ステント |
| JP6558569B2 (ja) * | 2015-05-21 | 2019-08-14 | ニプロ株式会社 | ステント |
| WO2017090747A1 (ja) * | 2015-11-26 | 2017-06-01 | 株式会社日本医療機器技研 | 生体吸収性ステント |
| WO2017143302A1 (en) * | 2016-02-17 | 2017-08-24 | Brigham Young University | Multi-stage stent devices and associated methods |
| CN109374558A (zh) * | 2018-12-11 | 2019-02-22 | 山东吉威医疗制品有限公司 | 一种无聚合物药物涂层洗脱支架体外释放度的测定方法 |
| EP3998049B1 (en) | 2019-07-09 | 2024-08-21 | Otsuka Medical Devices Co., Ltd. | Drug-eluting stent |
| CN110665072A (zh) * | 2019-11-23 | 2020-01-10 | 吉林省蔚来生物科技有限公司 | 一种靶向药物释放介入类医疗器械及其制备方法 |
| US11654036B2 (en) * | 2020-05-26 | 2023-05-23 | Elixir Medical Corporation | Anticoagulant compounds and methods and devices for their use |
| WO2021242783A1 (en) * | 2020-05-26 | 2021-12-02 | Elixir Medical Corporation | Anticoagulant compounds and methods and devices for their use |
| WO2022034905A1 (ja) | 2020-08-12 | 2022-02-17 | 康宏 正林 | ステント |
| CN114159197B (zh) * | 2022-02-14 | 2022-05-17 | 北京美中双和医疗器械股份有限公司 | 一种可降解生物医用镁合金药物洗脱血管支架及制备方法 |
| US20240342348A1 (en) * | 2023-04-12 | 2024-10-17 | Boston Scientific Scimed, Inc. | Medical devices including therapeutic coatings for local delivery of a direct anticoagulant |
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| JP3110931B2 (ja) | 1993-12-28 | 2000-11-20 | 第一製薬株式会社 | 平滑筋細胞増殖抑制作用を有するアルガトロバン製剤 |
| US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
| US7357942B2 (en) * | 1997-09-26 | 2008-04-15 | Abbott Laboratories | Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens |
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| WO2007032777A2 (en) | 2005-03-23 | 2007-03-22 | Abbott Laboratories | Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy |
| JP5285426B2 (ja) | 2005-10-14 | 2013-09-11 | アボット ラボラトリーズ | 医療デバイスを用いて、パクリタキセルとともにラパマイシン類似体を投与することについての組成物、システム、キット及び方法 |
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| JP4066440B2 (ja) | 2006-05-17 | 2008-03-26 | トーヨーエイテック株式会社 | ダイヤモンド様薄膜を備えた医療器具及びその製造方法 |
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| KR20100085179A (ko) * | 2007-09-04 | 2010-07-28 | 가부시키가이샤 니혼 스텐토 테크놀로지 | 약제 서방성 스텐트 |
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2008
- 2008-09-03 KR KR1020107013253A patent/KR20100085179A/ko not_active Abandoned
- 2008-09-03 CN CN201010267157.2A patent/CN101940802B/zh not_active Expired - Fee Related
- 2008-09-03 US US12/733,460 patent/US8409272B2/en not_active Expired - Fee Related
- 2008-09-03 JP JP2009531112A patent/JP5368991B2/ja not_active Expired - Fee Related
- 2008-09-03 KR KR20107007202A patent/KR20100068412A/ko not_active Abandoned
- 2008-09-03 CN CN200880105243.4A patent/CN101795719B/zh not_active Expired - Fee Related
- 2008-09-03 WO PCT/JP2008/002410 patent/WO2009031295A1/ja not_active Ceased
- 2008-09-03 EP EP08829751.0A patent/EP2201966A4/en not_active Withdrawn
- 2008-09-03 EP EP20100164082 patent/EP2258414A3/en not_active Withdrawn
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2010
- 2010-06-02 US US12/801,307 patent/US20100249914A1/en not_active Abandoned
- 2010-06-14 JP JP2010134943A patent/JP5369056B2/ja not_active Expired - Fee Related
- 2010-06-24 AU AU2010202640A patent/AU2010202640B2/en not_active Ceased
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2012
- 2012-06-08 US US13/492,290 patent/US8641756B2/en not_active Expired - Fee Related
- 2012-07-30 US US13/561,828 patent/US8968392B2/en not_active Expired - Fee Related
- 2012-12-28 US US13/729,630 patent/US9040111B2/en not_active Expired - Fee Related
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2013
- 2013-02-07 JP JP2013021872A patent/JP5636450B2/ja not_active Expired - Fee Related
- 2013-02-07 JP JP2013021873A patent/JP5636451B2/ja not_active Expired - Fee Related
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