WO2009031295A1 - 薬剤徐放性ステント - Google Patents

薬剤徐放性ステント Download PDF

Info

Publication number
WO2009031295A1
WO2009031295A1 PCT/JP2008/002410 JP2008002410W WO2009031295A1 WO 2009031295 A1 WO2009031295 A1 WO 2009031295A1 JP 2008002410 W JP2008002410 W JP 2008002410W WO 2009031295 A1 WO2009031295 A1 WO 2009031295A1
Authority
WO
WIPO (PCT)
Prior art keywords
stent
polymer
coating layer
weight
argatoroban
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/002410
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
Ikuo Omura
Zhen Yu Jin
Shuzo Yamashita
Hiroo Iwata
Akira Mochizuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Advanced Technologies Co Ltd
Japan Stent Technology Co Ltd
Tokai University Educational System
Original Assignee
Toyo Advanced Technologies Co Ltd
Japan Stent Technology Co Ltd
Tokai University Educational System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2008294278A priority Critical patent/AU2008294278C1/en
Priority to CN200880105243.4A priority patent/CN101795719B/zh
Priority to EP08829751.0A priority patent/EP2201966A4/en
Priority to JP2009531112A priority patent/JP5368991B2/ja
Priority to US12/733,460 priority patent/US8409272B2/en
Application filed by Toyo Advanced Technologies Co Ltd, Japan Stent Technology Co Ltd, Tokai University Educational System filed Critical Toyo Advanced Technologies Co Ltd
Publication of WO2009031295A1 publication Critical patent/WO2009031295A1/ja
Anticipated expiration legal-status Critical
Priority to US12/801,307 priority patent/US20100249914A1/en
Priority to AU2010202640A priority patent/AU2010202640B2/en
Priority to US13/492,290 priority patent/US8641756B2/en
Priority to US13/561,828 priority patent/US8968392B2/en
Priority to US13/729,630 priority patent/US9040111B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541—Adjacent bands are arranged out of phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PCT/JP2008/002410 2007-09-04 2008-09-03 薬剤徐放性ステント Ceased WO2009031295A1 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2008294278A AU2008294278C1 (en) 2007-09-04 2008-09-03 Stent for controlled drug release
CN200880105243.4A CN101795719B (zh) 2007-09-04 2008-09-03 药物缓释性支架
EP08829751.0A EP2201966A4 (en) 2007-09-04 2008-09-03 STENT FOR THE CONTROLLED RELEASE OF MEDICAMENTS
JP2009531112A JP5368991B2 (ja) 2007-09-04 2008-09-03 薬剤徐放性ステント
US12/733,460 US8409272B2 (en) 2007-09-04 2008-09-03 Sustained drug-releasing stent
US12/801,307 US20100249914A1 (en) 2007-09-04 2010-06-02 Sustained drug-releasing stent
AU2010202640A AU2010202640B2 (en) 2007-09-04 2010-06-24 Sustained drug-releasing stent
US13/492,290 US8641756B2 (en) 2007-09-04 2012-06-08 Sustained drug-releasing stent
US13/561,828 US8968392B2 (en) 2007-09-04 2012-07-30 Method of inhibiting vascular intimal hyperplasia using stent
US13/729,630 US9040111B2 (en) 2007-09-04 2012-12-28 Method of making a stent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-228788 2007-09-04
JP2007228788 2007-09-04

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US12/733,460 A-371-Of-International US8409272B2 (en) 2007-09-04 2008-09-03 Sustained drug-releasing stent
US73346010A Continuation 2007-09-04 2010-03-03
US12/801,307 Continuation US20100249914A1 (en) 2007-09-04 2010-06-02 Sustained drug-releasing stent
US13/492,290 Continuation US8641756B2 (en) 2007-09-04 2012-06-08 Sustained drug-releasing stent
US13/729,630 Division US9040111B2 (en) 2007-09-04 2012-12-28 Method of making a stent

Publications (1)

Publication Number Publication Date
WO2009031295A1 true WO2009031295A1 (ja) 2009-03-12

Family

ID=40428619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002410 Ceased WO2009031295A1 (ja) 2007-09-04 2008-09-03 薬剤徐放性ステント

Country Status (7)

Country Link
US (5) US8409272B2 (enExample)
EP (2) EP2201966A4 (enExample)
JP (4) JP5368991B2 (enExample)
KR (2) KR20100068412A (enExample)
CN (2) CN101795719B (enExample)
AU (1) AU2010202640B2 (enExample)
WO (1) WO2009031295A1 (enExample)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010090348A1 (ja) 2009-02-06 2010-08-12 学校法人慶應義塾 生体の管状器官に使用するステント
US8591571B2 (en) 2009-03-02 2013-11-26 Japan Stent Technology Co., Ltd. Drug-eluting stent
US8641756B2 (en) 2007-09-04 2014-02-04 Japan Stent Technology Co., Ltd. Sustained drug-releasing stent
WO2015125320A1 (ja) 2014-02-19 2015-08-27 株式会社Ｗｏｒｌｄ Ｍｅｄｉｓｈ 高柔軟性ステント
JP2016005533A (ja) * 2014-05-30 2016-01-14 株式会社日本ステントテクノロジー ステント
JP2017521114A (ja) * 2014-05-16 2017-08-03 テルモ株式会社 下肢末梢動脈疾患の治療方法
WO2022034905A1 (ja) 2020-08-12 2022-02-17 康宏 正林 ステント
JP2023527328A (ja) * 2020-05-26 2023-06-28 エリクシアー メディカル コーポレイション 抗凝固化合物ならびにその使用のための方法およびデバイス
US20240398593A1 (en) * 2022-02-14 2024-12-05 Amsinomed Medical Co., Ltd Degradable biomedical magnesium alloy drug-eluting vascular stent and preparation method

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110319987A1 (en) 2009-05-20 2011-12-29 Arsenal Medical Medical implant
US8992601B2 (en) 2009-05-20 2015-03-31 480 Biomedical, Inc. Medical implants
US8888840B2 (en) * 2009-05-20 2014-11-18 Boston Scientific Scimed, Inc. Drug eluting medical implant
EP3858299B1 (en) * 2009-05-20 2025-10-08 Lyra Therapeutics, Inc. Method of loading a self-expanding implant
US9309347B2 (en) 2009-05-20 2016-04-12 Biomedical, Inc. Bioresorbable thermoset polyester/urethane elastomers
US9265633B2 (en) 2009-05-20 2016-02-23 480 Biomedical, Inc. Drug-eluting medical implants
US12213666B2 (en) * 2010-09-30 2025-02-04 Cilag Gmbh International Tissue thickness compensator comprising layers
US10166128B2 (en) * 2011-01-14 2019-01-01 W. L. Gore & Associates. Inc. Lattice
EP3060174B1 (en) * 2013-10-22 2020-05-27 Concievalve LLC Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis
JP2015154921A (ja) * 2014-01-17 2015-08-27 株式会社日本ステントテクノロジー 薬剤徐放性ステント
CN110711056A (zh) * 2014-10-28 2020-01-21 株式会社Jimro 药物洗脱支架
JP2016163619A (ja) * 2015-03-06 2016-09-08 株式会社日本ステントテクノロジー 防食効果を利用したマグネシウムの分解速度制御
JP2016165375A (ja) * 2015-03-10 2016-09-15 株式会社日本ステントテクノロジー 防食被覆層を有するステントの製造方法
KR102630754B1 (ko) * 2015-03-16 2024-01-26 매직 립, 인코포레이티드 증강 현실 펄스 옥시미트리
JP6558569B2 (ja) * 2015-05-21 2019-08-14 ニプロ株式会社 ステント
WO2016163339A1 (ja) * 2015-04-07 2016-10-13 二プロ株式会社 ステント
AU2016361380B2 (en) 2015-11-26 2021-04-08 Japan Medical Device Technology Co., Ltd. Bioabsorbable stent
WO2017143302A1 (en) * 2016-02-17 2017-08-24 Brigham Young University Multi-stage stent devices and associated methods
CN109374558A (zh) * 2018-12-11 2019-02-22 山东吉威医疗制品有限公司 一种无聚合物药物涂层洗脱支架体外释放度的测定方法
CN114051417A (zh) 2019-07-09 2022-02-15 大塚医疗器械有限公司 药剂溶出型支架
CN110665072A (zh) * 2019-11-23 2020-01-10 吉林省蔚来生物科技有限公司 一种靶向药物释放介入类医疗器械及其制备方法
US11654036B2 (en) * 2020-05-26 2023-05-23 Elixir Medical Corporation Anticoagulant compounds and methods and devices for their use
WO2024215886A1 (en) * 2023-04-12 2024-10-17 Boston Scientific Scimed, Inc. Medical devices including therapeutic coatings for local delivery of a direct anticoagulant

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07196650A (ja) * 1993-12-28 1995-08-01 Dai Ichi Seiyaku Co Ltd 平滑筋細胞増殖抑制作用を有するアルガトロバン製剤
JP2001190687A (ja) 2000-01-07 2001-07-17 Kawasumi Lab Inc ステント及びステントグラフト
JP2003024452A (ja) * 2001-07-16 2003-01-28 Kawasumi Lab Inc ステント及びステントグラフト
WO2004022150A1 (ja) * 2002-08-23 2004-03-18 Japan As Represented By President Of National Cardiovascular Center ステント及びその製造方法
JP3605388B2 (ja) 2001-10-16 2004-12-22 川澄化学工業株式会社 ステント
JP3654627B2 (ja) 2000-04-20 2005-06-02 川澄化学工業株式会社 ステント
WO2007058190A1 (ja) 2005-11-16 2007-05-24 Tokai University Educational System 薬剤放出制御組成物および薬剤放出性医療器具
JP4066440B2 (ja) 2006-05-17 2008-03-26 トーヨーエイテック株式会社 ダイヤモンド様薄膜を備えた医療器具及びその製造方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US7357942B2 (en) * 1997-09-26 2008-04-15 Abbott Laboratories Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens
US7378105B2 (en) * 1997-09-26 2008-05-27 Abbott Laboratories Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens
WO2000015271A1 (fr) 1998-09-14 2000-03-23 Kawasumi Laboratories, Inc. Stent intravasculaire
US6953560B1 (en) * 2000-09-28 2005-10-11 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US7771468B2 (en) 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
EP1399094A4 (en) 2001-03-16 2004-07-28 Sts Biopolymers Inc MEDICAL STENT WITH MULTILAYERED POLYMER COVER
WO2002080996A1 (de) 2001-04-03 2002-10-17 Franz Herbst Medizinisches implantat und verfahren zu seiner herstellung
US20020168393A1 (en) 2001-05-08 2002-11-14 Ryota Sugimoto Implantable medical material and implantable medical device
JP2003033439A (ja) 2001-07-24 2003-02-04 Terumo Corp コーティングステントおよびその製造方法
WO2003034944A1 (de) * 2001-10-15 2003-05-01 Hemoteq Gmbh Beschichtung von stents zur verhinderung von restenose
US20060093771A1 (en) 2002-02-15 2006-05-04 Frantisek Rypacek Polymer coating for medical devices
AU2003215495B2 (en) 2002-02-15 2008-08-14 Gilead Palo Alto, Inc. Polymer coating for medical devices
EP1501566B1 (de) 2002-05-09 2008-08-13 Hemoteq AG Hemokompatibel beschichtete medizinprodukte, deren herstellung und verwendung
US7396539B1 (en) * 2002-06-21 2008-07-08 Advanced Cardiovascular Systems, Inc. Stent coatings with engineered drug release rate
US7033602B1 (en) * 2002-06-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
DE10237572A1 (de) * 2002-08-13 2004-02-26 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Stent mit polymerer Beschichtung
US8221495B2 (en) * 2002-11-07 2012-07-17 Abbott Laboratories Integration of therapeutic agent into a bioerodible medical device
JP4261222B2 (ja) 2003-03-06 2009-04-30 川澄化学工業株式会社 薬剤放出ステント
US7625399B2 (en) * 2003-04-24 2009-12-01 Cook Incorporated Intralumenally-implantable frames
JP2005170801A (ja) 2003-12-08 2005-06-30 Nipro Corp 被覆ステント
CA2558141C (en) * 2004-02-28 2012-03-06 Hemoteq Gmbh Biocompatible coating, method and use of medical surfaces
JP2007195883A (ja) * 2006-01-30 2007-08-09 Toyo Advanced Technologies Co Ltd ステント及びその製造方法
US8435287B2 (en) * 2004-03-30 2013-05-07 Toyo Advanced Technologies Co., Ltd. Stent and method for fabricating the same
JP2007236399A (ja) 2004-04-08 2007-09-20 Japan Stent Technology Co Ltd ポリマー被覆型ステント
US7229471B2 (en) * 2004-09-10 2007-06-12 Advanced Cardiovascular Systems, Inc. Compositions containing fast-leaching plasticizers for improved performance of medical devices
US7632307B2 (en) * 2004-12-16 2009-12-15 Advanced Cardiovascular Systems, Inc. Abluminal, multilayer coating constructs for drug-delivery stents
WO2007032777A2 (en) 2005-03-23 2007-03-22 Abbott Laboratories Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
WO2007046935A2 (en) 2005-10-14 2007-04-26 Abbott Laboratories Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices
US10029034B2 (en) 2005-12-15 2018-07-24 CARDINAL HEALTH SWITZERLAND 515 GmbH Drug-eluting articles with improved drug release profiles
JP4297221B2 (ja) 2006-02-15 2009-07-15 株式会社ホソカワ粉体技術研究所 薬剤溶出型ステントの製造方法
JP5217026B2 (ja) * 2006-02-28 2013-06-19 株式会社日本ステントテクノロジー ステント及びその製造方法
WO2007148714A1 (ja) 2006-06-21 2007-12-27 Kaneka Corporation リファマイシン誘導体を用いたインプラント
JP5288370B2 (ja) 2006-12-27 2013-09-11 独立行政法人産業技術総合研究所 生理活性物質を含む樹脂組成物とその製造方法
CN101795719B (zh) 2007-09-04 2014-07-09 株式会社日本斯滕特技术 药物缓释性支架

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07196650A (ja) * 1993-12-28 1995-08-01 Dai Ichi Seiyaku Co Ltd 平滑筋細胞増殖抑制作用を有するアルガトロバン製剤
JP2001190687A (ja) 2000-01-07 2001-07-17 Kawasumi Lab Inc ステント及びステントグラフト
JP3654627B2 (ja) 2000-04-20 2005-06-02 川澄化学工業株式会社 ステント
JP2003024452A (ja) * 2001-07-16 2003-01-28 Kawasumi Lab Inc ステント及びステントグラフト
JP3605388B2 (ja) 2001-10-16 2004-12-22 川澄化学工業株式会社 ステント
WO2004022150A1 (ja) * 2002-08-23 2004-03-18 Japan As Represented By President Of National Cardiovascular Center ステント及びその製造方法
WO2007058190A1 (ja) 2005-11-16 2007-05-24 Tokai University Educational System 薬剤放出制御組成物および薬剤放出性医療器具
JP4066440B2 (ja) 2006-05-17 2008-03-26 トーヨーエイテック株式会社 ダイヤモンド様薄膜を備えた医療器具及びその製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2201966A4

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8641756B2 (en) 2007-09-04 2014-02-04 Japan Stent Technology Co., Ltd. Sustained drug-releasing stent
US8968392B2 (en) 2007-09-04 2015-03-03 Japan Stent Technology Co., Ltd. Method of inhibiting vascular intimal hyperplasia using stent
US9040111B2 (en) 2007-09-04 2015-05-26 Japan Stent Technology Co., Ltd. Method of making a stent
WO2010090348A1 (ja) 2009-02-06 2010-08-12 学校法人慶應義塾 生体の管状器官に使用するステント
US8591571B2 (en) 2009-03-02 2013-11-26 Japan Stent Technology Co., Ltd. Drug-eluting stent
WO2015125320A1 (ja) 2014-02-19 2015-08-27 株式会社Ｗｏｒｌｄ Ｍｅｄｉｓｈ 高柔軟性ステント
JP2017521114A (ja) * 2014-05-16 2017-08-03 テルモ株式会社 下肢末梢動脈疾患の治療方法
JP2016005533A (ja) * 2014-05-30 2016-01-14 株式会社日本ステントテクノロジー ステント
JP2023527328A (ja) * 2020-05-26 2023-06-28 エリクシアー メディカル コーポレイション 抗凝固化合物ならびにその使用のための方法およびデバイス
WO2022034905A1 (ja) 2020-08-12 2022-02-17 康宏 正林 ステント
US20240398593A1 (en) * 2022-02-14 2024-12-05 Amsinomed Medical Co., Ltd Degradable biomedical magnesium alloy drug-eluting vascular stent and preparation method
US12409053B2 (en) * 2022-02-14 2025-09-09 Amsinomed Medical Co., Ltd Degradable biomedical magnesium alloy drug-eluting vascular stent and preparation method

Also Published As

Publication number Publication date
AU2008294278A1 (en) 2009-03-12
AU2008294278B2 (en) 2013-01-10
JP5369056B2 (ja) 2013-12-18
AU2008294278A8 (en) 2010-04-08
US20120310329A1 (en) 2012-12-06
AU2010202640A1 (en) 2010-07-15
US9040111B2 (en) 2015-05-26
EP2258414A2 (en) 2010-12-08
US8968392B2 (en) 2015-03-03
US20130115363A1 (en) 2013-05-09
JP2013126558A (ja) 2013-06-27
US20130018455A1 (en) 2013-01-17
EP2201966A1 (en) 2010-06-30
US8641756B2 (en) 2014-02-04
EP2201966A4 (en) 2013-06-26
CN101940802B (zh) 2015-02-04
US20100198344A1 (en) 2010-08-05
KR20100085179A (ko) 2010-07-28
JP5368991B2 (ja) 2013-12-18
AU2010202640B2 (en) 2013-01-10
JP2010264253A (ja) 2010-11-25
CN101795719B (zh) 2014-07-09
EP2258414A3 (en) 2014-08-27
JPWO2009031295A1 (ja) 2010-12-09
KR20100068412A (ko) 2010-06-23
US20100249914A1 (en) 2010-09-30
US8409272B2 (en) 2013-04-02
JP5636450B2 (ja) 2014-12-03
JP5636451B2 (ja) 2014-12-03
CN101795719A (zh) 2010-08-04
CN101940802A (zh) 2011-01-12
JP2013126557A (ja) 2013-06-27

Similar Documents

Publication Publication Date Title
WO2009031295A1 (ja) 薬剤徐放性ステント
WO2009059098A3 (en) Endoprosthesis coating
WO2007143351A3 (en) Implantable medical endoprostheses
WO2007130734A3 (en) Antimicrobial coating
WO2007100486A3 (en) Antifriction coatings, methods of producing such coatings and articles including such coatings
WO2008022803A3 (en) Extrusion coated substrate
WO2007100653A8 (en) Removable antimicrobial coating compositions and methods of use
WO2009097968A3 (de) Offenporige biokompatible oberflächenschicht für ein implantat, verfahren zur herstellung und verwendung
WO2010025078A3 (en) Endoprostheses with porous regions and non-polymeric coating
WO2007065720A3 (en) Hydrophilic coating composition for urinary catheter
WO2007048098A3 (en) Erosion resistant coatings
WO2010015709A3 (de) Wirkstoffhaltige fasernflächengebilde mit einstellbarer wirkstofffreisetzung, ihre anwendungen und verfahren zu ihrer herstellung
WO2007084361A3 (en) Coated medical devices and methods of making the same
WO2009064879A3 (en) Antimicrobial coatings for medical devices and methods for making and using them
EP1911468A3 (en) Antimicrobial implant
WO2007143609A3 (en) Use of plasma in formation of biodegradable stent coating
WO2006127946A3 (en) Multi-functional coatings on microporous substrates
WO2006020708A3 (en) Biologically-active adhesive articles and methods of manufacture
WO2008003298A3 (de) Herstellung, verfahren und verwendung von wirkstofffreisetzenden medizinprodukten zur permanenten offenhaltung von blutgefässen
WO2008034047A3 (en) Endoprosthesis with adjustable surface features
WO2010004396A3 (en) Friction- and wear-reducing coating
WO2009059166A3 (en) Endoprosthesis with porous reservoir and non-polymer diffusion layer
WO2006034145A3 (en) Flexible hydraulic compositions
WO2007058969A3 (en) Brazing material with continuous length layer of elastomer containing a flux
WO2007021844A3 (en) Coated substrate with properties of keratinous tissue

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880105243.4

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08829751

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009531112

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 1414/DELNP/2010

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 12733460

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008294278

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2008829751

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2008294278

Country of ref document: AU

Date of ref document: 20080903

Kind code of ref document: A

Ref document number: 20107007202

Country of ref document: KR

Kind code of ref document: A