JP2010248252A5

JP2010248252A5 -

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Publication number: JP2010248252A5
Authority: JP; Japan
Prior art keywords: inhibitor; less; dpiv; immunosuppression; inhibitor according
Prior art date: 2010-07-30
Legal status : Pending

Application number

JP2010172818A

Other languages

English (en)

Japanese (ja)

Other versions

JP2010248252A (ja

Filing date

2010-07-30

Publication date

2012-02-16

2010-07-30 Application filed filed Critical

2010-11-04 Publication of JP2010248252A publication Critical patent/JP2010248252A/ja

2012-02-16 Publication of JP2010248252A5 publication Critical patent/JP2010248252A5/ja

Status Pending legal-status Critical Current

Links

239000003112 inhibitor Substances 0.000 claims 34
102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims 11
101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims 11
206010062016 Immunosuppression Diseases 0.000 claims 6
230000001506 immunosuppresive effect Effects 0.000 claims 6
230000004153 glucose metabolism Effects 0.000 claims 4
230000005764 inhibitory process Effects 0.000 claims 4
208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 3
210000000987 immune system Anatomy 0.000 claims 3
150000003839 salts Chemical class 0.000 claims 3
239000007909 solid dosage form Substances 0.000 claims 3
101800000224 Glucagon-like peptide 1 Proteins 0.000 claims 2
241000282412 Homo Species 0.000 claims 2
102100040918 Pro-glucagon Human genes 0.000 claims 2
230000004075 alteration Effects 0.000 claims 2
230000004060 metabolic process Effects 0.000 claims 2
239000003826 tablet Substances 0.000 claims 2
239000002775 capsule Substances 0.000 claims 1
230000002401 inhibitory effect Effects 0.000 claims 1
239000006187 pill Substances 0.000 claims 1
GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims 1
230000017854 proteolysis Effects 0.000 claims 1

JP2010172818A 1998-02-02 2010-07-30 グルコース代謝を調節する方法、およびそれに関連する試薬 Pending JP2010248252A (ja)