JP2009531276A5 - - Google Patents
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- JP2009531276A5 JP2009531276A5 JP2008548032A JP2008548032A JP2009531276A5 JP 2009531276 A5 JP2009531276 A5 JP 2009531276A5 JP 2008548032 A JP2008548032 A JP 2008548032A JP 2008548032 A JP2008548032 A JP 2008548032A JP 2009531276 A5 JP2009531276 A5 JP 2009531276A5
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- acid
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- cancer
- amino
- syndrome
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- 0 **N(*)c1c(*)[n]nc1C1=NC(*)=C(*)*1 Chemical compound **N(*)c1c(*)[n]nc1C1=NC(*)=C(*)*1 0.000 description 8
- UZXACZRAUVKJFI-UHFFFAOYSA-N Cc1nc(cc(c(OC)c2)OC)c2[nH]1 Chemical compound Cc1nc(cc(c(OC)c2)OC)c2[nH]1 UZXACZRAUVKJFI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75533905P | 2005-12-30 | 2005-12-30 | |
| US60/755,339 | 2005-12-30 | ||
| GB0526607.7 | 2005-12-30 | ||
| GB0526607A GB0526607D0 (en) | 2005-12-30 | 2005-12-30 | Pharmaceutical compounds |
| US80621806P | 2006-06-29 | 2006-06-29 | |
| US60/806,218 | 2006-06-29 | ||
| PCT/GB2006/004954 WO2007077435A1 (en) | 2005-12-30 | 2006-12-29 | Pharmaceutical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531276A JP2009531276A (ja) | 2009-09-03 |
| JP2009531276A5 true JP2009531276A5 (enExample) | 2010-02-18 |
| JP5474354B2 JP5474354B2 (ja) | 2014-04-16 |
Family
ID=38006842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548032A Expired - Fee Related JP5474354B2 (ja) | 2005-12-30 | 2006-12-29 | 医薬化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8399442B2 (enExample) |
| EP (1) | EP1968579A1 (enExample) |
| JP (1) | JP5474354B2 (enExample) |
| WO (1) | WO2007077435A1 (enExample) |
Families Citing this family (63)
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| US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
| GB0720113D0 (en) * | 2007-10-15 | 2007-11-28 | Cambridge Cancer Diagnostics L | Diagnostic, prognostic and predictive testing for cancer |
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| HRP20151258T1 (hr) | 2009-08-07 | 2016-02-26 | Chugai Seiyaku Kabushiki Kaisha | Derivat aminopirazola |
| CA2794801C (en) | 2010-04-07 | 2019-01-15 | F. Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| WO2011143479A1 (en) * | 2010-05-12 | 2011-11-17 | Merial Limited | Injectable parasiticidal formulations of levamisole and macrocyclic lactones |
| US10006089B2 (en) | 2011-03-02 | 2018-06-26 | Beth Israel Deaconess Medical Center, Inc. | MCL-1 as a therapeutic target in SCFFBW7 deficient neoplasm |
| EP2760857A1 (en) | 2011-09-27 | 2014-08-06 | F.Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| WO2013063560A2 (en) * | 2011-10-27 | 2013-05-02 | New York University | INHIBITION OF c-MYC UBIQUITINATION TO PREVENT CANCER INITIATION AND PROGRESSION |
| CN108424456B (zh) | 2011-11-23 | 2022-04-26 | 医学免疫有限责任公司 | 特异于her3的结合分子及其用途 |
| EP2636752A1 (en) * | 2012-03-06 | 2013-09-11 | Universiteit Maastricht | In vitro method for determining disease outcome in pulmonary carcinoids. |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| US20150203589A1 (en) | 2012-07-24 | 2015-07-23 | The Trustees Of Columbia University In The City Of New York | Fusion proteins and methods thereof |
| BR112015004427A2 (pt) * | 2012-10-26 | 2017-07-04 | Hoffmann La Roche | compostos , métodos para o tratamento de um estado inflamatório , da artrite reumatóide , da asma , de um distúrbio imunológico e de um distúrbio imune e composição farmacêutica |
| PL403149A1 (pl) * | 2013-03-14 | 2014-09-15 | Celon Pharma Spółka Akcyjna | Nowe związki pochodne pirazolilobenzo[d]imidazolu |
| CA3280124A1 (en) | 2013-07-31 | 2025-10-31 | Avalyn Pharma Inc. | Aerosol imatinib compounds and uses thereof |
| US11305012B2 (en) | 2013-09-24 | 2022-04-19 | Medimmune, Llc | Binding molecules specific for HER3 and uses thereof |
| WO2015099127A1 (ja) | 2013-12-27 | 2015-07-02 | 中外製薬株式会社 | Fgfrゲートキーパー変異遺伝子およびそれを標的とする医薬 |
| ES2913339T3 (es) * | 2014-01-31 | 2022-06-01 | Draka Elevator Products Inc | Dispositivo sensor de detección sísmica para equipo de transporte vertical |
| US10745490B2 (en) | 2014-04-11 | 2020-08-18 | Celldex Therapeutics, Inc. | Anti-ErbB antibodies and methods of use thereof |
| KR20170012332A (ko) * | 2014-06-20 | 2017-02-02 | 아비라겐 테라퓨틱스, 인코포레이티드 | [2-[1-(6-메틸-3-피리다지닐)-4-피페리디닐]에톡시]-3-에톡시-1,2-벤즈이속사졸의 무수 결정성 유리 염기 형태 |
| RS63364B1 (sr) | 2014-08-11 | 2022-07-29 | Acerta Pharma Bv | Terapeutske kombinacije btk inhibitora, pd-1 inhibitora i/ili pd-l1 inhibitora |
| WO2016024232A1 (en) | 2014-08-11 | 2016-02-18 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor and/or a cdk 4/6 inhibitor |
| SMT202100674T1 (it) | 2014-08-11 | 2022-01-10 | Acerta Pharma Bv | Combinazioni terapeutiche di un inibitore di btk e un inibitore di bcl-2 |
| TWI746426B (zh) | 2014-11-16 | 2021-11-21 | 美商亞雷生物製藥股份有限公司 | (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型 |
| JP6762300B2 (ja) | 2015-06-17 | 2020-09-30 | 中外製薬株式会社 | アミノピラゾール誘導体 |
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| UA125025C2 (uk) | 2016-04-04 | 2021-12-29 | Локсо Онколоджі, Інк. | Способи лікування дитячих ракових захворювань |
| UA125026C2 (uk) | 2016-04-04 | 2021-12-29 | Локсо Онколоджі, Інк. | РІДКІ КОМПОЗИЦІЇ (S)-N-(5-((R)-2-(2,5-ДИФТОРФЕНІЛ)ПІРОЛІДИН-1-ІЛ)ПІРАЗОЛО[1,5-a]ПІРИМІДИН-3-ІЛ)-3-ГІДРОКСИПІРОЛІДИН-1-КАРБОКСАМІДУ |
| MX392604B (es) | 2016-05-18 | 2025-03-24 | Array Biopharma Inc | Procesos para la preparacion de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo. |
| MY199242A (en) | 2016-06-01 | 2023-10-22 | Samumed Llc | Process for preparing n-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| TWI752098B (zh) | 2016-10-10 | 2022-01-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JP6888101B2 (ja) | 2017-01-18 | 2021-06-16 | アレイ バイオファーマ インコーポレイテッド | RETキナーゼ阻害剤としての置換ピラゾロ[1,5−a]ピラジン化合物 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| JP2020510061A (ja) * | 2017-03-14 | 2020-04-02 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ピラゾロクロロフェニル化合物、組成物及びその使用方法 |
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| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
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| EP3752161A4 (en) * | 2018-02-15 | 2021-12-22 | Children's Hospital Medical Center | METHOD OF TREATMENT OF FIBROSE |
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| EP1853261B1 (de) | 2005-03-03 | 2017-01-11 | Universität des Saarlandes | Selektive hemmstoffe humaner corticoidsynthasen |
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| JP2009542608A (ja) | 2006-06-29 | 2009-12-03 | アステックス・セラピューティクス・リミテッド | 医薬組合せ剤 |
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-
2006
- 2006-12-29 JP JP2008548032A patent/JP5474354B2/ja not_active Expired - Fee Related
- 2006-12-29 US US12/159,054 patent/US8399442B2/en not_active Expired - Fee Related
- 2006-12-29 WO PCT/GB2006/004954 patent/WO2007077435A1/en not_active Ceased
- 2006-12-29 EP EP06831505A patent/EP1968579A1/en not_active Withdrawn
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