JP2009528824A5 - - Google Patents
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- JP2009528824A5 JP2009528824A5 JP2008557434A JP2008557434A JP2009528824A5 JP 2009528824 A5 JP2009528824 A5 JP 2009528824A5 JP 2008557434 A JP2008557434 A JP 2008557434A JP 2008557434 A JP2008557434 A JP 2008557434A JP 2009528824 A5 JP2009528824 A5 JP 2009528824A5
- Authority
- JP
- Japan
- Prior art keywords
- modified
- amino acid
- coli
- aars
- translation system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 23
- 235000001014 amino acid Nutrition 0.000 claims 22
- 108020004566 Transfer RNA Proteins 0.000 claims 20
- 150000001413 amino acids Chemical class 0.000 claims 20
- 210000004027 cell Anatomy 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 8
- 101000640990 Arabidopsis thaliana Tryptophan-tRNA ligase, chloroplastic/mitochondrial Proteins 0.000 claims 7
- 241000588724 Escherichia coli Species 0.000 claims 7
- 241000064099 Massilioclostridium coli Species 0.000 claims 7
- 108010003060 Methionine-tRNA ligase Proteins 0.000 claims 7
- 102100037206 Methionine-tRNA ligase, cytoplasmic Human genes 0.000 claims 7
- 102100034300 Tryptophan-tRNA ligase, cytoplasmic Human genes 0.000 claims 7
- -1 6-chloroindolyl Chemical group 0.000 claims 6
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
- 235000004279 alanine Nutrition 0.000 claims 6
- 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 claims 5
- 102100034298 Tyrosine-tRNA ligase, cytoplasmic Human genes 0.000 claims 5
- 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 claims 5
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 4
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- ROEBGGKWVJLWSP-MRVPVSSYSA-N (2r)-2-amino-3-(4-ethynyl-1h-pyrrol-3-yl)propanoic acid Chemical compound OC(=O)[C@H](N)CC1=CNC=C1C#C ROEBGGKWVJLWSP-MRVPVSSYSA-N 0.000 claims 2
- PEMUHKUIQHFMTH-QMMMGPOBSA-N (2s)-2-amino-3-(4-bromophenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(Br)C=C1 PEMUHKUIQHFMTH-QMMMGPOBSA-N 0.000 claims 2
- PPDNGMUGVMESGE-JTQLQIEISA-N (2s)-2-amino-3-(4-ethynylphenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(C#C)C=C1 PPDNGMUGVMESGE-JTQLQIEISA-N 0.000 claims 2
- JSXMFBNJRFXRCX-NSHDSACASA-N (2s)-2-amino-3-(4-prop-2-ynoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(OCC#C)C=C1 JSXMFBNJRFXRCX-NSHDSACASA-N 0.000 claims 2
- FLHDTNWRXMTPMP-NSHDSACASA-N (2s)-2-amino-3-(5-ethynyl-1h-indol-3-yl)propanoic acid Chemical compound C1=C(C#C)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 FLHDTNWRXMTPMP-NSHDSACASA-N 0.000 claims 2
- UIKHEWRXMDFLKN-NSHDSACASA-N (2s)-2-amino-3-(6-ethynyl-1h-indol-3-yl)propanoic acid Chemical compound C#CC1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 UIKHEWRXMDFLKN-NSHDSACASA-N 0.000 claims 2
- HTFFMYRVHHNNBE-YFKPBYRVSA-N (2s)-2-amino-6-azidohexanoic acid Chemical compound OC(=O)[C@@H](N)CCCCN=[N+]=[N-] HTFFMYRVHHNNBE-YFKPBYRVSA-N 0.000 claims 2
- ZXSBHXZKWRIEIA-JTQLQIEISA-N (2s)-3-(4-acetylphenyl)-2-azaniumylpropanoate Chemical compound CC(=O)C1=CC=C(C[C@H](N)C(O)=O)C=C1 ZXSBHXZKWRIEIA-JTQLQIEISA-N 0.000 claims 2
- AKVBCGQVQXPRLD-UHFFFAOYSA-N 2-aminooctanoic acid Chemical compound CCCCCCC(N)C(O)=O AKVBCGQVQXPRLD-UHFFFAOYSA-N 0.000 claims 2
- OFYAYGJCPXRNBL-UHFFFAOYSA-N 2-azaniumyl-3-naphthalen-1-ylpropanoate Chemical compound C1=CC=C2C(CC(N)C(O)=O)=CC=CC2=C1 OFYAYGJCPXRNBL-UHFFFAOYSA-N 0.000 claims 2
- PZNQZSRPDOEBMS-QMMMGPOBSA-N 4-iodo-L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(I)C=C1 PZNQZSRPDOEBMS-QMMMGPOBSA-N 0.000 claims 2
- 241001112695 Clostridiales Species 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 2
- NIGWMJHCCYYCSF-UHFFFAOYSA-N Fenclonine Chemical compound OC(=O)C(N)CC1=CC=C(Cl)C=C1 NIGWMJHCCYYCSF-UHFFFAOYSA-N 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 102000002265 Human Growth Hormone Human genes 0.000 claims 2
- 108010000521 Human Growth Hormone Proteins 0.000 claims 2
- 239000000854 Human Growth Hormone Substances 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- 241000589516 Pseudomonas Species 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 238000010348 incorporation Methods 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 claims 2
- XHBJLKMBAFTWJD-JTQLQIEISA-N (2s)-2-amino-3-(3-ethynylphenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=CC(C#C)=C1 XHBJLKMBAFTWJD-JTQLQIEISA-N 0.000 claims 1
- NEMHIKRLROONTL-QMMMGPOBSA-N (2s)-2-azaniumyl-3-(4-azidophenyl)propanoate Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N=[N+]=[N-])C=C1 NEMHIKRLROONTL-QMMMGPOBSA-N 0.000 claims 1
- NNWQLZWAZSJGLY-VKHMYHEASA-N (2s)-2-azaniumyl-4-azidobutanoate Chemical compound OC(=O)[C@@H](N)CCN=[N+]=[N-] NNWQLZWAZSJGLY-VKHMYHEASA-N 0.000 claims 1
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 1
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 1
- 108020005098 Anticodon Proteins 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- QWCKQJZIFLGMSD-VKHMYHEASA-N L-alpha-aminobutyric acid Chemical compound CC[C@H](N)C(O)=O QWCKQJZIFLGMSD-VKHMYHEASA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77937606P | 2006-03-03 | 2006-03-03 | |
| US77937506P | 2006-03-03 | 2006-03-03 | |
| US60/779,375 | 2006-03-03 | ||
| US60/779,376 | 2006-03-03 | ||
| PCT/US2007/005581 WO2007103307A2 (en) | 2006-03-03 | 2007-03-05 | Site-specific incorporation of amino acids into molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013095341A Division JP2013146274A (ja) | 2006-03-03 | 2013-04-30 | 分子へのアミノ酸の部位特異的な組み込み |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528824A JP2009528824A (ja) | 2009-08-13 |
| JP2009528824A5 true JP2009528824A5 (enExample) | 2011-04-14 |
| JP5808882B2 JP5808882B2 (ja) | 2015-11-10 |
Family
ID=38462077
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557434A Active JP5808882B2 (ja) | 2006-03-03 | 2007-03-05 | 分子へのアミノ酸の部位特異的な組み込み |
| JP2013095341A Pending JP2013146274A (ja) | 2006-03-03 | 2013-04-30 | 分子へのアミノ酸の部位特異的な組み込み |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013095341A Pending JP2013146274A (ja) | 2006-03-03 | 2013-04-30 | 分子へのアミノ酸の部位特異的な組み込み |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8518666B2 (enExample) |
| EP (1) | EP1999259B1 (enExample) |
| JP (2) | JP5808882B2 (enExample) |
| AU (2) | AU2007224019A1 (enExample) |
| CA (1) | CA2644474A1 (enExample) |
| DK (1) | DK1999259T3 (enExample) |
| ES (1) | ES2504521T3 (enExample) |
| PL (1) | PL1999259T3 (enExample) |
| PT (1) | PT1999259E (enExample) |
| SI (1) | SI1999259T1 (enExample) |
| WO (1) | WO2007103307A2 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| CA2653748A1 (en) * | 2006-05-02 | 2007-11-15 | Allozyne, Inc. | Non-natural amino acid substituted polypeptides |
| US20080096819A1 (en) * | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| CA2707840A1 (en) * | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| EP2220218A4 (en) * | 2007-11-02 | 2010-12-08 | Scripps Research Inst | GENETICALLY ENCODED BORONATE AMINO ACID |
| EP2379578A4 (en) | 2009-01-12 | 2012-05-02 | Sutro Biopharma Inc | DOUBLE-LOADING SYSTEM FOR THE SELECTIVE INTRODUCTION OF NON-NITIVE AMINO ACIDS IN PROTEINS DUE TO AN IN VITRO-SYNTHESIS PROCESS |
| ES2552773T3 (es) | 2009-02-27 | 2015-12-02 | Atyr Pharma, Inc. | Motivos estructurales de polipéptidos asociados con la actividad de señalización celular |
| RU2012123642A (ru) * | 2009-12-11 | 2014-01-20 | Кейз Вестерн Ризев Юнивесити | Аналоги инсулина, содержащие хлорированные аминокислоты |
| CA2797093C (en) | 2010-04-26 | 2019-10-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
| CA2797259C (en) | 2010-04-27 | 2020-09-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl trna synthetases |
| CA2797362C (en) | 2010-04-27 | 2020-12-08 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases |
| WO2011139853A2 (en) | 2010-04-28 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases |
| EP2563383B1 (en) | 2010-04-29 | 2017-03-01 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
| US8986680B2 (en) | 2010-04-29 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
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| CA2797977C (en) | 2010-05-03 | 2019-08-20 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
| AU2011248357B2 (en) | 2010-05-03 | 2017-02-23 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases |
| WO2011139986A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases |
| EP2566499B1 (en) | 2010-05-04 | 2017-01-25 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex |
| US9062301B2 (en) | 2010-05-04 | 2015-06-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases |
| CA2799197C (en) | 2010-05-14 | 2019-10-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases |
| US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
| AU2011258106B2 (en) | 2010-05-27 | 2017-02-23 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
| CN103118694B (zh) | 2010-06-01 | 2016-08-03 | Atyr医药公司 | 与赖氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| CA2804278C (en) | 2010-07-12 | 2021-07-13 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
| JP6116479B2 (ja) | 2010-07-12 | 2017-04-19 | エータイアー ファーマ， インコーポレイテッド | グリシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| EP2593126B1 (en) | 2010-07-12 | 2017-09-20 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| JP5964304B2 (ja) | 2010-08-25 | 2016-08-03 | エータイアー ファーマ， インコーポレイテッド | チロシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| KR20130096731A (ko) | 2010-09-08 | 2013-08-30 | 할로자임, 아이엔씨 | 조건부 활성 치료적 단백질을 평가，확인 또는 진화시키는 방법 |
| CA2812795C (en) | 2010-10-06 | 2021-08-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases |
| US20140140962A1 (en) * | 2011-04-29 | 2014-05-22 | The Research Foundation Of State University Of New York | Viruses modified with unnatural moieties and methods of use thereof |
| WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
| EP3199624B1 (en) | 2011-11-03 | 2019-09-11 | Yeda Research and Development Co. Ltd. | Transgenic plants resistant to non-protein amino acids |
| US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
| WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
| TWI852183B (zh) | 2011-12-28 | 2024-08-11 | 日商中外製藥股份有限公司 | 胜肽化合物之環化方法 |
| CN104220461A (zh) | 2011-12-29 | 2014-12-17 | Atyr医药公司 | 天冬氨酰-tRNA合成酶-FC缀合物 |
| WO2013188635A2 (en) * | 2012-06-14 | 2013-12-19 | The Trustees Of The University Of Pennsylvania | Novel methods of identifying proteins via n-terminal tagging and selective pull-down |
| CN114717206A (zh) | 2013-03-15 | 2022-07-08 | Atyr 医药公司 | 组氨酰-trna合成酶-fc缀合物 |
| EP2979168A4 (en) * | 2013-03-29 | 2016-11-23 | Univ Washington Ct Commerciali | SYSTEMS, ALGORITHMS AND SOFTWARE FOR THE DESIGN OF A MOLECULAR INVERSION PROBE (MIP) |
| EP2876165A1 (en) | 2013-11-22 | 2015-05-27 | ACIB GmbH | Improved method for producing modifed target polypeptides |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10815489B2 (en) | 2015-03-13 | 2020-10-27 | Chugai Seiyaku Kabushiki Kaisha | Modified aminoacyl-tRNA synthetase and use thereof |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| GB201600512D0 (en) * | 2016-01-12 | 2016-02-24 | Univ York | Recombinant protein production |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
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| SG10201912034UA (en) | 2017-02-08 | 2020-02-27 | Bristol Myers Squibb Co | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| JP6917050B2 (ja) * | 2017-03-06 | 2021-08-11 | 学校法人早稲田大学 | 最適特性を有する非天然型タンパク質の製造方法 |
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| EP3636656A4 (en) | 2017-06-09 | 2021-04-14 | Chugai Seiyaku Kabushiki Kaisha | METHOD OF SYNTHESIS OF PEPTIDE WITH N-SUBSTITUTED AMINO ACID |
| CA3070915C (en) * | 2017-07-25 | 2023-08-08 | Biocon Limited | Peptide mapping method for sequence identification of insulin & insulin analogues |
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| CN108588040B (zh) * | 2018-06-08 | 2021-06-15 | 中国医学科学院病原生物学研究所 | 重组MtMetRS、其晶体及它们在制备抗结核药物中的应用 |
| KR20210057124A (ko) * | 2018-09-11 | 2021-05-20 | 암브룩스, 인코포레이티드 | 인터류킨-2 폴리펩타이드 접합체 및 그의 용도 |
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| CN119143631A (zh) | 2018-11-30 | 2024-12-17 | 中外制药株式会社 | 用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法 |
| KR102850080B1 (ko) | 2018-12-26 | 2025-08-22 | 추가이 세이야쿠 가부시키가이샤 | 코돈 확장을 위한 변이 tRNA |
| JP2022525333A (ja) * | 2019-03-13 | 2022-05-12 | セント・ジュード・チルドレンズ・リサーチ・ホスピタル | 肺炎連鎖球菌の伝染を低減させるためのワクチン組成物および方法 |
| KR102994657B1 (ko) | 2019-03-15 | 2026-07-22 | 추가이 세이야쿠 가부시키가이샤 | 방향족 아미노산 유도체의 제조 방법 |
| EP4043478A4 (en) | 2019-11-07 | 2024-01-03 | Chugai Seiyaku Kabushiki Kaisha | CYCLIC PEPTIDE COMPOUND HAVING KRAS INHIBITING ACTION |
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| KR20220161422A (ko) | 2020-03-31 | 2022-12-06 | 프로토머 테크놀로지스 인크. | 비시날 디올에 대한 선택적인 반응을 위한 접합체 |
| AR122020A1 (es) | 2020-05-05 | 2022-08-03 | Genentech Inc | Sistemas y métodos para la conjugación específica de sitio de proteínas mediada por tirosinasa |
| KR20230028363A (ko) | 2020-06-25 | 2023-02-28 | 추가이 세이야쿠 가부시키가이샤 | 개변된 유전 암호표를 갖는 번역계 |
| CN116171164A (zh) | 2020-10-17 | 2023-05-26 | 太阳医药工业有限公司 | Glp-1/gip双重激动剂 |
| KR20230110505A (ko) | 2020-11-19 | 2023-07-24 | 프로토머 테크놀로지스 인크. | 방향족 붕소-함유 화합물 및 인슐린 유사체 |
| WO2023069816A2 (en) | 2021-09-20 | 2023-04-27 | The Broad Institute, Inc. | Compositions and methods for multiplex decoding of quadruplet codons |
| PE20251287A1 (es) | 2022-05-18 | 2025-05-14 | Protomer Tech Inc | Compuestos aromaticos que contienen boro y analogos de insulina relacionados |
| AU2023289670A1 (en) * | 2022-06-22 | 2025-01-23 | The University Of Chicago | ENGINEERED tRNA AND METHODS OF USE |
| CN116376851A (zh) * | 2022-08-25 | 2023-07-04 | 凯莱英医药集团（天津）股份有限公司 | 氨酰tRNA合酶突变体及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2106301C (en) | 1991-03-18 | 1999-04-06 | Chi-Huey Wong | Oligosaccharide enzyme substrates and inhibitors: method and compositions |
| DK0974111T3 (da) | 1997-04-11 | 2003-04-22 | California Inst Of Techn | Apparat og metode til automatiseret design af proteiner |
| US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| ES2464532T3 (es) * | 2001-04-19 | 2014-06-03 | The Scripps Research Institute | Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa |
| EP1490677A4 (en) * | 2002-02-27 | 2006-01-18 | California Inst Of Techn | COMPUTER METHOD FOR DESIGNING ENZYMES FOR THE INCORPORATION OF AMINO ACID ANALOGUES INTO PROTEINS |
| EP1558747B1 (en) | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| BRPI0507169A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
| US20050260711A1 (en) | 2004-03-30 | 2005-11-24 | Deepshikha Datta | Modulating pH-sensitive binding using non-natural amino acids |
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| JP2008507280A (ja) | 2004-07-21 | 2008-03-13 | アンブレツクス・インコーポレイテツド | 非天然コードアミノ酸を用いた生合成ポリペプチド |
| US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| WO2006045116A2 (en) | 2004-10-20 | 2006-04-27 | The Scripps Research Institute | In vivo site-specific incorporation of n-acetyl-galactosamine amino acids in eubacteria |
| NZ555308A (en) | 2004-12-22 | 2010-10-29 | Ambrx Inc | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| JP4990792B2 (ja) | 2004-12-22 | 2012-08-01 | アンブレツクス・インコーポレイテツド | アミノアシル−ｔＲＮＡシンテターゼの組成物およびこの使用 |
| AU2006255280A1 (en) | 2005-06-03 | 2006-12-14 | Ambrx, Inc. | Incorporation of non-naturally encoded amino acids into proteins |
| WO2007021297A1 (en) | 2005-08-18 | 2007-02-22 | Ambrx, Inc. | COMPOSITIONS OF tRNA AND USES THEREOF |
| KR101423898B1 (ko) | 2005-12-14 | 2014-07-28 | 암브룩스, 인코포레이티드 | 비-천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비-천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비-천연 아미노산 및 폴리펩티드의 용도 |
| AU2007215566A1 (en) | 2006-01-19 | 2007-08-23 | Ambrx, Inc. | Non-natural amino acid polypeptides having modulated immunogenicity |
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2007
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- 2007-03-05 CA CA002644474A patent/CA2644474A1/en not_active Abandoned
- 2007-03-05 DK DK07752295.1T patent/DK1999259T3/da active
- 2007-03-05 EP EP07752295.1A patent/EP1999259B1/en not_active Not-in-force
- 2007-03-05 US US11/682,272 patent/US8518666B2/en not_active Expired - Fee Related
- 2007-03-05 JP JP2008557434A patent/JP5808882B2/ja active Active
- 2007-03-05 WO PCT/US2007/005581 patent/WO2007103307A2/en not_active Ceased
- 2007-03-05 PL PL07752295T patent/PL1999259T3/pl unknown
- 2007-03-05 PT PT77522951T patent/PT1999259E/pt unknown
- 2007-03-05 ES ES07752295.1T patent/ES2504521T3/es active Active
- 2007-03-05 SI SI200731519T patent/SI1999259T1/sl unknown
-
2013
- 2013-04-30 JP JP2013095341A patent/JP2013146274A/ja active Pending
- 2013-08-16 US US13/969,368 patent/US8980581B2/en active Active
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2014
- 2014-05-20 AU AU2014202733A patent/AU2014202733A1/en not_active Abandoned
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