JP2008513040A5 - - Google Patents
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- Publication number
- JP2008513040A5 JP2008513040A5 JP2007533630A JP2007533630A JP2008513040A5 JP 2008513040 A5 JP2008513040 A5 JP 2008513040A5 JP 2007533630 A JP2007533630 A JP 2007533630A JP 2007533630 A JP2007533630 A JP 2007533630A JP 2008513040 A5 JP2008513040 A5 JP 2008513040A5
- Authority
- JP
- Japan
- Prior art keywords
- trna
- amino acid
- seq
- phe
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001413 amino acids Chemical class 0.000 claims 52
- 210000004027 cell Anatomy 0.000 claims 36
- 235000001014 amino acid Nutrition 0.000 claims 34
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 21
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 21
- 108091033319 polynucleotide Proteins 0.000 claims 21
- 102000040430 polynucleotide Human genes 0.000 claims 21
- 239000002157 polynucleotide Substances 0.000 claims 21
- DOCYTUNUHIGJTI-QMMMGPOBSA-N (2r)-2-[(2-nitrophenyl)methylamino]-3-sulfanylpropanoic acid Chemical compound OC(=O)[C@H](CS)NCC1=CC=CC=C1[N+]([O-])=O DOCYTUNUHIGJTI-QMMMGPOBSA-N 0.000 claims 20
- 108020004705 Codon Proteins 0.000 claims 17
- 235000018102 proteins Nutrition 0.000 claims 17
- 102000004169 proteins and genes Human genes 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 17
- AKVBCGQVQXPRLD-UHFFFAOYSA-N 2-aminooctanoic acid Chemical compound CCCCCCC(N)C(O)=O AKVBCGQVQXPRLD-UHFFFAOYSA-N 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 241000588724 Escherichia coli Species 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- GEYBMYRBIABFTA-VIFPVBQESA-N O-methyl-L-tyrosine Chemical compound COC1=CC=C(C[C@H](N)C(O)=O)C=C1 GEYBMYRBIABFTA-VIFPVBQESA-N 0.000 claims 5
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 125000001295 dansyl group Chemical group [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(*)(=O)=O 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 4
- 150000003355 serines Chemical class 0.000 claims 4
- 241001112695 Clostridiales Species 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 210000005253 yeast cell Anatomy 0.000 claims 3
- 241000203407 Methanocaldococcus jannaschii Species 0.000 claims 2
- 108020005038 Terminator Codon Proteins 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000004952 protein activity Effects 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- ZCIVZGYOBRGUMA-VIFPVBQESA-N (2r)-2-[benzyl(nitro)amino]-3-sulfanylpropanoic acid Chemical compound OC(=O)[C@H](CS)N([N+]([O-])=O)CC1=CC=CC=C1 ZCIVZGYOBRGUMA-VIFPVBQESA-N 0.000 claims 1
- KLSJWNVTNUYHDU-UHFFFAOYSA-N Amitrole Chemical compound NC1=NC=NN1 KLSJWNVTNUYHDU-UHFFFAOYSA-N 0.000 claims 1
- 108010016529 Bacillus amyloliquefaciens ribonuclease Proteins 0.000 claims 1
- 108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 claims 1
- 108010001515 Galectin 4 Proteins 0.000 claims 1
- 102100039556 Galectin-4 Human genes 0.000 claims 1
- 101100246753 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) pyrF gene Proteins 0.000 claims 1
- 108010071170 Leucine-tRNA ligase Proteins 0.000 claims 1
- 102100023339 Leucine-tRNA ligase, cytoplasmic Human genes 0.000 claims 1
- 241000203353 Methanococcus Species 0.000 claims 1
- 101150050575 URA3 gene Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000689 aminoacylating effect Effects 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims 1
- 229960005091 chloramphenicol Drugs 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61222304P | 2004-09-21 | 2004-09-21 | |
| US62062504P | 2004-10-19 | 2004-10-19 | |
| PCT/US2005/034002 WO2006034410A2 (en) | 2004-09-21 | 2005-09-21 | Adding photoregulated amino acids to the genetic code |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513040A JP2008513040A (ja) | 2008-05-01 |
| JP2008513040A5 true JP2008513040A5 (enExample) | 2008-11-13 |
Family
ID=36090678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533630A Abandoned JP2008513040A (ja) | 2004-09-21 | 2005-09-21 | 光調節型アミノ酸の遺伝コード付加 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20090181858A1 (enExample) |
| EP (1) | EP1797177A4 (enExample) |
| JP (1) | JP2008513040A (enExample) |
| WO (1) | WO2006034410A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2464532T3 (es) * | 2001-04-19 | 2014-06-03 | The Scripps Research Institute | Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa |
| EP1558747B1 (en) * | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| JP5642916B2 (ja) * | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| EP1794312A4 (en) * | 2004-09-22 | 2009-08-12 | Scripps Research Inst | LOCAL LABELING OF PROTEINS FOR NMR STUDIES |
| MX2007004892A (es) * | 2004-10-27 | 2007-08-16 | Scripps Research Inst | Componentes de traduccion ortogonales para la incorporacion in vivo de aminoacidos no naturales. |
| CA2624290A1 (en) * | 2005-10-12 | 2007-04-26 | Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| AU2007224019A1 (en) | 2006-03-03 | 2007-09-13 | California Institute Of Technology | Site-specific incorporation of amino acids into molecules |
| MX2008011470A (es) | 2006-03-09 | 2008-09-24 | Scripps Research Inst | Sistemas para la expresion de componentes de traduccion ortogonales en celulas huesped eubacterianas. |
| US7790847B2 (en) | 2006-03-16 | 2010-09-07 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
| US7807411B2 (en) * | 2006-05-23 | 2010-10-05 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| US8114627B2 (en) * | 2006-09-21 | 2012-02-14 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| CN101535338A (zh) * | 2006-10-18 | 2009-09-16 | 斯克利普斯研究院 | 在哺乳动物细胞中将非天然氨基酸遗传掺入蛋白质 |
| WO2008091863A1 (en) | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| WO2009049223A2 (en) * | 2007-10-10 | 2009-04-16 | Irm Llc | Methods and compositions for the site-selective incorporation of fluorinated amino acids into polypeptides |
| EP2217707B1 (en) * | 2007-10-25 | 2014-10-15 | The Scripps Research Institute | Genetic incorporation of 3-aminotyrosine into reductases |
| EP2220218A4 (en) * | 2007-11-02 | 2010-12-08 | Scripps Research Inst | GENETICALLY ENCODED BORONATE AMINO ACID |
| US9150849B2 (en) | 2007-11-02 | 2015-10-06 | The Scripps Research Institute | Directed evolution using proteins comprising unnatural amino acids |
| JP2011527886A (ja) | 2007-12-11 | 2011-11-10 | ザ スクリプス リサーチ インスティチュート | メタノール資化性酵母ピキア・パストリスにおけるインビボ非天然アミノ酸発現 |
| CA2712080A1 (en) * | 2008-02-08 | 2009-08-13 | The Scripps Research Institute | Breaking immunological tolerance with a genetically encoded unnatural amino acid |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| EP2370473B1 (en) | 2008-12-10 | 2016-05-11 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
| CA2792213A1 (en) * | 2010-03-05 | 2011-09-09 | Medical Research Council | Genetically encoded photo control |
| EP3381932A1 (en) | 2017-03-28 | 2018-10-03 | Technische Universität Berlin | Modified mussel proteins, uses thereof and related compounds |
| CN110637026A (zh) * | 2017-05-10 | 2019-12-31 | 慕尼黑工业大学 | 光转换的多肽及其用途 |
| AU2020210884A1 (en) * | 2019-01-25 | 2021-08-12 | Synthego Corporation | Systems and methods for modulating CRISPR activity |
| CA3150276A1 (en) * | 2019-08-08 | 2021-02-11 | Brickbio, Inc. | Aminoacyl-trna synthetases and cell lines for site-specific incorporation of unnatural amino acids |
| US20230313129A1 (en) * | 2020-08-07 | 2023-10-05 | Brickbio, Inc. | Stable cell lines for site-specific incorporation of unnatural amino acids |
| WO2025212981A1 (en) * | 2024-04-05 | 2025-10-09 | President And Fellows Of Harvard College | Orthogonal aminoacyl trna synthetase pairs for protein production |
| CN119219791B (zh) * | 2024-09-29 | 2025-08-12 | 西湖大学 | 光响应组装蛋白及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1558747B1 (en) * | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
-
2005
- 2005-09-21 US US11/662,749 patent/US20090181858A1/en not_active Abandoned
- 2005-09-21 WO PCT/US2005/034002 patent/WO2006034410A2/en not_active Ceased
- 2005-09-21 JP JP2007533630A patent/JP2008513040A/ja not_active Abandoned
- 2005-09-21 US US11/233,508 patent/US20060134746A1/en not_active Abandoned
- 2005-09-21 EP EP05815319A patent/EP1797177A4/en not_active Withdrawn
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