JP2008513040A - 光調節型アミノ酸の遺伝コード付加 - Google Patents

光調節型アミノ酸の遺伝コード付加 Download PDF

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Publication number
JP2008513040A
JP2008513040A JP2007533630A JP2007533630A JP2008513040A JP 2008513040 A JP2008513040 A JP 2008513040A JP 2007533630 A JP2007533630 A JP 2007533630A JP 2007533630 A JP2007533630 A JP 2007533630A JP 2008513040 A JP2008513040 A JP 2008513040A
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JP
Japan
Prior art keywords
trna
amino acid
protein
phe
azobenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2007533630A
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English (en)
Japanese (ja)
Other versions
JP2008513040A5 (enExample
Inventor
アレキサンダー・ディーターズ
ニング・ウー
ピーター・ジー．・シュルツ
デヴィッド・キング
アシュトン・クロップ・ティー．
モフア・ボース
ダン・グロフ
ジアンミング・ズィー
エリック・ブルッスタッド
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Scripps Research Institute
Original Assignee
Scripps Research Institute
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Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of JP2008513040A publication Critical patent/JP2008513040A/ja
Publication of JP2008513040A5 publication Critical patent/JP2008513040A5/ja
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2007533630A 2004-09-21 2005-09-21 光調節型アミノ酸の遺伝コード付加 Abandoned JP2008513040A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61222304P 2004-09-21 2004-09-21
US62062504P 2004-10-19 2004-10-19
PCT/US2005/034002 WO2006034410A2 (en) 2004-09-21 2005-09-21 Adding photoregulated amino acids to the genetic code

Publications (2)

Publication Number Publication Date
JP2008513040A true JP2008513040A (ja) 2008-05-01
JP2008513040A5 JP2008513040A5 (enExample) 2008-11-13

Family

ID=36090678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007533630A Abandoned JP2008513040A (ja) 2004-09-21 2005-09-21 光調節型アミノ酸の遺伝コード付加

Country Status (4)

Country Link
US (2) US20090181858A1 (enExample)
EP (1) EP1797177A4 (enExample)
JP (1) JP2008513040A (enExample)
WO (1) WO2006034410A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013521269A (ja) * 2010-03-05 2013-06-10 メディカル リサーチ カウンシル 遺伝的にコードされた光制御
JP2020520348A (ja) * 2017-05-10 2020-07-09 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP2022523055A (ja) * 2019-01-25 2022-04-21 シンテゴ コーポレイション Ｃｒｉｓｐｒ活性をモジュレートするための系および方法

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2464532T3 (es) * 2001-04-19 2014-06-03 The Scripps Research Institute Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa
EP1558747B1 (en) * 2002-10-16 2009-10-14 The Scripps Research Institute Glycoprotein synthesis
JP5642916B2 (ja) * 2003-04-17 2014-12-17 ザ スクリプス リサーチ インスティテュート 真核遺伝コードの拡張
WO2005019415A2 (en) 2003-07-07 2005-03-03 The Scripps Research Institute Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
US20050287639A1 (en) 2004-05-17 2005-12-29 California Institute Of Technology Methods of incorporating amino acid analogs into proteins
EP1794312A4 (en) * 2004-09-22 2009-08-12 Scripps Research Inst LOCAL LABELING OF PROTEINS FOR NMR STUDIES
MX2007004892A (es) * 2004-10-27 2007-08-16 Scripps Research Inst Componentes de traduccion ortogonales para la incorporacion in vivo de aminoacidos no naturales.
CA2624290A1 (en) * 2005-10-12 2007-04-26 Scripps Research Institute Selective posttranslational modification of phage-displayed polypeptides
AU2007224019A1 (en) 2006-03-03 2007-09-13 California Institute Of Technology Site-specific incorporation of amino acids into molecules
MX2008011470A (es) 2006-03-09 2008-09-24 Scripps Research Inst Sistemas para la expresion de componentes de traduccion ortogonales en celulas huesped eubacterianas.
US7790847B2 (en) 2006-03-16 2010-09-07 The Scripps Research Institute Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
US7807411B2 (en) * 2006-05-23 2010-10-05 The Scripps Research Institute Genetically encoded fluorescent coumarin amino acids
US8114627B2 (en) * 2006-09-21 2012-02-14 The Scripps Research Institute Genetically programmed expression of selectively sulfated proteins in eubacteria
CN101535338A (zh) * 2006-10-18 2009-09-16 斯克利普斯研究院 在哺乳动物细胞中将非天然氨基酸遗传掺入蛋白质
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
WO2009049223A2 (en) * 2007-10-10 2009-04-16 Irm Llc Methods and compositions for the site-selective incorporation of fluorinated amino acids into polypeptides
EP2217707B1 (en) * 2007-10-25 2014-10-15 The Scripps Research Institute Genetic incorporation of 3-aminotyrosine into reductases
EP2220218A4 (en) * 2007-11-02 2010-12-08 Scripps Research Inst GENETICALLY ENCODED BORONATE AMINO ACID
US9150849B2 (en) 2007-11-02 2015-10-06 The Scripps Research Institute Directed evolution using proteins comprising unnatural amino acids
JP2011527886A (ja) 2007-12-11 2011-11-10 ザ スクリプス リサーチ インスティチュート メタノール資化性酵母ピキア・パストリスにおけるインビボ非天然アミノ酸発現
CA2712080A1 (en) * 2008-02-08 2009-08-13 The Scripps Research Institute Breaking immunological tolerance with a genetically encoded unnatural amino acid
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
EP2370473B1 (en) 2008-12-10 2016-05-11 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
EP3381932A1 (en) 2017-03-28 2018-10-03 Technische Universität Berlin Modified mussel proteins, uses thereof and related compounds
CA3150276A1 (en) * 2019-08-08 2021-02-11 Brickbio, Inc. Aminoacyl-trna synthetases and cell lines for site-specific incorporation of unnatural amino acids
US20230313129A1 (en) * 2020-08-07 2023-10-05 Brickbio, Inc. Stable cell lines for site-specific incorporation of unnatural amino acids
WO2025212981A1 (en) * 2024-04-05 2025-10-09 President And Fellows Of Harvard College Orthogonal aminoacyl trna synthetase pairs for protein production
CN119219791B (zh) * 2024-09-29 2025-08-12 西湖大学 光响应组装蛋白及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1558747B1 (en) * 2002-10-16 2009-10-14 The Scripps Research Institute Glycoprotein synthesis

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013521269A (ja) * 2010-03-05 2013-06-10 メディカル リサーチ カウンシル 遺伝的にコードされた光制御
JP2020520348A (ja) * 2017-05-10 2020-07-09 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP7221537B2 (ja) 2017-05-10 2023-02-14 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP2022523055A (ja) * 2019-01-25 2022-04-21 シンテゴ コーポレイション Ｃｒｉｓｐｒ活性をモジュレートするための系および方法

Also Published As

Publication number Publication date
US20090181858A1 (en) 2009-07-16
WO2006034410A3 (en) 2006-08-03
WO2006034410A2 (en) 2006-03-30
EP1797177A2 (en) 2007-06-20
US20060134746A1 (en) 2006-06-22
EP1797177A4 (en) 2008-07-09

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