JP2008513040A - 光調節型アミノ酸の遺伝コード付加 - Google Patents

光調節型アミノ酸の遺伝コード付加 Download PDF

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Publication number
JP2008513040A
JP2008513040A JP2007533630A JP2007533630A JP2008513040A JP 2008513040 A JP2008513040 A JP 2008513040A JP 2007533630 A JP2007533630 A JP 2007533630A JP 2007533630 A JP2007533630 A JP 2007533630A JP 2008513040 A JP2008513040 A JP 2008513040A
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JP
Japan
Prior art keywords
trna
amino acid
protein
phe
azobenzyl
Prior art date
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Abandoned
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JP2007533630A
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English (en)
Japanese (ja)
Other versions
JP2008513040A5 (enExample
Inventor
アレキサンダー・ディーターズ
ニング・ウー
ピーター・ジー．・シュルツ
デヴィッド・キング
アシュトン・クロップ・ティー．
モフア・ボース
ダン・グロフ
ジアンミング・ズィー
エリック・ブルッスタッド
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Scripps Research Institute
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Scripps Research Institute
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Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of JP2008513040A publication Critical patent/JP2008513040A/ja
Publication of JP2008513040A5 publication Critical patent/JP2008513040A5/ja
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2007533630A 2004-09-21 2005-09-21 光調節型アミノ酸の遺伝コード付加 Abandoned JP2008513040A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61222304P 2004-09-21 2004-09-21
US62062504P 2004-10-19 2004-10-19
PCT/US2005/034002 WO2006034410A2 (en) 2004-09-21 2005-09-21 Adding photoregulated amino acids to the genetic code

Publications (2)

Publication Number Publication Date
JP2008513040A true JP2008513040A (ja) 2008-05-01
JP2008513040A5 JP2008513040A5 (enExample) 2008-11-13

Family

ID=36090678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007533630A Abandoned JP2008513040A (ja) 2004-09-21 2005-09-21 光調節型アミノ酸の遺伝コード付加

Country Status (4)

Country Link
US (2) US20090181858A1 (enExample)
EP (1) EP1797177A4 (enExample)
JP (1) JP2008513040A (enExample)
WO (1) WO2006034410A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013521269A (ja) * 2010-03-05 2013-06-10 メディカル リサーチ カウンシル 遺伝的にコードされた光制御
JP2020520348A (ja) * 2017-05-10 2020-07-09 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP2022523055A (ja) * 2019-01-25 2022-04-21 シンテゴ コーポレイション Ｃｒｉｓｐｒ活性をモジュレートするための系および方法

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1490483B1 (en) * 2001-04-19 2015-06-03 The Scripps Research Institute In vivo incorporation of unnatural amino acids
KR20050073559A (ko) * 2002-10-16 2005-07-14 더 스크립스 리서치 인스티튜트 당단백질 합성
CN103289960B (zh) 2003-04-17 2017-04-26 斯克利普斯研究院 扩展真核生物遗传密码
DE602004011789T2 (de) * 2003-07-07 2009-02-12 The Scripps Research Institute, La Jolla Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen
US20050287639A1 (en) 2004-05-17 2005-12-29 California Institute Of Technology Methods of incorporating amino acid analogs into proteins
JP2008513806A (ja) * 2004-09-22 2008-05-01 ザ スクリップス リサーチ インスティテュート Ｎｍｒ試験のための蛋白質の部位特異的標識
AU2005330514B2 (en) 2004-10-27 2011-05-12 The Scripps Research Institute Orthogonal translation components for the in vivo incorporation of unnatural amino acids
CA2624290A1 (en) * 2005-10-12 2007-04-26 Scripps Research Institute Selective posttranslational modification of phage-displayed polypeptides
JP5808882B2 (ja) 2006-03-03 2015-11-10 カリフォルニア インスティテュート オブ テクノロジー 分子へのアミノ酸の部位特異的な組み込み
CA2638763A1 (en) * 2006-03-09 2007-09-13 The Scripps Research Institute System for the expression of orthogonal translation components in eubacterial host cells
JP5249194B2 (ja) 2006-03-16 2013-07-31 ザ スクリプス リサーチ インスティチュート 非天然アミノ酸フェニルセレノシステインを含有するタンパク質の遺伝的にプログラムされた発現
BRPI0711811A2 (pt) * 2006-05-23 2011-12-06 Scripps Research Inst aminoácidos de cumarina fluorescente geneticamente codificados
CA2663052A1 (en) * 2006-09-21 2008-03-27 The Scripps Research Institute Genetically programmed expression of selectively sulfated proteins in eubacteria
US20080166766A1 (en) * 2006-10-18 2008-07-10 The Scripps Research Institute Genetic incorporation of unnatural amino acids into proteins in mammalian cells
US20080176861A1 (en) 2007-01-23 2008-07-24 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
WO2009049223A2 (en) * 2007-10-10 2009-04-16 Irm Llc Methods and compositions for the site-selective incorporation of fluorinated amino acids into polypeptides
KR20100088618A (ko) * 2007-10-25 2010-08-09 더 스크립스 리서치 인스티튜트 리덕타제 내로의 3-아미노티로신의 유전적 도입
BRPI0819092A2 (pt) 2007-11-02 2014-10-14 Scripps Research Inst Evolução direcionada usando proteínas que compreendem aminoácidos não naturais.
US20090148887A1 (en) * 2007-11-02 2009-06-11 The Scripps Research Institute Genetically encoded boronate amino acid
CN105647824A (zh) * 2007-12-11 2016-06-08 斯克利普斯研究院 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达
KR20100125290A (ko) * 2008-02-08 2010-11-30 더 스크립스 리서치 인스티튜트 유전적으로 코딩된 비천연 아미노산에 의한 면역 내성의 파괴
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
US8637306B2 (en) * 2008-12-10 2014-01-28 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
EP3381932A1 (en) 2017-03-28 2018-10-03 Technische Universität Berlin Modified mussel proteins, uses thereof and related compounds
US20220325269A1 (en) * 2019-08-08 2022-10-13 Brickbio, Inc. Aminoacyl-trna synthetases and cell lines for site-specific incorporation of unnatural amino acids
AU2021320894A1 (en) * 2020-08-07 2023-03-02 Brickbio, Inc. Stable cell lines for site-specific incorporation of unnatural amino acids
CN119219791B (zh) * 2024-09-29 2025-08-12 西湖大学 光响应组装蛋白及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050073559A (ko) * 2002-10-16 2005-07-14 더 스크립스 리서치 인스티튜트 당단백질 합성

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013521269A (ja) * 2010-03-05 2013-06-10 メディカル リサーチ カウンシル 遺伝的にコードされた光制御
JP2020520348A (ja) * 2017-05-10 2020-07-09 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP7221537B2 (ja) 2017-05-10 2023-02-14 テクニッシェ ウニベルシタット ミュンヘン 光切替可能ポリペプチドおよびその使用
JP2022523055A (ja) * 2019-01-25 2022-04-21 シンテゴ コーポレイション Ｃｒｉｓｐｒ活性をモジュレートするための系および方法

Also Published As

Publication number Publication date
EP1797177A2 (en) 2007-06-20
US20060134746A1 (en) 2006-06-22
WO2006034410A2 (en) 2006-03-30
EP1797177A4 (en) 2008-07-09
US20090181858A1 (en) 2009-07-16
WO2006034410A3 (en) 2006-08-03

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